Nuclear Fragmentation Cross Section Modeling for Space Radiation Applications

One of the most significant challenges to overcome on the journey to Mars is understanding the biological risk associated with the space radiation environment. Radiation transport codes are one of the tools necessary to quantify this risk. Due to the nature of the space radiation environment, it is of great importance that these transport codes are able to describe the breakup of heavy ions into smaller fragments|light ions in particular. For this, event generators within radiation transport codes rely on nuclear fragmentation codes to predict the products of high energy nuclear collisions. This manuscript documents the development of a nuclear fragmentation code: the Relativistic Abrasion-Ablation and Deexcitation Fragmentation Model (RAADFRG). RAADFRG is the product of a collaboration between the University of Tennessee and NASA\u27s Langley Research Center (LaRC), and is being developed for space radiation applications. Currently, total isotopic yield is of primary concern; however, future versions of the model must predict double differential isotopic yields. The collision model is a framework of smaller physics packages, each meant to describe a specific physical phenomenon within the abrasion-ablation heavy ion collision theory. The coalescence model, along with the collision framework architecture and development, are my primary original contributions

Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study

Background: The absence of a uniform and clinically relevant definition of severe postpartum haemorrhage hampers comparative studies and optimization of clinical management. The concept of persistent postpartum haemorrhage, based on refractoriness to initial first-line treatment, was proposed as an alternative to common definitions that are either based on estimations of blood loss or transfused units of packed red blood cells (RBC). We compared characteristics and outcomes of women with severe postpartum haemorrhage captured by these three types of definitions. Methods: In this large retrospective cohort study in 61 hospitals in the Netherlands we included 1391 consecutive women with postpartum haemorrhage who received either ≥4 units of RBC or a multicomponent transfusion. Clinical characteristics and outcomes of women with severe postpartum haemorrhage defined as persistent postpartum haemorrhage were compared to definitions based on estimated blood loss or transfused units of RBC within 24 h following birth. Adverse maternal outcome was a composite of maternal mortality, hysterectomy, arterial embolisation and intensive care unit admission. Results: One thousand two hundred sixty out of 1391 women (90.6%) with postpartum haemorrhage fulfilled the definition of persistent postpartum haemorrhage. The majority, 820/1260 (65.1%), fulfilled this definition within 1 h following birth, compared to 819/1391 (58.7%) applying the definition of ≥1 L blood loss and 37/845 (4.4%) applying the definition of ≥4 units of RBC. The definition persistent postpartum haemorrhage captured 430/471 adverse maternal outcomes (91.3%), compared to 471/471 (100%) for ≥1 L blood loss and 383/471 (81.3%) for ≥4 units of RBC. Persistent postpartum haemorrhage did not capture all adverse outcomes because of missing data on timing of initial, first-line treatment. Conclusion: The definition persistent postpartum haemo

Seed Population Preconditioning and Acceleration Observed by the Parker Solar Probe

A series of solar energetic particle (SEP) events was observed by the Integrated Science Investigation of the Sun (IS⊙IS) on the Parker Solar Probe (PSP) during the period from 2019 April 18 through 24. The PSP spacecraft was located near 0.48 au from the Sun on Parker spiral field lines that projected out to 1 au within ∼25° of the near-Earth spacecraft. These SEP events, though small compared to historically large SEP events, were among the largest observed thus far in the PSP mission and provide critical information about the space environment inside 1 au during SEP events. During this period, the Sun released multiple coronal mass ejections (CMEs). One of these CMEs observed was initiated on 2019 April 20 at 01:25 UTC, and the interplanetary CME (ICME) propagated out and passed over the PSP spacecraft. Observations by the Electromagnetic Fields Investigation show that the magnetic field structure was mostly radial throughout the passage of the compression region and the plasma that followed, indicating that PSP did not directly observe a flux rope internal to the ICME, consistent with the location of PSP on the ICME flank. Analysis using relativistic electrons observed near Earth by the Electron, Proton and Alpha Monitor on the Advanced Composition Explorer demonstrates the presence of electron seed populations (40–300 keV) during the events observed. The energy spectrum of the IS⊙IS-observed proton seed population below 1 MeV is close to the limit of possible stationary-state plasma distributions out of equilibrium. IS⊙IS observations reveal the enhancement of seed populations during the passage of the ICME, which likely indicates a key part of the preacceleration process that occurs close to the Sun

The radiation environment on the surface of Mars - Summary of model calculations and comparison to RAD data

The radiation environment at the Martian surface is, apart from occasional solar energetic particle events, dominated by galactic cosmic radiation, secondary particles produced in their interaction with the Martian atmosphere and albedo particles from the Martian regolith. The highly energetic primary cosmic radiation consists mainly of fully ionized nuclei creating a complex radiation field at the Martian surface. This complex field, its formation and its potential health risk posed to astronauts on future manned missions to Mars can only be fully understood using a combination of measurements and model calculations. In this work the outcome of a workshop held in June 2016 in Boulder, CO, USA is presented: experimental results from the Radiation Assessment Detector of the Mars Science Laboratory are compared to model results from GEANT4, HETC-HEDS, HZETRN, MCNP6, and PHITS. Charged and neutral particle spectra and dose rates measured between 15 November 2015 and 15 January 2016 and model results calculated for this time period are investigated

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

The helium (⁴He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. ⁴He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon (¹²C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions (¹H, ²H, ³H, ³He, and ⁴He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of ⁴He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs

Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles

The helium ((Formula presented.) He) component of the primary particles in the galactic cosmic ray spectrum makes significant contributions to the total astronaut radiation exposure. (Formula presented.) He ions are also desirable for direct applications in ion therapy. They contribute smaller projectile fragmentation than carbon ((Formula presented.) C) ions and smaller lateral beam spreading than protons. Space radiation protection and ion therapy applications need reliable nuclear reaction models and transport codes for energetic particles in matter. Neutrons and light ions ((Formula presented.) H, (Formula presented.) H, (Formula presented.) H, (Formula presented.) He, and (Formula presented.) He) are the most important secondary particles produced in space radiation and ion therapy nuclear reactions; these particles penetrate deeply and make large contributions to dose equivalent. Since neutrons and light ions may scatter at large angles, double differential cross sections are required by transport codes that propagate radiation fields through radiation shielding and human tissue. This work will review the importance of (Formula presented.) He projectiles to space radiation and ion therapy, and outline the present status of neutron and light ion production cross section measurements and modeling, with recommendations for future needs