15 research outputs found
Assessment of significant benefit for orphan medicinal products by European regulators may support subsequent relative effectiveness assessments by health technology assessment organizations
- Author
- Afd Pharmacoepi & Clinical Pharmacology
- de Ruijter Angela S.
- Goettsch Wim G.
- Larsson Kristina
- Leufkens Hubert G.M.
- Mantel-Teeuwisse Aukje K.
- Naumann-Winter Frauke
- O'Connor Daniel
- Pharmacoepidemiology and Clinical Pharmacology
- Sidiropoulos Iordanis
- Stoyanova-Beninska Violeta
- Tafuri Giovanni
- Vreman Rick A.
- Wolter Franziska
- Zawada Anna
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2020
- Field of study
To maintain orphan drug status at the time of market authorization, orphan medicinal products (OMPs) need to be assessed for all criteria, including significant benefit, by the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA). Subsequently, health technology assessment (HTA) organizations evaluate the same OMPs in their relative effectiveness assessments (REAs). This review investigates the similarities and differences between the two frameworks for six HTA organizations, including the European Network for HTA. We discuss differences between both assessment frameworks within five domains (clinical evidence used, patient population, intervention, comparators, and outcome measures) for all drugs. Five illustrative cases studies were selected for a qualitative review
Assessment of significant benefit for orphan medicinal products by European regulators may support subsequent relative effectiveness assessments by health technology assessment organizations
- Author
- Afd Pharmacoepi & Clinical Pharmacology
- de Ruijter Angela S.
- Goettsch Wim G.
- Larsson Kristina
- Leufkens Hubert G.M.
- Mantel-Teeuwisse Aukje K.
- Naumann-Winter Frauke
- O'Connor Daniel
- Pharmacoepidemiology and Clinical Pharmacology
- Sidiropoulos Iordanis
- Stoyanova-Beninska Violeta
- Tafuri Giovanni
- Vreman Rick A.
- Wolter Franziska
- Zawada Anna
- Publication venue
- Publication date
- 01/07/2020
- Field of study
To maintain orphan drug status at the time of market authorization, orphan medicinal products (OMPs) need to be assessed for all criteria, including significant benefit, by the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA). Subsequently, health technology assessment (HTA) organizations evaluate the same OMPs in their relative effectiveness assessments (REAs). This review investigates the similarities and differences between the two frameworks for six HTA organizations, including the European Network for HTA. We discuss differences between both assessment frameworks within five domains (clinical evidence used, patient population, intervention, comparators, and outcome measures) for all drugs. Five illustrative cases studies were selected for a qualitative review
Stoichiometry and kinetics of single and mixed substrate uptake in Aspergillus niger
- Author
- AC Colabardini
- AJA Maris van
- ALB Cruz
- Angela ten Pierick
- Cor Ras
- D Herbert
- E Young
- F Lameiras
- Francisca Lameiras
- GJ Ruijter
- H Ilyes
- H Ronne
- J Sloothaak
- J Sloothaak
- J Sloothaak
- JA Roels
- JA Tamayo-Ramos
- Joseph J. Heijnen
- K Rumbold
- M Flipphi
- MR Mashego
- N Fries
- PA Kuyk van
- RJ Gouka
- RP Schneider
- S Niedenführ
- S Schäuble
- T Portnoy
- TF Reis dos
- V Moses
- W Vishniac
- Walter M. van Gulik
- WR Souza de
- Y Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
- Author
- Abecasis Goncalo R
- Absher Devin
- Ahluwalia Tarunveer S
- Ahmad Shafqat
- Albrecht Eva
- Alves Alexessander Couto
- Andersson Ehm A
- Asselbergs Folkert W
- Assimes Themistocles L
- Bakker Stephan JL
- Baldassarre Damiano
- Banasik Karina
- Barata Llilda
- Barcella Matteo
- Barlassina Cristina
- Barroso Ines
- Beckmann Jacques S
- Beilby John
- Bellis Claire
- Benaglio Paola
- Bennett David A
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Bis Joshua C
- Blangero John
- Blüher Matthias
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Bonnefond Amélie
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid B
- Bornstein Stefan R
- Bottinger Erwin P
- Bouchard Claude
- Boucher Gabrielle
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Broer Linda
- Bruinenberg Marcel
- Buchman Aron S
- Böger Carsten A
- Cadby Gemma
- Campbell Harry
- Chakravarti Aravinda
- Chambers John C
- Chanock Stephen J
- CHARGE Consortium
- Chasman Daniel I
- Chen Yii-Der Ida
- Cheng Yu-Ching
- Chiang Charleston WK
- Chines Peter S
- Chu Su
- Claudi-Boehm Simone
- Clegg Deborah J
- Cole John
- Collins Francis S
- Cucca Francesco
- Cupples L Adrienne
- Cusi Daniele
- Czajkowski Jacek
- de Bakker Paul IW
- de Craen Anton JM
- de Faire Ulf
- de Geus Eco JC
- de Groot Lisette CPGM
- De Jager Philip L
- Dedoussis George
- Delgado Graciela
- Deloukas Panos
- Demirkan Ayse
- den Ruijter Hester M
- DIAGRAM Consortium
- Dimitriou Maria
- Duan Jubao
- Dueker Nicole
- Ehret Georg B
- Eiriksdottir Gudny
- Eklund Niina
- Enroth Stefan
- Erdmann Jeanette
- Eriksson Joel
- Eriksson Johan G
- Esko Tõnu
- Eury Elodie
- Evans Denis A
- Fall Tove
- Farmaki Aliki-Eleni
- Farrall Martin
- Feenstra Bjarke
- Feitosa Mary F
- Ferreira Teresa
- Ferrucci Luigi
- Fischer Krista
- Ford Ian
- Forouhi Nita
- Fox Caroline S
- Franke Lude
- Franks Paul W
- Frau Francesca
- Friedrich Nele
- Froguel Philippe
- Galesloot Tessel E
- Gansevoort Ron T
- Gejman Pablo V
- Geller Frank
- Gieger Christian
- Gigante Bruna
- GLGC Consortium
- Global-BPGen Consortium
- Glorioso Nicola
- Go Alan S
- Goel Anuj
- Gordon-Larsen Penny
- Gorski Mathias
- Gottesman Omri
- Graff Mariaelisa
- Grallert Harald
- Grammer Tanja B
- Grarup Niels
- Groop Leif C
- Gräßler Jürgen
- Grönberg Henrik
- Gu Yu-Mei
- Gudnason Vilmundur
- Gustafsson Stefan
- Gyllensten Ulf
- Haitjema Saskia
- Hall Per
- Ham Annelies C
- Hamsten Anders
- Hansen Torben
- Harris Tamara B
- Hartman Catharina A
- Hassinen Maija
- Hastie Nicholas
- Hattersley Andrew T
- Hayward Caroline
- Heard-Costa Nancy L
- Heath Andrew C
- Heid Iris M
- Heliövaara Markku
- Henders Anjali K
- Hengstenberg Christian
- Hernandez Dena
- Hicks Andrew A
- Hillege Hans
- Hingorani Aroon
- Hirschhorn Joel N
- Hofman Albert
- Holmen Oddgeir
- Hottenga Jouke-Jan
- Hovingh Kees G
- Hu Frank
- Huffman Jennifer E
- Hui Jennie
- Huikuri Heikki V
- Hunter David J
- Husemoen Lise L
- Hutri-Kähönen Nina
- Hveem Kristian
- Hysi Pirro G
- ICBP Consortium
- Illig Thomas
- Ingelsson Erik
- Jackson Anne U
- Jacobs Kevin B
- Jalilzadeh Shapour
- James Alan L
- Jansen Rick
- Jaquish Cashell E
- Johansson Åsa
- Jordan Joanne M
- Jukema J Wouter
- Jula Antti
- Juonala Markus
- Justice Anne E
- Jørgensen Torben
- Kaakinen Marika
- Kajantie Eero
- Kanoni Stavroula
- Kaplan Robert C
- Karaleftheri Maria
- Karjalainen Juha
- Kathiresan Sekar
- Khaw Kay-Tee
- Kiemeney Lambertus ALM
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Kittner Steven J
- Kivimaki Mika
- Kleber Marcus E
- Knekt Paul B
- Koenig Wolfgang
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Koskinen Seppo
- Kovacs Peter
- Krarup Nikolaj T
- Kratzer Wolfgang
