16 research outputs found
Shrinkage versus fragmentation response in neoadjuvantly treated oesophageal adenocarcinoma: significant prognostic relevance
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/05/2022
- Field of study
Aims: No consensus exists on the clinical value of tumour regression grading (TRG) systems for therapy effects of neoadjuvant chemoradiotherapy (nCRT) in oesophageal adenocarcinoma. Existing TRG systems lack standardization and reproducibility, and do not consider the morphological heterogeneity of tumour response. Therefore, we aim to identify morphological tumour regression patterns of oesophageal adenocarcinoma after nCRT and their association with survival. Methods and results: Patients with oesophageal adenocarcinoma, who underwent nCRT followed by surgery and achieved a partial response to nCRT, were identified from two Dutch upper-gastrointestinal (GI) centres (2005–18; test cohort). Resection specimens were scored for regression patterns by two independent observers according to a pre-defined three-step flowchart. The results were validated in an external cohort (2001–17). In total, 110 patients were included in the test cohort and 115 in the validation cohort. In the test cohort, two major regression patterns were identified: fragmentation (60%) and shrinkage (40%), with an excellent interobserver agreement (κ = 0.87). Here, patients with a fragmented pattern had a significantly higher pathological stage (stages III/IV: 52 versus 16%; P < 0.001), less downstaging (48 versus 91%; P < 0.001), a higher risk of recurrence [risk ratio (RR) = 2.9, 95% confidence interval (CI) = 1.5–5.6] and poorer 5-year overall survival (30 versus 80% respectively, P = 0.001). Conclusions: The validation cohort confirmed these findings, although had more advanced cases (case-stages = III/IV 91 versus 73%, P = 0.005) and a higher prevalence of fragmented-pattern cases (80 versus 60%, P = 0.002). When combining the cohorts in multivariate analysis, the pattern of response was an independent prognostic factor [hazard ratio (HR) = 1.76, 95% CI = 1.0–3.0]. In conclusion, we established an externally validated, reproducible and clinically relevant classification of tumour response
Bi-directional signaling between the intestinal epithelium and type-3 innate lymphoid cells regulates secretory dynamics and interleukin-22
- Author
- Publication venue
- Publication date
- 10/11/2023
- Field of study
Type-3 innate lymphoid cells (ILC3) respond to localized environmental cues to regulate homeostasis and orchestrate immunity in the intestine. The intestinal epithelium is an important upstream regulator and downstream target of ILC3 signaling, however, the complexity of mucosal tissues can hinder efforts to define specific interactions between these two compartments. Here, we employ a reductionist co-culture system of murine epithelial small intestinal organoids (SIO) with ILC3 to uncover bi-directional signaling mechanisms that underlie intestinal homeostasis. We report that ILC3 induce global transcriptional changes in intestinal epithelial cells, driving the enrichment of secretory goblet cell signatures. We find that SIO enriched for goblet cells promote NKp46+ ILC3 and interleukin (IL)-22 expression, which can feedback to induce IL-22-mediated epithelial transcriptional signatures. However, we show that epithelial regulation of ILC3 in this system is contact-dependent and demonstrate a role for epithelial Delta-Like-Canonical-Notch-Ligand (Dll) in driving IL-22 production by ILC3, via subset-specific Notch1-mediated activation of T-bet+ ILC3. Finally, by interfering with Notch ligand-receptor dynamics, ILC3 appear to upregulate epithelial Atoh1 to skew secretory lineage determination in SIO-ILC3 co-cultures. This research outlines two complimentary bi-directional signaling modules between the intestinal epithelium and ILC3, which may be relevant in intestinal homeostasis and disease.</p
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adriano Enrico
- Adrião Diana
- Ageel Saleh Al
- Ahmed Shakeel
- Aiello Marina
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Adam
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Anwar Kazi Rubayet
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asaki Motohiro
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atique Anika
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Berge Marcel van den
- Bergeaud Delphine
- Bergin Hazel
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Betz Adam
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Bihan Clément Le
- Bisoffi Zeno
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Bonelli Patrizia
- Bonfasius Aurelius
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Bounphiengsy Thipsavanh
- Bountthasavong Latsaniphone
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Bris Cyril Le
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Buonsenso Danilo
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Caminiti Caterina
- Camões João
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlacci Francesca
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Carvalho Leonor
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Cárcel Sheila
- Ceccato Adrian
- Cely Lina Morales
- Cerkovnik Shelby
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chaleunphon Bounthavy
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chatterjee Allegra
- Chau Nguyen Van Vinh
- Chen Anjellica
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chetta Alfredo Antonio
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chommanam Danoy
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Christy Nathaniel
- Chua Hiu Jian
- Chua Jonathan
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clifton Lei
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Cristella Cosimo
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Curto Elena Gallego
- Custodio Paula
- D'Aragon Frédérick
- D'Orleans Charles Crepy
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Piero Maria
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- De Rose Cristina
- de Silva Thushan
- de Velde Stijn Van
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Delfos Nathalie M.
- Deligiannis Ionna
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias Andrea
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M
- Dong Andy
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douangdala Phouvieng
- Douglas James Joshua
- Douma Renee
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dryden Murray
- Dubee Vincent
- Dubos François
- Dubot-Pérès Audrey
- Ducancelle Alexandre
- Duculan Toni
- Dudman Susanne
- Duggal Abhijit
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Economopoulos Giorgio
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Elyazar Iqbal
- Enderle Isabelle
- Endo Tomoyuki
- Eng Chan Chee
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Falher Georges Le
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Feltz Machteld Van der
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferrari Carlo
- Ferraz Mário
- Ferrão Joana
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Fevre Lucie Le
- Ficko Céline
- Figueiredo-Mello Claudia
- Finlayson William
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florence Aline-Marie
- Florio Letizia Lucia
- Flynn Brigid
- Flynn Deirdre
- Fogliazza Federica
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F
- Freire Marcela Vieira
- Friedrich Caren
- Fritz Ricardo
- Fry Stéphanie
- Fuentes Nora
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Gani Yasmin
- Garan Arthur
- Garcês Rui Caetano
- Garcia Rebekha
- Garcia-Diaz Julia
- Garcia-Gallo Esteban
- García Ruth N. Jorge
- Garimella Navya
- Garofalo Federica
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- ghisulal praveen kumar
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Goh Jin Yi
- Golob Jonathan
- Gomes Rui
- Gomez Kyle
- Gominet Marie
- Gonzalez Alicia
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard Cécile
- Goulenok Tiphaine
- Gómez-Junyent Joan
- Grable Margarite
- Graf Jeronimo
- Granado Rolando Claure-Del
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Greve Frank van Someren
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gulik Laura van
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamers Raph L.
- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
- Han Lim Yuen
- Haniffa Rashan
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hartman Alan
- Hashmi Junaid
- Hattem Jarne Van
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Heng Benedict Sim Lim
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez Diana
- Hernandez-Montfort Jaime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhlin
- Higgins Rupert
- Hinchion Rita
- Hing Nicholas Yee Liang
- Hingrat Quentin Le
- Hinton Samuel
- Hiraiwa Hiroaki
- Hirkani Haider
- Hitoto Hikombo
- Ho Antonia
- Ho Yi Bin
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoh Wei Han
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Houltham Stuart
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Ijaz Samreen
- Ikram M. Arfan
- Illana Carlos Cañada
- Illes Hajnal-Gabriela
- Imbert Patrick
- Inácio Hugo
- Ing Yun Sii
- Iñiguez Jonathan Samuel Chávez
- Iosifidis Elias
- Ippolito Mariachiara
- Irawany Vera
- Isgett Sarah
- Isidoro Tiago
- Ismail Nadiah
- Isnard Margaux
- Itai Junji
- Ito Asami
- Ivulich Daniel
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Janes Victoria
- Jaquet Pierre
- Jassat Waasila
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jaworsky Denise
- Jego Florence
- Jelani Anilawati Mat
- Jenum Synne
- Jimbo-Sotomayor Ruth
- Jimenez Juan Fernado Masa
- Joe Ong Yiaw
- Joseph Cédric
- Joseph Mark
- Joshi Swosti
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Jung Hanna
- Juzar Dafsah
- Kafif Ouifiya
- Kaguelidou Florentia
- Kaisbain Neerusha
- Kaleesvran Thavamany
- Kali Sabina
- Kalicinska Alina
- Kalomoiri Smaragdi
- Kamaluddin Muhammad Aisar Ayadi
- Kamaruddin Zul Amali Che
- Kamarudin Mohd Nazlin Bin
- Kamarudin Nadiah
- Kandamby Darshana Hewa
- Kandel Chris
- Kang Kong Yeow
- Karpayah Pratap
- Karsies Todd
- Kartsonaki Christiana
- Kartsonaki Christiana
- Kasugai Daisuke
- Kataria Anant
- Katz Kevin
- Kaur Aasmine
- Kay Christy
- Keane Hannah
- Keating Seán
- Kedia Pulak
- Kelly Andrea
- Kelly Aoife
- Kelly Claire
- Kelly Niamh
- Kelly Sadie
- Kelly Yvelynne
- Kelsey Maeve
- Kennedy Ryan
- Kennon Kalynn
- Keomany Sommay
- Kernan Maeve
- Kerroumi Younes
- Keshav Sharma
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kherajani Krish
- Kho Michelle E
- Khoo Denisa
- Khoo Ryan
- Khoo Saye
- Kiat Khor How
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kim Jae Burm
- Kimmoun Antoine
- Kindgen-Milles Detlef
- King Alexander
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R
- Kobbe Robin
- Kodippily Chamira
- Komatsu Mamoru
- Korten ISARIC Collaborator
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Krishnan Sudhir
- Krishnan Vinothini
- Kruglova Oksana
- Kumar Deepali
- Kumar Ganesh
- Kuriakose Dinesh
- Kurtzman Ethan
- Kusumastuti Neurinda Permata
- Kutsogiannis Demetrios
- Kutsyna Galyna
- Kyriakoulis Konstantinos
- L'Her Erwan
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Lasry Stéphane
- Lath Sakshi
- Launay Odile
- Laureillard Didier
- Lavie-Badie Yoan
- Law Andrew
- Lawrence Cassie
- Lawrence Teresa
- Le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee Biing Horng
- Lee Heng Gee
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Lee Yi Lin
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemeur Anthony
- Lemmink Gretchen
- Lene Ha Sha
- Lennon Jenny
- Leone Marc
- Leone Michela
- León Rafael
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Lester-Grant Amy
- Letizia Andrew
- Letrou Sophie
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- Lewandowska Katarzyna
- Liang Janet
- Liegeon Geoffrey
- Lim Kah Chuan
- Lim Wei Shen
- Lima Chantre
- Lina Bruno
- Lina Lim
- Lind Andreas
- Lingad Maja Katherine
- Lingas Guillaume
- Lion-Daolio Sylvie
- Lissauer Samantha
- Liu Keibun
- Livrozet Marine
- Lizotte Patricia
- Loforte Antonio
- Lolong Navy
- Loon Leong Chee
- Lopes Diogo
- Lopez-Colon Dalia
- Lopez-Revilla Jose W.
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lovelace-Macon Lara
- Low Lee Lee
- Lowik Marije
- Loy Jia Shyi
- Lucet Jean Christophe
- Luna Carlos M.
- Lungu Olguta
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
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- null null
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- Olliaro Piero L.
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- Paxton William A.
- Payen Jean-François
- Peake Sandra L
- Peariasamy Kalaiarasu
- Peariasamy Kalaiarasu M.
- Peek Giles J.
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
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- Peltan Ithan D.
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- Postma Douwe F.
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- Powis Jeff
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- Prinssen Anton
- Pritchard Mark G.
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- Rajahram Giri Shan
- Rajahram Giri Shan
- Ramakrishnan Nagarajan
- Ramalho José
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- Ridzuan Siti Nurul Atikah Ahmad
- Riera Jordi
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- Rios Ana L
- Rishu Asgar
- Rispal Patrick
- Risso Karine
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- Robertson David L.
