270 research outputs found
MiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1
The prevalence of metabolic syndrome (MetS) and obesity is an alarming health issue
worldwide. Obesity is characterized by an excessive accumulation of white adipose tissue (WAT),
and it is associated with diminished brown adipose tissue (BAT) activity. Twist1 acts as a negative
feedback regulator of BAT metabolism. Therefore, targeting Twist1 could become a strategy for
obesity and metabolic disease. Here, we have identified miR-337-3p as an upstream regulator
of Twist1. Increased miR-337-3p expression paralleled decreased expression of TWIST1 in BAT
compared to WAT. Overexpression of miR-337-3p in brown pre-adipocytes provoked a reduction in
Twist1 expression that was accompanied by increased expression of brown/mitochondrial markers.
Luciferase assays confirmed an interaction between the miR-337 seed sequence and Twist1 3
0UTR.
The inverse relationship between the expression of TWIST1 and miR-337 was finally validated in
adipose tissue samples from non-MetS and MetS subjects that demonstrated a dysregulation of the
miR-337-Twist1 molecular axis in MetS. The present study demonstrates that adipocyte miR-337-3p suppresses Twist1 repression and enhances the browning of adipocytes
Search for composite and exotic fermions at LEP 2
A search for unstable heavy fermions with the DELPHI detector at LEP is
reported. Sequential and non-canonical leptons, as well as excited leptons and
quarks, are considered. The data analysed correspond to an integrated
luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV
and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172
GeV and 161 GeV. The search for pair-produced new leptons establishes 95%
confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2,
depending on the channel. The search for singly produced excited leptons and
quarks establishes upper limits on the ratio of the coupling of the excited
fermio
Comparison of two methods of tear sampling for protein quantification by Bradford method
Search for charginos in e+e- interactions at sqrt(s) = 189 GeV
An update of the searches for charginos and gravitinos is presented, based on
a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector
in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was
found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a
centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by
combining the chargino searches with neutralino searches at the Z resonance
implies a limit on the mass of the lightest neutralino which, for a heavy
sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure
Aspectos biológicos de Dichelops melacanthus em três temperaturas, alimentados com grãos imaturos de milho 2B688Hx e 2B688
Search for lightest neutralino and stau pair production in light gravitino scenarios with stau NLSP
Promptly decaying lightest neutralinos and long-lived staus are searched for
in the context of light gravitino scenarios. It is assumed that the stau is the
next to lightest supersymmetric particle (NLSP) and that the lightest
neutralino is the next to NLSP (NNLSP). Data collected with the Delphi detector
at centre-of-mass energies from 161 to 183 \GeV are analysed. No evidence of
the production of these particles is found. Hence, lower mass limits for both
kinds of particles are set at 95% C.L.. The mass of gaugino-like neutralinos is
found to be greater than 71.5 GeV/c^2. In the search for long-lived stau,
masses less than 70.0 to 77.5 \GeVcc are excluded for gravitino masses from 10
to 150 \eVcc . Combining this search with the searches for stable heavy leptons
and Minimal Supersymmetric Standard Model staus a lower limit of 68.5 \GeVcc
may be set for the stau mas
Hadronization properties of b quarks compared to light quarks in e+e- -> q qbar from 183 to 200 GeV
The DELPHI detector at LEP has collected 54 pb^{-1} of data at a
centre-of-mass energy around 183 GeV during 1997, 158 pb^{-1} around 189 GeV
during 1998, and 187 pb^{-1} between 192 and 200 GeV during 1999. These data
were used to measure the average charged particle multiplicity in e+e- -> b
bbar events, _{bb}, and the difference delta_{bl} between _{bb} and the
multiplicity, _{ll}, in generic light quark (u,d,s) events: delta_{bl}(183
GeV) = 4.55 +/- 1.31 (stat) +/- 0.73 (syst) delta_{bl}(189 GeV) = 4.43 +/- 0.85
(stat) +/- 0.61 (syst) delta_{bl}(200 GeV) = 3.39 +/- 0.89 (stat) +/- 1.01
(syst). This result is consistent with QCD predictions, while it is
inconsistent with calculations assuming that the multiplicity accompanying the
decay of a heavy quark is independent of the mass of the quark itself.Comment: 13 pages, 2 figure
Filiação entre arenitos da formação Guará e sua cobertura pedológica no Rio Grande Do Sul
Inoculação Microbiana da Alfafa para Ensilagem sobre a Digestibilidade Aparente em Carneiros
Uso de extrato de levedura como fonte de carbono e de mediadores redox, para a degradação anaeróbia de corante azo
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