- Krüger Janine
- Kuh Diana
- Kumari Meena
- Kutalik Zoltán
- Kuusisto Johanna
- Kyriakou Theodosios
- Kähönen Mika
- Laakso Markku
- Lagou Vasiliki
- Lahti Jari
- Lakka Timo A
- Langenberg Claudia
- Lannfelt Lars
- Lanzani Chiara
- Launer Lenore J
- Leander Karin
- Lehne Benjamin
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F
- Lind Lars
- Lindgren Cecilia M
- Lindström Jaana
- Linneberg Allan
- Liu Yan-Ping
- Liu Youfang
- Lo Ken Sin
- Lobbens Stéphane
- Lokki Marja-Liisa
- Loos Ruth JF
- Lorentzon Mattias
- Lotay Vaneet
- Lu Yingchang
- Luan Jian'an
- Luben Robert
- Lyssenko Valeriya
- Madden Pamela AF
- Maerz Winfried
- MAGIC Consortium
- Magnusson Patrik K
- Mahajan Anubha
- Mangino Massimo
- Martin Nicholas G
- Mateo Leach Irene
- McArdle Wendy L
- McCarthy Mark I
- McKnight Barbara
- Medina-Gomez Carolina
- Melbye Mads
- Menni Cristina
- Merger Sigrun
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Mitchell Braxton D
- Mohlke Karen L
- Moll Frans L
- Monda Keri L
- Montasser May E
- Montgomery Grant W
- Morris Andrew P
- Murray Jeffrey C
- Musk Arthur W
- Mägi Reedik
- Männistö Satu
- Mäntyselkä Pekka
- Müller Gabriele
- Müller-Nurasyid Martina
- Narisu Narisu
- Neinast Michael D
- Nelis Mari
- Nieminen Markku S
- Njølstad Inger
- Nolte Ilja M
- North Kari E
- O'Connell Jeffrey R
- Ohlsson Claes
- Oldehinkel Albertine J
- Ong Kenneth
- Oostra Ben A
- Palmer Lyle J
- Palotie Aarno
- Pankow James S
- Panoutsopoulou Kalliope
- Pascoe Laura
- Pasterkamp Gerard
- Paternoster Lavinia
- Pedersen Nancy L
- Pedersen Oluf
- Penninx Brenda W
- Perola Markus
- Pers Tune H
- Pervjakova Natalia
- Peters Annette
- Pichler Irene
- Pilia Maria G
- Polašek Ozren
- Pouta Anneli
- Pramstaller Peter P
- Prokopenko Inga
- Psaty Bruce M
- Pérusse Louis
- Qi Lu
- Quertermous Thomas
- Raitakari Olli T
- Rankinen Tuomo
- Rao DC
- Rauramaa Rainer
- Rayner Nigel W
- Renström Frida
- Rheinberger Myriam
- Ribel-Madsen Rasmus
- Rice Kenneth M
- Rice Treva K
- Richards Marcus
- Ridker Paul M
- Rioux John D
- Rivadeneira Fernando
- Rivolta Carlo
- Rizzi Federica
- Rose Lynda M
- Rotter Jerome I
- Rudan Igor
- Ryan Kathy A
- Rüeger Sina
- Salo Perttu
- Salomaa Veikko
- Saltevo Juha
- Sanders Alan R
- Sanna Serena
- Sarzynski Mark A
- Sattar Naveed
- Scharnagl Hubert
- Schlessinger David
- Scholtens Salome
- Schunkert Heribert
- Schwarz Peter EH
- Scott Robert
- Scott William R
- Sebert Sylvain
- Sengupta Sebanti
- Sennblad Bengt
- Seufferlein Thomas
- Shi Jianxin
- Shuldiner Alan R
- Silveira Angela
- Simino Jeannette
- Sinisalo Juha
- Slagboom P Eline
- Smit Jan H
- Smith Albert Vernon
- Snieder Harold
- Southam Lorraine
- Sparsø Thomas H
- Spector Tim D
- Staessen Jan A
- Stančáková Alena
- Stefania Bandinelli
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Stolk Ronald P
- Strachan David P
- Strawbridge Rona J
- Stringham Heather M
- Stumvoll Michael
- Sung Yun Ju
- Swertz Morris A
- Swift Amy J
- Syvänen Ann-Christine
- Sørensen Thorkild IA
- Tachmazidou Ioanna
- Tan Sian-Tsung
- Tanaka Toshiko
- Tardif Jean-Claude
- Teslovich Tanya M
- Teumer Alexander
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tremblay Angelo
- Tremoli Elena
- Trompet Stella
- Tsafantakis Emmanouil
- Tuomilehto Jaakko
- Tyrer Jonathan
- Tönjes Anke
- Uitterlinden André G
- Uusitupa Matti
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van der Velde Nathalie
- van Dijk Suzanne C
- van Duijn Cornelia M
- van Schoor Natasja M
- van Setten Jessica
- van Vliet-Ostaptchouk Jana V
- Vandenput Liesbeth
- Verbeek André LM
- Vermeulen Sita H
- Verweij Niek
- Viikari Jorma S
- Vitart Veronique
- Vlachopoulou Efthymia
- Vohl Marie-Claude
- Vollenweider Peter
- Vonk Judith M
- Völker Uwe
- Völzke Henry
- Waeber Gérard
- Waite Lindsay L
- Waldenberger Melanie
- Walker Mark
- Walker Ryan W
- Wallaschofski Henri
- Wang Sophie R
- Wang Zhaoming
- Wareham Nicholas
- Watkins Hugh
- Wennauer Roman
- Westra Harm-Jan
- White Charles C
- Widén Elisabeth
- Wild Sarah H
- Willemsen Gonneke
- Willenborg Christina
- Wilsgaard Tom
- Wilson James F
- Winkler Thomas W
- Wong Andrew
- Wright Alan F
- Yang Jian
- Yengo Loïc
- Yerges-Armstrong Laura M
- Yu Lei
- Zeggini Eleftheria
- Zhang Weihua
- Zhao Jing Hua
- Zillikens M Carola
- Publication venue
- PLoS Genet
- Publication date
- 01/10/2015
- Field of study
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Author
- Abecasis Goncalo R
- Absher Devin
- Ahluwalia Tarunveer S
- Ahmad Shafqat
- Albrecht Eva
- Alves Alexessander Couto
- Andersson Ehm A
- Asselbergs Folkert W
- Assimes Themistocles L
- Bakker Stephan JL
- Baldassarre Damiano
- Banasik Karina
- Barata Llilda
- Barcella Matteo
- Barlassina Cristina
- Barroso Inês
- Beckmann Jacques S
- Beilby John
- Bellis Claire
- Benaglio Paola
- Bennett David A
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Bis Joshua C
- Blangero John
- Blüher Matthias
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Bonnefond Amélie
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid B
- Bornstein Stefan R
- Bottinger Erwin P
- Bouchard Claude
- Boucher Gabrielle
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Broer Linda
- Bruinenberg Marcel
- Buchman Aron S
- Böger Carsten A
- Cadby Gemma
- Campbell Harry
- Chakravarti Aravinda
- Chambers John C
- Chanock Stephen J
- Chasman Daniel I
- Chen Yii-Der Ida
- Cheng Yu-Ching
- Chiang Charleston WK
- Chines Peter S
- Chu Su
- Claudi-Boehm Simone
- Clegg Deborah J
- Cole John
- Collins Francis S
- Cucca Francesco
- Cupples L Adrienne
- Cusi Daniele
- Czajkowski Jacek
- de Bakker Paul IW
- de Craen Anton JM
- de Faire Ulf
- de Geus Eco JC
- de Groot Lisette CPGM
- De Jager Philip L
- Dedoussis George
- Delgado Graciela
- Deloukas Panos
- Demirkan Ayse
- den Ruijter Hester M
- Dimitriou Maria
- Duan Jubao
- Dueker Nicole
- Ehret Georg B
- Eiriksdottir Gudny
- Eklund Niina
- Enroth Stefan
- Erdmann Jeanette
- Eriksson Joel
- Eriksson Johan G
- Esko Tõnu
- Eury Elodie
- Evans Denis A
- Fall Tove
- Farmaki Aliki-Eleni
- Farrall Martin
- Feenstra Bjarke
- Feitosa Mary F
- Ferreira Teresa
- Ferrucci Luigi
- Fischer Krista
- Ford Ian
- Forouhi Nita G
- Fox Caroline S
- Franke Lude
- Franks Paul W
- Frau Francesca
- Friedrich Nele
- Froguel Philippe
- Galesloot Tessel E
- Gansevoort Ron T
- Gejman Pablo V
- Geller Frank
- Gieger Christian
- Gigante Bruna
- Glorioso Nicola
- Go Alan S
- Goel Anuj
- Gordon-Larsen Penny
- Gorski Mathias
- Gottesman Omri
- Graff Mariaelisa
- Grallert Harald
- Grammer Tanja B
- Grarup Niels
- Groop Leif C
- Gräßler Jürgen
- Grönberg Henrik
- Gu Yu-Mei
- Gudnason Vilmundur
- Gustafsson Stefan
- Gyllensten Ulf
- Haitjema Saskia
- Hall Per
- Ham Annelies C
- Hamsten Anders
- Hansen Torben
- Harris Tamara B
- Hartman Catharina A
- Hassinen Maija
- Hastie Nicholas
- Hattersley Andrew T
- Hayward Caroline
- Heard-Costa Nancy L
- Heath Andrew C
- Heid Iris M
- Heliövaara Markku
- Henders Anjali K
- Hengstenberg Christian
- Hernandez Dena
- Hicks Andrew A
- Hillege Hans
- Hingorani Aroon
- Hirschhorn Joel N
- Hofman Albert
- Holmen Oddgeir
- Hottenga Jouke-Jan
- Hovingh Kees G