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- Supic Dubravka
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- Syahrin Sarah
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- Szuldrzynski Konstanty
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- Taib Shahdattul Mawarni
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamisier Renaud
- Tamlihat Younes Ait
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- Tan Kim Keat
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- Tan Yan Chyi
- Tanaka Clarice
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M Azhari
- Tawfik Hassan
- Tedder Richard S.
- Tee Tze Yuan
- Teixeira João
- Tejada Sofia
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- Teoh Sze Kye
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- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thirumanickam Jananee
- Tho Leong Chin
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thurai Surain Raaj Thanga
- Thuy Duong Bich
- Thwaites Ryan S.
- Ticinesi Andrea
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S
- Timsit Jean-François
- Tissot Noémie
- Toh Jordan Zhien Yang
- Toki Maria
- Tonby Kristian
- Tonnii Sia Loong
- Torre Marta
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- Trapani Tony
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- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F.
- Turmel Jean-Marie
- Turnier Paul Le
- Turtle Lance C. W.
- Tveita Anders
- Twardowski Pawel
- Twillert Gitte Van
- Uchiyama Makoto
- Udayanga PG Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valentini Piero
- Valk Paul van der
- Valran Amélie
- Valzano Ilaria
- van Someren Greve Frank
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veen Ilonka van
- Veeran Shaminee
- Veislinger Aurélie
- Vekens Nicky Van Der
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Vishwanathan Gayatri
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vongsouvath Manivanh
- Vonkeman Harald
- Voort Peter Van der
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Werf Sylvie Van Der
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Patricia J
- Williams Virginie
- Willigen Hugo Van
- Wils Evert-Jan
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Xin Ci
- Wong Yew Sing
- Wright Natalie
- Xian Gan Ee
- Xian Lim Saio
- Xuan Kuan Pei
- Xynogalas Ioannis
- Yacoub Sophie
- Yakop Siti Rohani Binti Mohd
- Yamazaki Masaki
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zaidan Nor Zaila Binti
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zawadka Konrad
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 16/07/2024
- Field of study
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adam Elisabeth
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexander Peta MA
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Balazote Pablo Serrano
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Benny Binny
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Bozza Patricia T
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
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- Cidade Jose Pedro
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- Citarella Barbara Wanjiru
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- Combs Pamela
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- Connor Marie
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- Cooke Graham S
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- Dankwa Emmanuelle A
- Dantas Jorge
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
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- de Loughry Gillian
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- Delacroix Isabelle
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- Deligiannis Ionna
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- Docherty Annemarie B
- Doherty Helen
- Donnelly Christl A
- Donnelly Maria
- Donohue Chloe
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- Dussol Bertrand
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- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Eddington Devin P
- Egan Siobhan
- Eira Carla
- Ekow Harrison Samuel Bernard
- El Sanharawi Mohammed
- Elapavaluru Subbarao
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- Eliza Mohamed Nik Nur
- Ellerbroek Jacobien
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- Everding Anna Greti
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- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J
- Fanning Jonathon P
- Faria Pedro
- Fateena Hanan
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- Foley Claire
- Foley Jean
- Fonseca Claudio Duarte
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- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Fraser John F
- Freire Marcela Vieira
- Fritz Ricardo
- Fry Stéphanie
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
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- Goh Jin Yi
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- Goulenok Tiphaine
- Grable Margarite
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- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffee Matthew J
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
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- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
- Han Lim Yuen
- Haniffa Rashan
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M
- Harrison Janet
- Hartman Alan
- Hashmi Junaid
- Hayes Ailbhe
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- Heerman Jan
- Heggelund Lars
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- Hoshino Koji
- Houas Ikram
- Hough Catherine L
- Houltham Stuart
- Hssain Ali Ait
- Hulot Jean-Sébastien
- Humaid Felwa Bin
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- Ijaz Samreen
- Ikram M Arfan
- Illes Hajnal-Gabriela
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- Jego Florence
- Jelani Anilawati Mat
- Jenum Synne
- Jimbo-Sotomayor Ruth
- Jiménez Miguel Pedrera
- Joe Ong Yiaw
- Jorge García Ruth N
- Joseph Cédric
- Joseph Mark
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Jung Hanna
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- Kafif Ouifiya
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- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle E
- Khoo Denisa
- Khoo Ryan
- Khoo Saye
- Kiat Khor How
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
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- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R
- Komatsu Mamoru
- Kosgei Caroline
- Kpangon Arsène
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- Krishnan Sudhir
- Krishnan Vinothini
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- Kuan Pei Xuan
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- Kutsogiannis Demetrios
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- Kyriakoulis Konstantinos
- L'Her Erwan
- Lachatre Marie
- Lacoste Marie
- Laffey John G
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lalueza Antonio
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- Langelot-Richard Marie
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- Leathlobhair Niamh Ni
- Lee Low Lee
- Lee Biing Horng
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- Lee Jennifer
- Lee Su Hwan
- Lee Todd C
- Lee Yi Lin
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
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- LeTurnier Paul
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- Liang Hing Nicholas Yee
- Liegeon Geoffrey
- Lim Heng Benedict Sim
- Lim Kah Chuan
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- Liu Keibun
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- Lolong Navy
- Loon Leong Chee
- Lopes Diogo
- Lopez-Colon Dalia
- Loschner Anthony L
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lowik Marije
- Loy Jia Shyi
- Lucet Jean-Christophe
- Luna Carlos M
- Lungu Olguta
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- Maasikas Olavi
- Mabiala Oryane
- Machado Moïse
- Machado Sara
- Macheda Gabriel
- Madiha Hashmi
- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S
- Maillet Mylène
- Maitre Thomas
- Malfertheiner Maximilian
- Malik Nadia
- Mallon Paddy
- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
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- Markowicz Samuel
- Marques Ana
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- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martinez F Eduardo
- Martinot Martin
- Martins Ana
- Martins João
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- Martynenko Olga
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- Marzukie Marsilla
- Maslove David
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- Maxwell Michael
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- McArthur Colin
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- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McEvoy Natalie
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A
- McNally Paul
- McNicholas Bairbre
- McPartlan Elaine
- Meaney Edel
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- Mechlin Maggie
- Mehkri Omar
- Mele Ferruccio
- Melo Luis
- Mendes Joao Joao
- Menon Kusum
- Mentré France
- Mentzer Alexander J
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
- Merson Laura
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- Mestre Soizic Le
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- Meyer Dan
- Meynert Alison M
- Meysonnier Vanina
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- Mezidi Mehdi
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- Montes Claudia
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- Moore Sarah
- Moore Shona C
- Morlaes Louis Gerbaud
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- Motos Ana
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- Moyet Julien
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- Müller Fredrik
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- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oliveira João
- Oliveira Larissa
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- Ong David SY
- Ong Jee Yan
- Oosthuyzen Wilna
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- Openshaw Peter
- Orozco-Chamorro Claudia Milena
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- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William A
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- Peake Sandra L
- Peariasamy Kalaiarasu
- Peek Giles J
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
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- Pereira Rui
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- Postma Douwe F
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- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G
- Proença Lucia
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- Purcell Gregory
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- Ribeiro Ana Freitas
- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Rincon Diego Fernando Bautista
- Rios Ana L
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
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- Rosenberger Dorothea
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- Rossignol Patrick
- Rousset Stella
- Roy Carine
- Roze Benoît
- Russell Clark D
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- Ryckaert Steffi
- Rätsep Indrek
- Saba Isabela
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- Sarmento Banheiro Bruno
- Sarmiento Iam Claire E
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- Satyapriya Sree
- Satyawati Rumaisah
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- Schaffer Justin
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scicluna Brendan
- Scott Janet T
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvarajoo Mageswari
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G
- Senian Rasidah Bt
- Senneville Eric
- Sepulveda Claudia
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shahidan Syamin Asyraf
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- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A
- Shaw Victoria
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- Stiksrud Birgitte
- Stolz Eva
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- Streinu-Cercel Anca
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- Stuart David
