Indicadores De Desempenho Motor Como Preditores De Fragilidade Em Idosos Cadastrados Em Uma Unidade De Saúde Da Família

This study aimed to identify the motor performance tests more strongly associated with frailty and respective cut-off points and verify the best motor performance indicator as screening tool to discriminate frailty in elderly registered in Family Health Unit Participated in the study 139 elderly aged ≥60 years 105 women and 34 men The frailty was identified by the criteria of Fried et al (2001) The motor performance tests realized were: Handgrip strength (HS) sit-to-stand test walk test (WT) and pick up a pen test Logistic regression analysis was used to associate the motor performance tests and frailty The cutoff points were evaluated by parameters provided by Receiver Operating Characteristic curve (ROC) with significance level of 5% Data were analyzed using SPSS 210 and MedCalc The mean age was 7232 ± 84 The walk test was positively associated with frailty (OR 130; p <001) and handgrip strength in elderly women was inversely associated with frailty on feminine sex (OR 074; p <0001) The WT presented a cutoff 5s (sensitivity 889 and specificity 745%) and the handgrip in the women obtained a cutoff point 146 kgf (sensitivity 833 and specificity 790%) It was concluded that the walk test was the best screening indicator to discriminate the frailty in elderly both sexes registered in a Family Health Unit. © Edições Desafio Singular.122889

Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo models

Here, we investigated the biocompatibility of a bioactive sodium calcium silicate glass containing 2.6 mol% Nb2O5 (denoted BGPN2.6) and compare the results with the archetypal 45S5 bioglass. The glass bioactivity was tested using a range of in vitro and in vivo experiments to assess its suitability for bone regeneration applications. in vitro studies consisted of assessing the cytocompatibility of the BGPN2.6 glass with bone-marrow-derived mesenchymal stem cells (BM-MSCs). Systemic biocompatibility was verified by means of the quantification of biochemical markers and histopathology of liver, kidneys, and muscles. The glass genotoxicity was assessed using the micronucleus test. The regeneration of a calvarial defect was assessed using both qualitative and quantitative analysis of three-dimensional microcomputed tomography images. The BGPN2.6 glass was not cytotoxic to BM-MSCs. It is systemically biocompatible causing no signs of damage to high metabolic and excretory organs such as the liver and kidneys. No mutagenic potential was observed in the micronucleus test. MicroCT images showed that BGPN2.6 was able to nearly fully regenerate a critical-sized calvarial defect and was far superior to standard 45S5 Bioglass. Defects filled with BGPN2.6 glass showed over 90% coverage compare to just 66% for 45S5 Bioglass. For one animal the defect was completely filled in 8 weeks. These results clearly show that Nb-containing bioactive glasses are a safe and effective biomaterial for bone replacement

Current-Density Functional Theory of the Response of Solids

The response of an extended periodic system to a homogeneous field (of wave-vector $q=0$) cannot be obtained from a $q=0$ time-dependent density functional theory (TDDFT) calculation, because the Runge-Gross theorem does not apply. Time-dependent {\em current}-density functional theory is needed and demonstrates that one key ingredient missing from TDDFT is the macroscopic current. In the low-frequency limit, in certain cases, density polarization functional theory is recovered and a formally exact expression for the polarization functional is given.Comment: 5 pages, accepted in PR

On noise treatment in radio measurements of cosmic ray air showers

Precise measurements of the radio emission by cosmic ray air showers require an adequate treatment of noise. Unlike to usual experiments in particle physics, where noise always adds to the signal, radio noise can in principle decrease or increase the signal if it interferes by chance destructively or constructively. Consequently, noise cannot simply be subtracted from the signal, and its influence on amplitude and time measurement of radio pulses must be studied with care. First, noise has to be determined consistently with the definition of the radio signal which typically is the maximum field strength of the radio pulse. Second, the average impact of noise on radio pulse measurements at individual antennas is studied for LOPES. It is shown that a correct treatment of noise is especially important at low signal-to-noise ratios: noise can be the dominant source of uncertainty for pulse height and time measurements, and it can systematically flatten the slope of lateral distributions. The presented method can also be transfered to other experiments in radio and acoustic detection of cosmic rays and neutrinos.Comment: 4 pages, 6 figures, submitted to NIM A, Proceedings of ARENA 2010, Nantes, Franc

Air Shower Measurements with the LOPES Radio Antenna Array

LOPES is set up at the location of the KASCADE-Grande extensive air shower experiment in Karlsruhe, Germany and aims to measure and investigate radio pulses from Extensive Air Showers. Since radio waves suffer very little attenuation, radio measurements allow the detection of very distant or highly inclined showers. These waves can be recorded day and night, and provide a bolometric measure of the leptonic shower component. LOPES is designed as a digital radio interferometer using high bandwidths and fast data processing and profits from the reconstructed air shower observables of KASCADE-Grande. The LOPES antennas are absolutely amplitude calibrated allowing to reconstruct the electric field strength which can be compared with predictions from detailed Monte Carlo simulations. We report about the analysis of correlations present in the radio signals measured by the LOPES 30 antenna array. Additionally, LOPES operates antennas of a different type (LOPES-STAR) which are optimized for an application at the Pierre Auger Observatory. Status, recent results of the data analysis and further perspectives of LOPES and the possible large scale application of this new detection technique are discussed.Comment: 8 pages, 10 figures, Contribution to the Arena 2008 conference, Rome, June 200

The spectrum of high-energy cosmic rays measured with KASCADE-Grande

The energy spectrum of cosmic rays between 10**16 eV and 10**18 eV, derived from measurements of the shower size (total number of charged particles) and the total muon number of extensive air showers by the KASCADE-Grande experiment, is described. The resulting all-particle energy spectrum exhibits strong hints for a hardening of the spectrum at approximately 2x10**16 eV and a significant steepening at c. 8x10**16 eV. These observations challenge the view that the spectrum is a single power law between knee and ankle. Possible scenarios generating such features are discussed in terms of astrophysical processes that may explain the transition region from galactic to extragalactic origin of cosmic rays.Comment: accepted by Astroparticle Physics June 201

The LOPES experiment - recent results, status and perspectives

The LOPES experiment at the Karlsruhe Institute of Technology has been taking radio data in the frequency range from 40 to 80 MHz in coincidence with the KASCADE-Grande air shower detector since 2003. Various experimental configurations have been employed to study aspects such as the energy scaling, geomagnetic dependence, lateral distribution, and polarization of the radio emission from cosmic rays. The high quality per-event air shower information provided by KASCADE-Grande has been the key to many of these studies and has even allowed us to perform detailed per-event comparisons with simulations of the radio emission. In this article, we give an overview of results obtained by LOPES, and present the status and perspectives of the ever-evolving experiment.Comment: Proceedings of the ARENA2010 conference, Nantes, Franc

Investigation of the Properties of Galactic Cosmic Rays with the KASCADE-Grande Experiment

The properties of galactic cosmic rays are investigated with the KASCADE-Grande experiment in the energy range between $10^{14}$ and $10^{18}$ eV. Recent results are discussed. They concern mainly the all-particle energy spectrum and the elemental composition of cosmic rays.Comment: Proc. RICAP 09, Nucl. Instr. and Meth. in pres