Letter from Matilde M. de Soto and Maria Lydia Sanchez de Roman, Deputies of the Costa Rican Legislative Assembly, to Geraldine Ferraro

Letter from Matilde M. de Soto and Maria Lydia Sanchez de Roman, Deputies of the Costa Rican Legislative Assembly, to Geraldine Ferraro. Letter has handwritten notes and includes a Library of Congress translation.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1344/thumbnail.jp

Telegram from Matilde M. de Soto and Maria Lydia Sanchez de Roman, Deputies of the Costa Rican Legislative Assembly, to Geraldine Ferraro

Telegram from Matilde M. de Soto and Maria Lydia Sanchez de Roman, Deputies of the Costa Rican Legislative Assembly, to Geraldine Ferraro. Telegram includes Library of Congress translation.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1345/thumbnail.jp

Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life

Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD

A global experiment on motivating social distancing during the COVID-19 pandemic

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Telegram from Matilde M. de Soto and Maria Lydia Sanchez de Roman, Deputies of the Costa Rican Legislative Assembly, to Geraldine Ferraro

Telegram from Matilde M. de Soto and Maria Lydia Sanchez de Roman, Deputies of the Costa Rican Legislative Assembly, to Geraldine Ferraro. Telegram includes Library of Congress translation.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1345/thumbnail.jp

Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life

Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD

Primary constitutional MLH1 epimutations: a focal epigenetic event

Background: Constitutional MLH1 epimutations are characterised by monoallelic methylation of the MLH1 promoter throughout normal tissues, accompanied by allele-specific silencing. The mechanism underlying primary MLH1 epimutations is currently unknown. The aim of this study was to perform an in-depth characterisation of constitutional MLH1 epimutations targeting the aberrantly methylated region around MLH1 and other genomic loci. Methods: Twelve MLH1 epimutation carriers, 61 Lynch syndrome patients, and 41 healthy controls, were analysed by Infinium 450 K array.&nbsp;Targeted molecular techniques were used to characterise the MLH1 epimutation carriers and their inheritance pattern. Results: No nucleotide or structural variants were identified in-cis on the epimutated allele in 10 carriers, in which inter-generational methylation erasure was demonstrated in two, suggesting primary type of epimutation. CNVs outside the MLH1 locus were found in two cases. EPM2AIP1-MLH1 CpG island was identified as the sole differentially methylated region in MLH1 epimutation carriers compared to controls. Conclusion: Primary constitutional MLH1 epimutations arise as a focal epigenetic event at the EPM2AIP1-MLH1 CpG island in the absence of cis-acting genetic variants. Further molecular characterisation is needed to elucidate the mechanistic basis of MLH1 epimutations and their heritability/reversibility

The CARMENES search for exoplanets around M dwarfs: First visual-channel radial-velocity measurements and orbital parameter updates of seven M-dwarf planetary systems