- Su Richa
- Suen Gabriel
- Suen Jacky Y
- Sukumar Prasanth
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- Summers Charlotte
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- Suppiah Deepashankari
- Surovcová Magdalena
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- Syrigos Konstantinos
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- Tabrizi Shirin
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- Taib Shahdattul Mawarni
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tan Kim Keat
- Tan Yan Chyi
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M Azhari
- Tawfik Hassan
- Tedder Richard S
- Tee Tze Yuan
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Teoh Sze Kye
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- Thiberville Simon-Djamel
- Thill Benoît
- Thirumanickam Jananee
- Thompson Shaun
- Thomson David
- Thomson Emma C
- Thorpe Mathew
- Thwaites Ryan S
- Tierney Paul
- Tieroshyn Vadim
- Timsit Jean-François
- Tissot Noémie
- Toal Fiona
- Toki Maria
- Tonby Kristian
- Tonnii Sia Loong
- Torre Marta
- Torres Antoni
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- Towers Michael
- Trapani Tony
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F
- Turmel Jean-Marie
- Turtle Lance CW
- Tveita Anders
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- Van der Feltz Machteld
- van der Palen Job
- van der Valk Paul
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- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
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- van Someren Gréve Frank
- van Veen Ilonka
- Van Willigen Hugo
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
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- Vecham Pavan Kumar
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 30/06/2023
- Field of study
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
- Aasiyah Rashan
- Aasmine Kaur
- Abdulrahman Al-Fares
- Abhijit Duggal
- Adam Betz
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agamemnon Bakakos
- Agn??s Meybeck
- Agn??s Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Aidan Burrell
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisha Kalsoom Mufti
- Aisling Gavin
- Aisling Murphy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Alberto Cucino
- Alberto Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martin-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Martinelli
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J. Mentzer
- Alexander King
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Abbas
- Ali Ait Hssain
- Ali Hachemi
- Ali Liaquat
- Ali Raza
- Ali Rehan
- Alice Bogaarts
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Alison M. Meynert
- Alistair Nichol
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Lakshan Attanyake
- Am??lie Valran
- Amanda Corley
- Amanda Palacios
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Aroca
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Luiza Valle
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anant Kataria
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Tveita
- Andr?? Cabie
- Andr?? Dias
- Andr?? Roberto
- Andr??s Orquera
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Udy
- Andrey A Svistunov
- Andriy Bal
- Andy Dong
- Andy Law
- Aneela Altaf
- Angel Asensio
- Angel Sanchez-Miralles
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-H??l??ne Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Ant??nio Mesquita
- Anthony Gordon
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Henriquez
- Arabella Fahy
- Ardiyan Apriyana
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Ars??ne Kpangon
- Arsalan Rahutullah
- Arshad Taqi
- Arthur Garan
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- Asad Usman
- Asami Ito
- Asfia Sultana
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- Astarini Hidayah
- Atif Siddiqui
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- Audrey Barrelet
- Aur??lie Papadopoulos
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- Aur??lie Wiedemann
- Aurelius Bonfasius
- Aurore Bousquet
- Axelle Braconnier
- Azlan Mat Soom
- Azrina Ralib
- B. P. Sanka Ruwan Sri Darshana
- B??n??dicte Lefebvre
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- Indrek R??tsep
- Ingrid G. Bustos
- Ioana Grigoras
- Ioannis Trontzas
- Ioannis Xynogalas
- Ionna Deligiannis
- Iqbal Elyazar
- Iqbal Hussain
- Irene Aragao
- Irfan Khan
- Isabela Saba
- Isabella Bianchi
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- Isabelle Pironneau
- Issrah Jawad
- Ithan D. Peltan
- Ivo Castro
- J Kevin Baird
- J. Kenneth Baillie
- J. Perren Cobb
- J??r??me Dimet
- J??r??mie Guedj
- J??r??mie Pasquier
- Jack Song Chia
- Jacky Y. Suen
- Jacobien Ellerbroek
- Jade Ghosn
- Jae Burm Kim
- Jaganathan Selvanayagam
- Jai Madhok
- Jaime Cruz Rojo
- Jaime Hernandez-Montfort
- Jake Dunning
- Jamel Ortoleva
- James Joshua Douglas
- James Lee
- James Scott-Brown
- Jan Cato Holter
- Jan Heerman
- Jan-Erik Berdal
- Jananee Thirumanickam
- Janet Harrison
- Janet Liang
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Javier Maynar
- Javier Osatnik
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean Foley
- Jean-Beno??t Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-Fran??ois Payen
- Jean-Fran??ois Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-S??bastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
- Jeff Powis
- Jeffrey Aliudin
- Jeffrey Javidfar
- Jelmer Talsma
- Jennifer Clarke
- Jennifer Connolly
- Jennifer June
- Jenny Lennon
- Jeremy J. Farrar
- Jeronimo Graf
- Jess Gibson
- Jia Shyi Loy
- Jia Wei
- Jillian Deacon
- Jimmy Ming-Yang Hsu
- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Jo??o Alves
- Jo??o Cam
- Jo??o Estev??o
- Jo??o Martins
- Jo??o Melo Alves
- Jo??o Oliveira
- Jo??o Teixeira
- Joan G??mez-Junyent
- Joana Ferr??o
- Joanne Downey
- Joao Joao Mendes
- Joaqu??n Baruch
- Jodat Saleem
- Jodat Saleem
- Johann Auchabie
- Johannes Gebauer
- John Bourke
- John F. Fraser
- John G. Laffey
- John Marshall
- Johnny McKeown
- Jolanta Popielska
- Jonathan Chua
- Jonathan Crump
- Jonathan Golob
- Jonathan Remppis
- Jonathan Samuel Ch??vez I??iguez
- Jordan Zhien Yang Toh
- Jordi Rello
- Jordi Riera
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jos?? Casimiro
- Jos?? Ernesto Vidal
- Jos?? Luis Bernal Sobrino
- Jos?? Miguel Cisneros Herreros
- Jose Andres Calvache
- Jose I Nunez
- Jose M. Mandei
- Jose Pedro Cidade
- Joshua Solomon
- Josie Campisi
- Joy Ann Villanueva
- Juan Fernado Masa Jimenez
- Juan Fiorda
- Juan Jose Diaz Diaz
- Juan Luis Cruz Berm
- Juan Macias Sanchez
- Juan Pablo Horcajada
- Judit Villar
- Judy Gitahi
- Jules Bauer
- Julia Garcia-Diaz
- Julia Rodriguez Abreu
- Julian Chica
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Duthoit
- Juliette Patrier
- Juliette Romaru
- Junaid Hashmi
- Junaid Patel
- Junji Itai
- Justin Schaffer
- Justine Pages
- K??vin Alexandre
- K??vin Bouiller
- K??vin Didier
- Kah Chuan Lim
- Kai Zacharowski
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik M??ller
- Karolina Krawczyk
- Karolina Nowicka
- Kashif Memon
- Katarzyna Lewandowska
- Kate Ainscough
- Kate Calligy
- Katharina Weil
- Kathy Brickell
- Katie O'Hearn
- Kazali Enagnon Alidjnou
- Kazi Rubayet Anwar
- Keibun Liu
- Keiki Shimizu
- Keith Wille
- Kenneth A. McLean
- Ker Hong Bee
- Kevin Katz
- Khor How Kiat
- Kim Keat Tan
- Kishore Mangal
- Kizy Sanchez de Oliveira
- Koji Hoshino
- Kok Wei Hao
- Kollengode Ramanathan
- Kong Yeow Kang
- Konrad Zawadka
- Konstantinos Kyriakoulis
- Konstantinos Syrigos
- Konstanty Szuldrzynski
- Kota Hoshino
- Krishna Bhavsar
- Kristian Tonby
- Kuan Pei Xuan
- Kusum Menon
- Kyle Gomez
- Laetitia Bodenes
- Lai Hui Pang
- Lance C. W. Turtle
- Lara Absil
- Lara Lovelace-Macon
- Larissa Oliveira
- Lars Heggelund
- Lars S. Maier
- Laur??ne Azemar
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura van Gulik
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laveena Munshi
- Le Van Tan
- Leanne Hays
- Lee Lee Low
- Lenka Petrou
- Leonardo Salazar
- Leong Chee Loon
- Leong Chin-Tho
- Letizia Lucia Florio
- Liadain Reid
- Liadain Reid
- Liem Luong
- Lila Bouadma
- Liliana Resende
- Lim Lina
- Lim Saio Xian
- Lim Yuen Han
- Lina Morales Cely
- Linda Gail Skeie
- Linda O'Shea
- Lionel Eric Benjiman
- Lionel Piroth
- Lisa Mc Sweeney
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorenzo Bertolino
- Lorenzo Grazioli
- Lorna Murphy
- Lorraine McAndrew
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lovkesh Arora
- Lu??s Bento
- Lu??s Patr??o
- Lu??s Val-Flores
- Luca Brazzi
- Lucia Moro
- Lucia Proen??a
- Lucian Durham III
- Lucie Le Fevre
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Melo
- Luis Periel
- Luisa Quesada
- Lukas Arenz
- Lysa Tagherset
- M Azhari Taufik
- M??lanie Roriz
- M??rio Ferraz
- Ma??der Pagadoy
- Machteld van der Feltz
- Madiha Hashmi
- Maeve Kelsey
- Maeve Kernan
- Maeve Ryan
- Magdalena Surovcov??
- Mageswari Selvarajoo
- Maggie Mechlin
- Mahdad Noursadeghi
- Maia Rabaa
- Maire-Laure Casanova
- Maisa Guimar??es de Castro
- Makoto Uchiyama
- Malcolm G. Semple
- Malte Kohns Vasconcelos
- Mamoru Komatsu
- Mangala Narasimhan
- Manuel Etienne
- Manuel Rosa-Calatrava
- Maqsood Meher
- Mar??lia Fernandes
- Maram Zahran
- Marc Csete
- Marc Fabre
- Marc Lambert
- Marc Leone
- Marcel van den Berge
- Marcela Vieira Freire
- Marco Echeverria-Villalobos
- Marco Giani
- Mare Pejkovska
- Margarida Torres
- Margarite Grable
- Margaux Isnard
- Maria Amaral
- Maria Angelica Rivera Nu??ez
- Maria Boylan
- Maria de Piero
- Maria Donnelly
- Maria Ines Ribeiro
- Maria Joao Silva
- Maria Lawrensia Tampubolon
- Maria Pokorska-Spiewak
- Maria Ryan
- Maria Sousa Uva
- Maria Toki
- Maria Zambon
- Mariachiara Ippolito
- Mariana Casc??o
- Mariano Esperatti
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marieke Haalboom
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marije Lowik
- Marina Esposito-Farese
- Marina Lanza
- Marina Wainstein
- Marine Beluze
- Marine Livrozet
- Mario Palacios
- Marion Le Mar??chal
- Marion Noret
- Marion Schneider
- Marion Zabbe
- Marjolein Brusse-Keizer
- Mark de Boer
- Mark Downing
- Mark G. Pritchard
- Mark Joseph
- Marl??ne Murris
- Marlene Santos
- Marlice van Dyk
- Marsilla Marzukie
- Marta Alessi
- Marta Leal Santos
- Marta Sousa
- Martin Guego
- Martin Martinot
- Martina Escher
- Martina Hennessy
- Martine Remy
- Mary Copland
- Mary Mone
- Masahiro Fukuda
- Masaki Yamazaki
- Masliza Zahid
- Massimo Antonelli
- Massimo Gagliardi
- Massimo Palmarini
- Mathew Pulicken
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvall??e
- Mathilde Duplaix
- Matteo Puntoni
- Matteo Rossetti
- Matthew Brack
- Matthew Cummings
- Matthew Griffee
- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Mauro Panigada
- Max O'Donnell
- Maxime Hentzien
- Maximilian Malfertheiner
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Meera Chand
- Megan Coles
- Megan Marshal
- Meghena Mathew
- Mehdi Mezidi
- Mehul Desai
- Melissa Parker
- Menaldi Rasmin
- Merc?? Jourdain
- Mia Callahan
- Mical Paul
- Michael Collins
- Michael Maxwell
- Michael Piagnerelli
- Michael Rose
- Michael Schwameis
- Michael Sonntagbauer
- Michael Towers
- Michael Varrone
- Michaela Barnikel
- Michela Leone
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Michelle Smyth
- Miguel Pedrera Jim??nez
- Miguel Zambrano
- Minerva Cervantes-Gonzalez
- Minh Le
- Mireia Cantero
- Miriam O'Sullivan
- Mirjam Evers
- Mo??se Machado
- Mobin Chaudary
- Mohamed Fayed
- Mohammad Asim
- Mohammad Imran
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Bin Kamarudin
- Mohd Shahnaz Hasan
- Mohiuddin Shiekh
- Moirangthem Bikram Singh
- Monserrat Solis
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- Motohiro Asaki
- Muhammad Aisar Ayadi Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Hassin Basri
- Muhammad Hayat
- Mukesh Kumar
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mustehan Bashir
- Myl??ne Maillet
- Myung Jin Song
- Nad??ge Neant
- Nadeem Munir
- Nadia Baig
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nagarajan Ramakrishnan
- Nageswaran Narayanan
- Nahoko Shindo
- Namra N
- Naoki Shimizu
- Naseem Ali Shah
- Nasir Khoso
- Nassima Si Mohammed
- Natalie McEvoy
- Nataly Farshait
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gagn??
