1,153 research outputs found
Phytoestrogen agathisflavone ameliorates neuroinflammation-induced by LPS and IL-1β and protects neurons in cocultures of glia/neurons
Inflammation and oxidative stress are common aspects of most neurodegenerative diseases in the central nervous system. In this context, microglia and astrocytes are central to mediating the balance between neuroprotective and neurodestructive mechanisms. Flavonoids have potent anti-inflammatory and antioxidant properties. Here, we have examined the anti-inflammatory and neuroprotective potential of the flavonoid agathisflavone (FAB), which is derived from the Brazilian plant Poincianella pyramidalis, in in vitro models of neuroinflammation. Cocultures of neurons/glial cells were exposed to lipopolysaccharide (LPS, 1 µg/mL) or interleukin (IL)-1β (10 ng/mL) for 24 h and treated with FAB (0.1 and 1 µM, 24 h). FAB displayed a significant neuroprotective effect, as measured by nitric oxide (NO) production, Fluoro-Jade B (FJ-B) staining, and immunocytochemistry (ICC) for the neuronal marker β-tubulin and the cell death marker caspase-3, preserving neuronal soma and increasing neurite outgrowth. FAB significantly decreased the LPS-induced microglial proliferation, identified by ICC for Iba-1/bromodeoxyuridine (BrdU) and CD68 (microglia M1 profile marker). In contrast, FAB had no apparent effect on astrocytes, as determined by ICC for glial fibrillary acidic protein (GFAP). Furthermore, FAB protected against the cytodestructive and proinflammatory effects of IL-1β, a key cytokine that is released by activated microglia and astrocytes, and ICC showed that combined treatment of FAB with α and β estrogen receptor antagonists did not affect NF-κB expression. In addition, qPCR analysis demonstrated that FAB decreased the expression of proinflammatory molecules TNF-α, IL-1β, and connexins CCL5 and CCL2, as well as increased the expression of the regulatory molecule IL-10. Together, these findings indicate that FAB has a significant neuroprotective and anti-inflammatory effect in vitro, which may be considered as an adjuvant for the treatment of neurodegenerative diseases
A poorer nutritional status impacts quality of life in a sample population of elderly cancer patients
Rationale
Quality of Life (QoL) is impaired in cancer, and the elderly are particularly vulnerable to malnutrition. A diagnosis of cancer in elderly patients further exacerbates risks of negative health outcomes. Here we investigated associations between QoL and nutritional status in a sample population of mostly socially deprived elderly cancer patients.
Method
432 cancer patients were recruited for this cross-sectional study at point of admission to a tertiary referral hospital for cancer treatment. Patient-generated subjective global assessment (PG-SGA) assessed nutritional status. Functional assessment of cancer therapy- general (FACT-G) quantified QoL. Relationship between PG-SGA and QoL was assessed by Spearman correlation. PG-SGA outcomes were compared against FACT-G scores employing Mann–Whitney test. Bivariate Linear Regression Model was employed to investigate influences of sociodemographic, clinical and nutritional status upon QoL.
Results
37.5% of participants were malnourished or at risk. 39% were illiterate and 54.6% had family income lower than minimum wage. Malnourished patients showed lower FACT-G scores (76.8 vs. 84.7; p = 0.000). Poor nutritional diagnosis was inversely correlated with all QoL domains. Bivariate regression analysis showed that lower PG-SGA scores (βo =  − 1.00; p = 0.000) contributed to FACT-G score deterioration, the male gender showed better QoL scores, and other clinical and sociodemographic variables did not show relationship.
Conclusion
Poorer nutritional status was significantly associated with worsened physical, social, emotional and functional well-being QoL domains in elderly cancer patients. Poorer nutritional status is an independent risk factor for worsened QoL. Future policies aimed at particularly vulnerable populations may improve QoL and health outcomes
An Improved Description of the Dielectric Breakdown in Oxides Based on a Generalized Weibull distribution
In this work, we address modal parameter fluctuations in statistical
distributions describing charge-to-breakdown and/or
time-to-breakdown during the dielectric breakdown regime of
ultra-thin oxides, which are of high interest for the advancement of electronic
technology. We reobtain a generalized Weibull distribution (-Weibull), which
properly describes data when oxide thickness fluctuations are
present, in order to improve reliability assessment of ultra-thin oxides by
time-to-breakdown extrapolation and area scaling. The incorporation
of fluctuations allows a physical interpretation of the -Weibull
distribution in connection with the Tsallis statistics. In support to our
results, we analyze data of SiO-based MOS devices obtained
experimentally and theoretically through a percolation model, demonstrating an
advantageous description of the dielectric breakdown by the -Weibull
distribution.Comment: 5 pages, 3 figure
Qualidade pós-colheita de frutos de mangueira ("Mangifera indica" L.) var. 'Tommy Atkins' sob sistema orgânico no submédio São Francisco (Brasil)
O objetivo do trabalho foi avaliar a qualidade pós -
colheita de frutos de mangueira Tommy Atkins, cultivada sob
sistema orgânico. Os frutos foram avaliados logo ao
chegarem ao laboratório (0) e após armazenamento em
câmara fria a 10,5º ± 1 ºC e 85,5º ± 5 % de UR, durante, 14,
28 e 42 dias após a colheita (DAC), sendo que após cada
perÃodo, foram retirados da câmara fria e mantidos durante
quatro dias a 21 ± 1º C e 55-65 % de UR, após o que foram
caracterizados fÃsica, biológica e quÃmicamente. O
delineamento experimental foi em blocos inteiramente ao
acaso. As médias foram comparadas pelo teste de Tukey.
