3PAC: Enforcing Access Policies for Web Services

Web services fail to deliver on the promise of ubiquitous deployment and seamless interoperability due to the lack of a uniform, standards-based approach to all aspects of security. In particular, the enforcement of access policies in a service oriented architecture is not addressed adequately. We present a novel approach to the distribution and enforcement of credentials-based access policies for Web services (3PAC) which scales well and can be implemented in existing deployments

Single-mode delay time statistics for scattering by a chaotic cavity

We investigate the low-frequency dynamics for transmission or reflection of a wave by a cavity with chaotic scattering. We compute the probability distribution of the phase derivative phi'=d phi/d omega of the scattered wave amplitude, known as the single-mode delay time. In the case of a cavity connected to two single-mode waveguides we find a marked distinction between detection in transmission and in reflection: The distribution P(phi') vanishes for negative phi' in the first case but not in the second case.Comment: 10 pages including 3 figures; to be published in Physica Scripta (proceedings Nobel Symposium on Quantum Chaos

Green Function Monte Carlo with Stochastic Reconfiguration

A new method for the stabilization of the sign problem in the Green Function Monte Carlo technique is proposed. The method is devised for real lattice Hamiltonians and is based on an iterative ''stochastic reconfiguration'' scheme which introduces some bias but allows a stable simulation with constant sign. The systematic reduction of this bias is in principle possible. The method is applied to the frustrated J1-J2 Heisenberg model, and tested against exact diagonalization data. Evidence of a finite spin gap for J2/J1 >~ 0.4 is found in the thermodynamic limit.Comment: 13 pages, RevTeX + 3 encapsulated postscript figure

The ISOPHOT-MAMBO survey of 3CR radio sources: Further evidence for the unified schemes

We present the complete set of ISOPHOT observations of 3CR radio galaxies and quasars, which are contained in the ISO Data Archive, providing 75 mid- and far-infrared spectral energy distributions (SEDs) between 5 and 200 micron. For 28 sources they are supplemented with MAMBO 1.2 mm observations and for 15 sources with new submillimetre data from the SCUBA archive. We check the orientation-dependent unified scheme, in which the powerful FR2 narrow line galaxies are quasars viewed at high inclination, so that their nuclei are hidden behind a dust torus intercepting the optical-ultraviolet AGN radiation and reemitting it in the infrared. We find that (1) both the quasars and the galaxies show a high mid- to far-infrared luminosity ratio typical for powerful AGNs and (2) -- when matched in 178 MHz luminosity -- both show the same ratio of isotropic far-infrared to isotropic 178 MHz lobe power. Therefore, from our large sample investigated here we find strong evidence for the orientation-dependent unification of the powerful FR2 galaxies with the quasars.Comment: 16 pages, 7 figures, 3 tables, accepted by Astronomy & Astrophysic

Spitzer Observations of 3C Quasars and Radio Galaxies: Mid-Infrared Properties of Powerful Radio Sources

We have measured mid-infrared radiation from an orientation-unbiased sample of 3CRR galaxies and quasars at redshifts 0.4 < z < 1.2 with the IRS and MIPS instruments on the Spitzer Space Telescope. Powerful emission (L_24micron > 10^22.4 W/Hz/sr) was detected from all but one of the sources. We fit the Spitzer data as well as other measurements from the literature with synchrotron and dust components. The IRS data provide powerful constraints on the fits. At 15 microns, quasars are typically four times brighter than radio galaxies with the same isotropic radio power. Based on our fits, half of this difference can be attributed to the presence of non-thermal emission in the quasars but not the radio galaxies. The other half is consistent with dust absorption in the radio galaxies but not the quasars. Fitted optical depths are anti-correlated with core dominance, from which we infer an equatorial distribution of dust around the central engine. The median optical depth at 9.7 microns for objects with core-dominance factor R > 10^-2 is approximately 0.4; for objects with R < 10^-2, it is 1.1. We have thus addressed a long-standing question in the unification of FR II quasars and galaxies: quasars are more luminous in the mid-infrared than galaxies because of a combination of Doppler-boosted synchrotron emission in quasars and extinction in galaxies, both orientation-dependent effects.Comment: 42 pages, 14 figures plus two landscape tables. Accepted for publication in Ap

