On the formation of cyclones and anticyclones in a rotating fluid

It is commonly observed that the columnar vortices that dominate the large scales in homogeneous, rapidly rotating turbulence are predominantly cyclonic. This has prompted us to ask how this asymmetry arises. To provide a partial answer to this we look at the process of columnar vortex formation in a rotating fluid and, in particular, we examine how a localized region of swirl (an eddy) can convert itself into a columnar structure by inertial wave propagation. We show that, when the Rossby number (Ro) is small, the vortices evolve into columnar eddies through the radiation of linear inertial waves. When the Rossby number is large, on the other hand, no such column is formed. Rather, the eddy bursts radially outward under the action of the centrifugal force. There is no asymmetry between cyclonic and anticyclonic eddies for these two regimes. However, cyclones and anticyclones behave differently in the intermediate regime of Ro~1. Here we find that the transition from columnar vortex formation to radial bursting occurs at lower values of Ro for anticyclones, with the transition for anticyclones occurring at Ro~0.5, and that for cyclones at Ro~2. Thus, in a homogeneous turbulence experiment conducted at, say, Ro=1, we would expect to see more cyclones than anticyclones. The reason for this asymmetry at Ro~1 is explained

Hard x-ray photon-in-photon-out spectroscopy with lifetime resolution – of XAS, XES, RIXSS and HERFD

Spectroscopic techniques that aim to resolve the electronic configuration and local coordination of a central atom by detecting inner-shell radiative decays following photoexcitation using hard X-rays are presented. The experimental setup requires an X-ray spectrometer based on perfect crystal Bragg optics. The possibilities arising from non-resonant (X-Ray Emission Spectroscopy - XES) and resonant excitation (Resonant Inelastic X-Ray Scattering Spectroscopy – RIXSS, High-Energy-Resolution Fluorescence Detected (HERFD) XAS) are discussed when the instrumental energy broadenings of the primary (beamline) monochromator and the crystal spectrometer for x-ray emission detection are on the order of the core hole lifetimes of the intermediate and final electronic states. The small energy bandwidth in the emission detection yields line-sharpened absorption features. In transition metal compounds, electron-electron interactions as well as orbital splittings and fractional population can be revealed. Combination with EXAFS spectroscopy enables to extent the k-range beyond unwanted absorption edges in the sample that limit the EXAFS range in conventional absorption spectroscopy

The decay of Batchelor and Saffman rotating turbulence

The decay rate of isotropic and homogeneous turbulence is known to be affected by the large-scale spectrum of the initial perturbations, associated with at least two cannonical self-preserving solutions of the von K\'arm\'an-Howarth equation: the so-called Batchelor and Saffman spectra. The effect of long-range correlations in the decay of anisotropic flows is less clear, and recently it has been proposed that the decay rate of rotating turbulence may be independent of the large-scale spectrum of the initial perturbations. We analyze numerical simulations of freely decaying rotating turbulence with initial energy spectra $\sim k^4$ (Batchelor turbulence) and $\sim k^2$ (Saffman turbulence) and show that, while a self-similar decay cannot be identified for the total energy, the decay is indeed affected by long-range correlations. The decay of two-dimensional and three-dimensional modes follows distinct power laws in each case, which are consistent with predictions derived from the anisotropic von K\'arm\'an-Howarth equation, and with conservation of anisotropic integral quantities by the flow evolution

The decay of turbulence in rotating flows

We present a parametric space study of the decay of turbulence in rotating flows combining direct numerical simulations, large eddy simulations, and phenomenological theory. Several cases are considered: (1) the effect of varying the characteristic scale of the initial conditions when compared with the size of the box, to mimic "bounded" and "unbounded" flows; (2) the effect of helicity (correlation between the velocity and vorticity); (3) the effect of Rossby and Reynolds numbers; and (4) the effect of anisotropy in the initial conditions. Initial conditions include the Taylor-Green vortex, the Arn'old-Beltrami-Childress flow, and random flows with large-scale energy spectrum proportional to $k^4$. The decay laws obtained in the simulations for the energy, helicity, and enstrophy in each case can be explained with phenomenological arguments that separate the decay of two-dimensional from three-dimensional modes, and that take into account the role of helicity and rotation in slowing down the energy decay. The time evolution of the energy spectrum and development of anisotropies in the simulations are also discussed. Finally, the effect of rotation and helicity in the skewness and kurtosis of the flow is considered.Comment: Sections reordered to address comments by referee

Identification of signaling pathways in early mammary gland development by mouse genetics

The mammary gland develops as an appendage of the ectoderm. The prenatal stage of mammary development is hormone independent and is regulated by sequential and reciprocal signaling between the epithelium and the mesenchyme. A number of recent studies using human and mouse genetics, in particular targeted gene deletion and transgenic expression, have identified some of the signals that control specific steps in development. This process involves cell specification and proliferation, reciprocal tissue interactions and cell migration. Since some of these events are recapitulated during tumorigenesis, an understanding of these signaling pathways may contribute to the development of targeted therapies and novel drugs

p16 mutations/deletions are not frequent events in prostate cancer.

Cyclin-dependent kinase-4 inhibitor gene (p16INK4) has recently been mapped to chromosome 9p21. Homozygous deletions of this gene have been found at high frequency in cell lines derived from different types of tumours. These findings suggested therefore, that p16INK4 is a tumour-suppressor gene involved in a wide variety of human cancers. To investigate the frequency of p16INK mutations/deletions in prostate cancer, we screened 20 primary prostate tumours and four established cell lines by polymerase chain reaction (PCR) and single-strand conformation polymorphism (SSCP) analysis for exon 1 and exon 2. In contrast to most previous reports, no homozygous deletions were found in prostate cancer cell lines, but one cell line (DU145) has revealed to a mutation at codon 76. Only two SSCP shifts were detected in primary tumours: one of them corresponds to a mutation at codon 55 and the other one probably corresponds to a polymorphism. These data suggest that mutation of the p16INK4 gene is not a frequent genetic alteration implicated in prostate cancer development