11 research outputs found
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abul-Husn N. S.
- Acquilini D.
- Adams E. L.
- Adamsara A.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afrasiabi Z.
- Aguero D.
- Ahmadi S.
- Aksentijevich A.
- Al Harthi F.
- Al Mutairi A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aleagha A. E.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allos R.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A. M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- AlZahrani D.
- Amirsavadkouhi A.
- Amitrano S.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrews S. J.
- Andrews S. J.
- Andrews S. J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antinori A.
- Arabi Y. M.
- Arfan Ikram M.
- Armstrong J.
- Arning N.
- Arranz M. J.
- Arribas E.
- Arthur T. D.
- Artuso R.
- Arumugam P.
- Ascolillo S.
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- Auld D.
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- Barhoush E.
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- Bassetti M.
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- Beck A.
- Beckmann N. D.
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- Wang X.
- Wanying Z.
- Warmerdam R.
- Weiss S. T.
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- Wilson J. F.
- Wolford B.
- Wolford B.
- Woolley A. E.
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- Wyllie D. H.
- Xue X.
- Yadav A.
- Yassen A. M.
- Zanella I.
- Zeberg H.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zhou W.
- Zhou W.
- Zlatopolsky M.
- Zollner B. W. S.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Get PDFVariability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I. A. M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
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- Alotaibi S.
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- Amin V.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Get PDFCritical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2â4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
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- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
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- Souad Rahmouni
- Spencer Knight
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- Stefano Baratti
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- Susan Walker
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- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- VeÂŽronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Ăyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Get PDFVariability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- AgĂŒero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich W. C.
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Angelantonio Emanuele Di
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Anwar Mohammad
- Arabi Yaseen M.
- Arciero Elena
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Samina
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- AZARZAR Samira
- Bachetti Tiziana
- Baillie J. Kenneth
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Barda B.
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Biagio Antonio Di
- Bianchi Francesco
- Bibert Stéphanie
- Bibert Stéphanie
- Biesecker Les
- Biscarini Filippo
- Blay Natalia
- Bochud M.
- Bochud P. Y.
- Bochud P. Y.
- Bochud Pierre-Yves
- Bochud Pierre-Yves
- Boezen Marike
- Boillat Noémie
- Boillat-Blanco N.
- BottĂ Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bouras K.
- Bradford Yuki
- Brahier T.
- Brassard Nathalie
- Breen Gerome
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
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- Woolley Ann E.
- Wozniak H.
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- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
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- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- zu Bentrup F. Meyer
- Zucchi Patrizia
- Zyndorf Marissa
- Zöllner Sebastian
- Ă svold BjĂžrn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
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A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2022
- Field of study
No full textA first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdollahi H
- Abdullah T
- Abecasis GR
- Abedalthagafi M
- Abul-Husn NS
- Acquilini D
- Adams EL
- Adamsara A
- Adeleye O
- Adra D
- Afilalo J
- Afilalo M
- Afrasiabi Z
- AgĂŒero D
- Ahmadi S
- Akhtar S
- Aksentijevich A
- Al-Afghani H
- Al-Awdah L
- Alaamery M
- Alahmadey ZZ
- Alaverdian D
- Alavere H
- Albader A
- Albaiceta GM
- Albakri JK
- AlBardis H
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- Alghamdi B
- Alghamdi J
- Ali A
- Aliannejad R
- Aljawini N
- AlJohani S
- Alkwai S
- Allos R
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- Almohammed I
- Almutairi M
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- Alowayn AM
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- Arumugam P
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- Atkinson EG
- Aucella F
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- Ball CA
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- Barnes KC
- Baroni S
- Bartels M
- Bassetti M
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- Bee CE
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- Belisle A