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

20 pages, 7 figures, 1 table.-- PMID: 19467223 [PubMed].-- PMCID: PMC2756644.-- NIHMSID: NIHMS130041.-- Printed version published Sep 15, 2009.Aberrant cytosine methylation in promoter regions leads to gene silencing associated with cancer progression. A number of DNA methyltransferase inhibitors are known to reactivate silenced genes; including 5-azacytidine and 2-(1H)-pyrimidinone riboside (zebularine). Zebularine is a more stable, less cytotoxic inhibitor compared to 5-azacytidine. To determine the mechanistic basis for this difference, we carried out a detailed comparisons of the interaction between purified DNA methyltransferases and oligodeoxyribonucleotides (ODNs) containing either 5-azacytosine or 2-(1H)-pyrimidinone in place of the cytosine targeted for methylation. When incorporated into small ODNs, the rate of C5 DNA methyltransferase inhibition by both nucleosides is essentially identical. However, the stability and reversibility of the enzyme complex in the absence and presence of cofactor differs. 5-Azacytosine ODNs form complexes with C5 DNA methyltransferases that are irreversible when the 5-azacytosine ring is intact. ODNs containing 2-(1H)-pyrimidinone at the enzymatic target site are competitive inhibitors of both prokaryotic and mammalian DNA C5 methyltransferases. We determined that the ternary complexes between the enzymes, 2-(1H)-pyrimidinone inhibitor, and the cofactor S-adenosyl methionine are maintained through the formation of a reversible covalent interaction. The differing stability and reversibility of the covalent bonds may partially account for the observed differences in cytotoxicity between zebularine and 5-azacytidine inhibitors.Partial support for this work was provided by a grant from the NIH/NCI (R21CA91315) to J.K.C. and a fellowship from the Graduate College at UNMC to D.V.B. We are grateful to S. Kumar of New England Biolabs for providing us with Eschericia coli strain ER1727 containing the pUHE25HhaI plasmid. This research was also supported in part with funds from the Intramural Research Program of the NIH, Center for Cancer Research, NCI Frederick.Peer reviewe

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

20 pages, 7 figures, 1 table.-- PMID: 19467223 [PubMed].-- PMCID: PMC2756644.-- NIHMSID: NIHMS130041.-- Printed version published Sep 15, 2009.Aberrant cytosine methylation in promoter regions leads to gene silencing associated with cancer progression. A number of DNA methyltransferase inhibitors are known to reactivate silenced genes; including 5-azacytidine and 2-(1H)-pyrimidinone riboside (zebularine). Zebularine is a more stable, less cytotoxic inhibitor compared to 5-azacytidine. To determine the mechanistic basis for this difference, we carried out a detailed comparisons of the interaction between purified DNA methyltransferases and oligodeoxyribonucleotides (ODNs) containing either 5-azacytosine or 2-(1H)-pyrimidinone in place of the cytosine targeted for methylation. When incorporated into small ODNs, the rate of C5 DNA methyltransferase inhibition by both nucleosides is essentially identical. However, the stability and reversibility of the enzyme complex in the absence and presence of cofactor differs. 5-Azacytosine ODNs form complexes with C5 DNA methyltransferases that are irreversible when the 5-azacytosine ring is intact. ODNs containing 2-(1H)-pyrimidinone at the enzymatic target site are competitive inhibitors of both prokaryotic and mammalian DNA C5 methyltransferases. We determined that the ternary complexes between the enzymes, 2-(1H)-pyrimidinone inhibitor, and the cofactor S-adenosyl methionine are maintained through the formation of a reversible covalent interaction. The differing stability and reversibility of the covalent bonds may partially account for the observed differences in cytotoxicity between zebularine and 5-azacytidine inhibitors.Partial support for this work was provided by a grant from the NIH/NCI (R21CA91315) to J.K.C. and a fellowship from the Graduate College at UNMC to D.V.B. We are grateful to S. Kumar of New England Biolabs for providing us with Eschericia coli strain ER1727 containing the pUHE25HhaI plasmid. This research was also supported in part with funds from the Intramural Research Program of the NIH, Center for Cancer Research, NCI Frederick.Peer reviewe