- Nathalie Gault
- Nathalie M. Delfos
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Naveed Latif
- Navy Lolong
- Navya Garimella
- Nawal Salahuddin
- Nazreen Abu Bakar
- Necsoi Coca
- Neerusha Kaisbain
- Nelson Cardoso
- Nestor Luque
- Neurinda Permata Kusumastuti
- Ng Wing Yiu
- Ng Yong Muh
- Ng Yong Siang
- Nguyen Van Vinh Chau
- Niamh Feely
- Niamh Kelly
- Niamh Ni Leathlobhair
- Nicholas Rizer
- Nicholas Sedillot
- Nicholas Yee Liang Hing
- Nicholas Yuri Barbosa
- Nick Daneman
- Nicky Van Der Vekens
- Nicolas Benech
- Nicolas Brozzi
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Eliza Mohamed
- Nikita A Nekliudov
- Nilar Lwin
- Nina Buchtele
- Nina Jamieson
- Nipunie Rajapakse
- Nisreen Shiban
- No??mie Mercier
- No??mie Tissot
- No??mie Vanel
- Nobuaki Shime
- Nobuya Kitamura
- Noelia Garc??a Barrio
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Binti Zaidan
- Nora Fuentes
- Nuno Germano
- Nuno Martins
- Nur Amira
- Nurnaningsih Nurnaningsih
- Nurul Amani Mohd Noordin
- Nurul Faten Izzati Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sandulescu
- Obada Yousif
- Odile Launay
- Ogechukwu Menkiti
- Oksana Kruglova
- Olavi Maasikas
- Oleksa Rewa
- Olena Haidash
- Olga Martynenko
- Olguta Lungu
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Omar Mehkri
- Ong Yiaw Joe
- Oriane Pu??chal
- Orna Ni Choileain
- Oryane Mabiala
- Osama Khalid
- Osama Metwally
- Oscar Hoiting
- Ouifiya Kafif
- Pablo Blanco-Schweizer
- Pablo Serrano Balazote
- Paddy Mallon
- Palliya Guruge Pramodya Ishani Ishani
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Paolo Pelosi
- Parthena Savvidou
- Pascal Granier
- Patricia Fontela
- Patricia Gordon
- Patricia Lizotte
- Patricia Patricio
- Patrick Archambault
- Patrick Biston
- Patrick Breen
- Patrick Breen
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Kellam
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pauline Yeung Ng
- Pavan Kumar Vecham
- Pawel Twardowski
- Pedro Faria
- Pedro Povoa
- Peter de Vries
- Peter Doran
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Phil Gallagher
- Philippe Jouvet
- Philippine Eloy
- Phillip Mason
- Phoebe Ampaw
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-Fran??ois Sandrine
- Pierre-Marc Villeneuve
- Pierre-Marie Roger
- Pieter Depuydt
- Piret Sillaots
- Pleun Terpstra
- Polina Bugaeva
- Pompini Agustina Sitompul
- Pooja Varghese
- Pranya Sakiyalak
- Prasan Kumar Panda
- Prasanth Sukumar
- Pratap Karpayah
- Pratima Sharma
- praveen kumar ghisulal
- Priscila Diaz
- Prompak Nitayavardhana
- Punam Singh
- Qabas Alkhafajee
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain
- Rachael McConnochie
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas de Oliveira Fran??a
- Rafael Le??n
- Rafael Mahieu
- Rajavardhan Rangappa
- Rajeshwari Arali
- Rajyabardhan Pattnaik
- Rakesh Arora
- Rana Imran Sikander
- Raph Hamers
- Rapha??l Borie
- Rapha??l Favory
- Raquel Pinto
- Rashan Haniffa
- Rashid Nasim Khan
- Rasidah Bt Senian
- Raul Neto
- Ravi Kant
- Raymond Savio
- Razi Alalqam
- Rebecca Hamidfar
- Rebecca Holt
- Rebekha Garcia
- Renata Barbalho
- Renato Reis
- Renee Douma
- Ricard Ferrer-Roca
- Ricardo Fritz
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rita Hinchion
- Ritika Ranjan
- Rob Klont
- Robert A. Fowler
- Roberta Cavalin
- Roberto Andini
- Roberto Roncon-Albuquerque Jr
- Robin Kobbe
- Rodrigo Diaz
- Rog??rio Silva
- Rolando Claure Del Granado
- Romain Basmaci
- Romain Decours
- Romain Guery
- Roman Ullrich
- Romans Matulevics
- Rosanna De Rosa
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Gomes
- Rui Pereira
- Rumaisah Satyawati
- Ruth Jimbo-Sotomayor
- Ruth Lyons
- Ruth N. Jorge Garc??a
- Ryadh Pokeerbux
- Ryan Kennedy
- Ryan Khoo
- Ryan S. Thwaites
- Ryuzo Abe
- S??bastien Preau
- S??lvia Ferreira
- S??rgio Gai??o
- S??verine Ansart
- Saad Nseir
- Sabelline Bouchez
- Sabin Koirala
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saeeda Haider
- Saef Umar Barnett
- Saijad Orakzai
- Saima Kamal
- Sairah Sadaf
- Saleh Al Ageel
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samantha Strudwick
- Samira Laribi
- Samreen Ijaz
- Samual MacDonald
- Samuel Bernard Ekow Harrison
- Samuel Hinton
- Samuel Markowicz
- Samuel McElwee
- Sandrine Couffin-Cadiergues
- Sanjay Lakhey
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Taleb
- Sara Ventura
- Sarah Cormican
- Sarah E. McDonald
- Sarah Isgett
- Sarah MacDonald
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Se??n Keating
- Seamus Daly
- Sean Donohue
- Sebastian Vencken
- Sebastiano Maria Colombo
- Segol??ne Greffe
- Senthilkumar Alegesan
- Sergio Poli
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shakeel Ahmed
- Shaminee Veeran
- Sharma Keshav
- Shaun Thompson
- Shaunagh Browne
- Sheeba Hakak
- Sheharyar Ashraf
- Sheila C??rcel
- Sherry McDermott
- Sheryl Ann Abdukahil
- Shingo Adachi
- Shinichiro Ohshimo
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C. Moore
- Sia Loong Tonnii
- Silvia Casta??eda
- Silvia Lourenco
- Sim Choon Ean
- Sim??o Rodeia
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Simone Carelli
- Simone Piva
- Simreen Kaur Johal
- Siobhan Casey
- Siobhan Egan
- Siri Goepel
- Siti Nurul Atikah Ahmad Ridzuan
- Siti Rohani Binti Mohd Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Smaragdi Kalomoiri
- Sobia Masood
- Sobia Masood
- Sof??a Contreras
- Sofia Cardoso
- Sofia Prapa
- Sofia Tejada
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Sophie O'Halloran
- Sophie Yacoub
- Sravya Pudota
- Sree Satyapriya
- Srinivas Murthy
- St??phane Jaureguiberry
- St??phane Lasry
- St??phane Sallaberry
- St??phanie Cousse
- St??phanie Fry
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Rousset
- Stephan Schroll
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen Brett
- Stephen Knight
- Steven Anthony Webb
- Steven van Lelyveld
- Stijn Van de Velde
- Stuart Houltham
- Su Hwan Lee
- Subbarao Elapavaluru
- Subhash Acharya
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Sung-Min Cho
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Cabral
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suwarti Suwarti
- Suzanne Bennett
- Suzette Willems
- Swagata Tripathy
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Syed Muneeb
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- T. Eoin West
- T??nia Sequeira
- Tae Song
- Taha Pasha
- Tahira Jamal Mohamed
- Tak-Hyuk Oh
- Takako Akimoto
- Takayuki Ogura
- Taku Tanaka
- Takuya Shiga
- Tala Al-dabbous
- Tamara Seitz
- Tan Pei Wen
- Tanvir Alam
- Tarek Elshazly
- Tatiana Fonseca
- Tatsuya Kawasaki
- Tawnya Ogston
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Tessa Broadley
- Th??o Treoux
- Thalha Rashan
- Tharmini Ravi
- Tharwat Aisa
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timo Brandenburger
- Timo Tolppa
- Ting Soo Chow
- Tiphaine Goulenok
- Tjard Schermer
- Todd C. Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tomoyuki Endo
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- V??ctor Quir??s Gonz??lez
- V??ronique Lemee
- Vadim Tieroshyn
- Val??rie Gaborieau
- Val??rie Garrait
- Val??rie Gissot
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- van der Palen Job
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Manda
- Victoria McEneany
- Victoria Shaw
- Vieri Parrini
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Volkan Korten
- Waasila Jassat
- Wai Ching Sin
- Walter Picard
- Wan Fadzlina Wan Muhd Shukeri
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xavier S??nchez Choez
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zubair Umer
- Zul Amali Che Kamaruddin
- Zul Fakar
- Zulfiqar Sandhu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
International audienc
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz Mário
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko Céline
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González Víctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hasan Mohd Shahnaz
- Hashmi Junaid
- Hashmi Madiha
- Hayat Muhammad
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hitoto Hikombo
- Ho Antonia
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Imran Mohammad
- Imtiaz Aftab
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Ivulich Daniel
- Iñiguez Jonathan Samuel Chávez
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaquet Pierre
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Jego Florence
- Jenum Synne
- Jiménez Miguel Pedrera
- Joseph Cédric
- Joseph Mark
- Joshi Swosti
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Juzar Dafsah
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandel Chris
- Kanwal Darakhshan
- Kartsonaki Christiana
- Kataria Anant
- Katz Kevin
- Kay Christy
- Keane Hannah
- Keating Seán
- Kelly Andrea
- Kelly Aoife
- Kelly Claire
- Kelly Niamh
- Kelly Sadie
- Kelly Yvelynne
- Kelsey Maeve
- Kennon Kalynn
- Kernan Maeve
- Kerroumi Younes
- Keshav Sharma
- Khalid Imrana
- Khalid Osama
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Khan Quratul Ain
- Khan Rashid Nasim
- Khanal Sushil
- Khatak Abid
- Khawaja Amin
- Kho Michelle E.
- Khoo Saye
- Khoso Nasir
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
- Koirala Sabin
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Kruglova Oksana
- Kumar Deepali
- Kumar Mukesh
- Kuriakose Dinesh
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kutsyna Galyna
- Kyriakoulis Konstantinos
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lakhey Sanjay
- Lalueza Antonio
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Lasry Stéphane
- Latif Naveed
- Launay Odile
- Laureillard Didier
- Lavie-Badie Yoan
- Law Andrew
- Lawrence Cassie
- Lawrence Teresa
- Le Bihan Clément
- Le Bris Cyril
- Le Falher Georges
- Le Fevre Lucie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moal Gwenaël
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemeur Anthony
- Lemmink Gretchen
- Lennon Jenny
- Leone Marc
- Leone Michela
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Lester-Grant Amy
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- Lewandowska Katarzyna
- León Rafael
- Liaquat Ali
- Liegeon Geoffrey
- Lim Wei Shen
- Lima Chantre
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Livrozet Marine
- Lizotte Patricia
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lovelace-Macon Lara
- Lowik Marije
- Lucet Jean Christophe
- Luna Carlos M.
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Mabiala Oryane
- Machado Moïse
- Machado Sara
- Macheda Gabriel
- Madiha Hashmi
- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Malfertheiner Maximilian
- Malik Nadia
- Mallon Paddy
- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
- Mankikian Julie
- Manning Edmund
- Manuel Aldric
- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshal Megan
- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martinot Martin
- Martins Ana
- Martins João
- Martins Nuno
- Martucci Gennaro
- Martynenko Olga
- Marwali Eva Miranda
- Maslove David
- Mason Sabina
- Masood Sobia
- Matan Moshe
- Mathew Meghena
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Maxwell Michael
- Maynar Javier
- Mazzoni Thierry
- Mc Evoy Natalie
- Mc Sweeney Lisa
- McArthur Colin
- McArthur Colin
- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A.
- McNally Paul
- McNicholas Bairbre
- McPartlan Elaine
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Meher Maqsood
- Mele Ferruccio
- Melo Luis
- Memon Kashif
- Mendes Joao Joao
- Menkiti Ogechukwu
- Menon Kusum
- Mentré France
- Mentzer Alexander J.
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
- Mesquita António
- Metwally Osama
- Meybeck Agnès
- Meyer Dan
- Meynert Alison M.
- Meysonnier Vanina
- Meziane Amina
- Mezidi Mehdi
- Michelanglei Céline
- Michelet Isabelle
- Mihnovit Vladislav
- Mohammed Nassima Si
- Mohd-Hanafiah Farah Nadia
- Moin Asma
- Molina David
- Molinos Elena
- Molloy Brenda
- Mone Mary
- Monteiro Agostinho
- Monteiro Filipa Brás
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona C.
- Morlaes Louis Gerbaud
- Moro Lucia
- Motherway Catherine
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mufti Aisha Kalsoom
- Mullaert Jimmy
- Munblit Daniel
- Muneeb Syed
- Munir Nadeem
- Murphy Aisling
- Murphy Aisling
- Murphy Lorna
- Murris Marlène
- Murthy Srinivas
- Musaab Himed
- Muvindi Himasha
- Myrodia Dimitra Melia
- Müller Fredrik
- Müller Karl Erik
- Nagpal Dave
- Nagrebetsky Alex
- Narayanan Nageswaran
- Nazerali-Maitland Alasdair
- Neant Nadège
- Nekliudov Nikita
- Neto Ary Serpa
- Neto Raul
- Neumann Emily
- Ng Pauline Yeung
- Nghi Anthony
- Nguyen Duc
- Nichol Alistair
- Nitayavardhana Prompak
- Nonas Stephanie
- Nor Basri Mat
- Nor Basri Mat
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowinski Adam
- Nseir Saad
- Nunez Jose I.
- Nurnaningsih Nurnaningsih
- Nyamankolly Elsa
- Occhipinti Giovanna
- OConnor Derbrenn
- Ogston Tawnya
- Ogura Takayuki
- Oliveira João
- Oliveira Larissa
- Olliaro Piero L.
- Ong David S. Y.
- Oosthuyzen Wilna
- Opavsky Anne
- Openshaw Peter
- Orakzai Saijad
- Orozco-Chamorro Claudia Milena
- Ortoleva Jamel
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Oziol Eric
- O’Callaghan Annmarie
- O’Donnell Max
- O’Halloran Sophie
- O’Hearn Katie
- O’Shea Linda
- O’Sullivan Miriam
- Pagadoy Maïder
- Pages Justine
- Palacios Amanda
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Paneru Hem
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parke Rachael
- Parker Melissa
- Parra Briseida
- Pasha Taha
- Pasquier Jérémie
- Pastene Bruno
- Patauner Fabian
- Patricio Patricia
- Patrier Juliette
- Patrão Luís
- Patterson Lisa
- Pattnaik Rajyabardhan
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William A.
