A Method and a Device for Diagnostics of the Functional State of Peripheral Vessels of the Upper Limbs

The article suggests a method and a device for diagnostics of the functional state of peripheral vessels of the upper limbs, which provide identification of angiospastic disorders with a lower probability of falsenegative result, allowing thereby the quality of diagnostics to be improved. The suggested approach is based on combined application of laser Doppler flowmetry and contact thermometry during an occlusion test. The obtained results can be used in various fields of medicine for the development of multifunctional noninvasive diagnostic systems for the diagnosis and prevention of diseases associated with changes in the functional state of peripheral vessels

Procedure for Event Characterization in Pb-Pb Collisions at 40A GeV in the NA49 Experiment at the CERN SPS

The time evolution of the strongly interacting matter created in a heavy-ion collision depends on the initial geometry and the collision centrality. This makes important the experimental determination of the collision geometry. In this paper a procedure for event classification and estimation of the geometrical parameters in inelastic Pb-Pb collisions at the beam energy of 4

Non-invasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes with polyethylene glycol (PEG) and without PEG when administered orally. Fluorescence channel with a fiber probe series of multifunctional laser non-invasive diagnostic system "LAKK-M" (SPE "LAZMA" Ltd, Russia) was used as the measuring equipment

Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs

The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases. This paper is devoted to the development and application of the optical non-invasive diagnostic approach for the detection and evaluation of the severity of microcirculatory and metabolic disorders in rheumatic diseases and diabetes mellitus. The proposed methods include the joint use of laser Doppler flowmetry, absorption spectroscopy and fluorescence spectroscopy in combination with functional tests. This technique showed the high diagnostic importance for the detection of disturbances in peripheral microhaemodynamics. These methods have been successfully tested as additional diagnostic techniques in the field of rheumatology and endocrinology. The sensitivity and specificity of the proposed diagnostic procedures have been evaluated.<br/

The influence of local pressure on evaluation parameters of skin blood perfusion and fluorescence

This article presents the results of the study of the pressure applied on optical diagnostic probes as a significant factor affecting the results of measurements. During stepwise increasing and decreasing of local pressure on skin we conducted measurements using the methods of laser Doppler flowmetry and fluorescence spectroscopy. It was found out that pressure on optical probe has sufficient impact on skin microcirculation to affect registered fluorescence intensity. Data obtained in this study are of interest for design and development of diagnostic technologies for wearable devices. This data will also inform further investigation into issues of compensation of blood absorption influence on fluorescence spectrum, allowing increased accuracy and reproducibility of measurements by fluorescence spectroscopy methods in optical diagnosis

Investigation of Doppler spectra of laser radiation scattered inside hand skin during occlusion test

Laser Doppler flowmetry (LDF) is a method widely used in diagnosis of microcirculation diseases. It is well known that information about frequency distribution of Doppler spectrum of the laser radiation scattered by moving red blood cells (RBC) usually disappears after signal processing procedure. Photocurrent's spectrum distribution contains valuable diagnostic information about velocity distribution of the RBC. In this research it is proposed to compute the indexes of microcirculation in the sub-ranges of the Doppler spectrum as well as investigate the frequency distribution of the computed indexes

Noninvasive control of the transport function of fluorescent coloured liposomal nanoparticles

The use of liposomal nanoparticles with an incorporated active substance is an innovative and promising approach to diagnostics and therapy. The application of liposomal nanoparticle-based drugs allows for targeted localized delivery, overcomes the natural barriers within the body effectively, and minimizes possible side effects. Liposomes are able to contain a variety of ingredients with practically no limitations to their chemical composition, chemical properties, or size of constituent molecules. This study evaluated the ability to control the passage of fluorescent dye-filled liposomes through the intestinal mucosal barrier after oral administration. For this purpose, the increase in transcutaneous registered fluorescence from tetrabromofluorescein dye was recorded and analysed. Fluorescence intensity was measured at the proximal end of the tail of an animal model after oral administration of the liposomes. Measurements were taken at the excitation wavelengths of 365 and 450 nm. The fluorescence intensity in the group treated with the fluorescent contrast agent encapsulated in liposomal particles increased 140% of the initial level, but in the group treated with pure contrast agent, the increase in detected fluorescence intensity did not exceed 110%. Mice that received empty liposomes as well as the control group did not demonstrate statistically significant changes in fluorescence intensity. A potential application of our results is an express laser optical method of monitoring the transport of orally administered liposomal particles. The results can be used to help create new optical tools for use in the development of new drugs and in high-throughput screening used during their testing

Combined use of laser Doppler flowmetry and skin thermometry for functional diagnostics of intradermal finger vessels

We introduce a noninvasive diagnostic approach for functional monitoring of blood microflows in capillaries and thermoregulatory vessels within the skin. The measuring system is based on the combined use of laser Doppler flowmetry and skin contact thermometry. The obtained results suggest that monitoring of blood microcirculation during the occlusion, performed in conjunction with the skin temperature measurements in the thermally stabilized medium, has a great potential for quantitative assessment of angiospatic dysfunctions of the peripheral blood vessels. The indices of blood flow reserve and temperature response were measured and used as the primarily parameters of the functional diagnostics of the peripheral vessels of skin. Utilizing these parameters, a simple phenomenological model has been suggested to identify patients with angiospastic violations in the vascular system

Hygienic assessment of heaviness of the physical and neuropsychiatric load of surgeons

The purpose of the study is to give a hygienic assessment of the state of mental and somatic health of surgeons.Цель исследования – дать гигиеническую оценку состоянию психического и соматического здоровья врачей хирургов

Second virial coefficients of light nuclear clusters and their chemical freeze-out in nuclear collisions

Here we develop a new strategy to analyze the chemical freeze-out of light (anti)nuclei produced in high energy collisions of heavy atomic nuclei within an advanced version of the hadron resonance gas model. It is based on two different, but complementary approaches to model the hard-core repulsion between the light nuclei and hadrons. The first approach is based on an approximate treatment of the equivalent hard-core radius of a roomy nuclear cluster and pions, while the second approach is rigorously derived here using a self-consistent treatment of classical excluded volumes of light (anti)nuclei and hadrons. By construction, in a hadronic medium dominated by pions, both approaches should give the same results. Employing this strategy to the analysis of hadronic and light (anti)nuclei multiplicities measured by ALICE at $\sqrt{s_{NN}} =2.76$ TeV and by STAR at $\sqrt{s_{NN}} =200$ GeV, we got rid of the existing ambiguity in the description of light (anti)nuclei data and determined the chemical freeze-out parameters of nuclei with high accuracy and confidence. At ALICE energy the nuclei are frozen prior to the hadrons at the temperature $T = 175.1^{+2.3}_{-3.9}$ MeV, while at STAR energy there is a single freeze-out of hadrons and nuclei at the temperature $T = 167.2 \pm 3.9$ MeV. We argue that the found chemical freeze-out volumes of nuclei can be considered as the volumes of quark-gluon bags that produce the nuclei at the moment of hadronization.Comment: 15 pages, 4 figures, 3 table