63 research outputs found
Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury
- Author
- Dandan Tan
- Dandan Tan
- Haowen Zhang
- Haowen Zhang
- Jiasong Guo
- Jiasong Guo
- Jiasong Guo
- Jiasong Guo
- Jinkun Wen
- Jinkun Wen
- Junyao Deng
- Junyao Deng
- Lixia Li
- Lixia Li
- Lixia Li
- Mengjie Pan
- Mengjie Pan
- Muhua Lai
- Muhua Lai
- Xianghai Wang
- Xianghai Wang
- Xianghai Wang
- Xianghai Wang
- Xiaofang Hu
- Xiaofang Hu
- Xiaofang Hu
- Yuanyuan Li
- Yuanyuan Li
- Zhenlin Li
- Zhenlin Li
- Zhihao Fan
- Zhihao Fan
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/03/2019
- Field of study
Ascorbic acid (AA) is an essential micronutrient that has been safely used in the clinic for many years. The present study indicates that AA has an unexpected function in facilitating nerve regeneration. Using a mouse model of sciatic nerve crush injury, we found that AA can significantly accelerate axonal regrowth in the early stage [3 days post-injury (dpi)], a finding that was revealed by immunostaining and Western blotting for antibodies against GAP-43 and SCG10. On day 28 post-injury, histomorphometric assessments demonstrated that AA treatment increased the density, size, and remyelination of regenerated axons in the injured nerve and alleviated myoatrophy in the gastrocnemius. Moreover, the results from various behavioral tests and electrophysiological assays revealed that nerve injury-derived functional defects in motor and sensory behavior as well as in nerve conduction were significantly attenuated by treatment with AA. The potential mechanisms of AA in nerve regeneration were further explored by investigating the effects of AA on three types of cells involved in this process [neurons, Schwann cells (SCs) and macrophages] through a series of experiments. Overall, the data illustrated that AA treatment in cultured dorsal root ganglionic neurons resulted in increased neurite growth and lower expression of RhoA, which is an important inhibitory factor in neural regeneration. In SCs, proliferation, phagocytosis, and neurotrophin expression were all enhanced by AA. Meanwhile, AA treatment also improved proliferation, migration, phagocytosis, and anti-inflammatory polarization in macrophages. In conclusion, this study demonstrated that treatment with AA can promote the morphological and functional recovery of injured peripheral nerves and that this effect is potentially due to AA’s bioeffects on neurons, SCs and macrophages, three of most important types of cells involved in nerve injury and regeneration
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
- Author
- A. Abeshouse
- A. Ally
- A. Antenucci
- A. Arnaout
- A. Berchuck
- A. Bergeron
- A. Bossler
- A. Boussioutas
- A. Breggia
- A. Burnette
- A. Chen
- A. Clipca
- A. Davis
- A. De Rienzo
- A. De Rose
- A. Fehrenbach
- A. Gillis
- A. Gimenez-Roqueplo
- A. Gopalan
- A. Haddad
- A. Hartmann
- A. Jimeno
- A. Kastl
- A. Kendler
- A. Kibel
- A. Korkut
- A. Longatto-Filho
- A. Luna
- A. Malykh
- A. Mariamidze
- A. Mes-Masson
- A. Noss
- A. Ochoa
- A. Perin
- A. Piché
- A. Pickens
- A. Rao
- A. Sankarankuty
- A. Secord
- A. Sepulveda
- A. Shabunin
- A. Sharp
- A. Sood
- A. Spillane
- A. Tam
- A. Tischler
- A. Tsao
- A. Unterberg
- A. Vicha
- A. von Deimling
- A.C. Berger
- A.C. de Carvalho
- A.D. Cherniack
- A.D. Cherniack
- A.E. Sloan
- A.G. Robertson
- A.H. Bryce
- A.H. Perou
- A.J. Kovatich
- A.J. Kovatich
- A.J. Lazar
- A.J. Lazar
- A.J. Mungall
- A.K. Godwin
- A.L. Carvalho
- A.L. Guillermo
- A.M. Angulo Gonzalez
- A.M. Hegde
- A.P. Hoyle
- A.R. Metwalli
- A.V. Lee
- B. Bernard
- B. Campos
- B. Czerniak
- B. Deyarmin
- B. Drake
- B. Esmaeli
- B. Hermes
- B. Hernandez
- B. Kohl
- B. Kumar
- B. Pollo
- B. Rabeno
- B. Robinson
- B. Singh
- B. Tê
- B. Van Tine
- B. Wullich
- B.D. Phu
- B.E. Gross
- B.M. Broom
- B.P. O’
- B.S. Taylor
- B.Y. Karlan
- C. Adebamowo
- C. Andry
- C. Behrens
- C. Benz
- C. Bifulco
- C. Bradford
- C. Brewer
- C. Calatozzolo
- C. Carter
- C. Chen
- C. Cibulskis
- C. Fan
- C. Farver
- C. Feltmate
- C. Goparaju
- C. Guo
- C. Herold-Mende
- C. Hovens
- C. Jungk
- C. Kandoth
- C. Larson
- C. Logothetis
- C. Mcpherson
- C. Mirsaidi
- C. Moran
- C. Morrison
- C. Moser
- C. Sander
- C. Scapulatempo-Neto
- C. Schilero
- C. Shelton
- C. Shipman
- C. Stoehr
- C. Yau
- C.A. Miller
- C.C. Benz
- C.C. Fronick
- C.D. Jones
- C.D. Shriver
- C.D. Shriver
- C.D. Vocke
- C.H. Hagedorn
- C.J. Creighton
- C.K. Wong
- C.M. Cebulla
- C.M. Hutter
- C.M. Perou
- C.N. Landen
- C.P. Raut
- C.S. Shelley
- C.W. Seder
- D. Alvaro
- D. Aziz
- D. Beer
- D. Bell
- D. Bigner
- D. Brooks
- D. Chakravarty
- D. Chesla
- D. Crain
- D. Cramer
- D. Hoon
- D. Huntsman
- D. Lee
- D. Mallery
- D. Morton
- D. Murawa
- D. Muzny
- D. Nagorney
- D. O’
- D. Raymond
- D. Rice
- D. Schadendorf