- Payen Jean-François
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
- Peltan Ithan D.
- Pereira Rui
- Perez Daniel
- Periel Luis
- Perpoint Thomas
- Perrot Clara Mouton
- Pesenti Antonio
- Pestre Vincent
- Petrou Lenka
- Petrov-Sanchez Ventzislava
- Petrovic Michele
- Pettersen Frank Olav
- Peytavin Gilles
- Pharand Scott
- Picard Walter
- Picone Olivier
- Pierobon Carola
- Piersma Djura
- Pimentel Carlos
- Pinto Raquel
- Pires Catarina
- Pironneau Isabelle
- Piroth Lionel
- Pius Riinu
- Plantier Laurent
- Poissy Julien
- Pokeerbux Ryadh
- Poli Sergio
- Pollakis Georgios
- Ponscarme Diane
- Post Andra-Maris
- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Preau Sébastien
- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
- Pudota Sravya
- Pulicken Mathew
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quinones-Cardona Vilmaris
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rabindrarajan Ebenezer
- Rafael Aldo
- Rafiq Marie
- Rahutullah Arsalan
- Rainieri Fernando
- Ramachandran Pratheema
- Ramakrishnan Nagarajan
- Ramalho José
- Rammaert Blandine
- Ramos Grazielle Viana
- Rana Asim
- Rangappa Rajavardhan
- Ranjan Ritika
- Rapp Christophe
- Rashan Aasiyah
- Rashan Thalha
- Rasheed Ghulam
- Rasmin Menaldi
- Rau Cornelius
- Raza Ali
- Real Andre
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rehman Attaur
- Reid Liadain
- Reid Liadain
- Reikvam Dag Henrik
- Reis Renato
- Rello Jordi
- Remppis Jonathan
- Remy Martine
- Ren Hongru
- Renk Hanna
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Tiago
- Ribeiro Ana Freitas
- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rios Ana L.
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L.
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
- Roger Pierre-Marie
- Rojek Amanda
- Rojo Jaime Cruz
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossetti Matteo
- Rossignol Bénédicte
- Rossignol Patrick
- Rousset Stella
- Roy Carine
- Roze Benoît
- Rusmawatiningtyas Desy
- Russell Clark D.
- Ryan Maeve
- Ryan Maria
- Ryckaert Steffi
- Rätsep Indrek
- Saba Isabela
- Sadaf Sairah
- Sadat Musharaf
- Sahraei Valla
- Saidani Nadia
- Saint-Gilles Maximilien
- Sakiyalak Pranya
- Salahuddin Nawal
- Salazar Leonardo
- Saleem Jodat
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandhu Zulfiqar
- Sandrine Pierre-François
- Sandulescu Oana
- Sanharawi Mohammed El
- Sant Ceila Maria
- Santo Catarina Espírito
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- Santos Marta Leal
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Satyapriya Sree
- Satyawati Rumaisah
- Saviciute Egle
- Schaffer Justin
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvanayagam Jaganathan
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shah Naseem Ali
- Shamsah Mohammad
- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A.
- Shaw Victoria
- Sheharyar Ashraf
- Shetty Rajesh Mohan
- Shi Haixia
- Shiekh Mohiuddin
- Shimizu Keiki
- Shrapnel Sally
- Shrestha Pramesh Sundar
- Shrestha Shubha Kalyan
- Shukeri Wan Fadzlina Wan Muhd
- Shum Hoi Ping
- Sibiude Jeanne
- Siddiqui Atif
- Sigfrid Louise
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- Silva Maria Joao
- Silva Rogério
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- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Coilin
- Smyth Michelle
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Sobrino José Luis Bernal
- Solomon Joshua
- Solomon Tom
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- Sommet Agnès
- Song Myung Jin
- Song Rima
- Song Tae
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- Soum Edouard
- Sousa Ana Chora
- Sousa Marta
- Sperry Alexandra
- Spinuzza Elisabetta
- Sriskandan Shiranee
- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Surovcová Magdalena
- Svistunov Andrey
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tanaka Hiroyuki
- Taqdees Huda
- Taqi Arshad
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari
- Tawfik Hassan
- Tedder Richard S.
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
- Torre Marta
- Torres Antoni
- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Treoux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre K. vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart S. verine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-H. lène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller K. vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- de Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- de Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier K. vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet J. rôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou F. lix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival C. line
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou H. lène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz M. rio
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira S. lvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko C. line
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião S. rgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González V. ctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard C. cile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj J. rémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
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- Postma Douwe F.
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- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
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- Pulicken Mathew
- Purcell Gregory
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- Póvoas Diana
- Quesada Luisa
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- Quraishi Mohammed
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- Rabindrarajan Ebenezer
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- Streinu-Cercel Adrian
- Streinu-Cercel Anca
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- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
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- Trapani Tony
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- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- van der Vekens Nicky
- van der Voort Peter
- van der Werf Sylvie
- van Gulik Laura
- van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira C. sar
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik C. cile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adrião Diana
- Ageel Saleh Al
- Ahmed Shakeel
- Ain Quratul
- Ainscough Kate
- Aisa Tharwat
- Ait Hssain Ali
- Ait Tamlihat Younes
- Akimoto Takako
- Akmal Ernita
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alam Tanvir
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre K. vin
- Alfoudri Huda
- Ali Shah Naseem
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- Angoulvant François
- Ansart S. verine
- Anthonidass Sivanesen
- Antonelli Massimo
- Antunes de Brito Carlos Alexandre
- Anwar Kazi Rubayet
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arali Rajeshwari
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Aroca Ana
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asaki Motohiro
- Asensio Angel
- Ashley Elizabeth
- Ashraf Muhammad
- Ashraf Sheharyar
- Asim Mohammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Baird J. Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Bani-Sadr Firouzé
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- Occhipinti Giovanna
- OConnor Derbrenn
- Ogston Tawnya
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- Osatnik Javier
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- Pagadoy Maïder
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- Palacios Amanda
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- Pujo Semedi Bambang
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- Quirós González V. ctor
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- Rahman Rozanah Abd
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- Rajapakse Nipunie
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- Ramakrishnan Nagarajan
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- Ramli Ahmad Afiq
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- Rana Asim
- Rangappa Rajavardhan
- Ranjan Ritika
- Rapp Christophe
- Rashan Aasiyah
- Rashan Thalha
- Rasheed Ghulam
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- Ravi Tharmini
- Raza Ali
- Real Andre
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rehan Ali
- Rehman Attaur
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- Reikvam Dag Henrik
- Reis Renato
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- Renk Hanna
- Resende Liliana
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- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Tiago
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- Richardson Denise
- Richier Laurent
- Ridzuan Siti Nurul Atikah Ahmad
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- Rishu Asgar
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- Risso Karine
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- Rizer Nicholas
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- Rodriguez Abreu Julia
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- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Jr Roberto
- Roriz M. lanie
- Rosa-Calatrava Manuel
- Rose Michael
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- Rossanese Andrea
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- Sales Gabriele
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- Sivam Karisha
- Skogen Vegard
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- Smyth Coilin
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- Stone Amy
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- Stuart David
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- Sukumar Prasanth
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- Tan Le Van
- Tan Yan Chyi
- Tanaka Clarice
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
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- Taqi Arshad
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- Tattevin Pierre
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- Tawfik Hassan
- Tedder Richard S.
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- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Teoh Sze Kye
- Teotonio Vanessa
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thabit Alif Adlan Mohd
- Tham Zhang Duan
- Thangavelu Suvintheran
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
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- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tissot Noémie