- Hu Frank
- Huffman Jennifer E
- Hui Jennie
- Huikuri Heikki V
- Hunter David J
- Husemoen Lise L
- Hutri-Kähönen Nina
- Hveem Kristian
- Hysi Pirro G
- Illig Thomas
- Ingelsson Erik
- Jackson Anne U
- Jacobs Kevin B
- Jalilzadeh Shapour
- James Alan L
- Jansen Rick
- Jaquish Cashell E
- Johansson Åsa
- Jordan Joanne M
- Jukema J Wouter
- Jula Antti
- Juonala Markus
- Justice Anne E
- Jørgensen Torben
- Kaakinen Marika
- Kajantie Eero
- Kanoni Stavroula
- Kaplan Robert C
- Karaleftheri Maria
- Karjalainen Juha
- Kathiresan Sekar
- Khaw Kay Tee
- Kiemeney Lambertus ALM
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Kittner Steven J
- Kivimaki Mika
- Kleber Marcus E
- Knekt Paul B
- Koenig Wolfgang
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Jaspal S
- Koskinen Seppo
- Kovacs Peter
- Krarup Nikolaj T
- Kratzer Wolfgang
- Krüger Janine
- Kuh Diana
- Kumari Meena
- Kutalik Zoltán
- Kuusisto Johanna
- Kyriakou Theodosios
- Kähönen Mika
- Laakso Markku
- Lagou Vasiliki
- Lahti Jari
- Lakka Timo A
- Langenberg Claudia
- Lannfelt Lars
- Lanzani Chiara
- Launer Lenore J
- Leander Karin
- Lehne Benjamin
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F
- Lind Lars
- Lindgren Cecilia M
- Lindström Jaana
- Linneberg Allan
- Liu Yan-Ping
- Liu Youfang
- Lo Ken Sin
- Lobbens Stéphane
- Lokki Marja-Liisa
- Loos Ruth JF
- Lorentzon Mattias
- Lotay Vaneet
- Lu Yingchang
- Luan Jian'an
- Luben Robert
- Lyssenko Valeriya
- Madden Pamela AF
- Maerz Winfried
- Magnusson Patrik K
- Mahajan Anubha
- Mangino Massimo
- Martin Nicholas G
- Mateo Leach Irene
- McArdle Wendy L
- McCarthy Mark I
- McKnight Barbara
- Medina-Gomez Carolina
- Melbye Mads
- Menni Cristina
- Merger Sigrun
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Mitchell Braxton D
- Mohlke Karen L
- Moll Frans L
- Monda Keri L
- Montasser May E
- Montgomery Grant W
- Morris Andrew P
- Murray Jeffrey C
- Musk Arthur W
- Mägi Reedik
- Männistö Satu
- Mäntyselkä Pekka
- Müller Gabriele
- Müller-Nurasyid Martina
- Narisu Narisu
- Neinast Michael D
- Nelis Mari
- Nieminen Markku S
- Njølstad Inger
- Nolte Ilja M
- North Kari E
- O'Connell Jeffrey R
- Ohlsson Claes
- Oldehinkel Albertine J
- Ong Ken K
- Oostra Ben A
- Palmer Lyle J
- Palotie Aarno
- Pankow James S
- Panoutsopoulou Kalliope
- Pascoe Laura
- Pasterkamp Gerard
- Paternoster Lavinia
- Pedersen Nancy L
- Pedersen Oluf
- Penninx Brenda W
- Perola Markus
- Pers Tune H
- Pervjakova Natalia
- Peters Annette
- Pichler Irene
- Pilia Maria G
- Polašek Ozren
- Pouta Anneli
- Pramstaller Peter P
- Prokopenko Inga
- Psaty Bruce M
- Pérusse Louis
- Qi Lu
- Quertermous Thomas
- Raitakari Olli T
- Rankinen Tuomo
- Rao DC
- Rauramaa Rainer
- Rayner Nigel W
- Renström Frida
- Rheinberger Myriam
- Ribel-Madsen Rasmus
- Rice Kenneth M
- Rice Treva K
- Richards Marcus
- Ridker Paul M
- Rioux John D
- Rivadeneira Fernando
- Rivolta Carlo
- Rizzi Federica
- Rose Lynda M
- Rotter Jerome I
- Rudan Igor
- Ryan Kathy A
- Rüeger Sina
- Salo Perttu
- Salomaa Veikko
- Saltevo Juha
- Sanders Alan R
- Sanna Serena
- Sarzynski Mark A
- Sattar Naveed
- Scharnagl Hubert
- Schlessinger David
- Scholtens Salome
- Schunkert Heribert
- Schwarz Peter EH
- Scott Robert A
- Scott William R
- Sebert Sylvain
- Sengupta Sebanti
- Sennblad Bengt
- Seufferlein Thomas
- Shi Jianxin
- Shuldiner Alan R
- Silveira Angela
- Simino Jeannette
- Sinisalo Juha
- Slagboom P Eline
- Smit Jan H
- Smith Albert Vernon
- Snieder Harold
- Southam Lorraine
- Sparsø Thomas H
- Spector Tim D
- Staessen Jan A
- Stančáková Alena
- Stefania Bandinelli
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Stolk Ronald P
- Strachan David P
- Strawbridge Rona J
- Stringham Heather M
- Stumvoll Michael
- Sung Yun Ju
- Swertz Morris A
- Swift Amy J
- Syvänen Ann-Christine
- Sørensen Thorkild IA
- Tachmazidou Ioanna
- Tan Sian-Tsung
- Tanaka Toshiko
- Tardif Jean-Claude
- Teslovich Tanya M
- Teumer Alexander
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tremblay Angelo
- Tremoli Elena
- Trompet Stella
- Tsafantakis Emmanouil
- Tuomilehto Jaakko
- Tyrer Jonathan P
- Tönjes Anke
- Uitterlinden André G
- Uusitupa Matti
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- van der Velde Nathalie
- van Dijk Suzanne C
- van Duijn Cornelia M
- van Schoor Natasja M
- van Setten Jessica
- van Vliet-Ostaptchouk Jana V
- Vandenput Liesbeth
- Verbeek André LM
- Vermeulen Sita H
- Verweij Niek
- Viikari Jorma S
- Vitart Veronique
- Vlachopoulou Efthymia
- Vohl Marie-Claude
- Vollenweider Peter
- Vonk Judith M
- Völker Uwe
- Völzke Henry
- Waeber Gérard
- Waite Lindsay L
- Waldenberger Melanie
- Walker Mark
- Walker Ryan W
- Wallaschofski Henri
- Wang Sophie R
- Wang Zhaoming
- Wareham Nicholas J
- Watkins Hugh
- Wennauer Roman
- Westra Harm-Jan
- White Charles C
- Widén Elisabeth
- Wild Sarah H
- Willemsen Gonneke
- Willenborg Christina
- Wilsgaard Tom
- Wilson James F
- Winkler Thomas W
- Wong Andrew
- Wright Alan F
- Yang Jian
- Yengo Loïc
- Yerges-Armstrong Laura M
- Yu Lei
- Zeggini Eleftheria
- Zhang Weihua
- Zhao Jing Hua
- Zillikens M Carola
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/06/2016
- Field of study
[This corrects the article DOI: 10.1371/journal.pgen.1005378.].status: publishe
Recommended from our members
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
- Author
- Abecasis Goncalo
- Aben Katja K
- Alam Dewan S
- Alfred Tamuno
- Alharthi Sameer E
- Allison Matthew
- Amouyel Philippe
- Asselbergs Folkert W
- Auer Paul L
- Balkau Beverley
- Bang Lia E
- Barroso Inês
- Bastarache Lisa
- Benn Marianne
- Bergmann Sven
- Bielak Lawrence F
- Blüher Matthias
- Boehnke Michael
- Boeing Heiner
- Boerwinkle Eric
- Borecki Ingrid B
- Bork-Jensen Jette
- Bots Michiel L
- Bottinger Erwin P
- Bowden Donald W
- Bradfield Jonathan P
- Brandslund Ivan
- Breen Gerome
- Brilliant Murray H
- Broer Linda
- Brumat Marco
- Burt Amber A
- Butterworth Adam S
- Böger Carsten A
- Campbell Peter T
- Cappellani Stefania
- Carey David J
- Catamo Eulalia
- Caulfield Mark J
- Chambers John C
- Chasman Daniel I
- Chen Yii-Der Ida
- Chowdhury Rajiv
- Christensen Cramer
- Chu Audrey Y
- Cocca Massimiliano
- Collins Francis S
- Cook James P
- Corley Janie
- Cox Amanda J
- Crosslin David S
- Cuellar-Partida Gabriel
- D'Eustacchio Angela
- Danesh John
- Davies Gail
- de Bakker Paul IW
- de Groot Mark CH
- de Mutsert Renée
- Deary Ian J
- Dedoussis George
- Deloukas Panos
- Demerath Ellen W
- den Heijer Martin
- den Hollander Anneke I
- den Ruijter Hester M
- Dennis Joe G
- Denny Josh C
- Di Angelantonio Emanuele
- Drenos Fotios
- Du Mengmeng
- Dubé Marie-Pierre
- Dunning Alison M
- Easton Douglas F
- Edwards Todd L
- Ellinghaus David
- Ellinor Patrick T
- Elliott Paul
- Esko Tõnu
- Evangelou Evangelos
- Farmaki Aliki-Eleni
- Farooqi I. Sadaf
- Faul Jessica D
- Fauser Sascha
- Feitosa Mary F
- Feng Shuang
- Ferrannini Ele
- Ferrieres Jean
- Fine Rebecca S
- Florez Jose C
- Ford Ian
- Fornage Myriam
- Franco Oscar H
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Friedrich Nele
- Frikke-Schmidt Ruth
- Galbany Jordi Corominas
- Galesloot Tessel E.
