Monte-Carlo simulation of clinical and economic effectiveness of drugs (on example of antibiotics therapy of acute bronchitis with bronchospasm in children)

The study objective was to determine which antibiotics are optimal in the treatment of children with complicated acute bronchitis with bronchospasm. For that, a Monte-Carlo simulation was conducte

Methodology for determining the correlation of the clinical efficacy of therapy with the addition of a drug (for example, anti-asthma therapy in children)

Methodology for determining the correlation of the clinical efficacy of therapy with the addition of a drug (on example, clinical efficacy of montelukast in an anti-asthmatic therapy in pediatric patients

Ecological consequences of the playgrounds' reconstruction of specialized "park-stadium Khimmash", in Yekaterinburg

In connection with the World Cup in 2018 in the Russian Federation, including the qualifying matches of the World Championship in Yekaterinburg, the Government of the Sverdlovsk Regiondecided to place a training ground on the territory of the "Park-stadium Khimmash". For this purpose, a sports field reconstruction project was created and implemented. The article is devoted to the assessment of negative consequences for plantings of the "Park-stadium Khimmash" in Yekaterinburg as a result of the construction, which led to the destruction of 388 trees, 95 of them are pine trees. The park historically originated on the site of a natural pine plantation. Cutting down so many trees led to further disintegration of the stand. According to the project, the replacement of felled large park trees of pine and birch by willow and apple trees is recommended, which led to the destruction of natural landscapes that have survived in the urban environment. At the same time, not only the aesthetic perception is worsened, but the ecological criteria of the industrial area of the city are also reduced. First of all, the oxygen-producing possibilities of the plantation decreased, which is reflected in the economic assessment of the consequences. © 2019 IOP Publishing Ltd. All rights reserved

ESTIMATED RESERVES AND ESTIMATED LIABILITIES: THE PROBLEM OF INTERPRETATION IN THE SYSTEM OF RUSSIAN LEGAL REGULATION OF ACCOUNTING

The Russian legal framework for accounting of estimated reserves and estimated liabilities of commercial organizations for the existing terminology space, the problems of correlation of the economic essence of these accounting categories and current legislation, the value of correct application of terminology in accounting (financial) statements for a wide range of stakeholders has been analysed. Special attention has been paid to the distinctive features of estimated reserves and estimated liabilities in the prism of their economic essence. Based on the results of the study, proposals regarding the interpretation of the concepts of “estimated reserve” and “estimated liability” in the implementation of the program to reform the Russian system of legal regulation of accounting and preparation of accounting (financial) statements have been formulated

The small-scale variation of herb-layer community structure in a riparian mixed forest

The ground vegetation layer is the most diverse plant community in forest ecosystems. We have shown the role of spatial variables, soil properties and overstorey structure in spatial variation of the herb-layer community in a riparian mixed forest . The research was conducted in the "Dnipro-Orils’kiy" Nature Reserve (Ukraine). The research polygon was located in the forest in the floodplain of the River Protich, which is a left tributary of the River Dnipro. Plant abundance was quantified by measuring cover within an experimental polygon. The experimental polygon consisted of 7 transects, each comprising 15 test points. The distance between the rows in the site was 3 m. At the site we established a plot of 45 × 21 m, with 105 subplots of 3 × 3 m organized in a regular grid. A list of vascular plant species was composed for each 3 × 3 m subplot along with visual estimates of species cover projection. The plant community was represented by 43 species, of which 18.6% were phanerophytes, 39.5% were hemicryptophytes, 9.3% were therophytes, 7.0% were geophytes. An overall test of random labelling revealed the total nonrandom distribution of the tree stems within the site. The species-specific test of random labelling showed the nonrandom segregated distribution of Acer tataricum, Pyrus communis, Quercus robur, and Ulmus laevis. Crataegus monogyna and Euonymus europaeus were distributed randomly. The nearest neighbour of Acer tataricum was less likely to be Ulmus laevis. There was no direct spatial connection between Acer tataricum and other trees. Crataegus monogyna, Pyrus communis, Quercus robur and Euonymus europaeus were not segregated from all other species. The nearest neighbour of Ulmus laevis was less likely to be Acer tataricum. Constrained correspondence analysis (CCA) was applied as ordination approach. The forward selection procedure allowed us to select 6 soil variables which explain 28.3% of the herb-layer community variability. The list of the important soil variables includes soil mechanical impedance (at the depth 0–5, 30–35, 75–80, and 95–10 cm), soil moisture, and soil bulk density. The variation explained by pure spatial variables accounted for 11.0 %. The majority of the tree-distance structured variation in plant community composition was broad-scaled. The spatial scalograms were left-skewed asymmetric. Significant relationship was found between the pure spatial component of the community variation and a number of phytoindicator estimations, most important of which were the variability of damping and humidity. Tree stand was obseerved to be a considerable factor structuring both the herb-layer community and spatial variation of the physical properties of soil

