117 research outputs found
Towards More Precise Survey Photometry for PanSTARRS and LSST: Measuring Directly the Optical Transmission Spectrum of the Atmosphere
Motivated by the recognition that variation in the optical transmission of
the atmosphere is probably the main limitation to the precision of ground-based
CCD measurements of celestial fluxes, we review the physical processes that
attenuate the passage of light through the Earth's atmosphere. The next
generation of astronomical surveys, such as PanSTARRS and LSST, will greatly
benefit from dedicated apparatus to obtain atmospheric transmission data that
can be associated with each survey image. We review and compare various
approaches to this measurement problem, including photometry, spectroscopy, and
LIDAR. In conjunction with careful measurements of instrumental throughput,
atmospheric transmission measurements should allow next-generation imaging
surveys to produce photometry of unprecedented precision. Our primary concerns
are the real-time determination of aerosol scattering and absorption by water
along the line of sight, both of which can vary over the course of a night's
observations.Comment: 41 pages, 14 figures. Accepted PAS
Do High-Velocity Clouds trace the Dark Matter subhalo population?
Within the cosmological concordance model, Cold Dark Matter (CDM) subhalos
form the building blocks which merge hierarchically to more massive galaxies.
Since intergalactic gas is accreted by massive galaxies, observable e.g. as
high- velocity clouds (HVCs) around the Milky Way, with extremely low
metallicities, these can be suggested to represent the baryonic content of
primordial Dark Matter (DM) subhalos. Another possibility of their origin is
that they stem from disrupted satellite galaxies, but in this case, these gas
clouds move unaccompanied by a bound DM structure. Since HVCs are observed with
long gas tails and with irregular substructures, numerical models are performed
aiming at exploring their structure and compare them with observations. If HVCs
are engulfed by DM subhalos, their gas must leave the DM gravitational
potential and reflect this in their dynamics. On the other hand, the evolution
and survival of pure gas models must be tested to distinguish between
DM-dominated and DM-free clouds and to allow conclusions on their origin. The
models demonstrate that purely baryonic HVCs with low masses are disrupted by
ram-pressure stripping and Kelvin-Helmholtz instabilities, while more massive
ones survive, losing their initially spherical shape and develop significant
substructures including cometary elongations in the column density distribution
("head-tail structure"). On the contrary, HVCs with DM subhalos survive with
more than 90% of their gas mass still bound and spherically shaped, approaching
the Galactic disk like bullets. In addition, we find that velocity gradients
along the cometary head-tail structures does not necessarily offer a
possibility to distinguish between DM-dominated and purely gaseous HVCs.
Comparison of models with observations let us conclude that HVCs are not
embedded in a DM substructure and do not trace the cosmological subhalo
population.Comment: Accepted for publication in A&
High-Mass X-ray Binaries and the Spiral Structure of the Host Galaxy
We investigate the manifestation of the spiral structure in the distribution
of high-mass X-ray binaries (HMXBs) over the host galaxy. We construct the
simple kinematic model. It shows that the HMXBs should be displaced relative to
the spiral structure observed in such traditional star formation rate
indicators as the Halpha and FIR emissions because of their finite lifetimes.
Using Chandra observations of M51, we have studied the distribution of X-ray
sources relative to the spiral arms of this galaxy observed in Halpha. Based on
K-band data and background source number counts, we have separated the
contributions from high-mass and low-mass X-ray binaries and active galactic
nuclei. In agreement with model predictions, the distribution of HMXBs is wider
than that of bright HII regions concentrated in the region of ongoing star
formation. However, the statistical significance of this result is low, as is
the significance of the concentration of the total population of X-ray sources
to the spiral arms. We also predict the distribution of HMXBs in our Galaxy in
Galactic longitude. The distribution depends on the mean HMXB age and can
differ significantly from the distributions of such young objects as
ultracompact HII regions.Comment: 18 pages, 6 figures; Astronomy Letters, Vol. 33, No. 5, 2007, pp.