- Gan Wei
- Gandin Ilaria
- Gasparini Paolo
- Gibson Jane
- Giedraitis Vilmantas
- Giri Ayush
- Gjesing Anette P
- Gordon-Larsen Penny
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Mariaelisa
- Grant Struan FA
- Grarup Niels
- Griffiths Helen L
- Grove Megan L
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeff
- Hakonarson Hakon
- Hammerschlag Anke R
- Hansen Torben
- Harris Kathleen Mullan
- Harris Tamara B
- Hattersley Andrew T
- Have Christian T
- Hayward Caroline
- He Liang
- Heard-Costa Nancy L
- Heath Andrew C
- Heid Iris M
- Helgeland Øyvind
- Hendricks Audrey E
- Hernesniemi Jussi
- Hewitt Alex W
- Highland Heather M
- Hirschhorn Joel N
- Holmen Oddgeir L
- Hovingh G Kees
- Howson Joanna MM
- Hu Yao
- Huang Paul L
- Huffman Jennifer E
- Ikram M Arfan
- Ingelsson Erik
- Jackson Anne U
- Jansson Jan-Håkan
- Jarvik Gail P
- Jensen Gorm B
- Jia Yucheng
- Johansson Stefan
- Jukema J Wouter
- Justice Anne E
- Jørgensen Marit E
- Jørgensen Torben
- Kahali Bratati
- Kahn René S
- Kamstrup Pia R
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Karaleftheri Maria
- Kardia Sharon LR
- Karpe Fredrik
- Kathiresan Sekar
- Kee Frank
- Kiemeney Lambertus A
- Kim Eric
- Kitajima Hidetoshi
- Komulainen Pirjo
- Kooner Jaspal S
- Kooperberg Charles
- Korhonen Tellervo
- Kovacs Peter
- Kuivaniemi Helena
- Kutalik Zoltán
- Kuulasmaa Kari
- Kuusisto Johanna
- Kähönen Mika
- Laakso Markku
- Lakka Timo A
- Lamparter David
- Lange Ethan M
- Lange Leslie A
- Langenberg Claudia
- Larson Eric B
- Lee Nanette R
- Lehtimäki Terho
- Lempradl Adelheid
- Lettre Guillaume
- Lewis Cora E
- Li Huaixing
- Li Jin
- Li-Gao Ruifang
- Lin Honghuang
- Lin Keng-Hung
- Lin Li-An
- Lin Xu
- Lind Lars
- Lindgren Cecilia M
- Lindström Jaana
- Linneberg Allan
- Liu Ching-Ti
- Liu Dajiang J
- Liu Yongmei
- Lo Ken Sin
- Locke Adam E
- Loos Ruth JF
- Lophatananon Artitaya
- Lotery Andrew J
- Loukola Anu
- Lu Yingchang
- Luan Jian'an
- Lubitz Steven A
- Lyytikäinen Leo-Pekka
- Mahajan Anubha
- Manning Alisa K
- Marenne Gaëlle
- Marouli Eirini
- Masca Nicholas GD
- Mazul Angela L
- McCarthy Mark I
- McKean-Cowdin Roberta
- Medina-Gomez Carolina
- Medland Sarah E
- Meidtner Karina
- Milani Lili
- Mistry Vanisha
- Mitchell Paul
- Mohlke Karen L
- Moilanen Leena
- Moitry Marie
- Montgomery Grant W
- Mook-Kanamori Dennis O
- Moore Carmel
- Mori Trevor A
- Morris Andrew D
- Morris Andrew P
- Mudgal Poorva
- Munroe Patricia B
- Männistö Satu
- Müller-Nurasyid Martina
- Nalls Mike A
- Narisu Narisu
- Nelson Christopher P
- Neville Matt
- Ng Maggie CY
- Nielsen Sune F
- Nikus Kjell
- Njølstad Pål R
- Nordestgaard Børge G
- North Kari E
- Nyholt Dale R
- O'Connel Jeffrey R
- Olde Loohuis Loes M
- Ophoff Roel A
- Owen Katharine R
- O’Donoghue Michelle L.
- Packard Chris J
- Padmanabhan Sandosh
- Palmer Colin NA
- Palmer Nicholette D
- Pasterkamp Gerard
- Patel Aniruddh P
- Pattie Alison
- Pedersen Oluf
- Peissig Peggy L
- Peloso Gina M
- Pennell Craig E
- Perola Markus
- Perry James A
- Perry John RB
- Pers Tune H
- Person Thomas N
- Peters Annette
- Petersen Eva RB
- Peyser Patricia A
- Pirie Ailith
- Polasek Ozren
- Polderman Tinca J
- Pospisilik John A
- Puolijoki Hannu
- Raitakari Olli T
- Rasheed Asif
- Rauramaa Rainer
- Reilly Dermot F
- Reiner Alex P
- Renström Frida
- Rheinberger Myriam
- Ridker Paul M
- Rioux John D
- Rivadeneira Fernando
- Rivas Manuel A
- Roberts David J
- Robertson Neil R
- Robino Antonietta
- Rolandsson Olov
- Rotter Jerome I
- Rudan Igor
- Ruth Katherine S
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sapkota Yadav
- Sattar Naveed
- Schoen Robert E
- Schreiner Pamela J
- Schulze Matthias B
- Schurmann Claudia
- Scott Robert A
- Segura-Lepe Marcelo P
- Shah Svati H
- Sheu Wayne H-H
- Sim Xueling
- Sivapalaratnam Suthesh
- Slater Andrew J
- Small Kerrin S
- Smith Albert Vernon
- Southam Lorraine
- Spector Timothy D
- Speliotes Elizabeth K
- Starr John M
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen E
- Strauch Konstantin
- Stringham Heather M
- Stumvoll Michael
- Sun Liang
- Surendran Praveen
- Swift Amy J
- Tada Hayato
- Tansey Katherine E
- Tardif Jean-Claude
- Taylor Kent D
- Teumer Alexander
- Thompson Deborah J
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Thuesen Betina H
- Tromp Gerard
- Trompet Stella
- Tsafantakis Emmanouil
- Tuomilehto Jaakko
- Turcot Valérie
- Tybjaerg-Hansen Anne
- Tyrer Jonathan P
- Tönjes Anke
- Uher Rudolf
- Uitterlinden André G
- Uusitupa Matti
- van der Laan Sander W
- van Duijn Cornelia M
- van Leeuwen Nienke
- van Setten Jessica
- Vanhala Mauno
- Varbo Anette
- Varga Tibor V
- Varma Rohit
- Vedantam Sailaja
- Velez Edwards Digna R
- Vermeulen Sita H
- Veronesi Giovanni
- Vestergaard Henrik
- Vitart Veronique
- Vogt Thomas F
- Vuckovic Dragana
- Völker Uwe
- Wagenknecht Lynne E
- Walker Mark
- Wallentin Lars
- Wang Carol A
- Wang Feijie
- Wang Shuai
- Wang Yiqin
- Ware Erin B
- Wareham Nicholas J
- Warren Helen R
- Waterworth Dawn M
- Wessel Jennifer
- White Harvey D
- Willems Sara M
- Willer Cristen J
- Wilson James G
- Winkler Thomas W
- Witte Daniel R
- Wood Andrew R
- Wu Ying
- Yaghootkar Hanieh
- Yao Jie
- Yao Pang
- Yerges-Armstrong Laura M
- Young Kristin L
- Young Robin
- Zeggini Eleftheria
- Zhan Xiaowei
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zhou Wei
- Zondervan Krina T
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/07/2018
- Field of study
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which pinpointing causal genes remains challenging. Here, we combined data from 718,734 individuals to discover rare and low-frequency (MAF<5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which eight in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2, ZNF169) newly implicated in human obesity, two (MC4R, KSR2) previously observed in extreme obesity, and two variants in GIPR. Effect sizes of rare variants are ~10 times larger than of common variants, with the largest effect observed in carriers of an MC4R stop-codon (p.Tyr35Ter, MAF=0.01%), weighing ~7kg more than non-carriers. Pathway analyses confirmed enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically-supported therapeutic targets to treat obesity
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
- Author
- A. Gordon Robertson
- A. Gordon Robertson
- Adrian Ally
- Alan P. Hoyle
- Alexandrov
- Alicia Hawes
- Amie Radenbaugh
- Ana Claudia Latronico
- Andrew D. Cherniack
- Andrew J. Mungall
- Andrew D. Cherniack
- Angela Tam
- Anselmo
- Anthony J. Gill
- Anthony J. Gill
- Antonio M. Lerario