ENVIRONMENTAL OBLIGATIONS OF RUSSIAN ORGANIZATIONS: THE PARADOX OF INFORMATION DISCLOSURE DEPENDING ON APPLICABLE STANDARDS

The article сarries out an analysis of the reflection of the consequences of environmental disasters and the corresponding preventive measures on the example of the consolidated financial statements of the Group of mining and metallurgical companies “Norilsk Nickel” and the accounting (financial) statements of JSC “Norilsk-Taimyr energy company” (NTEK), which is part of this group. The paper pays particular attention to the relationship between recognized environmental protection obligations and applicable standards for the preparation  of accounting (financial) statements of commercial organizations and consolidated statements of groups that include these business entities. Based on the results of the study, the author formulates priority proposals to  improve the Russian system of normative regulation of disclosure of information about environmental obligations  in accounting (financial) statements

The role of RIG-I, AIM2 and IFI16 receptors for viral RNA and DNA in the pathogenesis of spontaneous and early missed miscarriage

Aim: to identify the features of the expression of mRNA of intracellular RIG-I, IFI16 and AIM2 receptors for viral RNA and DNA, and their signaling pathway proteins in the decidual tissue of patients with spontaneous and early missed miscarriage

Investigation of the Respiration Rate During Storage of Fruit Vegetables Under the Influence of Abiotic Factors

The aim of the work was to establish the influence of most important abiotic planting factors (temperature, precipitation quantity) on the respiratory rate of fruit vegetables at storage and also a possibility of correction of respiratory metabolism by post-harvest thermal processing by antioxidant compositions. Fruits of cucumbers of the hybrids Masha and Afina, bush pumpkins Kavili and Tamino, sweet pepper of the hybrids Nikita and Hercules, tomato of the varieties Novachok and Rio Grande Original were used for the studies. It was established, that the respiratory rate of pumpkin fruit vegetables is importantly influenced by the variety specificity. The respiratory level of pumpkin vegetables directly correlates with the sum of active temperatures of the period of fruits formation and reversibly – with precipitation and hydrothermal coefficient.The influence of the variety specificity for nightshade vegetables is leveled, and among meteorological planting conditions the important intense influence on the respiratory rate is realized by the sum of active temperatures of the period of fruits formation and ripening. Precipitation and hydrothermal coefficient have the important influence only on pepper fruits.It was established, that the use of post-harvest thermal processing by antioxidant compositions results in inhibition of respiratory processes in fruit vegetables at storage

Milk Urea Content and δ13C as Potential Tool for Differentiation of Milk from Organic and Conventional Low- and High-Input Farming Systems

The influence of farming type (conventional or organic) and production system (low-and high-input) on various quality characteristics of milk have been in the focus of studies over the last decade. The aim of this work was to evaluate the impact of different dairy management and production systems on carbon stable isotopes ratio (δ13C) and milk urea content. The samples of raw milk were collected each two weeks at certified organic high-input and low-input farms, conventional high-input and low-input farms in late indoor period and outdoor period. Data analysis showed clear difference between milk from organic high- and low-input farms with non-overlapping range between -22.90 ‰ and -24.70‰ for δ13С in protein fraction (equal 1.80‰) and between -25.90‰ and -28.20‰ (equal 2.30‰) for δ13С in fat fraction independently from season factor, as for Δδ13С (protein-fat) values in milk from high-input (1.50-3.00‰) and low-input (3.20-6.30‰) organic farms. Analysis of correlation between δ13С in protein fraction and milk urea content values showed that during late indoor period the most significant difference was detected between milk from organic low-input and conventional high-input farms (5.85‰ for δ13С in protein fraction and 4.65 mg/100 g of milk urea content). During outdoor period, the non-overlapping range was established for low-input and high-input organic farms (3.40‰ for δ13С in protein fraction and 10.77 mg/100 g of milk urea content). Results of δ13С values in fat and protein milk fractions, as combination of δ13С in protein fraction and milk urea content could be a potential tool for the distinguish of milk from different farming types, based on different feed composition