Why not join the Roman Catholic Church?

The title of this contribution is purposefully ambivalent.  It can be read as a rhetorical question: when there are so many good reasons to join the church of Rome, why should Protestants refrain from taking this step? The most important historical reason for the Reformation was the state of the church: the authority of the office, and the episcopacy were spoiled by abuse of that power. The access to Christ and his grace were blocked. To what degree is this reproach still viable? In recent years, from a Reformed and evangelical perspective, there have been many changes in that Church that have caused a rapprochement, and that have prompted many Protestants to become Roman Catholic. However, the title can also be read differently: as an argumentation against joining the Roman Catholic Church.  Accordingly, this chapter will elaborate upon both possibilities and offer a number of remarks on the choice itself

Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function

STUDY QUESTION: Do genetic variations in the DNA damage response pathway modify the adverse effect of alkylating agents on ovarian function in female childhood cancer survivors (CCS)? SUMMARY ANSWER: Female CCS carrying a common BR serine/threonine kinase 1 (BRSK1) gene variant appear to be at 2.5-fold increased odds of reduced ovarian function after treatment with high doses of alkylating chemotherapy. WHAT IS KNOWN ALREADY: Female CCS show large inter-individual variability in the impact of DNA-damaging alkylating chemotherapy, given as treatment of childhood cancer, on adult ovarian function. Genetic variants in DNA repair genes affecting ovarian function might explain this variability. STUDY DESIGN, SIZE, DURATION: CCS for the discovery cohort were identified from the Dutch Childhood Oncology Group (DCOG) LATER VEVO-study, a multi-centre retrospective cohort study evaluating fertility, ovarian reserve and risk of premature menopause among adult female 5-year survivors of childhood cancer. Female 5-year CCS, diagnosed with cancer and treated with chemotherapy before the age of 25 years, and aged 18 years or older at time of study were enrolled in the current study. Results from the discovery Dutch DCOG-LATER VEVO cohort (n = 285) were validated in the pan-European PanCareLIFE (n =465) and the USA-based St. Jude Lifetime Cohort (n = 391). PARTICIPANTS/MATERIALS, SETTING, METHODS: To evaluate ovarian function, anti-Miillerian hormone (AMH) levels were assessed in both the discovery cohort and the replication cohorts. Using additive genetic models in linear and logistic regression, five genetic variants involved in DNA damage response were analysed in relation to cyclophosphamide equivalent dose (CED) score and their impact on ovarian function. Results were then examined using fixed-effect meta-analysis. MAIN RESULTS AND THE ROLE OF CHANCE: Meta-analysis across the three independent cohorts showed a significant interaction effect (P= 3.0 x 10(-4)) between rs11668344 of BRSK 1 (allele frequency = 0.34) among CCS treated with high-dose alkylating agents (CED score >= 8000 mg/m(2)), resulting in a 2.5-fold increased odds of a reduced ovarian function (lowest AMH tertile) for CCS carrying one G allele compared to CCS without this allele (odds ratio genotype AA: 2.01 vs AG: 5.00). LIMITATIONS, REASONS FOR CAUTION: While low AMH levels can also identify poor responders in assisted reproductive technology, it needs to be emphasized that AMH remains a surrogate marker of ovarian function. WIDER IMPLICATIONS OF THE FINDINGS: Further research, validating our findings and identifying additional risk contributing genetic variants, may enable individualized counselling regarding treatment-related risks and necessity of fertility preservation procedures in girls with cancer

Time-integrated 3D approach of late Quaternary sediment-depocenter migration in the Tagus depositional system: From river valley to abyssal plain

Quantification of sediment volumes in continental to deep ocean basins is key to understanding processes of sediment distribution in source-to-sink depositional systems. Using our own and published data we present the first quantification of sediment-volume changes in basins along the course of a major southwest European river during the deglaciation. The salient points of this quantitative record in the Tagus and equivalent North Atlantic basins show crucial roles for sea level, climate and land-use in the distribution of sediments. The bypass of sediments starved the Tagus basins, and subsequently sedimentation mainly occurred on the Tagus Abyssal Plain during the sea-level lowstand of the Last Glacial Maximum. The main sediment depocenter rapidly shifted via the continental shelf to the Lower Tagus Valley during sea-level rise in the deglaciation period. Finally, the main sediment depocenter shifted further landward into the Lower Tagus Valley during sea-level high stand in the Holocene. During the high-stand phase (last 7 ky), sediment flux increased up to 2.5 times, due to climate and land-use changes. The average catchment denudation rate during the last 12 ky (0.04–0.1 mm/y) is in agreement with those of other European catchments. Our study clearly demonstrates the added value of detailed knowledge of 3D depocenter distribution, size and chronology. This allowed us to identify an increased sediment flux during the last 7 ky, which was not identified using local observations from boreholes alone. The uniqueness of the Tagus depositional system lies in the combination of a large accommodation space in the bedrock-confined Lower Tagus Valley, the steep lowstand-surface gradient and the narrow continental shelf with canyons indenting the shelf break