- D. Tan
- D. Tcaciuc
- D. Tirapelli
- D. Voet
- D.A. Levine
- D.A. Levine
- D.A. Wheeler
- D.I. Heiman
- D.J. Brat
- D.J. Van Den Berg
- D.J. Weisenberger
- D.M. Rassl
- D.M. Shin
- D.M. Wolf
- D.N. Hayes
- D.O. Vidal
- D.T. Maglinte
- E. Baudin
- E. Campo
- E. Castle
- E. Chuah
- E. Curley
- E. Gaudio
- E. Giné
- E. Kebebew
- E. Korpershoek
- E. Lipp
- E. Reznik
- E. Shinbro
- E. Swisher
- E. Thompson
- E. Zmuda
- E.C. Zwarthoff
- E.G. Van Meir
- E.L. Appelbaum
- E.M. Godwin
- E.M. Mora Pinero
- E.R. Duffy
- E.R. Mardis
- F. Beuschlein
- F. Brimo
- F. Carey
- F. Cheng
- F. Dimeco
- F. Facciolo
- F. Giuliante
- F. Khuri
- F. Meric-Bernstam
- F. Moiseenko
- F. Que
- F. Saad
- F. Sanchez-Vega
- F. Valdivieso
- F. Williams
- F. Zhao
- G. Barnett
- G. Bubley
- G. Carlos
- G. Carpino
- G. Finocchiaro
- G. Getz
- G. Gorincioi
- G. Grazi
- G. Long
- G. Manikhas
- G. Mann
- G. Mckercher
- G. Petersen
- G. Saksena
- G. Sauter
- G. Setdikova
- G. Sica
- G. Thomas
- G. Wolf
- G.B. Mills
- G.F. Gao
- H. Al-Ahmadie
- H. Colman
- H. Dinh
- H. Doddapaneni
- H. Fan
- H. Gabra
- H. Gavin
- H. Hai
- H. Hai
- H. Hibshoosh
- H. Huland
- H. Jianhong
- H. Juhl
- H. Kakavand
- H. Liang
- H. Noushmehr
- H. Pass
- H. Sekhon
- H. Shen
- H. Stoop
- H. Taubert
- H. Thai
- H. Timmers
- H. Yang
- H. Zaren
- H. Zhang
- H. Zhang
- H. Zhang
- H.C.S. Silveira
- H.G. Rosenthal
- H.J. Sofia
- H.K. Schmidt
- I. Alexopoulou
- I. Caraman
- I. Chemencedji
- I. de Bruijn
- I. Felau
- I. Forgie
- I. Shmulevich
- I. Stancul
- I. Wistuba
- I. Yang
- J. Armenia
- J. Bartlett
- J. Bennett
- J. Bondaruk
- J. Bowen
- J. Carlotti
- J. Catto
- J. Chabot
- J. Cheville
- J. Cho
- J. Creaney
- J. Dipersio
- J. Drummond
- J. Eckman
- J. Engel
- J. Eschbacher
- J. Fujimoto
- J. Fulop
- J. Galbraith
- J. Gao
- J. Gardner
- J. Gershenwald
- J. Harr
- J. Henderson
- J. Hess
- J. Hilty
- J. Houck
- J. Kim
- J. Kocher
- J. Lang
- J. Liu
- J. Liu
- J. Luketich
- J. Marks
- J. Martin
- J. Melamed
- J. Miller
- J. Moyer
- J. Myers
- J. Parfitt
- J. Park
- J. Paulauskis
- J. Phillips
- J. Powers
- J. Roach
- J. Santibanez
- J. Shih
- J. Simko
- J. Slotta-Huspenina
- J. Smith
- J. Stretch
- J. Thompson
- J. Waldmann
- J. Walker
- J. Wang
- J. Wang
- J. Wilmott
- J. Zhang
- J. Zhenlin
- J.(. Zhang
- J.A. Ajani
- J.A. Borgia
- J.A. Copland
- J.A. Demchok
- J.A. Hooke
- J.A. Martignetti
- J.B. Elder
- J.C. Zenklusen
- J.D. Yang
- J.E. Schein
- J.H. Fregnani
- J.I. Lee
- J.J. Olson
- J.L. Fantacone-Campbell
- J.M. Chan
- J.M. Gastier-Foster
- J.M. Stuart
- J.N. Weinstein
- J.S. Barnholtz-Sloan
- J.S. Dos Santos
- J.S. Parker
- J.T. Auman
- J.V. Simons
- K. Agnew
- K. Ahn
- K. Becker
- K. Birsoy
- K. Chang
- K. Chung
- K. Covington
- K. Delman
- K. Devine
- K. Evason
- K. Janssen
- K. Junker
- K. Kasaian
- K. Kopp
- K. Lau
- K. Lee
- K. Leinonen
- K. Magliocca
- K. Moore
- K. Moxley
- K. Mungall
- K. Pacak
- K. Rai
- K. Roggin
- K. Senecal
- K. Shannon
- K. Shimmel
- K. Smith-McCune
- K. Smolenski
- K. Tse
- K. Tucker
- K.A. Hoadley
- K.A. Hoadley
- K.C. Sexton
- K.E. van Kessel
- K.J. Kang
- K.M. Fong
- K.M. Leraas
- L. Cope
- L. Cuppini
- L. Danilova
- L. Desjardins
- L. Ding
- L. Haydu
- L. Jacobus
- L. Jun
- L. Konnor
- L. Kvecher
- L. Lacombe
- L. Landrum
- L. Lewis
- L. Lolla
- L. Looijenga
- L. Mattei
- L. Omberg
- L. Omberg
- L. Peterson
- L. Ramondetta
- L. Roberts
- L. Rozek
- L. Scarpace
- L. Schoenfield
- L. Wang
- L. Wei
- L. Wise
- L. Xuan
- L. Yang
- L. Yiling
- L. Zhang
- L.A. Donehower
- L.A. Fulton
- L.A. Zach
- L.E. Mose
- L.M. Poisson
- L.S. Schmidt
- M. Albert
- M. Aymerich
- M. Bailey
- M. Balasundaram
- M. Behera
- M. Bellair
- M. Birrer
- M. Borad
- M. Carney
- M. Cernat
- M. Couce
- M. Deqin
- M. Dinkin
- M. Dubina
- M. Farnell
- M. Fassnacht
- M. Feldman
- M. Gerken
- M. Goodman
- M. Graefen
- M. Iacocca
- M. Ittmann
- M. Kasapi
- M. Kendrick
- M. Knudson
- M. Ladanyi
- M. Latour
- M. Mannelli
- M. Marino
- M. Mayo
- M. Mcgraw
- M. Meyerson
- M. Milhem
- M. Miller
- M. Moncrieff
- M. Morgan
- M. Muto
- M. Nelson
- M. Peto
- M. Pirtac
- M. Pool
- M. Prados
- M. Prince
- M. Quinn
- M. Quintero-Aguilo
- M. Rivera
- M. Ryan
- M. Schiffman
- M. Sherman
- M. Sheth
- M. Stanton
- M. Stern
- M. Synott
- M. Tavobilov
- M. Torbenson
- M. Wang
- M. Wiznerowicz
- M. Yussanne
- M.A. Marra
- M.A. Rubin
- M.C. Bragazzi
- M.D. Mclellan
- M.D. Wilkerson
- M.G. Cordes
- M.G. Nissan
- M.G. Soloway
- M.H. Abdel-Rahman
- M.H. Kucherlapati
- M.J. Liptay
- M.L. Anderson
- M.L. Ferguson
- M.S. Bootwalla
- M.S. Lawrence
- M.S. Noble
- N. Botnariuc
- N. Chambwe
- N. Corcoran
- N. Dhalla
- N. Gehlenborg
- N. Giama
- N. Girard
- N. Hayward
- N. Horowitz
- N. Kwok-Shing
- N. Schultz
- N. Thiessen
- N. Van Bang
- N. Wentzensen
- N.A. Pennell
- N.C. Ramirez
- N.D. Aredes
- N.L. Lehman
- N.P. Hung