- Antonio M. Lerario
- Aprill Watanabe
- Arjun Rao
- Assie
- Benjamin J. Raphael
- Benjamin J. Raphael
- Berenice B. Mendonca
- Bertherat
- Bertrand Dousset
- Beuschlein
- Bilimoria
- Blasco
- Bradley A. Murray
- Bradley A. Murray
- Brittany Downs
- Bruce Robinson
- Bruno Allolio
- Calebiro
- Carl Morrison
- Carmelo Gaudioso
- Carmen Helsel
- Carolyn M. Hutter
- Carrie Sougnez
- Carter
- Catherine Crawford
- Chan
- Charles M. Perou
- Chris Sander
- Christian Buhay
- Christine Kovar
- Christopher Benz
- Chu
- Ciriello
- Corbin D. Jones
- Cristina Ronchi
- D. Neil Hayes
- Daniel J. Weisenberger
- Darlene Lee
- David A. Wheeler
- David Haussler
- David I. Heiman
- David J. Van Den Berg
- David A. Wheeler
- Davoli
- de Reynies
- de Ruijter
- Denise Brooks
- Detlef K. Bartsch
- Ding
- Divya Kalra
- Donghui Tan
- Donna Morton
- Donna Muzny
- Doug Voet
- Electron Kebebew
- Electron Kebebew
- Else
- Else
- Else
- Erik Zmuda
- Eve Shinbrot
- Fassnacht
- Fassnacht
- Felix Beuschlein
- Felix Beuschlein
- Futreal
- Gad Getz
- Gary D. Hammer
- Gary D. Hammer
- Giordano
- Giordano
- Giordano
- Giovanni Ciriello
- Giovanni Ciriello
- Goh
- Gong
- Gordon B. Mills
- Gordon Saksena
- Guillaume Assie
- Guillaume Assié
- Hailei Zhang
- Haiyan I. Li
- Harindra Arachchi
- Harsha Doddapaneni
- Heaphy
- Heidi J. Sofia
- Hoon Kim
- Hsin-Ta Wu
- Hsin-Tu Wu
- Hsing
- Huang
- Huyen Dinh
- Ilya Shmulevich
- Ina Felau
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- James G. Herman
- Janae V. Simons
- Janine LoBello
- Jay Bowen
- Jean C. Zenklusen
- Jeffrey Roach
- Jen Jen Yeh
- Jennifer Drummond
- Jens Waldmann
- Jens Waldmann
- Jia Liu
- Jianhong Hu
- Jianjiong Gao
- Jiashan (Julia) Zhang
- Jingchun Zhu
- Jireh Santibanez
- Joel S. Parker
- John A. Demchok
- John N. Weinstein
- Juhlin
- Juliann Shih
- Juliann Shih
- Julie M. Gastier-Foster
- Julien Baboud
- Jung
- Junyuan Wu
- Juok Cho
- Jérôme Bertherat
- Jérôme Bertherat
- Kanishka Sircar
- Karen Mungall
- Katayoon Kasaian
- Katherine A. Hoadley
- Katherine A. Hoadley
- Kenna R. Mills Shaw
- Kimberly J. Bussey
- Kimberly J. Bussey
- Kirschner
- Kosuke Yoshihara
- Kristen M. Leraas
- Krivtsov
- Kyle Covington
- Lawrence
- Lawrence
- Laxmi Lolla
- Leiserson
- Leslie M. Cope
- Leslie M. Cope
- Letouze
- Liming Yang
- Lina Shao
- Lina Shao
- Linda Amble
- Lionel Groussin
- Lisa Wise
- Lisle E. Mose
- Liu
- Liu Xi
- Lora Lewis
- Ludmila Danilova
- Ludmila Danilova
- Lynda Chin
- Lynette Lim
- Madson Almeida
- Madson Q. Almeida
- Mahmoud Dahdouli
- Marc Ladanyi
- Marco A. Marra
- Marcus Quinkler
- Margaret Morgan
- Margi Sheth
- Maria Candida Barisson Fragoso
- Maria C.B.V. Fragoso
- Mark Gerken
- Martin Fassnacht
- Martin Fassnacht
- Martin Reincke
- Maser
- Mathilde Sibony
- Matthew D. Wilkerson
- Matthew G. Soloway
- Matthew Meyerson
- Matthew Meyerson
- Matthias Kroiss
- McPherson
- Mermel
- Miao
- Michael J. Demeure
- Michael Mayo
- Michael S. Lawrence
- Michael S. Noble
- Michael J. Demeure
- Michelle Bellair
- Michelle Vinco
- Miller
- Miruna Balasundaram
- Moiz S. Bootwalla
- Mouhammed Amir Habra
- Mouhammed A. Habra
- Nikolaus Schultz
- Nilsa C. Ramirez
- Nina Thiessen
- Ninad Dewal
- Ninad Dewal
- Nipun Kakkar
- Noreen Dhalla
- Olena Morozova
- Olena Morozova
- Ozgur Mete
- Ozgur Mete
- Palacios
- Patsy Soon
- Payal Sipahimalani
- Pei Lin
- Peter J. Park
- Peter W. Laird
- Phillip H. Lai
- Pinto
- Piotr A. Mieczkowski
- Qiang Sun
- Qianghu Wang
- Raju Kucherlapati
- Rameen Beroukhim
- Ranabir Guin
- Rashi Naresh
- Raymond
- Reanne Bowlby
- Rebecca Carlsen
- Rehan Akbani
- Rehan Akbani
- Richard A. Moffitt
- Richard A. Moore
- Richard Gibbs
- Richard A. Moffitt
- Robert A. Holt
- Roel G.W. Verhaak
- Roel G.W. Verhaak
- Rohini Raman
- Rossella Libé
- Roy Tarnuzzer
- Rozek
- Saianand Balu
- Sam Meier
- Sandy Lee
- Sara Coppens
- Sara Sadeghi
- Scott Frazer
- Scott L. Carter
- Seungchan Kim
- Seungchan Kim
- Shaowu Meng
- Sheila Reynolds
- Shelley Alonso
- Shiyun Ling
- Silviu Sbiera
- Siyuan Zheng
- Siyuan Zheng
- Stacey B. Gabriel
- Stan B. Sidhu
- Stan B. Sidhu
- Stephen Baylin
- Steven E. Schumacher
- Steven J.M. Jones
- Stewart
- Stuart R. Jefferys
- Sudha Chudamani
- Sylvia L. Asa
- Sylvia L. Asa
- Tanja Davidsen
- Tara M. Lichtenberg
- Theo A. Knijnenburg
- Theo A. Knijnenburg
- Thirlwell
- Thomas J. Giordano
- Thomas J. Giordano
- Timo Deutschbein
- Timothy Defreitas
- Timothy G. Whitsett
- Timothy G. Whitsett
- Tissier
- Tobias Else
- Tobias Else
- Todd Pihl
- Tom Bodenheimer
- Toni K. Choueiri
- Toni K. Choueiri
- Torres-Garcia
- Umadevi Veluvolu
- Van Allen
- Victoria M. Raymond
- Walker Hale
- Wei Zhang
- Weiss
- Wenbin Liu
- Wenyi Wang
- Wiam Bshara
- William E. Rainey
- William E. Rainey
- Yan Shi
- Yaron S.N. Butterfield
- Ye Wu
- Yi Han
- Yiling Lu
- Yoshihara
- Yoshihara
- Yu Fan
- Yunhu Wan
- Yussanne Ma
- Zack
- Zack Sanborn
- Zhang
- Zhenlin Ju
- Zhining Wang
- Ziad Khan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Author
- Aarno Palotie
- Alan F. Wright
- Alan L. James
- Alan R. Sanders
- Alan R. Shuldiner
- Alan S. Go
- Albert Hofman
- Albert Vernon Smith
- Albertine J. Oldehinkel
- Alena Stančáková
- Alexander Teumer
- Alexessander Couto Alves
- Aliki-Eleni Farmaki
- Allan Linneberg
- Amy J. Swift
- Amélie Bonnefond
- Anders Hamsten
- Andres Metspalu
- Andrew A Hicks
- Andrew C. Heath
- Andrew P. Morris
- Andrew T. Hattersley
- Andrew Wong
- André G. Uitterlinden
- André L. M. Verbeek
- Angela Silveira
- Angelo Tremblay
- Anjali K. Henders
- Anke Tönjes
- Ann-Christine Syvänen
- Anne E. Justice
- Anne U. Jackson
- Anneli Pouta
- Annelies C. Ham
- Annette Peters
- Anton J. M. de Craen
- Antti Jula
- Anubha Mahajan
- Anuj Goel
- Aravinda Chakravarti
- Aron S Buchman
- Aroon Hingorani
- Arthur W. Musk
- Ayse Demirkan
- Bandinelli Stefania
- Barbara McKnight
- Barbara Thorand
- Ben A. Oostra
- Bengt Sennblad
- Benjamin Lehne
- Bernhard O. Boehm
- Bjarke Feenstra
- Braxton D. Mitchell
- Brenda W. Penninx
- Bruce M. Psaty
- Bruna Gigante
- Carlo Rivolta
- Carolina Medina-Gomez
- Caroline Hayward
- Caroline S. Fox
- Carsten A. Böger
- Cashell E. Jaquish
- Catharina A. Hartman
- Cecilia M. Lindgren
- Charles C. White
- Charleston W. K. Chiang
- Chiara Lanzani
- Christian Gieger
- Christian Hengstenberg
- Christina Willenborg
- Claes Ohlsson
- Claire Bellis
- Claude Bouchard
- Claudia Langenberg
- Cornelia M. van Duijn
- Cristina Barlassina
- Cristina Menni
- D. C. Rao
- Damiano Baldassarre
- Daniel I. Chasman
- Daniele Cusi
- David A. Bennett
- David J. Hunter