- Toh Jordan Zhien Yang
- Toki Maria
- Tolppa Timo
- Tonby Kristian
- Tonnii Sia Loong
- Torres Santos-Olmo Rosario Maria
- Torres Antoni
- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Traynor Damien
- Treoux Théo
- Trieu Huynh Trung
- Tripathy Swagata
- Tromeur C. cile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Tveita Anders
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Umer Zubair
- Uribe Alberto
- Usman Asad
- Vajdovics Cristinava
- Val-Flores Luís
- Valle Ana Luiza
- Valran Amélie
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- van den Berge Marcel
- van der Feltz Machteld
- van der Valk Paul
- van der Vekens Nicky
- van der Voort Peter
- van der Werf Sylvie
- van Dyk Marlice
- van Gulik Laura
- van Hattem Jarne
- van Lelyveld Steven
- van Netten Carolien
- van Twillert Gitte
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasudayan Shoban Raj
- Vauchy Charline
- Vaughan Helen
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira C. sar
- Vijayan Deepak
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Vinh Chau Nguyen Van
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Wan Muhd Shukeri Wan Fadzlina
- Wang Chih-Hsien
- Webb Steven Anthony
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wing Yiu Ng
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xuan Kuan Pei
- Xynogalas Ioannis
- Yacoub Sophie
- Yakop Siti Rohani Binti Mohd
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yee Liang Hing Nicholas
- Yelnik C. cile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zaidan Nor Zaila Binti
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zawadka Konrad
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2021
- Field of study
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasmine Kaur
- Abby Hurd
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abid Khatak
- Adam Ali
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Aftab Imtiaz
- Agamemnon Bakakos
- Agnieszka Oldakowska
- Agnès Meybeck
- Agnès Sommet
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisha Kalsoom Mufti
- Aisling Gavin
- Aisling Murphy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Alberto Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martin-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexander King
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Ait Hssain
- Ali Hachemi
- Ali Liaquat
- Ali Raza
- Alice Bogaarts
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Alison M Meynert
- Allegra Chatterjee
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Amanda Corley
- Amanda Palacios
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amin Khawaja
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Hackmann
- Amy Lester-Grant
- Amy Stone
- Amélie Valran
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anand Thakur
- Anant Kataria
- Anatoliy Gavrylov
- Anders Benjamin Kildal
- Anders Tveita
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Hershey
- Andrew Udy
- Andrey Svistunov
- Andriy Bal
- André Cabie
- André Dias
- André Roberto
- Andy Dong
- Andy Law
- Aneela Altaf
- Angel Asensio
- Angel Sanchez-Miralles
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Ankana Satya
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B Docherty
- Annmarie O Callaghan
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ricchiuto
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- António Mesquita
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Henriquez-Trujillo
- Arabella Fahy
- Ardiyan Apriyana
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsalan Rahutullah
- Arshad Taqi
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Ashraf Sheharyar
- Asim Rana
- Asma Moin
- Astarini Hidayah
- Atif Siddiqui
- Attaur Rehman
- Audrey Barrelet
- Aurelius Bonfasius
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Ayodhia Pitaloka
- Azlan Mat Soom
- B P Sanka Ruwan Sri Darshana
- Bailey Cassandra
- Baillie J Kenneth
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barrio Noelia García
- Baruch Joaquín
- Basanta Gauli
- Basri Mat Nor
- Beane Abigail
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefevre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernhard Roessler
- Bertrand Dussol
- Bianca Boxma
- Biing Horng Lee
- Birgitte Stiksrud
- Blake Mergler
- Blandine Rammaert
- Blumberg Lucille
- Bouchra Loufti
- Bozza Fernando
- Brenda Molloy
- Brenda Reeve
- Brendan Scicluna
- Brian Marsh
- Brigitte Elharrar
- Briseida Parra
- Broadley Tessa
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Budha Charan Singh
- Burrell Aidan
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Caitriona Cody
- Calvin Wong
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlos Alexandre Antunes de Brito
- Carlos Lumbreras Bermejo
- Carlos M Luna
- Carlos Pimentel
- Carmen Infante Dominguez
- Carola Pierobon
- Carolien van Netten
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Carson Gail
- Cassidy Codan
- Cassie Lawrence
- Catarina Pires
- Catarina Silva
- Catherine A Shaw
- Catherine Blier
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L Hough
- Catherine Marquis
- Catherine Motherway
- Cecile Azoulay
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Chantre Lima
- Charbel Maroun Eid
- Charlene Da Silveira
- Charles Crepy D'Orleans
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Robba
- Chiara Simona Cardellino
- Chiara Vitiello
- Chih-Hsien Wang
- Chloe Donohue
- Chris Kandel
- Chris McKay
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Buesaquillo
- Christian Prebensen
- Christian Rabaud
- Christophe Fraser
- Christophe Rapp
- Christopher A Green
- Christy Kay
- Ci Wong Xin
- Citarella Barbara Wanjiru
- Claire Andréjak
- Claire Foley
- Claire Kelly
- Claire Levy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudia Sepulveda
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Cleide Barrigoto
- Clotilde Allavena
- Clément Le Bihan
- Coilin Smyth
- Colin McArthur
- Colin McArthur
- Colin McCloskey
- Coline Jaud-Fischer
- Colleen Curran
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Cosimo Cristella
- Courtney Greene
- Cristina De Rose
- Cristinava Vajdovics
- Cynthia Alegre
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cécile Yelnik
- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Dafsah Juzar
- Dag Henrik Reikvam
- Dagens Andrew
- Daisuke Kasugai
- Dalia Lopez-Colon
- Damien Bouhour
- Dan Meyer
- Daniel Glikman
- Daniel Haber
- Daniel Ivulich
- Daniel Marino
- Daniel Mathieu
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- Danilo Buonsenso
- Dankwa Emmanuelle A
- Darakhshan Kanwal
- Dario Sinatti
- Darren Dahly
- Darshana Hewa Kandamby
- Dave Nagpal
- David Bellemare
- David Dean
- David L Robertson
- David Maslove
- David Molina
- David Richardson
- David Stuart
- David Thomson
- David Zucman
- Davide Chiumello
- Dawn Higgins
- Debby Bogaert
- Decy Subekti
- Deepak Vijayan
- Deepali Kumar
- Deepashankari Suppiah
- Dehbia Benkerrou
- Deirdre Flynn
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Denise Battaglini
- Denise Foster
- Denise Jaworsky
- Denise Richardson
- Denisse Bazan Dow
- Derbrenn OConnor
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana Adrião
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Bastos Porto
- Diego de Mendoza
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Dimitra Melia Myrodia
- Dinesh Kuriakose
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Domenico Luca Grieco
- Dominic So
- Dominique Deplanque
- Dominique Luton
- Donnelly Christl A
- Dori-Ann Martin
- Dorothea Rosenberger
- Dorothy Breen
- Dounia Bouhmani
- Douwe F Postma
- Drashti Patel
- Dubravka Supic
- Duc Nguyen
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- Srinivas Murthy
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Huo
- Stella Rousset
- Stephan Schroll
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Stijn Van de Velde
- Streinu-Cercel Anca
- Stuart Houltham
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Su Hwan Lee
- Subbarao Elapavaluru
- Subhash Acharya
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Sung-Min Cho
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Cabral
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suwarti Suwarti
- Suzanne Bennett
- Suzette Willems
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Syed Muneeb
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Sílvia Ferreira
- T Eoin West
- Taccone Fabio
- Tae Song
- Taha Pasha
- Tahira Jamal Mohamed
- Tak-Hyuk Oh
- Takako Akimoto
- Takayuki Ogura
- Taku Tanaka
- Tala Al-Dabbous
- Tamara Seitz
- Tan Pei Wen
- Tarek Elshazly
- Tatiana Fonseca
- Tawnya Ogston
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Thalha Rashan
- Tharmini Ravi
- Tharwat Aisa
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tjard Schermer
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tomoyuki Endo
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Vadim Tieroshyn
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vecham Pavan Kumar
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Janes
- Victoria Manda
- Victoria McEneany
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Véronique Lemee
- Víctor Quirós González
- Wai Ching Sin
- Walter Picard
- Wan Fadzlina Wan Muhd Shukeri
- Wei Han Hoh
- Wei Shen Lim
- Wei Jia
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Wils Evert-Jan
- Wim Dieperink
- Wing Yiu Ng
- Xavier Duval
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zul Fakar
- Zulfiqar Sandhu
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 28/02/2023
- Field of study
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death
Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
- Author
- A T Landers
- Aaron Lawson McLean
- Abbey Paton
- Abdel Razzaq Khalaf
- Abdul Hafiz Alias
- Abdurrahman Ahmad
- Abegail Salvana
- Abigail Keen
- Abigail Patrick
- Abraham Hulst
- Acela G Lopez
- Adam Evans
- Adam Rehak
- Adamu Muhammad Sarki
- Ade Nurkacan Dursin
- Ade Susanti
- Adela Ruiz
- Adeline Rankin
- Ademola Talabi
- Adenekan Adetoye
- Adeoluwa Tayo
- Adeyinka Ademola
- Aditi Kulkarni
- Aditi Naik
- Aditi Shrivastava
- Adriana Krepil
- Adrianna Woolsey
- Adrianna Woolsey
- Adrienne Carr
- Afolabi Owojuyigbe
- Aggeliki Bairaktari
- Agoritsa Tsioka
- Agostino Roasio
- Ahamed Khader
- Ahmad Sufian Ab Rahman
- Ahmed Ahmed
- Ahmed El-Sayed
- Ahmed Saloojee
- Ahmed Sayeed
- Aida Tantri
- Aida Tantri
- Aikaterini Chatzimichali
- Aikaterini Kyparissi
- Aikaterini Makatounaki
- Aisling Clarkson
- Ajay Gupta
- Akanmu Durodola
- Akbar Vohra
- Akbar Vohra
- Akbar Vohra
- Akbar Vohra
- Akram Fuad
- Alae Conradie
- Alasdair Scott
- Alastair Rose
