Oncogenic osteomalacia: report of two cases

La osteomalacia oncogénica es una enfermedad rara. Existen descriptos alrededor de 337 casos. Es ocasionada por un tumor productor del factor de crecimiento fibroblástico 23 (FGF-23), hormona que disminuye la reabsorción tubular de fosfatos y altera la hidroxilación renal de la vitamina D, con hipofosfatemia, hiperfosfaturia y niveles bajos de calcitriol. Se presentan dos pacientes de 44 y 70 años, que consultaron por dolores óseos generalizados de aproximadamente un año de evolución en los que se hallaron alteraciones bioquímicas compatibles con osteomalacia hipofosfatémica. En el primer caso se realizó la resección de una tumoración en tejido celular subcutáneo del pie derecho, un año después del diagnóstico clínico. Luego de la exéresis, se disminuyó el aporte de fosfatos que recibía el paciente, pero reaparecieron los dolores al intentar suspenderlos. Ocho años más tarde, hubo recidiva local de la tumoración por lo que se efectuó resección completa. Después de la misma, se logró suspender el aporte de fosfatos. En el segundo caso, el paciente se estudió con tomografía por emisión de positrones con 18F-fluorodesoxiglucosa, hallando formación nodular hipermetabólica en partes blandas de antepie derecho, de 2.26 cm de diámetro. Luego de su escisión se pudo suspender el aporte de fosfatos. Ambos pacientes se encuentran asintomáticos con indicadores de metabolismo fosfocálcico normales. El diagnóstico anatomopatológico en ambos fue un tumor mesenquimático fosfatúrico, variante mixta del tejido conectivo, la entidad más frecuentemente asociada a la osteomalacia oncogénica.Oncogenic osteomalacia is a rare disease. It is caused by a tumor that produces fibroblast growth factor 23, a hormone that decreases the tubular phosphate reabsorption and impairs renal hydroxylation of vitamin D. This leads to hyperphosphaturia with hypophosphatemia and low calcitriol levels. About 337 cases have been reported and we studied two cases; 44 and 70 year-old men who sought medical attention complaining of suffering diffuse bone pain over a period of approximately one year. In both cases, a laboratory test showed biochemical alterations compatible with a hypophosphatemic osteomalacia. In the first case, a soft tissue tumor of the right foot was removed, one year after the diagnosis. The patient was allowed to diminish the phosphate intake, but symptoms reappeared at this time. Eight years later, a local recurrence of the tumor was noted. A complete excision was now performed. The patient was able to finally interrupt the phosphate intake. In the second case, an F-18 fluorodeoxyglucose positron emission tomography, with computed tomography revealed a 2.26 cm diameter hypermetabolic nodule in the soft tissue of the right forefoot. After its removal, the patient discontinued the phosphate intake. Both patients are asymptomatic and show a regular phosphocalcic laboratory evaluation. The histopathological diagnosis was, in both cases, a phosphaturic mesenchymal tumor, a mixed connective tissue variant. This is the prototypical variant of these tumors.Fil: Jercovich, Fernando. Fundación Medica de Mar del Plata. Hospital Privado de Comunidad; ArgentinaFil: Moncet, Daniel. Fundación Medica de Mar del Plata. Hospital Privado de Comunidad; ArgentinaFil: Babini, Silvia. Fundación Medica de Mar del Plata. Hospital Privado de Comunidad; ArgentinaFil: Zoppi, Jorge. Fundación Medica de Mar del Plata. Hospital Privado de Comunidad; ArgentinaFil: Graciolli, Fabiana. Universidade de Sao Paulo; BrasilFil: Oliveri, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentin

Law, archive and event in Slavery Brazil: meanigs of freedom in Free Born Law

Neste artigo, por recorte metodológico, analisamos sentidos de liberdade que se materializam na Lei do Ventre Livre, enquanto acontecimento discursivo, relacionado ao arquivo de leis abolicionistas/emancipacionistas brasileiras, a qual revela a positivação dos costumes: uma forma de imbricação de dois direitos: Consuetudinário e Positivo. Consideramos especificamente casos de rupturas instauradas por essa lei. Como aporte teórico, seguimos Zoppi-Fontana (2002, 2005) que, fazendo uso da noção de arquivo, postulada por Pêcheux (1982, p. 57), memória e acontecimento para a análise de textos legais, considera a materialidade da língua (sistema sintático) na discursividade (inscrição de efeitos linguísticos materiais na história) do arquivo.PALAVRAS-CHAVE:Discurso Jurídico. Semântica. Escravidão. Lei do Ventre Livre. ABSTRACT This paper analyses meaning of freedom in the Brazilian Free Born Law (Lei do Ventre Livre), as discursive event, related to the archive of brazilian abolitionist laws. We postulate that this Law reveals a imbrincation of Positive Law and Consuetudinary Law. So, we analise specifically ruptures in that legal text. As theoretical framework, we base on Zoppi-Fontana (2002, 2005), who uses notions of archive, by Pe?cheux (1982, p. 57), memory and event, for investigation of legal texts, taking into account the language materiality (sintactic system) inscribed in the discursiveness of the archive.KEYWORDS: Legal Discourse. Semantics. Slavery. Free Born Law.This paper analyses meaning of freedom in the Brazilian Free Born Law (Lei do Ventre Livre), as discursive event, related to the archive of brazilian abolitionist laws. We postulate that this Law reveals a imbrincation of Positive Law and Consuetudinary Law. So, we analise specifically ruptures in that legal text. As theoretical framework, we base on Zoppi-Fontana (2002, 2005), who uses notions of archive, by Pe?cheux (1982, p. 57), memory and event, for investigation of legal texts, taking into account the language materiality (sintactic system) inscribed in the discursiveness of the archive.KEYWORDS: Legal Discourse. Semantics. Slavery. Free Born Law

