Use of Policy Risk Assessment Results in Political Decision Making

The RAPID project established, during the first period, a thematic network of risk assessment experts, including relevant partners in the ten countries involved, the "Risk assessor database". The project devoted a specific activity, a single work package, to the dissemination and discussion of the methodology developed during" first two years of the project. National workshops were planned in each country to facilitate integrated knowledge translation activity, using a participatory approach to increase potential knowledge-users awareness on the RAPID project, and to engage them in using the RAPID guidance. Workshops were conceived to present case studies and the RAPID guidance to a targeted audience, to discuss and collect further insights, and integrate different perspectives in the final version of the policy evaluation methodology. However, national workshops also actively contributed to develop evidence based methodological guidance and increase its quality and relevance for potential users by bridging know-do gap between researchers and stakeholders; by involving decision makers and potential users in the knowledge creation process; by facilitating diverse stakeholder participation from governmental, academic and private sectors, carefully identified by national RAPID surveys as having direct expertise in the field of risk assessment. The cultural and administrative differences existing in the countries involved in RAPID guarantee the inclusion of a wide range of perspectives. Results of the national workshops helped to identify barriers and solutions for using the guidance, for adapting necessary changes to it and for communicating results to other potential users.

Public Health, Policy Analysis, Risk Assessment,and Impact Assessment

Public health has been defined as "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals"(Winslow 1920) or as "the art of applying science in the context of politics so as to reduce inequalities in health while ensuring the best health for the greatest number"(WHO1998). As the challenges of public health have evolved, from sanitary surveillance and infectious diseases in the past, to chronic diseases, lifestyle factors,socioeconomic conditions, occupational and environmental health determinants,health reforms and others, so have the methods of assessment advanced by research technologies development. The new health threats and epidemics, such as AIDS, SARS (Severe Acute Respiratory Syndrome), influenza H5N1, or emergencies like natural disasters or bioterrorism, effects of globalization and migration present new tasks to public health governance requiring new working methods.

Have regional inequalities in life expectancy widened within the European Union between 1991 and 2008?

<b>BACKGROUND:</b> Health inequalities have widened within and between many European countries over recent decades, but Europe-wide sub-national trends have been largely overlooked. For regions across the European Union (EU), we assess how geographical inequalities (i.e., between regions) and sociospatial inequalities (i.e., between regions grouped by an area-level measure of average household income) in male and female life expectancy have changed between 1991 and 2008.<p></p> <b>METHODS:</b> Household income, life expectancy at birth and population count data were obtained for 129 regions (level 2 Nomenclature of Statistical Territorial Units, 'NUTS') in 13 European countries with 1991-2008 data (2008 population = 272 million). We assessed temporal changes in the range of life expectancies, for all regions and for Western and Eastern European regions separately.<p></p> <b>RESULTS:</b> Between 1991 and 2008, the geographical range of life expectancies found among European regions remained relatively constant, with the exception of life expectancy among male Eastern Europeans, for whom the range widened by 2.8 years. Sociospatial inequalities in life expectancy (1999-2008 data only) remained constant for all regions combined and for Western Europe, but more than doubled in size for male Eastern Europeans. For female Eastern Europeans, life expectancy was unrelated to regional household income.<p></p> <b>CONCLUSIONS:</b>Regional life-expectancy inequalities in the EU have not narrowed over 2 decades, despite efforts to reduce them. Household income differences across European regions may partly explain these inequalities. As inequalities transcend national borders, reduction efforts may require EU-wide coordination in addition to national efforts.<p></p&gt

Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

© 2014, Springer Science+Business Media New York. We studied the effect of neuropeptide Y in concentrations of 10–10-10–6 M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y produced a biphasic effect in 21-day-old rats, which was manifested in the increase and subsequent decrease in myocardial contractility. Neuropeptide Y had little effect on myocardial contractility of 100-day-old animals

Preservice Elementary Teachers Create Mathematical Mystery Object Boxes to Review and Teach Numeration, Algebra, Geometry, and Measurement

A study was conducted with forty-seven preservice childhood (elementary) education teachers (42 F, 5 M) enrolled in two mathematics methods classes taught by the same instructor to determine the effect of these college students making curriculum materials appropriate for upper elementary students on the preservice teachers\u27 knowledge of numeration, algebra, geometry, and measurement. A Mathematical Mystery Object Box is a box containing a set of objects with corresponding clue cards. The student reads the mathematical clues addressing numeration, algebra, geometry, and measurement and attempts to locate the object that satisfies them, checking work with the picture of the correct object on the reverse side of each clue card. The study used an identical pretest/posttest design with a 20-item instrument tied to the New York State Standards for Mathematics for grades four through six. Preservice teacher scores on the pretest administered the first day of class were low (mean = 54%, standard deviation = 18%). However, without any class instruction or review, but through creating teaching materials for elementary students, the posttest scores of preservice teachers increased significantly on the posttest given nine weeks later (mean = 71%, s. d. = 14%). This indicates the amount of learning that occurs when preparing materials to teach others. Example mystery object box materials created by the preservice teachers are provided

Trends in Occupational Exposure to Styrene in the European Glass Fibre-Reinforced Plastics Industry

Aim: This study presents temporal trends of styrene exposure for workers in the European glass fibre-reinforced plastics (GRP) industry during the period 1966–2002

Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles

Relative contributions of pre-existing vs de novo genomic variation to adaptation are poorly understood, especially in polyploid organisms. We assess this in high resolution using autotetraploid Arabidopsis arenosa, which repeatedly adapted to toxic serpentine soils that exhibit skewed elemental profiles. Leveraging a fivefold replicated serpentine invasion, we assess selection on SNPs and structural variants (TEs) in 78 resequenced individuals and discover significant parallelism in candidate genes involved in ion homeostasis. We further model parallel selection and infer repeated sweeps on a shared pool of variants in nearly all these loci, supporting theoretical expectations. A single striking exception is represented by TWO PORE CHANNEL 1, which exhibits convergent evolution from independent de novo mutations at an identical, otherwise conserved site at the calcium channel selectivity gate. Taken together, this suggests that polyploid populations can rapidly adapt to environmental extremes, calling on both pre-existing variation and novel polymorphisms

Perspectives in visual imaging for marine biology and ecology: from acquisition to understanding

Durden J, Schoening T, Althaus F, et al. Perspectives in Visual Imaging for Marine Biology and Ecology: From Acquisition to Understanding. In: Hughes RN, Hughes DJ, Smith IP, Dale AC, eds. Oceanography and Marine Biology: An Annual Review. 54. Boca Raton: CRC Press; 2016: 1-72