- N.V. Tien
- O. Bathe
- O. Mariani
- O. Olabode
- O. Paklina
- O. Potapova
- O. Voronina
- P. Anur
- P. Disaia
- P. Drwiega
- P. Glenn
- P. Hansen
- P. Hersey
- P. Lin
- P. Lohavanichbutr
- P. Nair
- P. Nguyen
- P. Sipahimalani
- P. Spellman
- P. Swanson
- P. Tamboli
- P. Tennstedt
- P. Troncoso
- P. Wakely
- P. Westervelt
- P. Yena
- P.A. Mieczkowski
- P.A. Pinto
- P.D. Castro
- P.H. Lai
- P.R. Carroll
- P.R. Dottino
- P.T. Hanh
- P.W. Laird
- Q. Sun
- Q.T. Ostrom
- R. Akbani
- R. Berkowitz
- R. Beroukhim
- R. Bowlby
- R. Bowman
- R. Broaddus
- R. Bueno
- R. Carlsen
- R. de Krijger
- R. Dhanasekaran
- R. Dhir
- R. Duell
- R. Ghossein
- R. Glenn
- R. Govindan
- R. Holt
- R. Kefford
- R. Kemp
- R. Korst
- R. Kramer
- R. Kundra
- R. Lechan
- R. Madan
- R. Mandt
- R. Mannel
- R. Mclendon
- R. Merola
- R. Naresh
- R. Penny
- R. Pilarski
- R. Postier
- R. Saw
- R. Scolyer
- R. Sheridan
- R. Sigmund
- R. Simon
- R. Singh
- R. Smallridge
- R. Steele
- R. Stoehr
- R. Tamakawa
- R. Tarnuzzer
- R. Thorp
- R. Warnick
- R. Worrell
- R. Zuna
- R.A. Gibbs
- R.A. Moore
- R.C. Rintoul
- R.H. Thompson
- R.J. Mural
- R.K. Kelley
- R.K. Wilson
- R.M. Reis
- R.S. Fulton
- R.S. Kanchi
- R.S. Kucherlapati
- S. Balu
- S. Baylin
- S. Bell
- S. Chevalier
- S. Chudamani
- S. Cottingham
- S. Cuzzubbo
- S. Doruc
- S. Force
- S. Frazer
- S. Gilbert
- S. Heath
- S. Kalkanis
- S. Kendall
- S. Lee
- S. Ling
- S. Maithel
- S. Mccall
- S. Meier
- S. Meng
- S. Morris
- S. Mura
- S. Porten
- S. Ramalingam
- S. Reynolds
- S. Roman-Roman
- S. Sadeghi
- S. Sifri
- S. Signoretti
- S. Singer
- S. Somiari
- S. Stepa
- S. Tao
- S. Vandenberg
- S. Wach
- S.B. Gabriel
- S.E. Schumacher
- S.J. Caesar-Johnson
- S.J.M. Jones
- S.L. Asa
- S.M. Phillips
- S.M. Staugaitis
- S.N. Adebamowo
- S.O. Sumer
- S.R. Jefferys
- T. Akeredolu
- T. Bocklage
- T. Bodenheimer
- T. Broudy
- T. Carey
- T. Costello
- T. Defreitas
- T. Flotte
- T. Giordano
- T. Hinoue
- T. Knijnenburg
- T. Knutson
- T. Ley
- T. Lichtenberg
- T. Mikkelsen
- T. Naska
- T. Owonikoko
- T. Patel
- T. Pihl
- T. Schlomm
- T. Shelton
- T. Skelly
- T. Smyrk
- T. Thompson
- T. Wang
- T. Wong
- T. Zelinka
- T.A. Chan
- T.M. Lichtenberg
- U. Veluvolu
- V. Cardinale
- V. Chandan
- V. Dhankani
- V. Jakrot
- V. Korchina
- V. Lyadov
- V. Reuter
- V. Thorsson
- V. Thorsson
- W. Barrett
- W. Eijckenboom
- W. Hale
- W. Kycler
- W. Liu
- W. Oosterhuis
- W. Urba
- W. Ye
- W. Zhang
- W. Zhou
- W.E. Grizzle
- W.G. Richards
- W.J. Edenfield
- W.K. Chatila
- W.K. Rathmell
- W.M. Linehan
- X. Liu
- X. Liu
- X. Sastre
- Y. Han
- Y. Liu
- Y. Shi
- Y. Sun
- Y. Tang
- Y. Wan
- Y. Wolinsky
- Z. Wang
- Z.J. Heins
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chatterjee Sujash S.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Chen Ting-Wen
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Chiu Hua-Sheng
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose SebastiĂŁo
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando LĂłpez
- Gunaratne Preethi H.
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Pan Yinghong
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Ektaben
- Patel Tushar
- Patil Sagar L.
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Singh Vivek P.
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Somvanshi Sonal
- Sood Anil
- Sood Anil K.
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Jonathan
- Stuart Joshua M.
- Su Tao
- Sumazin Pavel
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- TĂŞtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Wanding
- Zmuda Erik
- Zorman Barry
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Angulo Gonzalez Ana Maria
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Ayer Donald E.
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Cheng Feixiong
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose SebastiĂŁo
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Eisenman Robert N.
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grandori Carla
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando LĂłpez
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hurlin Peter J.
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Mora Pinero Edna M.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Richardson Anne B.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schaub Franz X.
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shaw Reid
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Jonathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Trivedi Mihir
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- TĂŞtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Ventura Andrea
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhang Xiaoyang
- Zhao Fengmei
- Zhao Wei
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brennan Kevin