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- Below J
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- Bennett D
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- Bernardo D
- Biagio AD
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- Bibert S
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- Biscarini F
- Blay N
- Bochud M
- Bochud P-Y
- Bochud P-Y
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- Boezen M
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- Buring JE
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- Butler-Laporte G
- Butterworth AS
- Buxbaum JD
- Caldarelli GP
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- Cantor MN
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- Capitani K
- Cappelli S
- Carella M
- Carey DJ
- Carreras A
- Carriero ML
- Castaño-Vinyals G
- Castelli F
- Castori M
- Catena E
- Caulfield MJ
- Ceri S
- Cerny A
- Chamnanphon M
- Chan G
- Chang X
- Chang X
- Chariyavilaskul P
- Charney AW
- Chasman DI
- Chassot J
- Chassé M
- Chaudhary K
- Chavan S
- Chen H-H
- Cheng N
- Chetruengchai W
- Chittoor G
- Cho JH
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- Claassen S
- Claringbould A
- Clerc O
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- Coiro G
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- ColobrĂĄn R
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- Conen A
- Conticini E
- Cordioli M
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- COVID-19 Host Genetics Initiative
- Coviello DA
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- Nkambul L
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- Tiseo G
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- Underwood SJ
- Vaghi M
- Valente S
- Valentino F
- van Blokland I
- van Heel D
- van Heel DA
- van Heel DA
- Van Singer M
- Vecchia M
- Veerapen K
- Venn LD
- Venturelli S
- Vergori A
- Verma A
- Verma SS
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- Vincenti A
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- Vollenweider P
- von Hohenstaufen KA
- von Mering C
- Vonk JM
- Vulesevic B
- Wain LV
- Walker S
- Walters RK
- Wang J
- Wang X
- Wanying Z
- Warmerdam R
- Weiss ST
- Wicks SJ
- Willer C
- Williams AT
- Wilson DJ
- Wilson JF
- Wolford B
- Wolford B
- Wolford B
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- Wyllie DH
- Xue X
- Yadav A
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- Zanella I
- Zeberg H
- Zguro K
- Zhang M
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- Zhou W
- Zhou W
- Zlatopolsky M
- zu Bentrup FM
- Zucchi P
- Zyndorf M
- Zöllner S
- Ă svold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Get PDFA second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- AgĂŒero D
- Ahmad HF
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Ahram M
- Ai M
- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Jaâafreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
- Al-Sarraj Y
- Alamer LM
- Alasdair F
- Alawneh FM
- Alawneh LM
- Albaiceta GM
- Albano G
- Albillos A
- Albrecht W
- Aldridge J
- Alexander P
- Alfonso J
- Alhousani TN
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Aliberti S
- ALjalamdeh M
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allen U
- Allibone S
- Allison KS
- Allouzy SK
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almoguera B
- Alpuche-Aranda C
- AlRawashdeh TJ
- Alsafadi DB
- Alshaer W
- Alsoub FS
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alzuraiqi MR
- Amamio M
- Aman NF
- Amin V
- Amiya S
- Ampuero J
- Anan R
- Anastasescu E
- Andersen S
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andrade V
- Andreou P
- Andreu-Bernabeu Ă
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrews S
- Andrews SJ
- Angelini C
- Ansari AI
- Antcliffe D
- Antoine P
- Antony S
- Anumakonda V
- Anwer M
- Anzai T
- Apetri E
- Aquino M
- Aquino-GĂĄlvez A
- Arai D
- Arakelyan A
- Arana-Arri E
- Arana-Arri E
- Arango C
- Aravindan L
- Arbane G
- Archer K
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- Arias SS
- Arif S
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- Armistead J
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- Armstrong J
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- Armstrong R
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- Arora M
- Arranz MJ
- Arranz MJ
- Arribas-Rodriguez E
- Artiga M-J
- Arumugam P
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- Aslibekyan S
- Asselta R
- Astin-Chamberlain R
- Atayeva N
- Athanasiou L
- Atkinson EG
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- Atwal I
- Augustin M
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- Ălvarez BG
- Ăvila-Arcos MA
- Ăvila-Arcos MC
- Ăzer O
- Ăberla K
- ĂorsteinsdĂłttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Get PDFA first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdollahi H
- Abdullah T
- Abecasis GR
- Abedalthagafi M
- Abul-Husn NS
- Acquilini D
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- Zanella I
- Zeberg H
- Zguro K
- Zhang M
- Zhao JH
- Zhou W
- Zhou W
- Zlatopolsky M
- zu Bentrup FM
- Zucchi P
- Zyndorf M
- Zöllner S
- Ă svold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textCOVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19
- Author
- A Cerny (13566592)
- A Conen (13566478)
- A Guillet (13566487)
- A Munting (13566535)