- David P. Strachan
- David Schlessinger
- Deborah J. Clegg
- Dena Hernandez
- Denis A. Evans
- Devin Absher
- Diana Kuh
- Dorret I. Boomsma
- Douglas F. Levinson
- Eco J. C. de Geus
- Eero Kajantie
- Efthymia Vlachopoulou
- Ehm A. Andersson
- Eleftheria Zeggini
- Elena Tremoli
- Elisabeth Widén
- Elodie Eury
- Emmanouil Tsafantakis
- Eric Boerwinkle
- Erik Ingelsson
- Erwin P. Bottinger
- Eva Albrecht
- Evelin Mihailov
- Fabrice Bonnet
- Federica Rizzi
- Fernando Rivadeneira
- Folkert W. Asselbergs
- Francesca Frau
- Francesco Cucca
- Francis S. Collins
- Frank Geller
- Frank Hu
- Frans L. Moll
- Frida Renström
- Gabriele Müller
- Gabrielle Boucher
- Gemma Cadby
- Georg B. Ehret
- George Dedoussis
- Gerard Pasterkamp
- Goncalo R. Abecasis
- Gonneke Willemsen
- Graciela Delgado
- Grant W. Montgomery
- Gudmar Thorleifsson
- Gudny Eiriksdottir
- Guillaume Lettre
- Gérard Waeber
- Hans Hillege
- Harald Grallert
- Harm-Jan Westra
- Harold Snieder
- Harry Campbell
- Heather A. Boyd
- Heather M. Stringham
- Heikki A. Koistinen
- Heikki V. Huikuri
- Henri Wallaschofski
- Henrik Grönberg
- Henry Völzke
- Heribert Schunkert
- Hester M. den Ruijter
- Hubert Scharnagl
- Hugh Watkins
- Ian Ford
- Igor Rudan
- Ilja M. Nolte
- Inga Prokopenko
- Inger Njølstad
- Ingrid B. Borecki
- Inês Barroso
- Ioanna Tachmazidou
- Irene Mateo Leach
- Irene Pichler
- Iris M. Heid
- Ivana Kolcic
- J. Wouter Jukema
- Jaakko Tuomilehto
- Jaana Lindström
- Jacek Czajkowski
- Jacques S. Beckmann
- James F. Wilson
- James S. Pankow
- Jan A. Staessen
- Jan H. Smit
- Jana V. van Vliet-Ostaptchouk
- Janine Krüger
- Jari Lahti
- Jaspal S. Kooner
- Jean-Claude Tardif
- Jeanette Erdmann
- Jeannette Simino
- Jeffrey C. Murray
- Jeffrey R. O'Connell
- Jennie Hui
- Jennifer E. Huffman
- Jennifer L. Bragg-Gresham
- Jerome I. Rotter
- Jessica van Setten
- Jian Yang
- Jian'an Luan
- Jianxin Shi
- Jing Hua Zhao
- Joanne M. Jordan
- Joel Eriksson
- Joel N. Hirschhorn
- Johan G. Eriksson
- Johanna Kuusisto
- John Beilby
- John Blangero
- John C. Chambers
- John Cole
- John D. Rioux
- Jonathan P. Tyrer
- Jorma S. Viikari
- Joshua C. Bis
- Jouke-Jan Hottenga
- Jubao Duan
- Judith M. Vonk
- Juha Karjalainen
- Juha Saltevo
- Juha Sinisalo
- Jürgen Gräßler
- Kalliope Panoutsopoulou
- Karen L. Mohlke
- Kari E. North
- Kari Stefansson
- Karin Leander
- Karina Banasik
- Kathleen Stirrups
- Kathy A. Ryan
- Kay Tee Khaw
- Kees G Hovingh
- Ken K. Ong
- Ken Sin Lo
- Kenneth M. Rice
- Keri L. Monda
- Kevin B. Jacobs
- Krista Fischer
- Kristian Hveem
- L. Adrienne Cupples
- Lambertus A. L. M. Kiemeney
- Lars Lannfelt
- Lars Lind
- Laura M. Yerges-Armstrong
- Laura Pascoe
- Lavinia Paternoster
- Leena Kinnunen
- Lei Yu
- Leif C. Groop
- Lenore J. Launer
- Liesbeth Vandenput
- Lili Milani
- Linda Broer
- Lindsay L. Waite
- Lise L. Husemoen
- Lisette C. P. G. M. de Groot
- Llilda Barata
- Lori L. Bonnycastle
- Lorraine Southam
- Louis Pérusse
- Loïc Yengo
- Lu Qi
- Lude Franke
- Luigi Ferrucci
- Lyle J Palmer
- Lynda M. Rose
- M. Carola Zillikens
- Mads Melbye
- Maija Hassinen
- Marcel Bruinenberg
- Marcus E. Kleber
- Marcus Richards
- Mari Nelis
- Maria Dimitriou
- Maria G. Pilia
- Maria Karaleftheri
- Mariaelisa Graff
- Marie-Claude Vohl
- Marika Kaakinen
- Marja-Liisa Lokki
- Mark A. Sarzynski
- Mark I. McCarthy
- Mark Walker
- Markku Heliövaara
- Markku Laakso
- Markku S. Nieminen
- Markus Juonala
- Markus Perola
- Martin Farrall
- Martina Müller-Nurasyid
- Mary F. Feitosa
- Massimo Mangino
- Mathias Gorski
- Matteo Barcella
- Matthias Blüher
- Matti Uusitupa
- Mattias Lorentzon
- May E. Montasser
- Meena Kumari
- Melanie Waldenberger
- Michael Boehnke
- Michael D. Neinast
- Michael Stumvoll
- Mika Kivimaki
- Mika Kähönen
- Morris A Swertz
- Myriam Rheinberger
- Nancy L. Heard-Costa
- Nancy L. Pedersen
- Narisu Narisu
- Natalia Pervjakova
- Natasja M. van Schoor
- Nathalie van der Velde
- Naveed Sattar
- Nele Friedrich
- Nicholas G Martin
- Nicholas Hastie
- Nicholas J. Wareham
- Nicola Glorioso
- Nicole Dueker
- Niek Verweij
- Niels Grarup
- Nigel W. Rayner
- Niina Eklund
- Nikolaj T. Krarup
- Nina Hutri-Kähönen
- Nita G. Forouhi
- Oddgeir Holmen
- Olli T. Raitakari
- Oluf Pedersen
- Omri Gottesman
- Ozren Polašek
- P. Eline Slagboom
- Pablo V. Gejman
- Pamela A. F. Madden
- Panos Deloukas
- Paola Benaglio
- Patrik K. Magnusson
- Paul B. Knekt
- Paul I. W. de Bakker
- Paul M. Ridker
- Paul W. Franks
- Pekka Mäntyselkä
- Penny Gordon-Larsen
- Per Hall
- Perttu Salo
- Peter E. H. Schwarz
- Peter J. van der Most
- Peter Kovacs
- Peter P. Pramstaller
- Peter S. Chines
- Peter Vollenweider
- Philip L. De Jager
- Philippe Froguel
- Pim van der Harst
- Pirro G. Hysi
- Rainer Rauramaa
- Rasmus Ribel-Madsen
- Reedik Mägi
- Richard N. Bergman
- Rick Jansen
- Robert A. Scott
- Robert C. Kaplan
- Robert Luben
- Roman Wennauer
- Ron T. Gansevoort
- Rona J. Strawbridge
- Ronald P. Stolk
- Ruth J. F. Loos
- Ryan W. Walker
- Salome Scholtens
- Sander W van der Laan
- Sarah H. Wild
- Saskia Haitjema
- Satu Männistö
- Sebanti Sengupta
- Sekar Kathiresan
- Seppo Koskinen
- Serena Sanna
- Shafqat Ahmad
- Shapour Jalilzadeh
- Sian-Tsung Tan
- Sigrun Merger
- Simone Claudi-Boehm
- Sina Rüeger
- Sita H. Vermeulen
- Sonja I. Berndt
- Sophie R. Wang
- Stavroula Kanoni
- Stefan Enroth
- Stefan Gustafsson
- Stefan R. Bornstein
- Stella Trompet
- Stephan J. L. Bakker
- Stephen J. Chanock
- Steven J. Kittner
- Stéphane Lobbens
- Su Chu
- Suzanne C. van Dijk
- Sven Bergmann
- Sylvain Sebert
- Tamara B. Harris
- Tanja B. Grammer
- Tanya M. Teslovich
- Tarunveer S. Ahluwalia
- Teresa Ferreira
- Terho Lehtimäki
- Tessel E. Galesloot
- Themistocles L. Assimes
- Theodosios Kyriakou
- Thomas H. Sparsø
- Thomas Illig
- Thomas Quertermous
- Thomas Seufferlein
- Thomas W. Winkler
- Thorkild I. A. Sørensen
- Tim D. Spector
- Timo A. Lakka
- Tom Wilsgaard
- Torben Hansen
- Torben Jørgensen
- Toshiko Tanaka
- Tove Fall
- Treva K. Rice
- Tune H. Pers
- Tuomas O. Kilpeläinen
- Tuomo Rankinen
- Tõnu Esko
- Ulf de Faire
- Ulf Gyllensten
- Unnur Thorsteinsdottir
- Uwe Völker
- Valeriya Lyssenko
- Valgerdur Steinthorsdottir
- Vaneet Lotay
- Vasiliki Lagou
- Veikko Salomaa
- Veronique Vitart
- Vilmundur Gudnason
- Weihua Zhang
- Wendy L. McArdle
- William R. Scott
- Winfried Maerz
- Wolfgang Koenig
- Wolfgang Kratzer
- Yan-Ping Liu
- Yii-Der Ida Chen
- Yingchang Lu
- Youfang Liu
- Yu-Ching Cheng
- Yu-Mei Gu
- Yun Ju Sung
- Zhaoming Wang
- Zoltán Kutalik
- Åsa Johansson
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Age-dependent BMI loci.