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Bullman Susan
- Burnette Andrew
- Byers Lauren Averett
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campbell Joshua D.
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Chen Jianhong
- Chen Ting-Wen
- Chen Zhong
- Cheng Feixiong
- Cheng Hui
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Chiu Hua-Sheng
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Coarfa Cristian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Diao Lixia
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Larry
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose SebastiĂŁo
- Dottino Peter R.
- Drake Bettina
- Drill Esther
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flores Elsa R.
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gay Carl M.
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Gevaert Olivier
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando LĂłpez
- Gunaratne Preethi
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Wencai
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mungall Karen L.
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Ojesina Akinyemi I.
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pedamallu Chandra Sekhar
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pickering Curtis R.
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Prunello Marcos
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rader Janet S.
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Rustgi Anil K.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Andre
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Shen Hui
- Shen Ronglei
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Onathan
- Stuart Joshua M.
- Stuart Joshua M.
- Su Tao
- Sumazin Pavel
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Alison M.
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsai Kenneth Y.
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- TĂŞtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Van Waes Carter
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Walter Vonn
- Wan Yunhu
- Wang Chen
- Wang Jing
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Jane H.
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Batiste Rebecca
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- Defreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- Dimeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- Dipersio John
- Disaia Philip
- Doddapaneni Harshavardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose SebastiĂŁo
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando LĂłpez
- Guo Charles
- Gupta Rajarsi
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Hou Le
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kurc Tahsin
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mccall Shannon
- Mcgraw Mary
- Mckercher Ginette
- Mclellan Michael D.
- Mclendon Roger
- Mcpherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nguyen Vu
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- O'Brien Daniel
- O'Neill Brian Patrick
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rao Arvind U. K.
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Saltz Joel
- Samaras Dimitris
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharma Ashish
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shmulevich Ilya
- Shriver Craig D.
- Shroyer Kenneth R.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C. S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Pankaj
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Onathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Thorsson VĂ©steinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- TĂŞtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Arnam John
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- Vandenberg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhao Tianhao
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL
maps are derived through computational staining using a convolutional neural network trained to
classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and
correlation with overall survival. TIL map structural patterns were grouped using standard
histopathological parameters. These patterns are enriched in particular T cell subpopulations
derived from molecular measures. TIL densities and spatial structure were differentially enriched
among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial
infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic
patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for
the TCGA image archives with insights into the tumor-immune microenvironment
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
- Author
- Akbani Rehan
- Allolio Bruno
- Ally Adrian
- Almeida Madson Q.