- Alba Perez Gonzalez
- Albert Tsui
- Alberto Lisi
- Alberto Premoli
- Alberto Ramirez
- Alberto Zangrillo
- Alda Martins
- Aleaxandra Moustaka
- Alejandra Romero Rodrigo
- Alejandro Duca
- Alejandro Suarez-de-la-Rica
- Aleksandr Iurin
- Aleksandr Molkov
- Aleksandr Samoilenko
- Aleksandr Tchekulaev
- Alessandra Bettinelli
- Alessandro Gatta
- Alessandro Marchesi
- Alex Looseley
- Alex Ragan
- Alexander Bates
- Alexander Chan
- Alexander Durst
- Alexander Fowler
- Alexander Freethy
- Alexander Ishimaru
- Alexander Kulikov
- Alexander Tolmasov
- Alexandra Abrunhosa
- Alexandra Charlalampidoy
- Alexandra Dumitrescu
- Alexandra Papaioannou
- Alexandra Torborg
- Alexandra Williams
- Alexandra Wolfer
- Alexandra Wolfer
- Alexandre Ouattara
- Alexandros Andreou
- Alexey Karelov
- Alfonso Munoz-López
- Alhafidz Hamdan
- Alhassan Datti Mohammed
- Ali Elabib
- Ali Vahedi
- Aliaksandra Parashchanka
- Alice Stevens
- Alifia Tameem
- Alison Donna
- Alison Ghosh
- Alison Knaggs
- Alison Liddle
- Alison Paton
- Alison Wilson
- Alistair Hellewell
- Alycon Walker
- Alyson Andrew
- Amabra Dodiyi-Manuel
- Amanda Cowton
- Amanda Datson
- Amanda Finch
- Amanda Jansen van Vuuren
- Amanda Lofting
- Amanda Lyle
- Amanda Miñana
- Amos Obobolo
- Amy Stevens
- Ana Cristina Miranda Martins Costa
- Ana Flavia Brotto
- Ana Izquierdo Palomares
- Ana Margarida Santos
- Ana Maria Vilela Dos Santos
- Anahi Perlas
- Anastasia Koutsikou
- Anastasia Spartinou
- Anastasia Vachlioti Vachlioti
- Anastasios Katsourakis
- Anders Oldner
- Andre Bernard
- Andre Bernard
- Andre Bernard
- Andrea Sibilio
- Andrea Stocker
- Andreas Asimakos
- Andreas Eichwalder
- Andreas Filippopoulos
- Andreas Fleischer
- Andreas Flossos
- Andreas Hoeft
- Andreas Hoeft
- Andreas Weyland
- Andreea Balanescu
- Andreea Stefan
- Andreu Cueva
- Andrew Barnett
- Andrew Berg
- Andrew Biffen
- Andrew Brennan
- Andrew Brown
- Andrew Burtenshaw
- Andrew Claxton
- Andrew Cruikshanks
- Andrew Donovan
- Andrew Macalister Hall
- Andrew McDonald
- Andrew Milne
- Andrew Pool
- Andrew Ratcliffe
- Andrew Rhodes
- Andrew Selman
- Andrew Smith
- Andrew Suen
- Andrew Suen
- Andrew Suen
- Andrew Swain
- Andrew Torrance
- Andrew Woodgate
- Andrey Lubnin
- Andri Kurnia
- Andriy Krystopchuk
- Andromachi Efthymiadi
- Andy Kwok
- Anette Barbre Pedersen
- Angela Freschini
- Angela King
- Angela Morgan
- Angela Pinder
- Angela Sanchez
- Angelantonio Pascazio
- Angeliki Tsagkaraki
- Angelo Benevento
- Angelo Porto
- Angels Lozano
- Angie Dempster
- Angus Turner
- Angus Turner
- Anil Madaree
- Anisha Perera
- Anisoara Codita
- Anisoglou Sousana
- Anita Alias
- Anjali Bilolikar
- Ankie Koopman-van Gemert
- Anmol Yagnik
- Ann De Bruyne
- Ann Vanluchene
- Anna Fouracres
- Anna Musgrave
- Anna Ratcliffe
- Anna Reyes
- Anna Roshchina
- Anna Spring
- Anna Thomas
- Anna Valle Beltran
- Annabel Pearson
- Anne Adolfsson
- Anne Wesonga Shikanda
- Anneliese Moerman
- Annemarie Brunswicker
- Annette Nilsson
- Annie Smith
- Annika Hedin
- Annika Hedin
- Annika Yuliana
- Anthi Skoufi
- Anthony Adenekan
- Anthony Kennedy
- Anthony Watson
- Antoine Meyer
- Antoine Tesniere
- Antonina Webombesa
- Antonio Colangelo
- Antonio Katime
- Antonio Martins
- Antonio Pata
- Antonis Totis
- Antony Clyde
- António Armando Furtado Paiva
- Anuforo Grace
- Anupa Ramnarain
- Anuschka Langner
- Apostolos Armaganidis
- Apostolos Prionas
- Arantxa Mas
- Arash Afshari
- Archontoula Xifara
- Arian Lena
- Aristeidis Vakalos
- Arlo Whitehouse
- Armando Adolfo Alvarez Flores
- Armin Sablotzki
- Arnaud Steyaert
- Arrash Yassaee
- Art Wallace
- Artem Dunay
- Arthur Bouwman
- Arthur Bouwman
- Arun Kochhar
- Arvind Karthikeyan
- Aryabiantara Arya
- Arystarch Makowski
- Asako Shida
- Ashish Dasrath
- Ashley Hinther
- Ashley Hinther
- Ashok Chhabra
- Ashok Raj
- Aspasia Papailia
- Asuncion Marques Parra
- Athanasia Tsirogianni
- Athanasios Provatidis
- Athena Lavrentieva
- Athina Anagnou
- Athina Lavrentieva
- Atideb Mitra
- Atideb Mitra
- Attila Jonas
- Atul Garg
- Atul Kulkarni
- Atul Kulkarni
- Audrey Pospiech
- Augustine A Adeolu
- Aurélien Venara
- Aurélien Venara
- Avesh Singh
- Axe Robert
- Axel Ramminger
- Axel Sylvan
- Ayyaz Hussain
- Babatunde Babasola Osinaike
- Badru Adewale
- Bala Pillay
- Baolei Guo
- Baoli Cheng
- Baoling Zhang
- Barton Thiessen
- Bas van Zaane
- Bassanio Law
- Bastiaan Brand
- Beata Misztal
- Beatrix Laetsch
- Beatriz Castaño
- Beatriz Castaño Moreira
- Bei Liu
- Beibei Dong
- Belinda Senta Küsel
- Ben Burston
- Ben Chandler
- Ben Grey
- Ben Skinner
- Benchao Hou
- Benedikt Preckel
- Bengt Klarin
- Benjamin Bolaji
- Benjamin Harris
- Benjamin Post
- Bernadette Rowe
- Bernard Hadebe
- Bernardo Bollen Pinto
- Bernardo Maia
- Bernhard Walder
- Beth Port
- Bhagwan Singh
- Bhagyashree Netke
- Bhagyesh Shah
- Bhavesh Raithatha
- Bhavika Daya
- Bianca Purcarin
- Bianca van den Berg
- Bimalshakth Bunwarie
- Bin Li
- Binbin Ji
- Bing Zhao
- Birender Balain
- Birgitte Brandsborg
- Bisola Onajin-Obembe
- Bjorn Heyse
- Blaylock Heather
- Bo Li
- Bo Lu
- Bo Meng
- Bo Zhao
- Bobby Krishnachetty
- Bodil Steen Rasmussen
- Bonita Funk
- Boris Schiltz
- Bosun Hong
- Brendon Manikkam
- Brennan C. Kahan
- Brian Bateman
- Brian Hopkins
- Brian Rhadamantyne Ramon
- Bright Obasuyi
- Brillyan Jehosua
- Bruce Biccard
- Bruce M Biccard
- Bruna Ferreira da Costa Fischer
- Bruno Janssen
- Bryant Helen
- Burair Geddoa
- Burhan Shawki
- Byron Ramesh
- Bárbara Vázquez Vicente
- Caixia Li
- Calim Neder Neto
- Calin Mitre
- Cambell Bennett
- Candice Wilscott-Davids
- Carel Cairns
- Carine Smitz
- Carl Widmark
- Carl-Heinz Kruse
- Carla Bankewitz
- Carla Maria Rodrigues
- Carla Nau
- Carla Tinti
- Carlo Alberto Volta
- Carlos B Hernandez
- Carlos Conde
- Carlos Delgado Navarro
- Carlos Ferrando
- Carmen Vaida
- Carol Gray
- Carol Jeffs
- Carol McArthur
- Carola Wiegand-Loehnert
- Carolina Soledad Romero Garcia
- Caroline Abernethy
- Caroline Azevedo
- Caroline Hamilton
- Caroline Holaubek
- Caroline Prégardien
- Caroline Vanpeteghem
- Caroline Wrey Brown
- Carolyn Brooks
- Carolyn Colvin
- Carolyn Czepanski
- Carolyn Fowler
- Carolyn Lee
- Carrie Kelly
- Carys Lewis
- Catherine Boereboom
- Catherine Gray
- Catherine Harden
- Catherine Hicks
- Cathy Lawson
- Ce Zhou
- Ceri Beaton
- Cesar Aldecoa
- Cesar Aldecoa
- Chamika Abayasinghe
- Chan Kelly
- Chang Joon Kim
- Changlin He
- Changshun Huang
- Chantal Rajah
- Chao Chen
- Chao Qin
- Chao Wu
- Charde Naylor
- Chardé Naylor
- Charles Hennings
- Charles Otim Tom
- Charlotte Anderson
- Charlotte Davies
- Charlotte Downes
- Charlotte Ritchie
- Charlotte Thomas
- Cheme Andersen
- Chen Chen
- Cheng Ong
- Cheng Wong Weng
- Chettan Bhula
- Chew Kiok Lee
- Chi Cheong Joe Lam
- Chi Pang Yip
- Chi Wu
- Chiara Alloj
- Chiara Colangelo
- Chiat Fong Liew
- Ching Yue Janice Hung
- Chinmay Patvardhan
- Chiun Chen Jee
- Chloe O'Hara
- Chong Zhao
- Chris Evans
- Chris King
- Chris Marquis
- Chris Pemberton
- Christa Boer
- Christel Huygens
- Christella Alphonsus
- Christian Buerkle
- Christian Gastaldi
- Christian Kampik
- Christian Szabo
- Christian Von Heymann
- Christiane Kubitzek
- Christina Arnaoutoglou
- Christina Bali
- Christina Iasonidou
- Christina Lavdaiou
- Christina Wasmund
- Christine Boyd
- Christine Carroll
- Christine Härtl
- Christol Bizios
- Christoph Hofer
- Christoph Hofer
- Christophe Gaudin
- Christopher Applewhaite
- Christopher Applewhaite
- Christopher Eggleston
- Christopher Munns
- Christopher Smith
- Christopher Soll
- Christopher Thomas
- Christopher Wong
- Christos Chronis
- Christos Loumpias
- Christos Panagiotakis Panagiotakis
- Christos Tsigris
- Chrysavgi Giannaki
- Chuanyu Sun
- Chun Kwong Eric Chung
- Chun-Xiao Liu
- Cifra Elna
- Ciresica Diaconescu
- Ciro Morgese
- Clair Harris
- Claire Calderwood
- Claire Kurasz
- Claire Lampiri Lampiri
- Claire Mestanza
- Claire Pegg
- Claire Prince
- Clare Attwood
- Clare Blackwell
- Clare Bullock
- Clare Mellis
- Clare Mewies
- Clare Morkane
- Clarissa Cheah
- Claudio Piras
- Claus Hovendal
- Clementina Oana Dumitrascu
- Clio Kapaktsi
- Cloro Paolo Maria
- Colette Anderson
- Colette Seasman
- Colin Bergin
- Colin McAdam
- Colin McCartney
- Concepcion Rubio
- Conor Bentley
- Conway Daniel
- Conyu Shen
- Coral Smith
- Cormac Kelly
- Corrado Bottini
- Craig Jones
- Crisitiano Aguzzoli
- Cristian Remus Harsan
- Cristina Ciobanu
- Cristina Hartmann
- Cristina Paula Carp
- Cristina Petrisor
- Cristina Prata Amendola
- Cristina Romao
- Cristina Saiz
- Cristina Salta
- Cristina Tudor
- Cucu Africander
- Cui-Cui Kong
- Célia Duarte
- Dachun Zhou
- Dagmara A Legutko
- Daiana Taddeo
- Dajiang Yuan
- Dan Corneci
- Dana Bruma
- Dana Tomescu
- Danai Balfoussia
- Daniel Hadfield
- Daniel Martin
- Daniel Paz Martín
- Daniel Polakovic
- Daniel Polakovich
- Daniel Rusu
- Daniela Denisa Cernea
- Daniela Filipescu
- Daniela Ionescu
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- Daniela Souza
- Daniele Corti
- Daniella Bodansky
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- Davies Simon
- Davina McAllister
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- Edward Mathney
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- Edwin Wilberforce-Turton
- Edyta Niebrzegowska
- Efstratios Mainas
- Efthimios Charitos
- Ehab Helmy Abdel Goad
- Eilidh Mcintyre
- Eirini Oloktsidou
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- Eka Yudha Lantang
- Eke Ijuo
- Elaine Coughlan
- Elaine Paul
- Elaine Walker
- Eleanor Jones
- Eleftheria Dalampini
- Eleftherios Papadakis
- Elena Arnaoutoglou
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- Elena Moizo
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- Eleonora Costanzo
- Eliana Caser
- Elias Athanasakis
- Elias Onuora
- Elinor Wighton
- Elisabeth Schneider
- Elisavet Geromarkaki
- Elisavet Lisari
- Elissaios Kontis
- Elitza Sardareva
- Eliza Moldovan
- Elizabeth Attrill
- Elizabeth Hawes
- Elizabeth Tinuoye
- Elke Czeslick
- Elke Falk
- Elke Schindler
- Ellada Kiourtzieva
- Ellen Waymouth
- Elli Kalliafa
- Elna Cifra
- Emad Geddoa
- Emad Geddoa
- Emanuel Cirstea
- Emer Berntsen
- Emer Berntsen
- Emil Hodzovic
- Emil Loots
- Emilia Pătrăşcanu
- Emilio Maseda
- Emilio Pozzi
- Emily Gar Yee Koo
- Emily Garrett
- Emily Johnson
- Emily Lisseter
- Emma Andrews
- Emma Brennan
- Emma Dalton
- Emma Durant
- Emma Forsans
- Emma Glasgow
- Emma Nofal
- Emma Plunkett
- Emma Spowart
- Emma Urias
- Emma-Jane Smith
- Emmanouhl Lilitsis
- Emmanuel Bua
- Emmanuel Ezekiel
- Emmanuel Futier
- Emmanuel Futier
- Emmanuel Oyebamiji
- Eneshia Padayachee
- Eng Ching Guok
- Enman Zhang
- Erendira Jocelin Dominguez Avila
- Erez Ben-Menachem
- Eric Weber
- Erik Lilja Secher
- Erlinda Yeh
- Ernesto Pastor Martinez
