281 research outputs found
Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes
Despite moderate heritability estimates, progress in uncovering the molecular substrate underpinning major depressive disorder (MDD) has been slow. In this study, we used prefrontal cortex (PFC) gene expression from a genetic rat model of MDD to inform probe set prioritization in PFC in a human post-mortem study to uncover genes and gene pathways associated with MDD. Gene expression differences between Flinders sensitive (FSL) and Flinders resistant (FRL) rat lines were statistically evaluated using the RankProd, non-parametric algorithm. Top ranking probe sets in the rat study were subsequently used to prioritize orthologous selection in a human PFC in a case?control post-mortem study on MDD from the Stanley Brain Consortium. Candidate genes in the human post-mortem study were then tested against a matched control sample using the RankProd method. A total of 1767 probe sets were differentially expressed in the PFC between FSL and FRL rat lines at (qless than or equal to0.001). A total of 898 orthologous probe sets was found on Affymetrix?s HG-U95A chip used in the human study. Correcting for the number of multiple, non-independent tests, 20 probe sets were found to be significantly dysregulated between human cases and controls at qless than or equal to0.05. These probe sets tagged the expression profile of 18 human genes (11 upregulated and seven downregulated). Using an integrative rat?human study, a number of convergent genes that may have a role in pathogenesis of MDD were uncovered. Eighty percent of these genes were functionally associated with a key stress response signalling cascade, involving NF-?B (nuclear factor kappa-light-chain-enhancer of activated B cells), AP-1 (activator protein 1) and ERK/MAPK, which has been systematically associated with MDD, neuroplasticity and neurogenesis
Suppressed pi^0 Production at Large Transverse Momentum in Central Au+Au Collisions at sqrt(s_NN) = 200 GeV
Transverse momentum spectra of neutral pions in the range 1 < p_T < 10 GeV/c
have been measured at mid-rapidity by the PHENIX experiment at RHIC in Au+Au
collisions at sqrt(s_NN) = 200 GeV. The pi^0 multiplicity in central reactions
is significantly below the yields measured at the same sqrt(s_NN) in peripheral
Au+Au and p+p reactions scaled by the number of nucleon-nucleon collisions. For
the most central bin, the suppression factor is ~2.5 at p_T = 2 GeV/c and
increases to ~4-5 at p_T ~= 4 GeV/c. At larger p_T, the suppression remains
constant within errors. The deficit is already apparent in semi-peripheral
reactions and increases smoothly with centrality.Comment: 326 authors, 6 pages text, RevTeX, 3 figures, 2 tables. Submitted to
PRL. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
J/Psi Production in Au-Au Collisions at sqrt(s_NN) = 200 GeV at the Relativistic Heavy Ion Collider
First results on charm quarkonia production in heavy ion collisions at the
Relativistic Heavy Ion Collider (RHIC) are presented. The yield of J/Psi's
measured in the PHENIX experiment via electron-positron decay pairs at
mid-rapidity for Au-Au reactions at sqrt(s_NN) = 200 GeV are analyzed as a
function of collision centrality. For this analysis we have studied 49.3
million minimum bias Au-Au reactions. We present the J/Psi invariant yield
dN/dy for peripheral and mid-central reactions. For the most central collisions
where we observe no signal above background, we quote 90% confidence level
upper limits. We compare these results with our J/Psi measurement from
proton-proton reactions at the same energy. We find that our measurements are
not consistent with models that predict strong enhancement relative to binary
collision scaling.Comment: 325 authors, 11 pages text, 6 figures, 4 tables, RevTeX 4. Accepted
for publication as a regular article in Physical Review C. This version has
minor changes to respond to referee suggestions. Plain text data tables for
the points plotted in figures for this and previous PHENIX publications are
publicly available at http://www.phenix.bnl.gov/papers.htm
Scaling properties of proton and anti-proton production in sqrt(s_NN) = 200 GeV Au + Au collisions
We report on the yield of protons and anti-protons, as a function of
centrality and transverse momentum, in Au+Au collisions at sqrt(s_NN) = 200 GeV
measured at mid-rapidity by the PHENIX experiment at RHIC. In central
collisions at intermediate transverse momenta (1.5 < p_T < 4.5 GeV/c) a
significant fraction of all produced particles are protons and anti-protons.