- Alonso Shelley
- Amble Linda
- Arachchi Harindra
- Asa Sylvia L.
- Assie Guillaume
- Auman J. Todd
- Baboud Julien
- Balasundaram Miruna
- Balu Saianand
- Bartsch Detlef K.
- Baylin Stephen
- Bellair Michelle
- Benz Christopher
- Beroukhim Rameen
- Bertherat JĂ©rĂ´me
- Beuschlein Felix
- Bodenheimer Tom
- Bootwalla Moiz S.
- Bowen Jay
- Bowlby Reanne
- Brooks Denise
- Bshara Wiam
- Buhay Christian
- Bussey Kimberly J.
- Butterfield Yaron S.N.
- Carlsen Rebecca
- Carter Scott L.
- Cherniack Andrew D.
- Chin Lynda
- Cho Juok
- Choueiri Toni K.
- Chudamani Sudha
- Ciriello Giovanni
- Cope Leslie M.
- Coppens Sara
- Covington Kyle
- Crawford Catherine
- Dahdouli Mahmoud
- Danilova Ludmila
- Davidsen Tanja
- Defreitas Timothy
- Demchok John A.
- Demeure Michael J.
- Deutschbein Timo
- Dewal Ninad
- Dhalla Noreen
- Dinh Huyen
- Doddapaneni Harsha
- Dousset Bertrand
- Downs Brittany
- Drummond Jennifer
- Else Tobias
- Fan Yu
- Fassnacht Martin
- Felau Ina
- Fragoso Maria C.B.V.
- Frazer Scott
- Gabriel Stacey B.
- Gao Jianjiong
- Gastier-Foster Julie M.
- Gaudioso Carmelo
- Gerken Mark
- Getz Gad
- Gibbs Richard
- Gill Anthony J.
- Giordano Thomas J.
- Groussin Lionel
- Guin Ranabir
- Habra Mouhammed A.
- Hale Walker
- Hammer Gary D.
- Han Yi
- Haussler David
- Hawes Alicia
- Hayes D. Neil
- Heiman David I.
- Helsel Carmen
- Herman James G.
- Hoadley Katherine A.
- Holt Robert A.
- Hoyle Alan P.
- Hu Jianhong
- Hutter Carolyn M.
- Jefferys Stuart R.
- Jones Corbin D.
- Jones Steven J.M.
- Ju Zhenlin
- Kakkar Nipun
- Kalra Divya
- Kasaian Katayoon
- Kebebew Electron
- Khan Ziad
- Kim Hoon
- Kim Jaegil
- Kim Seungchan
- Knijnenburg Theo A.
- Kovar Christine
- Kroiss Matthias
- Kucherlapati Raju
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Latronico Ana Claudia
- Lawrence Michael S.
- Lee Darlene
- Lee Sandy
- Leraas Kristen M.
- Lerario Antonio M.
- Lewis Lora
- Li Haiyan I.
- Libé Rossella
- Lichtenberg Tara M.
- Lim Lynette
- Lin Pei
- Ling Shiyun
- Liu Jia
- Liu Wenbin
- LoBello Janine
- Lolla Laxmi
- Lu Yiling
- Ma Yussanne
- Marra Marco A.
- Mayo Michael
- Meier Sam
- Mendonca Berenice B.
- Meng Shaowu
- Mete Ozgur
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mills Gordon B.
- Moffitt Richard A.
- Moore Richard A.
- Morgan Margaret
- Morozova Olena
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Mungall Andrew J.
- Mungall Karen
- Murray Bradley A.
- Muzny Donna
- Naresh Rashi
- Noble Michael S.
- Park Peter J.
- Parker Joel S.
- Perou Charles M.
- Pihl Todd
- Quinkler Marcus
- Radenbaugh Amie
- Rainey William E.
- Raman Rohini
- Ramirez Nilsa C.
- Rao Arjun
- Raphael Benjamin J.
- Raymond Victoria M.
- Reincke Martin
- Reynolds Sheila
- Roach Jeffrey
- Robertson A. Gordon
- Robinson Bruce
- Ronchi Cristina
- Sadeghi Sara
- Saksena Gordon
- Sanborn Zack
- Sander Chris
- Santibanez Jireh
- Sbiera Silviu
- Schein Jacqueline E.
- Schultz Nikolaus
- Schumacher Steven E.
- Shao Lina
- Shaw Kenna R. Mills
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shinbrot Eve
- Shmulevich Ilya
- Sibony Mathilde
- Sidhu Stan B.
- Simons Janae V.
- Sipahimalani Payal
- Sircar Kanishka
- Sofia Heidi J.
- Soloway Matthew G.
- Soon Patsy
- Sougnez Carrie
- Sun Qiang
- Tam Angela
- Tan Donghui
- Tarnuzzer Roy
- Thiessen Nina
- Van Den Berg David J.
- Veluvolu Umadevi
- Verhaak Roel G.W.
- Vinco Michelle
- Voet Doug
- Waldmann Jens
- Wan Yunhu
- Wang Qianghu
- Wang Wenyi
- Wang Zhining
- Watanabe Aprill
- Weinstein John N.
- Weisenberger Daniel J.
- Wheeler David A.
- Whitsett Timothy G.
- Wilkerson Matthew D.