- Author
- Aarno Palotie (41342)
- Alan F. Wright (150085)
- Alan L. James (174634)
- Alan R. Sanders (802573)
- Alan R. Shuldiner (110828)
- Alan S. Go (802557)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Albertine J. Oldehinkel (306724)
- Alena Stančáková (197764)
- Alexander Teumer (112757)
- Alexessander Couto Alves (131470)
- Aliki-Eleni Farmaki (802556)
- Allan Linneberg (139773)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andres Metspalu (61760)
- Andrew A Hicks (802582)
- Andrew C. Heath (127152)
- Andrew P. Morris (145709)
- Andrew T. Hattersley (146736)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- André L. M. Verbeek (630882)
- Angela Silveira (162071)
- Angelo Tremblay (289899)
- Anjali K. Henders (168652)
- Anke Tönjes (103703)
- Ann-Christine Syvänen (57309)
- Anne E. Justice (802539)
- Anne U. Jackson (145702)
- Anneli Pouta (116626)
- Annelies C. Ham (802560)
- Annette Peters (62601)
- Anton J. M. de Craen (188398)
- Antti Jula (37961)
- Anubha Mahajan (206768)
- Anuj Goel (258576)
- Aravinda Chakravarti (77021)
- Aron S Buchman (802553)
- Aroon Hingorani (256127)
- Arthur W. Musk (174646)
- Ayse Demirkan (174933)
- Bandinelli Stefania (802586)
- Barbara McKnight (103714)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bengt Sennblad (43745)
- Benjamin Lehne (215790)
- Bernhard O. Boehm (203595)
- Bjarke Feenstra (206249)
- Braxton D. Mitchell (110791)
- Brenda W. Penninx (238627)
- Bruce M. Psaty (103721)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Carsten A. Böger (174833)
- Cashell E. Jaquish (262620)
- Catharina A. Hartman (590692)
- Cecilia M. Lindgren (145706)
- Charles C. White (165363)
- Charleston W. K. Chiang (252222)
- Chiara Lanzani (221729)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Willenborg (147937)
- Claes Ohlsson (1924)
- Claire Bellis (321396)
- Claude Bouchard (111107)
- Claudia Langenberg (160616)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Cristina Menni (108973)
- D. C. Rao (163457)
- Damiano Baldassarre (610592)
- Daniel I. Chasman (120866)
- Daniele Cusi (136954)
- David A. Bennett (229710)
- David J. Hunter (50227)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Dena Hernandez (215322)
- Denis A. Evans (802581)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dorret I. Boomsma (109746)
- Douglas F. Levinson (171384)
- Eco J. C. de Geus (109745)
- Eero Kajantie (178523)
- Efthymia Vlachopoulou (488309)
- Ehm A. Andersson (197743)
- Eleftheria Zeggini (21702)
- Elena Tremoli (74641)
- Elisabeth Widén (3212700)
- Elodie Eury (548413)
- Emmanouil Tsafantakis (802577)
- Eric Boerwinkle (36288)
- Erik Ingelsson (232651)
- Erwin P. Bottinger (3212694)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Fabrice Bonnet (367574)
- Federica Rizzi (376091)
- Fernando Rivadeneira (61551)
- Folkert W. Asselbergs (113684)
- Francesca Frau (136957)
- Francesco Cucca (145742)
- Francis S. Collins (82181)
- Frank Geller (73672)
- Frank Hu (297670)
- Frans L. Moll (50185)
- Frida Renström (198690)
- Gabriele Müller (373622)
- Gabrielle Boucher (215508)
- Gemma Cadby (174601)
- Georg B. Ehret (124487)
- George Dedoussis (160919)
- Gerard Pasterkamp (50194)
- Goncalo R. Abecasis (3212703)
- Gonneke Willemsen (75573)
- Graciela Delgado (802545)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Gudny Eiriksdottir (8872)
- Guillaume Lettre (163230)
- Gérard Waeber (111536)
- Hans Hillege (802562)
- Harald Grallert (72666)
- Harm-Jan Westra (102374)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heather A. Boyd (206266)
- Heather M. Stringham (198678)
- Heikki A. Koistinen (129541)
- Heikki V. Huikuri (215625)
- Henri Wallaschofski (112750)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Hester M. den Ruijter (398185)
- Hubert Scharnagl (435522)
- Hugh Watkins (62729)
- Ian Ford (30666)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger Njølstad (211908)
- Ingrid B. Borecki (113678)
- Inês Barroso (2144)
- Ioanna Tachmazidou (32161)
- Irene Mateo Leach (128869)
- Irene Pichler (76506)
- Iris M. Heid (87553)
- Ivana Kolcic (3212697)
- J. Wouter Jukema (127361)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jacek Czajkowski (802542)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- James S. Pankow (174656)
- Jan A. Staessen (174667)
- Jan H. Smit (426685)
- Jana V. van Vliet-Ostaptchouk (179472)
- Janine Krüger (442511)
- Jari Lahti (149903)
- Jaspal S. Kooner (163553)
- Jean-Claude Tardif (79699)
- Jeanette Erdmann (44256)
- Jeannette Simino (802544)
- Jeffrey C. Murray (134603)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer E. Huffman (220403)
- Jennifer L. Bragg-Gresham (198672)
- Jerome I. Rotter (103729)
- Jessica van Setten (802551)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joanne M. Jordan (802583)
- Joel Eriksson (149940)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John Beilby (405654)
- John Blangero (28885)
- John C. Chambers (163544)
- John Cole (392281)
- John D. Rioux (215621)
- Jonathan P. Tyrer (757938)
- Jorma S. Viikari (115555)
- Joshua C. Bis (183182)
- Jouke-Jan Hottenga (75574)
- Jubao Duan (802555)
- Judith M. Vonk (71591)
- Juha Karjalainen (102376)
- Juha Saltevo (802585)
- Juha Sinisalo (418995)
- Jürgen Gräßler (802558)
- Kalliope Panoutsopoulou (174570)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Stefansson (26484)
- Karin Leander (256394)
- Karina Banasik (140500)
- Kathleen Stirrups (145729)
- Kathy A. Ryan (802548)
- Kay Tee Khaw (566687)
- Kees G Hovingh (802564)
- Ken K. Ong (188600)
- Ken Sin Lo (457887)
- Kenneth M. Rice (802572)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- L. Adrienne Cupples (113601)
- Lambertus A. L. M. Kiemeney (219492)
- Lars Lannfelt (333066)
- Lars Lind (88400)
- Laura M. Yerges-Armstrong (153186)
- Laura Pascoe (802547)
- Lavinia Paternoster (153181)
- Leena Kinnunen (392541)
- Lei Yu (70258)
- Leif C. Groop (198713)
- Lenore J. Launer (110269)
- Liesbeth Vandenput (149975)
- Lili Milani (73375)
- Linda Broer (183140)
- Lindsay L. Waite (392538)
- Lise L. Husemoen (802565)
- Lisette C. P. G. M. de Groot (234302)
- Llilda Barata (802541)
- Lori L. Bonnycastle (262574)
- Lorraine Southam (802549)
- Louis Pérusse (198689)
- Loïc Yengo (160556)
- Lu Qi (160573)
- Lude Franke (102406)
- Luigi Ferrucci (150038)
- Lyle J Palmer (28834)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Mads Melbye (206301)
- Maija Hassinen (802561)
- Marcel Bruinenberg (354277)
- Marcus E. Kleber (106276)
- Marcus Richards (306829)
- Mari Nelis (61755)
- Maria Dimitriou (160853)
- Maria G. Pilia (802570)