Tratamento da luxação anterior recidivante do ombro pela técnica de Bristow-Latarjet

Objectives: To describe the clinical and radiographic results of patients with recurrent anterior shoulder dislocation treated with the Bristow-Latarjet technique. Material and Methods: Retrospective case series including 44 patients (45 shoulders) with anterior shoulder instability who underwent the Bristow-Latarjet procedure, including 86% of male patients and 80% with traumatic dislocations. The graft was fixed "standing", as used in the Bristow technique, in 84% of the shoulders, and "lying", as proposed by Latarjet, in 16%, using 1 metal screw in all cases, and washer in 20% of the surgeries. Results: The follow-up was 19.25 ± 10.24 months. We obtained 96% of good results, with 2 recurrences presented as subluxation. Of the 36 patients who practiced sports, 89% had good results. Graft healing occurred in 62% of cases. The graft was positioned below the glenoid equator in 84% of the cases, and less than 10 mm from its edge in 98%. The external rotation had a limitation of 20.7º ± 15.9º, while the internal rotation was limited in 4.0º ± 9.6º. The limitation of external and internal rotation and the position of the graft ("standing" or "lying") did not correlate with graft healing (p> 0.05). Bicortical fixation was positively correlated with healing (p <0.001). Conclusion: The Bristow-Latarjet technique is indicated for the treatment of recurrent anterior dislocations and subluxations of the shoulder. It is a safe treatment method, which can be used in people with intense physical activity. Limiting shoulder mobility does not prevent patients from returning to their usual occupations, as well as, in most of them, from playing sports with the same performance as before the surgery. Level of evidence: IV, Case SeriesObjetivos: Descrever os resultados clínicos e radiográficos do tratamento da luxação anterior recidivante do ombro pela técnica de Bristow-Latarjet. Material e Métodos: Série de casos retrospectiva, incluindo 44 pacientes (45 ombros) com instabilidade anterior do ombro submetidos à técnica de Bristow-Latarjet, incluindo 86% de pacientes do sexo masculino e 80% com luxações traumáticas. O enxerto foi fixado "em pé" em 84% dos ombros, e "deitado" em 16%, utilizando 1 parafuso metálico, com uso de arruela em 20% das cirurgias. Resultados: O seguimento foi de 19,25 ± 10,24 meses. Obtivemos 96% de bons resultados, sendo 2 recidivas sob a forma de subluxação. Dos 36 pacientes que praticavam esporte, 89% apresentaram bons resultados. A consolidação ocorreu em 62% dos casos. O enxerto foi posicionado  abaixo do equador da glenoide em 84% das vezes, e a menos de 10 mm da sua borda em 98%. A rotação externa apresentou limitação de 20,7º ± 15,9º, enquanto a rotação interna 4,0º ± 9,6º. A limitação da rotação externa e da rotação interna e a posição do enxerto ("em pé" ou 'deitado") não se correlacionaram com a consolidação do enxerto (p>0,05). A fixação bicortical correlacionou-se positivamente com a consolidação (p<0,001). Conclusão: A técnica de Bristow-Latarjet está indicada para o tratamento das luxações e subluxações anteriores recidivantes do ombro. É um método de tratamento seguro, que pode ser utilizado em pessoas com atividade física intensa. A limitação da mobilidade do ombro não impede os pacientes de voltarem às suas ocupações habituais, bem como, na maioria deles, de praticar esporte com desempenho igual ao de antes da operação. Nível de evidência: IV, Série de Caso

Marine Biodiversity in the Caribbean: Regional Estimates and Distribution Patterns

This paper provides an analysis of the distribution patterns of marine biodiversity and summarizes the major activities of the Census of Marine Life program in the Caribbean region. The coastal Caribbean region is a large marine ecosystem (LME) characterized by coral reefs, mangroves, and seagrasses, but including other environments, such as sandy beaches and rocky shores. These tropical ecosystems incorporate a high diversity of associated flora and fauna, and the nations that border the Caribbean collectively encompass a major global marine biodiversity hot spot. We analyze the state of knowledge of marine biodiversity based on the geographic distribution of georeferenced species records and regional taxonomic lists. A total of 12,046 marine species are reported in this paper for the Caribbean region. These include representatives from 31 animal phyla, two plant phyla, one group of Chromista, and three groups of Protoctista. Sampling effort has been greatest in shallow, nearshore waters, where there is relatively good coverage of species records; offshore and deep environments have been less studied. Additionally, we found that the currently accepted classification of marine ecoregions of the Caribbean did not apply for the benthic distributions of five relatively well known taxonomic groups. Coastal species richness tends to concentrate along the Antillean arc (Cuba to the southernmost Antilles) and the northern coast of South America (Venezuela – Colombia), while no pattern can be observed in the deep sea with the available data. Several factors make it impossible to determine the extent to which these distribution patterns accurately reflect the true situation for marine biodiversity in general: (1) highly localized concentrations of collecting effort and a lack of collecting in many areas and ecosystems, (2) high variability among collecting methods, (3) limited taxonomic expertise for many groups, and (4) differing levels of activity in the study of different taxa