- Wise Lisa
- Wu Hsin-Ta
- Wu Junyuan
- Wu Ye
- Xi Liu
- Yang Liming
- Yeh Jen Jen
- Yoshihara Kosuke
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Jiashan
- Zhang Wei
- Zheng Siyuan
- Zhu Jingchun
- Zmuda Erik
- Publication venue
- Publication date
- 01/01/2016
- Field of study
SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
- Author
- A. Abeshouse
- A. Ally
- A. Antenucci
- A. Arnaout
- A. Berchuck
- A. Bergeron
- A. Bossler
- A. Boussioutas
- A. Breggia
- A. Burnette
- A. Chen
- A. Clipca
- A. Davis
- A. De Rienzo
- A. De Rose
- A. Fehrenbach
- A. Gillis
- A. Gimenez-Roqueplo
- A. Gopalan
- A. Haddad
- A. Hartmann
- A. Jimeno
- A. Kastl
- A. Kendler
- A. Kibel
- A. Korkut
- A. Longatto-Filho
- A. Luna
- A. Malykh
- A. Mariamidze
- A. Mes-Masson
- A. Noss
- A. Ochoa
- A. Perin
- A. Piché
- A. Pickens
- A. Rao
- A. Sankarankuty
- A. Secord
- A. Sepulveda
- A. Shabunin
- A. Sharp
- A. Sood
- A. Spillane
- A. Tam
- A. Tischler
- A. Tsao
- A. Unterberg
- A. Vicha
- A. von Deimling
- A.C. Berger
- A.C. de Carvalho
- A.D. Cherniack
- A.E. Sloan
- A.G. Robertson
- A.H. Bryce
- A.H. Perou
- A.J. Kovatich
- A.J. Lazar
- A.J. Lazar
- A.J. Lazar
- A.J. Mungall
- A.K. Godwin
- A.L. Carvalho
- A.L. Guillermo
- A.M. Hegde
- A.M.A. Gonzalez
- A.P. Hoyle
- A.R. Metwalli
- B. Bernard
- B. Campos
- B. Czerniak
- B. Deyarmin
- B. Drake
- B. Esmaeli
- B. Hermes
- B. Hernandez
- B. Kohl
- B. Kumar
- B. Pollo
- B. Rabeno
- B. Robinson
- B. Singh
- B. Tê
- B. Van Tine
- B. Wullich
- B.A. Van Tine
- B.A. Van Tine
- B.D. Phu
- B.E. Gross
- B.M. Broom
- B.P. O’
- B.S. Taylor
- B.Y. Karlan
- C. Adebamowo
- C. Andry
- C. Behrens
- C. Benz
- C. Bifulco
- C. Bradford
- C. Brewer
- C. Calatozzolo
- C. Carter
- C. Chen
- C. Cibulskis
- C. Fan
- C. Farver
- C. Feltmate
- C. Goparaju
- C. Guo
- C. Herold-Mende
- C. Hovens
- C. Jungk
- C. Kandoth
- C. Larson
- C. Logothetis
- C. Mcpherson
- C. Mirsaidi
- C. Moran
- C. Morrison
- C. Moser
- C. Sander
- C. Scapulatempo-Neto
- C. Schilero
- C. Shelton
- C. Shipman
- C. Stoehr
- C. Yau
- C.A. Miller
- C.C. Fronick
- C.D. Jones
- C.D. Shriver
- C.D. Vocke
- C.G. Carlotti
- C.H. Hagedorn
- C.J. Creighton
- C.K. Wong
- C.M. Cebulla
- C.M. Hutter
- C.M. Perou
- C.N. Landen
- C.P. Raut
- C.S. Shelley
- C.W. Seder
- D. Alvaro
- D. Aziz
- D. Beer
- D. Bell
- D. Bigner
- D. Brooks
- D. Chakravarty
- D. Chesla
- D. Crain
- D. Cramer
- D. Hoon
- D. Huntsman
- D. Lee
- D. Mallery
- D. Morton
- D. Murawa
- D. Muzny
- D. Nagorney
- D. O’
- D. Raymond
- D. Rice
- D. Schadendorf
- D. Tan
- D. Tcaciuc
- D. Tirapelli
- D. Voet
- D.A. Levine
- D.A. Wheeler
- D.I. Heiman
- D.J. Brat
- D.J. Van Den Berg
- D.J. Weisenberger
- D.M. Rassl
- D.M. Shin
- D.N. Hayes
- D.O. Vidal
- D.T. Maglinte
- E. Baudin
- E. Campo
- E. Castle
- E. Chuah
- E. Curley
- E. Gaudio
- E. Giné
- E. Kebebew
- E. Korpershoek
- E. Lipp
- E. Reznik
- E. Shinbrot
- E. Swisher
- E. Thompson
- E. Zmuda
- E.C. Zwarthoff
- E.G. Van Meir
- E.L. Appelbaum
- E.M. Godwin
- E.M.M. Pinero
- E.R. Duffy
- E.R. Mardis
- F. Beuschlein
- F. Brimo
- F. Carey
- F. Chen
- F. Chen
- F. Cheng
- F. Dimeco
- F. Facciolo
- F. Giuliante
- F. Khuri
- F. Meric-Bernstam
- F. Moiseenko
- F. Que
- F. Saad
- F. Sanchez-Vega
- F. Valdivieso
- F. Williams
- F. Zhao
- G. Barnett
- G. Bubley
- G. Carpino
- G. Finocchiaro
- G. Getz
- G. Gorincioi
- G. Grazi
- G. Long
- G. Manikhas
- G. Mann
- G. Mckercher
- G. Mutharasu
- G. Petersen