Creation and providence

Reformed thought on creation is throughout its history deeply influenced by the knowledge that this world comes from the triune God, who we know as Father, Son, and Spirit. The world is approached with the expectation that it somehow bears the traces of the Father, Christ, and the Spirit. God remains actively involved in the continuation of his creation. Already in Calvin’s work this aspect is very clear in his rejection of the Epicurean idea of distant divinity who does not interact with the world. The continued reality of God’s rule as sovereign over all that exists is one of the basic elements of the Reformed theological tradition. At the same time it has been and still is one of the most contested doctrines

God and His Works from an Entrepreneurship Perspective

This article explores to what extent God and his works can be understood in terms of entrepreneurship. We give several theological reasons for using this lens, and we survey briefly the use of the word 'oikonomia' in the New Testament, the early church, and Reformed theology. Thereafter, we investigate how the entrepreneurship metaphor fits the narrative of the Bible. We argue that by looking at how features of entrepreneurship can be found in the way in which the triune God acts, we obtain a more comprehensive view on our history as a risky drama between God and humanity. The metaphor also highlights the important role played by humans in letting creation flourish

The Moral Status of Wealth Creation in Early-Modern Reformed Confessions

This article examines the moral status of wealth creation, particularly within its theological and religious contexts, across Reformed confessions from the sixteenth and seventeenth centuries. These confessional standards are a key source for the moral teaching of Reformed churches, and their treatments of the eighth commandment demonstrate a relatively nuanced and sophisticated view of wealth. Rather than simply denouncing wealth itself as intrinsically evil, these confessional standards, from a variety of national and ecclesial contexts, both on the European continent and Britain, provide a basis for viewing wealth creation as a moral good, even while warning against excess, temptation, and vices such as avarice and envy. This survey of the treatments of wealth from a diverse set of Reformed confessional standards provides a foundation for understanding a critical element in the formation of Reformed, and more broadly Protestant, economic ethics in the early-modern period

Prayer Healing: A Case Study Research Protocol

Context • Prayer healing is a common practice in many religious communities around the world. Even in the highly secularized Dutch society, cases of prayer healing are occasionally reported in the media, often generating public attention. There is an ongoing debate regarding whether such miraculous cures do actually occur and how to interpret them. Objective • The aim of the article was to present a research protocol for the investigation of reported cases of remarkable and/or unexplained healing after prayer. Design • The research team developed a method to perform a retrospective, case-based study of prayer healing. Reported prayer healings can be investigated systematically in accordance with a step-by-step methodology. The focus is on understanding the healing by studying it from multiple perspectives, using both medical judgment and patients' narratives collected by qualitative methods Setting • The study occurred at Vrije Universiteit (VU) and VU Medical Center (Amsterdam, Netherlands) as well as the general medical practice of the first author. Participants • Potential participants could be any individuals in the Netherlands or neighboring countries who claim to have been healed through prayer. The reports of healing came from multiple sources, including the research team's medical practices and their direct vicinities, newspaper articles, prayer healers, and medical colleagues. Outcome Measures • Medical data were obtained before and after prayer. Subsequently, a member of a research team and of a medical assessment committee made a standardized judgment that evaluated whether a cure was clinically remarkable or scientifically unexplained. The participants' experiences and insider perspectives were studied, using in-depth interviews in accordance with a qualitative research methodology, to gain insight into the perceptions and explanations of the cures that were offered by participants and by the members of the medical assessment committee. The medical findings and participants' experiences were weighed and interpreted based on a transdisciplinary framework, including biopsychosocial and theological perspectives, with reference to a conceptual framework derived from Ian Barbour's typology of positions in the science-religion debate. Conclusion • A case-based, research study protocol that compares medical and experiential findings and that interprets and structures those findings with reference to Ian Barbour's conceptual model is an innovative way of gaining deeper insight into the nature of remarkable and/or unexplained cures

A Dutch Study of Remarkable Recoveries After Prayer: How to Deal with Uncertainties of Explanation

This article addresses cases of remarkable recoveries related to healing after prayer. We sought to investigate how people who experienced remarkable recoveries re-construct and give meaning to these experiences, and examine the role that epistemic frameworks available to them, play in this process. Basing ourselves on horizontal epistemology and using grounded theory, we conducted this qualitative empirical research in the Netherlands in 2016–2021. It draws on 14 in-depth interviews. These 14 cases were selected from a group of 27 cases, which were evaluated by a medical assessment team at the Amsterdam University Medical Centre. Each of the participants had experienced a remarkable recovery during or after prayer. The analysis of the interviews, which is based on the grounded theory approach, resulted in three overarching themes, placing possible explanations of the recoveries within (1) the medical discourse, (2) biographical discourse, and (3) a discourse of spiritual and religious transformation. Juxtaposition of these explanatory frameworks provides a way to understand better the transformative experience that underlies remarkable recoveries. Uncertainty regarding an explanation is a component of knowing and can facilitate a dialogue between various domains of knowledge