They show a centrality-scaling behavior different from that of pions. The
p-bar/pion and p/pion ratios are enhanced compared to peripheral Au+Au, p+p,
and electron+positron collisions. This enhancement is limited to p_T < 5 GeV/c
as deduced from the ratio of charged hadrons to pi^0 measured in the range 1.5
< p_T < 9 GeV/c.Comment: 325 authors, 6 pages text, 4 figures, RevTeX 4. Minor changes to text
and figures to meet PRL length restrictions; no changes to figures;
resubmitted to PRL. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
Deuteron and antideuteron production in Au+Au collisions at sqrt(s_NN)=200 GeV
The production of deuterons and antideuterons in the transverse momentum
range 1.1 < p_T < 4.3 GeV/c at mid-rapidity in Au + Au collisions at
sqrt(s_NN)=200 GeV has been studied by the PHENIX experiment at RHIC. A
coalescence analysis comparing the deuteron and antideuteron spectra with those
of protons and antiprotons, has been performed. The coalescence probability is
equal for both deuterons and antideuterons and increases as a function of p_T,
which is consistent with an expanding collision zone. Comparing (anti)proton
yields p_bar/p = 0.73 +/- 0.01, with (anti)deuteron yields: d_bar/d = 0.47 +/-
0.03, we estimate that n_bar/n = 0.64 +/- 0.04.Comment: 326 authors, 6 pages text, 5 figures, 1 Table. Submitted to PRL.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Mid-Rapidity Direct-Photon Production in p+p Collisions at sqrt(s) = 200 GeV
A measurement of direct photons in p+p collisions at sqrt(s)=200 GeV is
presented. A photon excess above background from pi^0 --> gamma+gamma, eta -->
gamma+gamma, and other decays is observed in the transverse momentum range 5.5
< p_T < 7 GeV/c. The result is compared to a next-to-leading-order perturbative
QCD calculation. Within errors, good agreement is found between the QCD
calculation and the measured result.Comment: 330 authors, 7 pages text, RevTeX, 2 figures, 2 tables. Submitted to
Physical Review D. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
A Detailed Study of High-pT Neutral Pion Suppression and Azimuthal Anisotropy in Au+Au Collisions at \sqrt{s_{NN}} = 200 GeV
Measurements of neutral pion production at midrapidity in sqrt(s_NN) = 200
GeV Au+Au collisions as a function of transverse momentum, p_T, collision
centrality, and angle with respect to reaction plane are presented. The data
represent the final pi^0 results from the PHENIX experiment for the first RHIC
Au+Au run at design center-of-mass-energy. They include additional data
obtained using the PHENIX Level-2 trigger with more than a factor of three
increase in statistics over previously published results for p_T > 6 GeV/c. We
evaluate the suppression in the yield of high-p_T pi^0's relative to point-like
scaling expectations using the nuclear modification factor R_AA. We present the
p_T dependence of R_AA for nine bins in collision centrality. We separately
integrate R_AA over larger p_T bins to show more precisely the centrality
dependence of the high-p_T suppression. We then evaluate the dependence of the
high-p_T suppression on the emission angle \Delta\phi of the pions with respect
to event reaction plane for 7 bins in collision centrality. We show that the
yields of high-p_T pi^0's vary strongly with \Delta\phi, consistent with prior
measurements. We show that this variation persists in the most peripheral bin
accessible in this analysis. For the peripheral bins we observe no suppression
for neutral pions produced aligned with the reaction plane while the yield of
pi^0's produced perpendicular to the reaction plane is suppressed by more than
a factor of 2. We analyze the combined centrality and \Delta\phi dependence of
the pi^0 suppression in different p_T bins using different possible
descriptions of parton energy loss dependence on jet path-length averages to
determine whether a single geometric picture can explain the observed
suppression pattern.Comment: 330 authors, pages text, RevTeX4, figures, tables. Submitted to
Physical Review C. Plain text data tables for the points plotted in figures
for this and previous PHENIX publications are (or will be) publicly available
at http://www.phenix.bnl.gov/papers.htm
Evidence for a long-range component in the pion emission source in Au+Au collisions at sqrt(s_NN) = 200 GeV
Emission source functions are extracted from correlation functions
constructed from charged pions produced at mid-rapidity in Au+Au collisions at
sqrt(s_NN)=200 GeV. The source parameters extracted from these functions at low
k_T, give first indications of a long tail for the pion emission source. The
source extension cannot be explained solely by simple kinematic considerations.
The possible role of a halo of secondary pions from resonance emissions is
explored.Comment: 334 authors, 6 pages, 3 figures, no tables. Submitted to Phys. Rev.
Lett. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Measurement of Single Muons at Forward Rapidity in p+p Collisions at sqrt(s) = 200 GeV and Implications for Charm Production
Muon production at forward rapidity (1.5 < |\eta| < 1.8) has been measured by
the PHENIX experiment over the transverse momentum range 1 < p_T \le 3 GeV/c in
sqrt(s) = 200 GeV p+p collisions at the Relativistic Heavy Ion Collider. After
statistically subtracting contributions from light hadron decays an excess
remains which is attributed to the semileptonic decays of hadrons carrying
heavy flavor, i.e. charm quarks or, at high p_T, bottom quarks. The resulting
muon spectrum from heavy flavor decays is compared to PYTHIA and a
next-to-leading order perturbative QCD calculation. PYTHIA is used to determine
the charm quark spectrum that would produce the observed muon excess. The
corresponding differential cross section for charm quark production at forward
rapidity is determined to be d\sigma_(c c^bar)/dy|_(y=1.6)=0.243 +/- 0.013
(stat.) +/- 0.105 (data syst.) ^(+0.049)_(-0.087) (PYTHIA syst.) mb.Comment: 329 authors, pages text, 18 figures, tables. Submitted to Physical
Review D. Plain text data tables for the points plotted in figures for this
and previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
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