- Ernst Trampitsch
- Estefania Cabezuelo
- Estefania Gracia
- Esther Lee
- Esther Romero
- Euan McGregor
- Eugen Tincu
- Evaleen Victoria Malgapo
- Evangelia Andreadaki
- Evangelia Vetsiou
- Evangelos Michos
- Evangelos Photi
- Evdoxia Tsigou
- Evelien Schreurs
- Evgeny Grigoryev
- Ewen Griffiths
- Eymorfia Apagaki
- F Noorbhai
- Fadhel Alherz
- Faisal Siddiqui
- Faizal Zuhri Aziz
- Fan Tao
- Fan Yin Kwok
- Fang Cai
- Fang Du
- Fang Du
- Fang Yuan
- Fangfang Miao
- Fara Nur Idayu Abd Ghafar
- Farhad Alexander-Sefre
- Federico Ghignone
- Fei Wang
- Fei-Fei Liu
- Feifei Chen
- Felicia Asudo
- Felicity Mackenzie
- Fengxin Lu
- Fengying Guo
- Fernanda Beck Tabajara
- Fernanda Bettega
- Fernande Lois
- Fernando Dias
- Fernando Pérez Martín
- Fernando Rua
- Filomena Faria
- Fiona Bottrill
- Fiona Davis
- Fiona Gilmour
- Fiona Kabagenyi
- Fiona Mc Neela
- Flaviu Tosa
- Flora Souri
- Florent Wallet
- Florentina Mihaescu
- Florian Jelschen
- Florian Reichle
- Florian Scherz
- Folayemi Faponle
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- Qiong Xu
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- Qiuhong Yang
- Qiuting Zeng
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- Rubendraj R Chetty
- Rubeshan Naidoo
- Rudy Harris
- Rui Freitas Mendonça Correia da Silva
- Rui Moreno
- Rui Moreno
- Rui Xue
- Ruilin Zhang
- Rune Sarauw Lundsgaard
- Rupert Broomby
- Rupert M Pearse
- Rupert M. Pearse
- Rusnah Ab Rahman
- Russ Hewson
- Russell Hewson
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- Ruvashni Naidoo
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- Ryan Salter
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- Sabine Ethgen
- Safauldeensalem Albaj
- Sahayam Santa
- Sahely Flores Risco
- Saiful Aizar Kesut
- Sailaja Pothuneedi
- Sailaja Pothuneedi
- Salim Tayeh
- Sally Anne Pearson
- Sally Humphreys
- Sally Wright
- Salome Cruz
- Salvador Fernández
- Sam Montasser
- Sam Papadopoullos
- Samantha Allen
- Samantha Keenan
- Sameer Garg
- Sameer Somanath
- Samir Patel
- Samson Tou
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- Sanda Maria Copotoiu
- Sandeep Varma
- Sandra Dias
- Sandra Holmström
- Sandra Jumbe
- Sanghamitra Mishra
- Sanjay Shah
- Sanjeev Garg
- Santiago Garcia Del Valle
- Saoirse Lyons
- Sara Jane Allen
- Sara Lyckner
- Sara Pick
- Sara Pick
- Sara Rêgo
- Sara Scott
- Sarah Ali
- Sarah Bates
- Sarah Bowrey
- Sarah Buckley
- Sarah Cavanagh
- Sarah Cooper
- Sarah Craw
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- Sarah James
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- Sarah Moreton
- Sarah Rasip
- Sarah Scourfield
- Sarah Welsh
- Sarah Williams
- Satwant Gill
- Satwant Kaur
- Saul Sundayi
- Saul Velaz Dominguez
- Savino Spadaro
- Scott Beattie
- Scott Beattie
- Scott Beattie
- Scott Nicol
- Sean Mcmullan
- Sebastian Tranca
- Seigne Richard
- Seleen Cheah
- Selina Sewpersad
- Semarawima Wima
- Serge Molliex
- Sergey Puzanov
- Sergi Tormo
- Shafa Ullah
- Shailendra Sham
- Shalil Solanki
- Shan Luo
- Shane McQuoid
- Shanglong Yao
- Shantal Deepak
- Shara McDonald
- Shardha Chandrasekharan
- Sharif Darwish
- Sharon Cacala
- Sharon Cotterell
- Shasha Chen
- Shashikant Yegnaram
- Shaun Naidoo
- Sheba Predeep
- Shelley Baillie
- Sheng Wang
- Shenhui Jin
- Shenhui Wang
- Sheraz Markar
- Sherezade Tovar Doncel
- Sheshagiri Bengeri
- Sheshendrasurian Visvalingam
- Shihai Zhang
- Shilpaja Karpate
- Shirley Pyke
- Shiv Chande
- Shiva Tripathi
- Shiva Tripathi
- Shixia Xu
- Shiyu Chen
- Shobhit Arya
- Shu Kai Ma
- Shuangfei Hu
- Shuangjia Yang
- Shuchi Kaushik
- Shuchun Yu
- Shuijing Wu
- Shun Wang
- Shuna Zhao
- Shuying Fu
- Si Yuan Dai
- Sian Gallard
- Sian Thomas
- Sibongile J Mothae
- Siegfried Veit
- Siew Ching Tan
- Sigismond Lasocki
- Sijia Chen
- Silvano Cardellino
- Silvia Martín
- Silvia Sanchez-Morcillo
- Simao Esteves
- Simeon Olateju
- Simon Bisgaard Heintzelmann
- Simon Chau
- Simon Davis
- Simon Hill
- Simon Large
- Simon Lawson
- Simon Lewthwaite
- Simon Nørgaard Granum
- Simon Pickard
- Simon Varley
- Simona Margarit
- Simone Haselberger
- Sindiswa Ntloko
- Sinead Kelly
- Siobhan Hoare
- Sofia Kokkini
- Sofia Marques
- Sofia Serra
- Solange R Nahum
- Somasundaram Jeyanthan
- Song Huang
- Sonia Sampson
- Sonja Meier
- Sonya Daniel
- Sophia Tsiligiannis
- Sophie Gray
- Sophie Mathoulin
- Sotannde Sola
- Sotirios Bristogiannis
- Sotirios Georgios Popeskou
- Speranza Bocchino
- Spyros Zakynthinos
- Srikanth Chukkambotla
- Stanislav Pugachev
- Stavros Tsampalas
- Stefaan Bouchez
- Stefan Angermair
- Stefan Breitenstein
- Stefan de Hert
- Stefan De Hert
- Stefan Wildi
- Stephan Holliger
- Stephan Thilen
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- Stephanie Jones
- Stephen Barrett
- Stephen Choi
- Stephen John Roberts
- Stephen Kowalski
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- Stephen Phillips
- Stephen Webb
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- Steve White
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- Steven Kleopoulos
- Steven Takemoto
- Steyn van Wyk
- Stuart White
- Stylianos Gaitanakis
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- Stéphane de Rudnicki
- Su Meng
- Subash Chirkut
- Sudha Bechan
- Sudheer Karlakki
- Sue Hesketh
- Sue Olliff
- Suhas Kumar
- Sujith Basanth
- Sukhada Savarkar
- Sukumar Nagaiah
- Suman Mewa Kinoo
- Sumara Niman
- Sumayer Sanghera
- Sumitra Lahiri
- Suneetha Venugopal
- Sunny Karadia
- Suparna Das
- Suren R Ramphal
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- Susanne Sonnemann
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- Susilo Chandra
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- Swarna Baskar Sharma
- Swati Karmarkar
- Swati Pande
- Sze Meng Wong
- Sérgio Baldisserotto
- Søren Hübertz Smith
- Taeyang Kim
- Tahania Ahmad
- Tahania Ahmed
- Talvinder Gill
- Tamara Brunete
- Tamas Szakmany
- Tamas Szakmany
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- Thomas Mencke
- Thomas Owen
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- Thomas Smith
- Thuli Biyase
- Tiago do Nascimento Cabral
- Tian Yu
- Tianlong Wang
- Tianqin Yang
- Tianzhao Zheng
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- Tim Short
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- Timothy Salmond
- Tina Kobborg
- Ting Zhao
- Tingju Hu
- Tinuolac Adigun
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- Tokunbo Olajumoke
- Tom Abbott
- Tom Burrows
- Tom Jacobs
- Tom Jowitt
- Tom Lawson
- Tom Lawton
- Tom van Zundert
- Tonia Onyeka
- Tony Smith
- Tony Wong
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- Tracey Lowery
- Tracey Nolan
- Tracey Nolan
- Tracey Roberts
- Tracy Lam
- Tracy Norton
- Tracy-Lee Jansen
- Tressy Pitt-Kerby
- Troy Wildes
- Tse Siang Tan
- Tunde Osinaike
- Ucu Nurhadiat Abidin
- Ulf Kessler
- Ulrich Goebel
- Ulrika Winstone
- Uma Shastri
- Umar Musa Sule
- Ummi Azmira Ahmad Azam
- Urs Zingg
- Utara Hartawan Utara
- Vaia Aliki Rompou
- Valentin Tutunaru
- Valentina Paola Plumari
- Valentina Testa
- Valentina Tulupova
- Valerie Banner-Goodspeed
- Valerie Serra Maudet
- Valerie Smit-Fun
- Valeriy Levin
- Vandana Agarwal
- Vanessa Beavis
- Vanessa Beavis
- Vanessa Beavis
- Vanessa Nesbitt
- Varvara Vanessa Gardikou
- Vasileia Nyktari
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- Vasileios Ourailoglou
- Vasilios Bouris
- Vasilios Koulouras
- Veerle Van Mossevelde
- Vera Guttenthaler
- Veronica Cherrett
- Veronika Cakova
- Vicari Sottosanti
- Vicente Chisbert Cuenca
- Vicky Hills
- Victor Anillo
- Victor Aspelund Liljequist
- Victor Ionita
- Victor Raji
- Victoria Bennett
- Victoria Boggiano
- Victoria Freeman
- Victoria Frost
- Victoria Lambourne
- Victoria Martinson
- Victoria Phelps
- Vieri Parrini
- Vikas Kaura
- Vilavan Koompirochana
- Vimal Hariharan
- Vincent Chan
- Vineshykaa Ramesh Kumar
- Vinícius Nascimento
- Vishal Narwani
- Vishendran Govindasamy
- Vivek Sinha
- Vivesh Rughubar
- Vlad Kushakovsky
- Vladimir Kretov
- Vladislav Belskiy
- Vukani T Manzini
- Vítor Miguel Pinho-Oliveira
- Wai Cheong Soon
- Wai Kit Jacky Chan
- Wangpin Xiao
- Warren Paul Kuhn
- Wei Ren
- Wei Xiao
- Weihong Zhao
- Weilin Sung
- Weilu Zhao
- Weiwei Zhang
- Weixing Wang
- Wendy Bertram
- Wendy Joan Barrett
- Weng Ken Chan
- Wenhui Huang
- Werner Schmid
- Werner Schmid
- Weslley Mendes
- Widnyana Made Wid
- William Almeida
- William Foers
- William Peat
- Wilson Binh Quan Huynh
- Wilson Fabio Serna Martínez
- Wilton van Klei
- Wing LamWong
- Wing Sze Li
- Wing Yan Lam
- Wiryana Made Wir
- Wolfgang Buhre
- Wolfgang Buhre
- Wujun Geng
- Xenia Souvatzis
- Xian-Jin Zhou
- Xianfu Lu
- Xiangming Fang
- Xianwen Hu
- Xiao Hong Wen
- Xiaocui Lv
- Xiaodong Ge
- Xiaodong Qiu
- Xiaoguang Zhang
- Xiaohua Zou
- Xiaolan Hu
- Xiaolin Zhang
- Xiaomao Zhu
- Xiaoqin Li
- Xiaoyan Zhang
- Xiaoying Li
- Xiaoying Zhao
- Xiaoyu Li
- Xiaoyun Shi
- Xiapei Xiong
- Xin He
- Xindan Du
- Xinjian Lu
- Xinmei Jiang
- Xinyu Qi
- Xiu-Li Wang
- Xiumei Song
- Xiuxiu Zhuang
- Xuewu Lin
- Xuming Hu
- Yan Jing
- Yan Leng
- Yan Pan
- Yan Zhang
- Yana Ilyina
- Yanbing Bi
- Yanfei Xia
- Yang Liu
- Yang Yang
- Yangwen Ou
- Yangyang Han
- Yanling Li
- Yanming Huang
- Yanqiu Ai
- Yapping Zhang
- Yaqi Li
- Yaqiu Chen
- Yassr Al-Soudaine
- Yavor Metodiev
- Yazhou Wen
- Yazhuo Yuan
- Ye Zhang
- Yelong Ren
- Yemi Adelaja
- Yetong Li
- Yew Ching Lee
- Yi Liu
- Yi Zhong
- Yi Zhu
- Yijiao Chen
- Yijun Chen
- Yik Lam Chan
- Ying Cao
- Yingfen Xiong
- Yingping Liang
- Yixiu Yan
- Yiyi Shi
- Yonghao Yu
- Yongjie Chen
- Yongqing Guo
- Yongtao Sun
- Yongzhong Tang
- Yoni van Duivenvoorde
- Youliang Tong
- Yousif Saeed
- Yousra Ahmad
- Yu Fan
- Yu Sun
- Yuan Hsuan Chang
- Yuan Liang Woon
- Yuan Zhang
- Yuanming Pan
- Yuanyuan Pan
- Yue Fei
- Yuehong Qi
- Yuejiang Liu
- Yuelan Wang
- Yugang Shi
- Yuhong Li
- Yuksel Gercek
- Yun Bai
- Yun Ren
- Yunbin Fu
- Yunchang Mo
- Yunfei Cai
- Yunlin Feng
- Yunzhi Ling
- Yurui Yao
- Yushio Cheing
- Yusuf Ameer
- Yuting Wang
- Yves Jaquet
- Yvonne Hack
- Yvonne Selibea
- Zaheer Moolla
- Zaid Makzal
- Zane Farina
- Zhang Chen
- Zhen Dan Peng
- Zhen Wang
- Zhen Wang
- Zheng Guo
- Zhengyuan Liu
- Zhenrong Ji
- Zhi Wang
- Zhipeng Wang
- Zhipeng Zhu
- Zhisong Li
- Zhiting Wen
- Zhong-Yuan Xia
- Zhongming Cao
- Zi-Ying Shen
- Zin Nico
- Ziqiang Miao
- Zoe Davies
- Zoe Drinkwater
- Zoe Whitman
- Zulkarnain Hamzah
- Álvaro Réa-Neto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This was an investigator initiated study funded by Nestle Health Sciences through an unrestricted research grant, and by a National Institute for Health Research (UK) Professorship held by RP. The study was sponsored by Queen Mary University of London