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans – anteaters, sloths, and armadillos – have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with 24 domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, ten anteaters, and six sloths. Our dataset includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data-paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the south of the USA, Mexico, and Caribbean countries at the northern portion of the Neotropics, to its austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n=5,941), and Cyclopes sp. has the fewest (n=240). The armadillo species with the most data is Dasypus novemcinctus (n=11,588), and the least recorded for Calyptophractus retusus (n=33). With regards to sloth species, Bradypus variegatus has the most records (n=962), and Bradypus pygmaeus has the fewest (n=12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other datasets of Neotropical Series which will become available very soon (i.e. Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans dataset

Proyecto, investigación e innovación en urbanismo, arquitectura y diseño industrial

Actas de congresoLas VII Jornadas de Investigación “Encuentro y Reflexión” y I Jornadas de Investigación de becarios y doctorandos. Proyecto, investigación e innovación en Urbanismo, Arquitectura y Diseño Industrial se centraron en cuatro ejes: el proyecto; la dimensión tecnológica y la gestión; la dimensión social y cultural y la enseñanza en Arquitectura, Urbanismo y Diseño Industrial, sustentados en las líneas prioritarias de investigación definidas epistemológicamente en el Consejo Asesor de Ciencia y Tecnología de esta Universidad Nacional de Córdoba. Con el objetivo de afianzar continuidad, formación y transferencia de métodos, metodología y recursos se incorporó becarios y doctorandos de los Institutos de investigación. La Comisión Honoraria la integraron las tres Secretarias de Investigación de la Facultad, arquitectas Marta Polo, quien fundó y María del Carmen Franchello y Nora Gutiérrez Crespo quienes continuaron la tradición de la buena práctica del debate en la cotidianeidad de la propia Facultad. Los textos que conforman las VII Jornadas son los avances y resultados de las investigaciones realizadas en el bienio 2016-2018.Fil: Novello, María Alejandra. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Repiso, Luciana. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Mir, Guillermo. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Brizuela, Natalia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Herrera, Fernanda. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Períes, Lucas. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Romo, Claudia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Gordillo, Natalia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Andrade, Elena Beatriz. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; Argentin

Chronic blockade of cannabinoid CB 2 receptors induces anxiolytic-like actions associated with alterations in GABA A receptors

BACKGROUND AND PURPOSE The aim of this study was to explore the effects of CB 2 receptor agonist and antagonist in the regulation of anxiety-like behaviours. EXPERIMENTAL APPROACHES Effects of acute and chronic treatment with the CB 2 receptor agonist JWH133 and CB 2 receptor antagonist AM630 were evaluated in the light-dark box (LDB) and elevated plus maze (EPM) tests in Swiss ICR mice. CB 2 receptor, GABA Aα 2 and GABA Aγ 2 gene and protein expression in the cortex and amygdala of mice chronically treated with JWH133 or AM630 were examined by RT-PCR and Western blot. Effects of chronic AM630 treatment were evaluated in spontaneously anxious DBA/2 mice in LDB. KEY RESULTS Acute JWH133 treatment failed to produce any effect. Acute AM630 treatment increased anxiety and was blocked by pre-treatment with JWH133. Chronic JWH133 treatment increased anxiety-like behaviour whereas chronic AM630 treatment was anxiolytic in LDB and EPM tests. Chronic AM630 treatment increased gene and reduced protein expression of CB 2 receptors, GABA Aα 2 and GABA Aγ 2 in cortex and amygdala. Chronic JWH133 treatment resulted in opposite gene and protein alterations. In addition, chronic AM630 administration decreased the anxiety of DBA/2 mice in the LDB test. CONCLUSIONS AND IMPLICATIONS The opposing behavioural and molecular changes observed after chronic treatment with AM630 or JWH133 support the key role of CB 2 receptors in the regulation of anxiety. Indeed, the efficacy of AM630 in reducing the anxiety of the spontaneously anxious DBA/2 strain of mice strengthens the potential of the CB 2 receptor as a new target in the treatment of anxiety-related disorders. © 2011 The British Pharmacological Society.This research was supported by grants from Ministry of Science and Innovation (SAF 2008-01106) and Ministry of Health (RETICS RD06/0001/1004, Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER and PNSD 2007/061) to JM. MSGG is a predoctoral fellow of the Ministry of Science and Innovation. AR is a technician supported by RETICS.Peer Reviewe