299-30
Estimating Incidence Curves of Several Infections Using Symptom Surveillance Data
We introduce a method for estimating incidence curves of several co-circulating infectious pathogens, where each infection has its own probabilities of particular symptom profiles. Our deconvolution method utilizes weekly surveillance data on symptoms from a defined population as well as additional data on symptoms from a sample of virologically confirmed infectious episodes. We illustrate this method by numerical simulations and by using data from a survey conducted on the University of Michigan campus. Last, we describe the data needs to make such estimates accurate
Factors affecting phage D29 infection: a tool to investigate different growth states of mycobacteria
Bacteriophages D29 and TM4 are able to infect a wide range of mycobacteria, including pathogenic and non pathogenic species. Successful phage infection of both fast- and slow-growing mycobacteria can be rapidly detected using the phage amplification assay. Using this method, the effect of oxygen limitation during culture of mycobacteria on the success of phage infection was studied. Both D29 and TM4 were able to infect cultures of M. smegmatis and Mycobacterium avium subspecies paratuberculosis (MAP) grown in liquid with aeration. However when cultures were grown under oxygen limiting conditions, only TM4 could productively infect the cells. Cell attachment assays showed that D29 could bind to the cells surface but did not complete the lytic cycle. The ability of D29 to productively infect the cells was rapidly recovered (within 1 day) when the cultures were returned to an aerobic environment and this recovery required de novo RNA synthesis. These results indicated that under oxygen limiting conditions the cells are entering a growth state which inhibits phage D29 replication, and this change in host cell biology which can be detected by using both phage D29 and TM4 in the phage amplification assay
Risk Factors and Immunity in a Nationally Representative Population following the 2009 Influenza A(H1N1) Pandemic
Understanding immunity, incidence and risk factors of the 2009 influenza A(H1N1) pandemic (2009 H1N1) through a national seroprevalence study is necessary for informing public health interventions and disease modelling.We collected 1687 serum samples and individual risk factor data between November-2009 to March-2010, three months after the end of the 2009 H1N1 wave in New Zealand. Participants were randomly sampled from selected general practices countrywide and hospitals in the Auckland region. Baseline immunity was measured from 521 sera collected during 2004 to April-2009. Haemagglutination inhibition (HI) antibody titres of ≥1∶40 against 2009 H1N1 were considered seroprotective as well as seropositive. The overall community seroprevalence was 26.7% (CI:22.6–29.4). The seroprevalence varied across age and ethnicity. Children aged 5–19 years had the highest seroprevalence (46.7%;CI:38.3–55.0), a significant increase from the baseline (14%;CI:7.2–20.8). Older adults aged ≥60 had no significant difference in seroprevalence between the serosurvey (24.8%;CI:18.7–30.9) and baseline (22.6%;CI:15.3–30.0). Pacific peoples had the highest seroprevalence (49.5%;CI:35.1–64.0). There was no significant difference in seroprevalence between both primary (29.6%;CI:22.6–36.5) and secondary healthcare workers (25.3%;CI:20.8–29.8) and community participants. No significant regional variation was observed. Multivariate analysis indicated age as the most important risk factor followed by ethnicity. Previous seasonal influenza vaccination was associated with higher HI titres. Approximately 45.2% of seropositive individuals reported no symptoms.Based on age and ethnicity standardisation to the New Zealand Population, about 29.5% of New Zealanders had antibody titers at a level consistent with immunity to 2009 H1N1. Around 18.3% of New Zealanders were infected with the virus during the first wave including about one child in every three. Older people were protected due to pre-existing immunity. Age was the most important factor associated with infection followed by ethnicity. Healthcare workers did not appear to have an increased risk of infection compared with the general population
Clinical Trials and Medical Care: Defining the Therapeutic Misconception
A key component of informed consent to participate in medical research includes understanding that research is not the same as treatment
Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer
Correction to Kleiner HE, Krishnan P, Tubbs J, Smith M, Meschonat C, Shi R, Lowery-Nordberg M, Adegboyega P, Unger M, Cardelli J et al: Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer. J Exp Clin Cancer Res 2009, 28:5
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