The smokeless tobacco habit and DNA damage : a systematic review and meta-analysis

The aim of this systematic review was to evaluate the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. We searched PubMed, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE. We also surveyed gray literature. We included only clinical trials that compare the frequency of micronuclei or other DNA damage in the oral mucosa of adults that have smokeless tobacco habits compared to adults that not have these habits. Quality assessments of the selected trials were evaluated by two independent reviewers, using the Effective Public Health Practice Project ? (EPHPP) with modifications. After the database screening and removal of duplicates, 2574 studies were identified. After title screening, 172 studies remained, and this number was reduced to 25 after careful examination of the abstracts. The standardized mean difference of the frequency of micronuclei between groups was 1.88, with a 95% confidence interval of 1.40 to 2.36 (p< 0.00001). In all analyses heterogeneity was detected. Despite the heterogeneity of studies, the frequency of micronuclei was significant bigger in adults who have the smokeless tobacco habit when compared to those not have this habit. The same occurred with the frequency of binucleated cells, karyolisis and karyorrhexis

Amlodipine-induced gingival overgrowth – Review and Case Report / Crescimento gengival induzido por Amlodipina - Revisão e Relato de Caso

Gingival overgrowth or enlargement is among one of the most important clinical features of gingival pathology frequently seen in periodontal clinic. Gingival overgrowth is a serious side e?ect that accompanies the use of amlodipine. Amlodipine is a comparatively new calcium channel blocker and is being used with increasing frequency in the management of hypertension and angina pectoris. Pertinent management depends on precisely diagnosing the origin of overgrowth. Cessation or change of drug and meticulous plaque control often leads to regression of the lesion, which however might need surgical correction for optimal maintenance of gingival health. The purpose of this article is to present a case report and highlight significant aspects of Amlodipine-Induced Gingival Overgrowth (AIGO)

Injection of platelet aggregates in facial rejuvenation: a systematic review

Introduction: This systematic review was conducted to assess whether the use of a platelet aggregate injection with or without associated facial rejuvenation techniques favors facial rejuvenation in adult patients. Methods: Randomized clinical trials that compared the use of techniques for facial rejuvenation alone with the same techniques coupled with the injection of platelet aggregates were searched. The search was performed in indexed databases and in the gray literature. The Cochrane Collaboration bias risk tool was applied to assess the quality of the studies. Results: In total, 7137 articles were identified. Only four studies remained in the qualitative synthesis, and the others were considered as having undefined bias risk in the key domains. Conclusion: There are few studies in the literature that compare the use of platelet aggregates in facial rejuvenation and those that are available have a risk of "undefined" or "high" bias. There is a need for more well-designed clinical studies comparing the use of platelet aggregate injection with or without associated facial rejuvenation techniques

Histomorphometric analysis of biological responses following the use of pure hydroxyapatite and hydroxyapatite with collagen: a study in dorsal subcutaneous tissue of rats / Análise histomorfométrica das respostas biológicas após a utilização de hidroxiapatite pura e hidroxiapatite com colagénio: um estudo no tecido subcutâneo dorsal de ratos

Purpose: The aim of this study was to evaluate the biological responses resulting from the implantation of two types of experimental hydroxyapatite – Pure Ha (HaP) and Ha with collagen (HaCol) and compare them with a third type HaAlobone (commercial) – on dorsal subcutaneous tissue of female rats. Methods: Forty-five animals were used (15 in each group), which were sacrificed 7, 15, and 30 days after operation. The specimens were fixed, stained with hematoxylin and eosin, and then evaluated for inflammatory reactions with a light microscope. Results: The three experimental groups showed a high inflammatory response after 7 days. The inflammatory response was seen to decrease sharply after 15 days. After 30 days, the foreign body reactions were seen to reduce significantly, and an organized collagen tissue was observed. The results showed that the types of hydroxyapatite tested – HaP and HaCol – are biocompatible. When compared with the commercially available hydroxyapatite, these new biomaterials showed similar biocompatibility performance.CLINICAL SIGNIFICANCE: The new hydroxyapatite tested are considered biocompatible

Effects of At-home Bleaching in Smokers: 30-month Follow-up

Objective: This clinical study evaluated the color longevity after 30 months of at-home bleaching with 10% carbamide peroxide (CP) in smokers and nonsmokers. Methods: Sixty patients, 30 smokers and 30 nonsmokers, were subjected to bleaching with 10% CP (Whiteness Perfect–FGM) for three hours daily for three weeks. The color was measured at baseline and at one month and 30 months after the completion of dental bleaching using the shade guide Vita classical organized by value (DSGU) and the shade guide Vita Bleachedguide 3D-MASTER. At the 30-month recall, the color was assessed before and after dental prophylaxis. Data from color evaluation were analyzed by two-way repeated-measures analysis of variance and Tukey test for the contrast of means (a=0.05). Results: Twenty-one smokers and 22 nonsmokers attended the 30 month recall. For both shade guides, only the main factor of assessment time was statistically significant (p,0.001). Effective whitening was observed in both groups at the baseline, which was stable at one month. However, color rebound was observed after 30 months for both groups of participants when color was measured before and after dental prophylaxis. Conclusion: Thirty months after at-home bleaching with 10% CP gel, dental darkening was detected in both groups, which cannot be solely attributed to stains caused by extrinsic staining from daily food, drinks, and smoke (in smokers)