- G. Saksena
- G. Sauter
- G. Setdikova
- G. Sica
- G. Thomas
- G. Wolf
- G.B. Mills
- G.F. Gao
- H. Al-Ahmadie
- H. Colman
- H. Dinh
- H. Doddapaneni
- H. Fan
- H. Gabra
- H. Gavin
- H. Hai
- H. Hibshoosh
- H. Huland
- H. Jianhong
- H. Juhl
- H. Kakavand
- H. Liang
- H. Noushmehr
- H. Pass
- H. Sekhon
- H. Shen
- H. Stoop
- H. Taubert
- H. Thai
- H. Timmers
- H. Yang
- H. Zaren
- H. Zhang
- H. Zhang
- H. Zhang
- H.C.S. Silveira
- H.G. Rosenthal
- H.J. Sofia
- H.K. Schmidt
- I. Alexopoulou
- I. Caraman
- I. Chemencedji
- I. de Bruijn
- I. Felau
- I. Forgie
- I. Shmulevich
- I. Shmulevich
- I. Shmulevich
- I. Stancul
- I. Wistuba
- I. Yang
- J. Armenia
- J. Bartlett
- J. Bennett
- J. Bondaruk
- J. Bowen
- J. Catto
- J. Chabot
- J. Cheville
- J. Cho
- J. Creaney
- J. Dipersio
- J. Drummond
- J. Eckman
- J. Engel
- J. Eschbacher
- J. Fujimoto
- J. Fulop
- J. Galbraith
- J. Gao
- J. Gardner
- J. Gershenwald
- J. Harr
- J. Henderson
- J. Hess
- J. Hilty
- J. Houck
- J. Kim
- J. Kocher
- J. Lang
- J. Liu
- J. Luketich
- J. Marks
- J. Martin
- J. Melamed
- J. Miller
- J. Moyer
- J. Myers
- J. Parfitt
- J. Park
- J. Paulauskis
- J. Phillips
- J. Powers
- J. Roach
- J. Santibanez
- J. Shih
- J. Simko
- J. Slotta-Huspenina
- J. Smith
- J. Stretch
- J. Thompson
- J. Waldmann
- J. Walker
- J. Wang
- J. Wang
- J. Wilmott
- J. Zhang
- J. Zhenlin
- J.(. Zhang
- J.A. Ajani
- J.A. Borgia
- J.A. Copland
- J.A. Demchok
- J.A. Hooke
- J.A. Martignetti
- J.B. Elder
- J.C. Zenklusen
- J.D. Yang
- J.E. Schein
- J.H. Fregnani
- J.I. Lee
- J.J. Olson
- J.L. Fantacone-Campbell
- J.M. Chan
- J.M. Gastier-Foster
- J.M. Stuart
- J.N. Weinstein
- J.S. Barnholtz-Sloan
- J.S. Dos Santos
- J.S. Parker
- J.T. Auman
- J.V. Simons
- K. Agnew
- K. Ahn
- K. Becker
- K. Birsoy
- K. Chang
- K. Chen
- K. Chen
- K. Chung
- K. Covington
- K. Delman
- K. Devine
- K. Evason
- K. Janssen
- K. Junker
- K. Kasaian
- K. Kopp
- K. Lau
- K. Lee
- K. Leinonen
- K. Magliocca
- K. Moore
- K. Moxley
- K. Mungall
- K. Pacak
- K. Rai
- K. Roggin
- K. Senecal
- K. Shannon
- K. Shimmel
- K. Smith-McCune
- K. Smolenski
- K. Tse
- K. Tucker
- K.A. Hoadley
- K.C. Sexton
- K.E. van Kessel
- K.J. Kang
- K.M. Fong
- K.M. Leraas
- L. Cope
- L. Cuppini
- L. Danilova
- L. Desjardins
- L. Ding
- L. Ding
- L. Ding
- L. Haydu
- L. Jacobus
- L. Jun
- L. Konnor
- L. Kvecher
- L. Lacombe
- L. Landrum
- L. Lewis
- L. Lolla
- L. Looijenga
- L. Mattei
- L. Omberg
- L. Peterson
- L. Ramondetta
- L. Roberts
- L. Rozek
- L. Scarpace
- L. Schoenfield
- L. Wang
- L. Wei
- L. Wise
- L. Xuan
- L. Yang
- L. Yao
- L. Yiling
- L. Zhang
- L.A. Donehower
- L.A. Fulton
- L.A. Zach
- L.E. Mose
- L.S. Schmidt
- M. Albert
- M. Aymerich
- M. Bailey
- M. Balasundaram
- M. Behera
- M. Bellair
- M. Birrer
- M. Borad
- M. Carney
- M. Cernat
- M. Couce
- M. Deqin
- M. Dinkin
- M. Dubina
- M. Farnell
- M. Fassnacht
- M. Feldman
- M. Gerken
- M. Goodman
- M. Graefen
- M. Iacocca
- M. Ittmann
- M. Kasapi
- M. Kendrick
- M. Knudson
- M. Ladanyi
- M. Latour
- M. Mannelli
- M. Marino
- M. Mayo
- M. Mcgraw
- M. Meyerson
- M. Milhem
- M. Miller
- M. Moncrieff
- M. Morgan
- M. Muto
- M. Nelson
- M. Nykter
- M. Nykter
- M. Peto
- M. Pirtac
- M. Pool
- M. Prados
- M. Prince
- M. Quinn
- M. Quintero-Aguilo
- M. Rivera
- M. Ryan
- M. Schiffman
- M. Sherman
- M. Sheth
- M. Stanton
- M. Stern
- M. Synott
- M. Tavobilov
- M. Torbenson
- M. Wang
- M. Wiznerowicz
- M. Yussanne
- M.A. Marra
- M.A. Rubin
