977 research outputs found
Reduced neural connectivity but increased task-related activity during working memory in de novo Parkinson patients
Objective: Patients with Parkinson's disease (PD) often suffer from impairments in executive functions, such as working memory deficits. It is widely held that dopamine depletion in the striatum contributes to these impairments through decreased activity and connectivity between task-related brain networks. We investigated this hypothesis by studying task-related network activity and connectivity within a sample of de novo patients with PD, versus healthy controls, during a visuospatial working memory task. Methods: Sixteen de novo PD patients and 35 matched healthy controls performed a visuospatial n-back task while we measured their behavioral performance and neural activity using functional magnetic resonance imaging. We constructed regions-of-interest in the bilateral inferior parietal cortex (IPC), bilateral dorsolateral prefrontal cortex (DLPFC), and bilateral caudate nucleus to investigate group differences in task-related activity. We studied network connectivity by assessing the functional connectivity of the bilateral DLPFC and by assessing effective connectivity within the frontoparietal and the frontostriatal networks. Results: PD patients, compared with controls, showed trend-significantly decreased task accuracy, significantly increased task-related activity in the left DLPFC and a trend-significant increase in activity of the right DLPFC, left caudate nucleus, and left IPC. Furthermore, we found reduced functional connectivity of the DLPFC with other task-related regions, such as the inferior and superior frontal gyri, in the PD group, and group differences in effective connectivity within the frontoparietal network. Interpretation: These findings suggest that the increase in working memory-related brain activity in PD patients is compensatory to maintain behavioral performance in the presence of network deficits. Hum Brain Mapp 36:1554-1566, 2015. (c) 2015 Wiley Periodicals, Inc
Emotion regulation before and after transcranial magnetic stimulation in obsessive compulsive disorder
Impaired emotion regulation may underlie exaggerated emotional reactivity in patients with obsessive compulsive disorder (OCD), yet instructed emotion regulation has never been studied in the disorder. METHOD: This study aimed to assess the neural correlates of emotion processing and regulation in 43 medication-free OCD patients and 38 matched healthy controls, and additionally test if these can be modulated by stimulatory (patients) and inhibitory (controls) repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (dlPFC). Participants performed an emotion regulation task during functional magnetic resonance imaging before and after a single session of randomly assigned real or sham rTMS. Effect of group and rTMS were assessed on self-reported distress ratings and brain activity in frontal-limbic regions of interest. RESULTS: Patients had higher distress ratings than controls during emotion provocation, but similar rates of distress reduction after voluntary emotion regulation. OCD patients compared with controls showed altered amygdala responsiveness during symptom provocation and diminished left dlPFC activity and frontal-amygdala connectivity during emotion regulation. Real v. sham dlPFC stimulation differentially modulated frontal-amygdala connectivity during emotion regulation in OCD patients. CONCLUSIONS: We propose that the increased emotional reactivity in OCD may be due to a deficit in emotion regulation caused by a failure of cognitive control exerted by the dorsal frontal cortex. Modulatory rTMS over the left dlPFC may influence automatic emotion regulation capabilities by influencing frontal-limbic connectivity
Global burned area and biomass burning emissions from small fires
In several biomes, including croplands, wooded savannas, and tropical forests, many small fires occur each year that are well below the detection limit of the current generation of global burned area products derived from moderate resolution surface reflectance imagery. Although these fires often generate thermal anomalies that can be detected by satellites, their contributions to burned area and carbon fluxes have not been systematically quantified across different regions and continents. Here we developed a preliminary method for combining 1-km thermal anomalies (active fires) and 500 m burned area observations from the Moderate Resolution Imaging Spectroradiometer (MODIS) to estimate the influence of these fires. In our approach, we calculated the number of active fires inside and outside of 500 m burn scars derived from reflectance data. We estimated small fire burned area by computing the difference normalized burn ratio (dNBR) for these two sets of active fires and then combining these observations with other information. In a final step, we used the Global Fire Emissions Database version 3 (GFED3) biogeochemical model to estimate the impact of these fires on biomass burning emissions. We found that the spatial distribution of active fires and 500 m burned areas were in close agreement in ecosystems that experience large fires, including savannas across southern Africa and Australia and boreal forests in North America and Eurasia. In other areas, however, we observed many active fires outside of burned area perimeters. Fire radiative power was lower for this class of active fires. Small fires substantially increased burned area in several continental-scale regions, including Equatorial Asia (157%), Central America (143%), and Southeast Asia (90%) during 2001–2010. Globally, accounting for small fires increased total burned area by approximately by 35%, from 345 Mha/yr to 464 Mha/yr. A formal quantification of uncertainties was not possible, but sensitivity analyses of key model parameters caused estimates of global burned area increases from small fires to vary between 24% and 54%. Biomass burning carbon emissions increased by 35% at a global scale when small fires were included in GFED3, from 1.9 Pg C/yr to 2.5 Pg C/yr. The contribution of tropical forest fires to year-to-year variability in carbon fluxes increased because small fires amplified emissions from Central America, South America and Southeast Asia—regions where drought stress and burned area varied considerably from year to year in response to El Nino-Southern Oscillation and other climate modes
Fire-Related Carbon Emissions from Land Use Transitions in Southern Amazonia