Os frutos foram avaliados quanto a: perda de água e a
aparência, danos mecânicos, coloração da casca, firmeza
da polpa, ocorrência de colapso interno, escurecimento de
lenticelas, danos por lesões devido ao ataque de
Lasiodiplodia, Colletotrichum ou por Alternaria ou por tripes;
SST, ATT e o pH da polpa. As mangas estavam aptas para
o consumo por volta dos 18 DAC, tempo, mais do que
suficiente para se proceder ao transporte do produto até
mercados distantes, como o americano e o europeu
Discriminating among Earth composition models using geo-antineutrinos
It has been estimated that the entire Earth generates heat corresponding to
about 40 TW (equivalent to 10,000 nuclear power plants) which is considered to
originate mainly from the radioactive decay of elements like U, Th and K,
deposited in the crust and mantle of the Earth. Radioactivity of these elements
produce not only heat but also antineutrinos (called geo-antineutrinos) which
can be observed by terrestrial detectors. We investigate the possibility of
discriminating among Earth composition models predicting different total
radiogenic heat generation, by observing such geo-antineutrinos at Kamioka and
Gran Sasso, assuming KamLAND and Borexino (type) detectors, respectively, at
these places. By simulating the future geo-antineutrino data as well as reactor
antineutrino background contributions, we try to establish to which extent we
can discriminate among Earth composition models for given exposures (in units
of kt yr) at these two sites on our planet. We use also information on
neutrino mixing parameters coming from solar neutrino data as well as KamLAND
reactor antineutrino data, in order to estimate the number of geo-antineutrino
induced events.Comment: 24 pages, 10 figures, final version to appear in JHE
Cross-sectional Survey of Hantavirus Infection, Brazil
A cross-sectional serosurvey was conducted to assess the proportion of persons exposed to hantaviruses in a virus-endemic area of the state of Minas Gerais, Brazil. Findings of this study suggested the presence of >1 hantaviruses circulating in this region causing hantavirus pulmonary syndrome, mild disease, or asymptomatic infection
Causas de variação da produção de leite em um rebanho da raça Holandesa em São Carlos, SP
Avaliação de CaracterÃsticas QuÃmicas do Solo Durante a Decomposição Cadavérica e suas Aplicações à QuÃmica Forense
The estimation of the Post-Mortem Interval (PMI) is a primordial parameter in the investigation of crimes against life. In tropical climate areas, the cadaveric decomposition occurs in an accelerated form, preventing the PMI estimation by usual methods. Understanding how different circumstances affect the cadaveric composition is very important to develop methods that enable the PMI estimation in several climatic conditions. One of the alternatives, however not much explored in Brazil, refers to the use of soil chemistry for the determination of longstanding PMIs. In this research, variations in soil chemical properties were monitored during swine carcasses cadaverous decomposition in a tropical forest area in order to recognize patterns and evaluate the applicability of these by the criminal expertise. Among the evaluated characteristics are the levels of pH, inorganic nitrogen (ammonia and nitrate), total nitrogen, carbon nitrogen proportion (C: N), exchangeable aluminum, available phosphorus and macro and micronutrients. The results showed distinct variations according to the decomposition phases observed and also to the way the carcasses were deposited in the study environment (above or below the soil), evidencing the possibility of using these variations in the development of models for the prediction of postmortem intervals lasting up to 67 days. © 2018 Secretaria Regional do Rio de Janeiro da Sociedade Brasileira de Quimica. All rights reserved
Toward an internally consistent astronomical distance scale
Accurate astronomical distance determination is crucial for all fields in
astrophysics, from Galactic to cosmological scales. Despite, or perhaps because
of, significant efforts to determine accurate distances, using a wide range of
methods, tracers, and techniques, an internally consistent astronomical
distance framework has not yet been established. We review current efforts to
homogenize the Local Group's distance framework, with particular emphasis on
the potential of RR Lyrae stars as distance indicators, and attempt to extend
this in an internally consistent manner to cosmological distances. Calibration
based on Type Ia supernovae and distance determinations based on gravitational
lensing represent particularly promising approaches. We provide a positive
outlook to improvements to the status quo expected from future surveys,
missions, and facilities. Astronomical distance determination has clearly
reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press
(chapter 8 of a special collection resulting from the May 2016 ISSI-BJ
workshop on Astronomical Distance Determination in the Space Age
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