The appendix tables are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/609/A117Context. The main goal of the CARMENES survey is to find Earth-mass planets around nearby M-dwarf stars. Seven M dwarfs included in the CARMENES sample had been observed before with HIRES and HARPS and either were reported to have one short period planetary companion (GJ 15 A, GJ 176, GJ 436, GJ 536 and GJ 1148) or are multiple planetary systems (GJ 581 and GJ 876). Aims. We aim to report new precise optical radial velocity measurements for these planet hosts and test the overall capabilities of CARMENES. Methods. We combined our CARMENES precise Doppler measurements with those available from HIRES and HARPS and derived new orbital parameters for the systems. Bona-fide single planet systems were fitted with a Keplerian model. The multiple planet systems were analyzed using a self-consistent dynamical model and their best fit orbits were tested for long-term stability. Results. We confirm or provide supportive arguments for planets around all the investigated stars except for GJ 15 A, for which we find that the post-discovery HIRES data and our CARMENES data do not show a signal at 11.4 days. Although we cannot confirm the super-Earth planet GJ 15 Ab, we show evidence for a possible long-period (P = 7030 d) Saturn-mass (msini = 51.8M) planet around GJ 15 A. In addition, based on our CARMENES and HIRES data we discover a second planet around GJ 1148, for which we estimate a period P = 532.6 days, eccentricity e = 0.342 and minimum mass msini = 68.1M. Conclusions. The CARMENES optical radial velocities have similar precision and overall scatter when compared to the Doppler measurements conducted with HARPS and HIRES. We conclude that CARMENES is an instrument that is up to the challenge of discovering rocky planets around low-mass stars.© ESO, 2018.CARMENES is an instrument for the Centro Astronomico Hispano-Aleman de Calar Alto (CAHA, Almeria, Spain). CARMENES is funded by the German Max-Planck-Gesellschaft (MPG), the Spanish Consejo Superior de Investigaciones Cientificas (CSIC), the European Union through FEDER/ERF FICTS-2011-02 funds, and the members of the CARMENES Consortium (Max-Planck-Institut fur Astronomie, Instituto de Astrofisica de Andalucia, Landessternwarte Konigstuhl, Institut de Ciencies de l'Espai, Insitut fur Astrophysik Gottingen, Universidad Complutense de Madrid, Thuringer Landessternwarte Tautenburg, Instituto de Astrofisica de Canarias, Hamburger Sternwarte, Centro de Astrobiologia and Centro Astronomico Hispano-Aleman), with additional contributions by the Spanish Ministry of Economy, the German Science Foundation (DFG), the Klaus Tschira Stiftung, the states of Baden-Wurttemberg and Niedersachsen, the DFG Research Unit FOR2544 >Blue Planets around Red Stars>, and by the Junta de Andalucia. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This work used the Systemic Console package (Meschiari et al. 2009) for cross-checking our Keplerian and Dynamical fits and the python package astroML (VanderPlas et al. 2012) for the calculation of the GLS periodogram. The IEEC-CSIC team acknowledges support by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Fondo Europeo de Desarrollo Regional (FEDER) through grant ESP2016-80435-C2-1-R, as well as the support of the Generalitat de Catalunya/CERCA programme. The IAA-CSIC team acknowledges support by the Spanish Ministry of Economy and Competitiveness (MINECO) through grants AYA2014-54348-C03-01 and AYA2016-79425-C3-3-P as well as FEDER funds. The UCM team acknowledges support by the Spanish Ministry of Economy and Competitiveness (MINECO) from projects AYA2015-68012-C2-2-P and AYA2016-79425- C3-1,2,3-P and the Spanish Ministerio de Educacion, Cultura y Deporte, programa de Formacion de Profesorado Universitario, under grant FPU15/01476. T. T. and M.K. thank to Jan Rybizki for the very helpful discussion in the early phases of this work. V.J.S.B. is supported by grant AYA2015-69350-C3-2-P from the Spanish Ministry of Economy and Competiveness (MINECO). J.C.S. acknowledges funding support from Spanish public funds for research under project ESP2015-65712-C5-5-R (MINECO/FEDER), and under Research Fellowship program >Ramon y Cajal> with reference RYC2012-09913 (MINECO/FEDER). The contributions of M.A. were supported by DLR (Deutsches Zentrum fur Luft- und Raumfahrt) through the grants 50OW0204 and 50OO1501. J.L.-S. acknowledges the Office of Naval Research Global (award No. N62909-15- 1-2011) for support. C.d.B. acknowledges that this work has been supported by Mexican CONACyT research grant CB-2012-183007 and the Spanish Ministry of Economy and Competitivity through projects AYA2014-54348-C3-2-R. J.I.G.H., and R.R. acknowledge financial support from the Spanish Ministry project MINECO AYA2014-56359-P. J.I.G.H. also acknowledges financial support from the Spanish MINECO under the 2013 Ramon y Cajal program MINECO RYC-2013-14875. V. Wolthoff acknowledges funding from the DFG Research Unit FOR2544 >Blue Planets around Red Stars>, project No. RE 2694/4-1.We thank the anonymous referee for the excellent comments that helped to improve the quality of this paper