- Maria Karaleftheri (802567)
- Mariaelisa Graff (802540)
- Marie-Claude Vohl (684717)
- Marika Kaakinen (116620)
- Marja-Liisa Lokki (156903)
- Mark A. Sarzynski (111091)
- Mark I. McCarthy (145748)
- Mark Walker (21700)
- Markku Heliövaara (81299)
- Markku Laakso (197777)
- Markku S. Nieminen (782650)
- Markus Juonala (186368)
- Markus Perola (62544)
- Martin Farrall (62715)
- Martina Müller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Mathias Gorski (174849)
- Matteo Barcella (606697)
- Matthias Blüher (103713)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- May E. Montasser (540942)
- Meena Kumari (95278)
- Melanie Waldenberger (236985)
- Michael Boehnke (145750)
- Michael D. Neinast (802543)
- Michael Stumvoll (103716)
- Mika Kivimaki (2222011)
- Mika Kähönen (131499)
- Morris A Swertz (802576)
- Myriam Rheinberger (802571)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Natalia Pervjakova (763742)
- Natasja M. van Schoor (61552)
- Nathalie van der Velde (359786)
- Naveed Sattar (8785)
- Nele Friedrich (329201)
- Nicholas G Martin (62000)
- Nicholas Hastie (190796)
- Nicholas J. Wareham (110277)
- Nicola Glorioso (136971)
- Nicole Dueker (170183)
- Niek Verweij (128858)
- Niels Grarup (154019)
- Nigel W. Rayner (181865)
- Niina Eklund (149841)
- Nikolaj T. Krarup (231671)
- Nina Hutri-Kähönen (186365)
- Nita G. Forouhi (130774)
- Oddgeir Holmen (802563)
- Olli T. Raitakari (115559)
- Oluf Pedersen (140525)
- Omri Gottesman (133442)
- Ozren Polašek (149888)
- P. Eline Slagboom (28184)
- Pablo V. Gejman (171372)
- Pamela A. F. Madden (127156)
- Panos Deloukas (21564)
- Paola Benaglio (225134)
- Patrik K. Magnusson (156885)
- Paul B. Knekt (802584)
- Paul I. W. de Bakker (61332)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Pekka Mäntyselkä (671981)
- Penny Gordon-Larsen (455043)
- Per Hall (23544)
- Perttu Salo (177200)
- Peter E. H. Schwarz (261982)
- Peter J. van der Most (657357)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Peter Vollenweider (93049)
- Philip L. De Jager (202972)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Pirro G. Hysi (110207)
- Rainer Rauramaa (211915)
- Rasmus Ribel-Madsen (113392)
- Reedik Mägi (667294)
- Richard N. Bergman (160594)
- Rick Jansen (198642)
- Robert A. Scott (160581)
- Robert C. Kaplan (262625)
- Robert Luben (153220)
- Roman Wennauer (802579)
- Ron T. Gansevoort (111233)
- Rona J. Strawbridge (419006)
- Ronald P. Stolk (111251)
- Ruth J. F. Loos (110224)
- Ryan W. Walker (802578)
- Salome Scholtens (721805)
- Sander W van der Laan (802550)
- Sarah H. Wild (130180)
- Saskia Haitjema (802546)
- Satu Männistö (201550)
- Sebanti Sengupta (802574)
- Sekar Kathiresan (60585)
- Seppo Koskinen (65668)
- Serena Sanna (145737)
- Shafqat Ahmad (437775)
- Shapour Jalilzadeh (802566)
- Sian-Tsung Tan (614011)
- Sigrun Merger (802569)
- Simone Claudi-Boehm (802554)
- Sina Rüeger (606696)
- Sita H. Vermeulen (160844)
- Sonja I. Berndt (202053)
- Sophie R. Wang (802552)
- Stavroula Kanoni (160847)
- Stefan Enroth (189126)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stella Trompet (174901)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steven J. Kittner (170212)
- Stéphane Lobbens (58251)
- Su Chu (589076)
- Suzanne C. van Dijk (802580)
- Sven Bergmann (20384)
- Sylvain Sebert (159293)
- Tamara B. Harris (110195)
- Tanja B. Grammer (106285)
- Tanya M. Teslovich (145718)
- Tarunveer S. Ahluwalia (418885)
- Teresa Ferreira (418982)
- Terho Lehtimäki (49739)
- Tessel E. Galesloot (171815)
- Themistocles L. Assimes (111675)
- Theodosios Kyriakou (258572)
- Thomas H. Sparsø (802575)
- Thomas Illig (44906)
- Thomas Quertermous (94604)
- Thomas Seufferlein (232037)
- Thomas W. Winkler (174716)
- Thorkild I. A. Sørensen (37671)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Tom Wilsgaard (321883)
- Torben Hansen (140523)
- Torben Jørgensen (154033)
- Toshiko Tanaka (174638)
- Tove Fall (201258)
- Treva K. Rice (208312)
- Tune H. Pers (250824)
- Tuomas O. Kilpeläinen (145704)
- Tuomo Rankinen (111101)
- Tõnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Uwe Völker (112748)
- Valeriya Lyssenko (11998)
- Valgerdur Steinthorsdottir (160577)
- Vaneet Lotay (133447)
- Vasiliki Lagou (149920)
- Veikko Salomaa (62543)
- Veronique Vitart (149854)
- Vilmundur Gudnason (8873)
- Weihua Zhang (44940)
- Wendy L. McArdle (110155)
- William R. Scott (391938)
- Winfried Maerz (510322)
- Wolfgang Koenig (26222)
- Wolfgang Kratzer (802568)
- Yan-Ping Liu (412255)
- Yii-Der Ida Chen (113593)
- Yingchang Lu (149264)
- Youfang Liu (278133)
- Yu-Ching Cheng (546877)
- Yu-Mei Gu (802559)
- Yun Ju Sung (91479)
- Zhaoming Wang (50224)
- Zoltán Kutalik (174641)
- Åsa Johansson (84687)
- Publication venue
- Publication date
- Field of study
<p>Effect estimates (beta ±95CI) per standard deviation in BMI and risk allele for loci showing age-differences in men & women ≤50y compared to men & women >50y. Loci are ordered by greater magnitude of effect in men & women ≤50y compared to men & women >50y. (95%CI: 95% confidence interval; BMI: body mass index; SD: standard deviation, *Newly identified loci).</p
Forty-four WHR<sub>adjBMI</sub> loci showing significant sex-differences.
- Author
- Aarno Palotie (41342)
- Alan F. Wright (150085)
- Alan L. James (174634)
- Alan R. Sanders (802573)
- Alan R. Shuldiner (110828)
- Alan S. Go (802557)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Albertine J. Oldehinkel (306724)
- Alena Stančáková (197764)
- Alexander Teumer (112757)
- Alexessander Couto Alves (131470)
- Aliki-Eleni Farmaki (802556)
- Allan Linneberg (139773)
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- Publication venue
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<p>Chr: Chromosome; Pos: position; EAF: Effect Allele Frequency; EA: Effect allele; OA: Other allele</p><p><sup>a</sup> ‘Yes’ if the locus is mentioned as WHR<sub>adjBMI</sub> locus for the first time</p><p><sup>b</sup> ‘Yes’ if the sex-difference in the effect on WHR<sub>adjBMI</sub> is reported for the first time</p><p><sup>c</sup> Effect allele is according to the WHR<sub>adjBMI</sub> increasing allele according to the associated sex.</p><p>The table shows the sex-specific (age-group combined) results, ordered by largest, positive effect in women to largest, negative effect in women. The age- and sex-specific results (four strata), more detailed information on the loci and on the screens for which they were detected are given in <b><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005378#pgen.1005378.s021" target="_blank">S5 Table</a></b>.</p