- A Perret (13566628)
- Aarno Palotie (41342)
- Abdolmajid Hosseini (13566952)
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- Part Peterson (13566430)
- Pascale Huynen (13566271)
- Patrick Deelen (187548)
- Patrick Turley (7725947)
- Patrizia Zucchi (316158)
- Pattama Torvorapanit (13566958)
- Paul H Lee (8383278)
- Paul M Ridker (7949642)
- Paul Naaber (7116242)
- Paul O'Reilly (614014)
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- Pietro Pinoli (7842704)
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- Raili Allos (13566436)
- Rana Hasanato (13567123)
- Rasoul Aliannejad (10054106)
- Ravaglia Sabrina (13566802)
- Raymond Chung (1955386)
- Raymond K Walters (13566184)
- Reedik Magi (61757)
- Renato Polimanti (3043917)
- Renzo Scaggiante (6104627)
- Riccardo Colombo (94203)
- Richard C Trembath (9257558)
- Richard H Scott (13567189)
- Richard J Packer (11075223)
- Rita Perna (13566829)
- Roaa T Halawani (13567141)
- Robert C Free (8880545)
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- Robert Frithiof (348314)
- Robert P Sebra (13567000)
- Robert Warmerdam (13566973)
- Roberta Russo (587655)
- Robin Lerner (13566895)
- Roger Colobran (824193)
- Ron Do (201540)
- Rosangela Artuso (13566787)
- Rossella Tita (9265091)
- Rui Li (4631)
- Ruth JF Loos (3810124)
- Ryan C Thompson (13566994)
- S Estoppey Younes (13566583)
- S Foucras (13566493)
- S Gonseth Nussle (13566577)
- Sabine Claassen (13566256)
- Sabino Scolletta (65043)
- Sabrina Ravaglia (6410091)
- Saeideh Ahmadi (13566940)
- Salam Massadeh (6628496)
- Saleh Alqahtani (3315315)
- Sam Bryant (13566172)
- Sam Choi (1977952)
- Sameer Chavan (3947117)
- Sameera AlJohani (3632836)
- Sami Koskelainen (13566451)
- Samina Ashraf (13566868)
- Samira Azarzar (13566268)
- Samuli Ripatti (144251)
- Sandra P Smieszek (13567231)
- Sandro Mancarella (9467152)
- Sandro Panese (6444245)
- Sang Hyuck Lee (13566892)
- Sanni Ruotsalainen (13566448)
- Sara Alotaibi (13567108)
- Sara Amitrano (9656605)
- Sara Pigazzini (13566247)
- Sarah Alkwai (13567126)
- Sarah Finer (237152)
- Sarah G Earle (13567204)
- Sauro Luchi (13566805)
- Saverio Giuseppe Parisi (4026326)
- Scott T Weiss (9407556)
- Sebastian Garcia-Madrona (13567324)
- Sebastian Zollner (13566925)
- Semira Gonseth Nussle (13566460)
- Serafina Valente (3753733)
- Serena Ludovisi (13566814)
- Serghei Mangul (4973068)
- Sergio Daga (11283239)
- Seyed Behrooz Mohseni Moghaddam (13566943)
- Shaheen Akhtar (192582)
- Shang-Kuan Lin (13567207)
- Shannon McCurdy (11944312)
- Shapna Hussain (13566886)
- Shawn N Murphy (4802670)
- Shawneequa Callier (13567228)
- Shea J Andrews (13566199)
- Shefa Miah (13566901)
- Shefali S Verma (13567090)
- Shona M Kerr (8950520)
- Silvia Baroni (2156290)
- Silvia Cappelli (13566712)
- Silvia Rojo (13567306)
- Simona Dei (13566808)
- Simona Marcantonio (9656611)
- Simona Sarzi-Braga (13566784)
- Simone Furini (173392)
- Slayton J Underwood (13566208)
- Sophie Venturelli (9326809)
- Souad Rahmouni (320501)
- Spencer Knight (13566223)
- Stefania Mantovani (202342)
- Stefano Baratti (13566817)
- Stefano Busani (735718)
- Stefano Ceri (3614225)
- Stefano Rusconi (237803)
- Stephanie Bibert (316131)
- Stephanie Gofflot (790863)
- Stephen J Wicks (13566349)
- Steven Ascolillo (13566991)
- Stuart C Sealfon (13566205)
- Sulggi Lee (5979596)
- Susan Walker (469919)
- Susanna Croci (11283263)
- Susanna Guerrini (13566682)
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- T Egger (13566625)
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- Tala Abdullah (10905739)
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- Tess Levy (11503363)
- Thanyawee Puthanakit (615421)
- Thitima B Suttichet (13566961)
- Tim D Spector (8543481)
- Tiziana Bachetti (361249)
- Tom Fowler (3624713)
- Tomas Segura (13567309)
- Tomislav Maricic (178988)
- Tomoko Nakanishi (344291)
- Tonu Esko (3310785)
- Tooraj Mirshahi (547507)
- Tormod Rogne (4818324)
- Triin Laisk (6103775)
- Tullio Trotta (13566769)
- V D'Acremont (13566580)
- V Eric Kerchberger (13566334)
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- Valentina Anemoli (13566724)
- Vasilios Polymeropoulos (13567237)
- Veronica Rico (13567261)
- Veronica Robles (7338719)
- Veronique Erard (13566466)
- Victor Moreno (748751)
- Vijay G Sankaran (13566175)
- Vincent Mooser (47546)
- Vincenzo Forgetta (756326)
- Voraphoj Nilaratanakul (13566964)
- Vorasuk Shotelersuk (581000)
- Walaa A Felemban (13567150)
- Walaa M El-Lawaty (13566397)
- Walid T Khafaga (13566394)
- Wanna Chetruengchai (9659225)
- Wanying Zhu (1567963)
- Watsamon Jantarabenjakul (9504660)
- WC Albrich (13566586)
- Wei Zhou (24328)
- Wenhan Lu (8908976)
- Werner Albrich (5541584)
- Xavier Farre (10317580)
- Xiao Chang (43560)
- Xiaoqing Xue (6116318)
- Xueyang Wang (6813818)
- Y Lannepoudenx (13566508)
- Yan Sun (22436)
- Yaseen M Arabi (12041017)
- Yasmine Belhaj (13566250)
- Yasser M El-Sherbiny (13566358)
- Yen-Chen Anne Feng (9983636)
- Yuk-Lam Ho (7010873)
- Yuki Bradford (496693)
- Yunsung Lee (10670517)
- Yuval Itan (260527)
- Yves Beguin (264097)
- Zaman Afrasiabi (10905751)
- Zeinab Naderpour (10054118)
- Ziab Z Alahmadey (13567144)
- Publication venue
- Publication date
- 03/08/2022
- Field of study
No full textThe COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5âmillion control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p