High-frequency dynamics of wave localisation

We study the effect of localisation on the propagation of a pulse through a multi-mode disordered waveguide. The correlator of the transmitted wave amplitude u at two frequencies differing by delta_omega has for large delta_omega the stretched exponential tail ~exp(-sqrt{tau_D delta_omega/2}). The time constant tau_D=L^2/D is given by the diffusion coefficient D, even if the length L of the waveguide is much greater than the localisation length xi. Localisation has the effect of multiplying the correlator by a frequency-independent factor exp(-L/2xi), which disappears upon breaking time-reversal symmetry.Comment: 3 pages, 1 figur

The heating mechanism for the warm/cool dust in powerful, radio-loud AGN

The uncertainty surrounding the nature of the heating mechanism for the dust that emits at mid- to far-IR (MFIR) wavelengths in active galaxies limits our understanding of the links between active galactic nuclei (AGN) and galaxy evolution, as well as our ability to interpret the prodigious infrared and sub-mm emission of some of the most distant galaxies in the Universe. Here we report deep Spitzer observations of a complete sample of powerful, intermediate redshift (0.05 < z < 0.7) radio galaxies and quasars. We show that AGN power, as traced by [OIII]5007 emission, is strongly correlated with both the mid-IR (24 micron) and the far-IR (70 micron) luminosities, however, with increased scatter in the 70 micron correlation. A major cause of this increased scatter is a group of objects that falls above the main correlation and displays evidence for prodigious recent star formation activity at optical wavelengths, along with relatively cool MFIR colours. These results provide evidence that illumination by the AGN is the primary heating mechanism for the dust emitting at both 24 and 70 microns, with starbursts dominating the heating of the cool dust in only 20 -- 30% of objects. This implies that powerful AGN are not always accompanied by the type of luminous starbursts that are characteristic of the peak of activity in major gas-rich mergers.Comment: 13 pages, 3 figures. Accepted for publication in astrophysical journal letter

Three-dimensional radiative transfer models of clumpy tori in Seyfert galaxies

Tori of Active Galactic Nuclei are made up of a mixture of hot and cold gas, as well as dust. In order to protect the dust grains from destruction by the hot gas as well as by the energetic radiation of the accretion disk, the dust is often assumed to be distributed in clouds. In our new 3D model of AGN dust tori, the torus is modelled as a wedge-shaped disk in which dusty clouds are randomly distributed, by taking the dust density distribution of the corresponding continuous model into account. We especially concentrate on the differences between clumpy and continuous models in terms of the temperature distributions, the surface brightness distributions and interferometric visibilities, as well as spectral energy distributions. To this end, we employ radiative transfer calculations with the help of the 3D Monte Carlo code MC3D. In a second step, interferometric visibilities are calculated from the simulated surface brightness distributions, which can be directly compared to observations with the MIDI instrument. The radial temperature distributions of clumpy models possess significantly enhanced scatter compared to the continuous cases. Even at large distances, clouds can be heated directly by the central accretion disk. The existence of the silicate 10 micron-feature in absorption or in emission depends sensitively on the distribution, the size and optical depth of clouds in the innermost part of the torus, due to shadowing effects of clouds there. This explains failure and success of previous modelling efforts of clumpy tori. After adapting the parameters of our clumpy standard model to the circumstances of the Seyfert 2 Circinus galaxy, it can qualitatively explain recent mid-infrared interferometric observations performed with MIDI, as well as high resolution spectral data.Comment: 15 pages, 23 figures, accepted by A&