Nanofilled/nanohybrid and hybrid resin-based composite in patients with direct restorations in posterior teeth: A systematic review and meta-analysis

Objective: A systematic review and a meta-analysis were performed to answer the following research question: Are there differences in the color match and surface texture of nanofilled/nanohybrid and hybrid composite in patients with direct posterior restorations? Data: Randomized clinical trials that compared nanofilled/nanohybrid and hybrid composite in direct restoration in posterior teeth were included. For the analysis of the bias the risk of bias tool (RoB) was used. Metaanalyses of different pairs (nanofilled vs. hybrid and nanohybrid vs. hybrid composite) were conducted for surface texture and color match and other secondary outcomes at different follow-ups, using a random effects model. Heterogeneity was assessed with the Cochran Q test and I2 statistics. GRADE was used to assess the quality of the evidence. Sources: A search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library and SIGLE, without restrictions. IADR abstracts (2001–2019), unpublished and ongoing trials registries, dissertations and theses were also searched. Study selection: 28 studies remained. No study was considered to be at low RoB; four studies were judged to have high RoB, and the remaining were judged to have unclear RoB. Results: For the primary and secondary outcomes variables no significant differences were detected between nanofilled/nanohybrid restorations and hybrid composite restorations in any of the study follow-ups (p>0.08). The body of evidence for surface texture and color match was classified as moderate or low. Conclusion: No evidence of difference was found between nanofilled/nanohybrid and hybrid composite in any of the clinical parameters evaluated.National Council for Scientific and Technological Development (CNPq) 303332/2017-4 308286/2019-7 CAPES 00

A expansão rápida de maxila muda a posição natural da cabeça em crianças com constrição maxilar? Uma revisão sistemática e meta-análise

Objective: a systematic review was performed to evaluate the natural head position (NHP) in children with maxillary constriction before and after rapid maxillary expansion (RME). Material and Methods: a comprehensive search was carried out in the MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE without restrictions. The annual conference of the IADR abstracts (1990–2017) and unpublished and ongoing trials registry were also searched. Dissertations and theses were searched using the ProQuest Dissertations and “Periódicos CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) Theses Databases”. The studies compared the natural head position in patients submitted rapid maxillary expansion (RME) and untreated patients both with maxillary constriction. Results: a total of 3023 studies were identified, three remained in qualitative study and all these studies were considered at “unclear” risk of bias in the key domains. Only two studies presented similar data to be included in the meta-analysis. Both studies evaluated the natural head position, through the angle between nasion-sella line and true vertical (SN-Ver). The meta-analyses demonstrated that after 12 months follow-up, the SN-Ver angle decreased by 3.39 degrees (95% confidence interval [CI]=0.57 to 6.21; p=0.02). Conclusion: the RME promoted increase in SN-VER angle in child after 12 months for intervention; however, there are few studies in the literature about this topic, and there is a need of further well-designed trials to investigate this alteration.Objetivo: uma revisão sistemática foi realizada para avaliar se a posição natural da cabeça (PNS) muda em crianças com constrição maxilar antes e após expansão rápida da maxila (ERM). Material e método: uma pesquisa foi realizada no MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO e Cochrane Library sem restrições. Também foram pesquisadas a conferência anual dos resumos da IADR (1990–2017) e o registro de ensaios não publicados e em andamento. As dissertações e teses foram pesquisadas usando os bancos de dados ProQuest Dissertations e “Periódicos CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) de Teses”. Os estudos compararam a posição natural da cabeça em pacientes submetidos a expansão rápida da maxila (ERM) e pacientes não tratados, ambos com constrição maxilar. Resultados: um total de 3023 estudos foram identificados, três permaneceram em estudo qualitativo e todos esses estudos foram considerados de risco "pouco claro" de viés nos principais domínios. Apenas dois estudos apresentaram dados semelhantes para serem incluídos na meta-análise. Ambos os estudos avaliaram a posição natural da cabeça, através do ângulo entre a linha násio-sela e a vertical verdadeira (SN-Ver). As meta-análises demonstraram que, após 12 meses de acompanhamento, o ângulo SN-Ver diminuiu 3,39 graus (intervalo de confiança de 95% [IC] = 0,57 a 6,21; p = 0,02). Conclusão: o ERM promoveu aumento do ângulo SN-VER na criança após 12 meses de intervenção; no entanto, existem poucos estudos na literatura sobre esse tópico, e há necessidade de mais estudos bem delineados para investigar essa alteração