- M.A. Wyczalkowski
- M.C. Bragazzi
- M.C. Wendl
- M.C. Wendl
- M.D. Mclellan
- M.D. Wilkerson
- M.G. Cordes
- M.G. Nissan
- M.G. Soloway
- M.H. Abdel-Rahman
- M.H. Kucherlapati
- M.J. Liptay
- M.L. Anderson
- M.L. Ferguson
- M.S. Bootwalla
- M.S. Lawrence
- M.S. Noble
- N. Botnariuc
- N. Chambwe
- N. Corcoran
- N. Dhalla
- N. Gehlenborg
- N. Giama
- N. Girard
- N. Hayward
- N. Horowitz
- N. Kwok-Shing
- N. Schultz
- N. Thiessen
- N. Van Bang
- N. Wentzensen
- N.A. Pennell
- N.C. Ramirez
- N.D. Aredes
- N.L. Lehman
- N.P. Hung
- N.V. Tien
- O. Bathe
- O. Mariani
- O. Olabode
- O. Paklina
- O. Potapova
- O. Voronina
- P. Anur
- P. Disaia
- P. Drwiega
- P. Glenn
- P. Hansen
- P. Hersey
- P. Lin
- P. Lohavanichbutr
- P. Nair
- P. Nguyen
- P. Sipahimalani
- P. Spellman
- P. Swanson
- P. Tamboli
- P. Tennstedt
- P. Troncoso
- P. Wakely
- P. Westervelt
- P. Yena
- P.A. Mieczkowski
- P.A. Pinto
- P.D. Castro
- P.H. Lai
- P.R. Carroll
- P.R. Dottino
- P.T. Hanh
- P.W. Laird
- Q. Gao
- Q. Sun
- Q.T. Ostrom
- R. Akbani
- R. Berkowitz
- R. Beroukhim
- R. Bowlby
- R. Bowman
- R. Broaddus
- R. Bueno
- R. Carlsen
- R. de Krijger
- R. Dhanasekaran
- R. Dhir
- R. Duell
- R. Ghossein
- R. Glenn
- R. Govindan
- R. Holt
- R. Kefford
- R. Kemp
- R. Korst
- R. Kramer
- R. Kundra
- R. Lechan
- R. Madan
- R. Mandt
- R. Mannel
- R. Mclendon
- R. Merola
- R. Naresh
- R. Penny
- R. Pilarski
- R. Postier
- R. Saw
- R. Scolyer
- R. Sheridan
- R. Sigmund
- R. Simon
- R. Singh
- R. Smallridge
- R. Steele
- R. Stoehr
- R. Tamakawa
- R. Tarnuzzer
- R. Thorp
- R. Vij
- R. Vij
- R. Warnick
- R. Worrell
- R. Zuna
- R.A. Gibbs
- R.A. Moore
- R.C. Fields
- R.C. Fields
- R.C. Rintoul
- R.G. Jayasinghe
- R.H. Thompson
- R.J. Mural
- R.K. Kelley
- R.K. Wilson
- R.M. Reis
- R.S. Fulton
- R.S. Kanchi
- R.S. Kucherlapati
- S. Balu
- S. Baylin
- S. Bell
- S. Cao
- S. Chevalier
- S. Chudamani
- S. Cottingham
- S. Cuzzubbo
- S. Doruc
- S. Force
- S. Frazer
- S. Gilbert
- S. Heath
- S. Kalkanis
- S. Kendall
- S. Lee
- S. Ling
- S. Maithel
- S. Mccall
- S. Meier
- S. Meng
- S. Morris
- S. Mura
- S. Porten
- S. Ramalingam
- S. Reynolds
- S. Roman-Roman
- S. Sadeghi
- S. Sifri
- S. Signoretti
- S. Singer
- S. Somiari
- S. Stepa
- S. Tao
- S. Vandenberg
- S. Wach
- S.B. Gabriel
- S.E. Schumacher
- S.J. Caesar-Johnson
- S.J.M. Jones
- S.L. Asa
- S.M. Foltz
- S.M. Phillips
- S.M. Reynolds
- S.M. Staugaitis
- S.N. Adebamowo
- S.O. Sumer
- S.Q. Sun
- S.R. Jefferys
- T. Akeredolu
- T. Bocklage
- T. Bodenheimer
- T. Broudy
- T. Carey
- T. Costello
- T. Defreitas
- T. Flotte
- T. Giordano
- T. Hinoue
- T. Knijnenburg
- T. Knutson
- T. Ley
- T. Mikkelsen
- T. Naska
- T. Owonikoko
- T. Patel
- T. Pihl
- T. Schlomm
- T. Shelton
- T. Skelly
- T. Smyrk
- T. Thompson
- T. Wang
- T. Wong
- T. Zelinka
- T.A. Chan
- T.M. Lichtenberg
- U. Veluvolu
- V. Cardinale
- V. Chandan
- V. Dhankani
- V. Jakrot
- V. Korchina
- V. Lyadov
- V. Reuter
- V. Thorsson
- W. Barrett
- W. Eijckenboom
- W. Hale
- W. Kycler
- W. Liang
- W. Liao
- W. Liu
- W. Oosterhuis
- W. Urba
- W. Ye
- W. Zhang
- W. Zhou
- W.E. Grizzle
- W.G. Richards
- W.J. Edenfield
- W.K. Chatila
- W.K. Rathmell
- W.M. Linehan
- X. Liu
- X. Liu
- X. Sastre
- Y. Han
- Y. Lihua
- Y. Liu
- Y. Shi
- Y. Sun
- Y. Tang
- Y. Wan
- Y. Wolinsky
- Z. Wang
- Z.J. Heins
- Publication venue
- Cell Rep
- Publication date
- 01/01/2018
- Field of study
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
- …