Various land-use transitions in the tropics contribute to atmospheric carbon emissions, including forest conversion for small-scale farming, cattle ranching, and production of commodities such as soya and palm oil. These transitions involve fire as an effective and inexpensive means for clearing. We applied the DECAF (DEforestation CArbon Fluxes) model to Mato Grosso, Brazil to estimate fire emissions from various land-use transitions during 2001-2005. Fires associated with deforestation contributed 67 Tg C/yr (17 and 50 Tg C/yr from conversion to cropland and pasture, respectively), while conversion of savannas and existing cattle pasture to cropland contributed 17 Tg C/yr and pasture maintenance fires 6 Tg C/yr. Large clearings (>100 ha/yr) contributed 67% of emissions but comprised only 10% of deforestation events. From a policy perspective, results imply that intensification of agricultural production on already-cleared land and policies to discourage large clearings would reduce the major sources of emissions from fires in this region. Copyright 2008 by the American Geophysical Union
HIFI Spectroscopy of submm Lines in Nuclei of Actively Star Forming Galaxies
We present a systematic survey of multiple velocity-resolved HO spectra
using Herschel/HIFI towards nine nearby actively star forming galaxies. The
ground-state and low-excitation lines (E) show
profiles with emission and absorption blended together, while absorption-free
medium-excitation lines ()
typically display line shapes similar to CO. We analyze the HIFI observation
together with archival SPIRE/PACS HO data using a state-of-the-art 3D
radiative transfer code which includes the interaction between continuum and
line emission. The water excitation models are combined with information on the
dust- and CO spectral line energy distribution to determine the physical
structure of the interstellar medium (ISM). We identify two ISM components that
are common to all galaxies: A warm (),
dense () phase which dominates the
emission of medium-excitation HO lines. This gas phase also dominates the
FIR emission and the CO intensities for . In addition a cold
(), dense () more extended phase is present. It outputs the emission
in the low-excitation HO lines and typically also produces the prominent
line absorption features. For the two ULIRGs in our sample (Arp 220 and Mrk
231) an even hotter and more compact (R pc) region is present
which is possibly linked to AGN activity. We find that collisions dominate the
water excitation in the cold gas and for lines with
and in the warm and hot component, respectively.
Higher energy levels are mainly excited by IR pumping.Comment: Accepted by ApJ, in pres
H_2 emission arises outside photodissociation regions in ultra-luminous infrared galaxies
Ultra-luminous infrared galaxies are among the most luminous objects in the
local universe and are thought to be powered by intense star formation. It has
been shown that in these objects the rotational spectral lines of molecular
hydrogen observed at mid-infrared wavelengths are not affected by dust
obscuration, leaving unresolved the source of excitation of this emission. Here
I report an analysis of archival Spitzer Space Telescope data on ultra-luminous
infrared galaxies and demonstrate that star formation regions are buried inside
optically thick clouds of gas and dust, so that dust obscuration affects
star-formation indicators but not molecular hydrogen. I thereby establish that
the emission of H_2 is not co-spatial with the buried starburst activity and
originates outside the obscured regions. This is rather surprising in light of
the standard view that H_2 emission is directly associated with star-formation
activity. Instead, I propose that H_2 emission in these objects traces shocks
in the surrounding material, which are in turn excited by interactions with
nearby galaxies, and that powerful large-scale shocks cooling by means of H_2
emission may be much more common than previously thought. In the early
universe, a boost in H_2 emission by this process may speed up the cooling of
matter as it collapsed to form the first stars and galaxies and would make
these first structures more readily observable.Comment: Main text and supplemental information, 21 pages including 6 figures,
2 table
Fire decline in dry tropical ecosystems enhances decadal land carbon sink
The terrestrial carbon sink has significantly increased in the past decades, but the underlying mechanisms are still unclear. The current synthesis of process-based estimates of land and ocean sinks requires an additional sink of 0.6 PgC yr⁻¹ in the last decade to explain the observed airborne fraction. A concurrent global fire decline was observed in association with tropical agriculture expansion and landscape fragmentation. Here we show that a decline of 0.2 ± 0.1 PgC yr⁻¹ in fire emissions during 2008–2014 relative to 2001–2007 also induced an additional carbon sink enhancement of 0.4 ± 0.2 PgC yr⁻¹ attributable to carbon cycle feedbacks, amounting to a combined sink increase comparable to the 0.6 PgC yr⁻¹ budget imbalance. Our results suggest that the indirect effects of fire, in addition to the direct emissions, is an overlooked mechanism for explaining decadal-scale changes in the land carbon sink and highlight the importance of fire management in climate mitigation
ALMA Observations of Warm Molecular Gas and Cold Dust in NGC 34
We present ALMA Cycle-0 observations of the CO (6-5) line emission
(rest-frame frequency = 691.473 GHz) and of the 435 dust continuum
emission in the nuclear region of NGC 34, a local luminous infrared galaxy
(LIRG) at a distance of 84 Mpc (1" = 407 pc) which contains a Seyfert 2 active
galactic nucleus (AGN) and a nuclear starburst. The CO emission is well
resolved by the ALMA beam (), with an integrated flux of
. Both the morphology
and kinematics of the CO (6-5) emission are rather regular, consistent with a
compact rotating disk with a size of 200 pc. A significant emission feature is
detected on the red-shifted wing of the line profile at the frequency of the
line, with an integrated flux of . However, it cannot be ruled out
that the feature is due to an outflow of warm dense gas with a mean velocity of
. The continuum is resolved into an elongated
configuration, and the observed flux corresponds to a dust mass of . An unresolved central core () contributes of the continuum flux and of
the CO (6-5) flux, consistent with insignificant contributions of the AGN to
both emissions. Both the CO (6-5) and continuum spatial distributions suggest a
very high gas column density () in the nuclear
region at .Comment: 10 pages, 13 figures, accepted for publication in Astrophysical
Journa
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