Clinical efficacy of a combination of propofol and etomidate in pediatric anesthesia, and its effect on vital indices in patients

Purpose: To study the clinical effectiveness of a combination of propofol and etomidate as pediatric anesthesia, and its influence on some vital factors in the patients.Methods: A total of 104 children who underwent appendectomy, hepatobiliary surgery and excision of bone tumor in Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China from June 2018 to June 2020, were selected for this retrospective study. The patients were divided into groups A, B and C. In group A, 40 patients received the combination of propofol and etomidate, 32 patients received propofol only, while group C comprised 32 patients who received etomidate only. Vital indices such as anesthesia induction time, wake-up time after surgery, anesthetic effect, and adverse reactions were determined.Results: In group A, the mean arterial pressure (MAP) and heart rate (HR) were improved; anesthesia induction time and wake-up time after surgery were shorter, and anesthetic effect was more obvious in children with grades I and II. However, there was no grade III anesthetic effect, although there was a lower incidence of adverse reactions in this group.Conclusion: The use of a combination of propofol and etomidate results in higher clinical efficacy of pediatric anesthesia than either propofol or etomidate alone. Furthermore, the combination produces better quality of vital indices in the patients

Clinical efficacy of a combination of propofol and etomidate in pediatric anesthesia, and its effect on vital indices in patients

Purpose: To study the clinical effectiveness of a combination of propofol and etomidate as pediatricanesthesia, and its influence on some vital factors in the patients.Methods: A total of 104 children who underwent appendectomy, hepatobiliary surgery and excision ofbone tumor in Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China from June 2018 to June 2020, were selected for this retrospective study. The patients were divided into groups A, B and C. In group A, 40 patients received the combination of propofol and etomidate, 32 patients received propofol only, while group C comprised 32 patients who received etomidate only. Vital indices such asanesthesia induction time, wake-up time after surgery, anesthetic effect, and adverse reactions were determined.Results: In group A, the mean arterial pressure (MAP) and heart rate (HR) were improved; anesthesia induction time and wake-up time after surgery were shorter, and anesthetic effect was more obvious in children with grades I and II. However, there was no grade III anesthetic effect, although there was a lower incidence of adverse reactions in this group.Conclusion: The use of a combination of propofol and etomidate results in higher clinical efficacy of pediatric anesthesia than either propofol or etomidate alone. Furthermore, the combination produces better quality of vital indices in the patient

Environmental impact assessments of the Three Gorges Project in China: issues and interventions

The paper takes China's authoritative Environmental Impact Statement for the Yangzi (Yangtze) Three Gorges Project (TGP) in 1992 as a benchmark against which to evaluate emerging major environmental outcomes since the initial impoundment of the Three Gorges reservoir in 2003. The paper particularly examines five crucial environmental aspects and associated causal factors. The five domains include human resettlement and the carrying capacity of local environments (especially land), water quality, reservoir sedimentation and downstream riverbed erosion, soil erosion, and seismic activity and geological hazards. Lessons from the environmental impact assessments of the TGP are: (1) hydro project planning needs to take place at a broader scale, and a strategic environmental assessment at a broader scale is necessary in advance of individual environmental impact assessments; (2) national policy and planning adjustments need to react quickly to the impact changes of large projects; (3) long-term environmental monitoring systems and joint operations with other large projects in the upstream areas of a river basin should be established, and the cross-impacts of climate change on projects and possible impacts of projects on regional or local climate considered. © 2013 Elsevier B.V.Xibao Xu, Yan Tan, Guishan Yan

Testing av mekanisk påkjenning på solcelle

Solenergi industrien er den raskest voksende fornybar energi-sektoren over hele verden; reduksjon av silisium wafer tykkelse uten å øke wafer styrke kan føre til en høy brudd-prosent under påfølgende håndtering og prosessings skritt. Sprekkdannelse i solceller har blitt en av dem viktigste årsakene til solcelle svikt og avvisning. Derfor er det viktig å vurdere den mekaniske styrken av solceller. [21] Formålet med dette prosjektet er å forstå den mekaniske oppførselen til silisium solceller. En deloppgave var å teste silisium solceller og wafer ved en tre punkts bøye test maskin, det er to typer tester som ble gjennomført: brudd-test og syklus-test, testene gir informasjon om brudd og bøye-stryke av cellene. På grunn av de skjebnesvangre feilene, for eksempel små sprekker som ligger innenfor wafer overflaten og finger avbrytelse som ikke kan visuelt observeres i bildet som er tatt av en typisk CCD IR kamera. For å fremheve de indre og ytre feilene som reduserer konvensjon effektiviteten av silisium solcelle etter brudd og syklus test, ble prøvene tatt av elektroluminescens (EL) avbildningsteknikk. Til slutt brukte vi scannig mikroskop får se utmattings over flate av solcelle og wafer

MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway

Allergic rhinitis (AR) is one of the most common chronic diseases. This study examined whether microRNA (miR)-182-5p plays a role in AR by regulating toll-like receptor 4 (TLR4). First, data demonstrated that TLR4 was a target of miR-182-5p. Subsequently, AR mouse model was established to explore the role of miR-182-5p and TLR4 in AR in vivo. Initially, quantitative reverse transcription-PCR (qRT-PCR) analysis indicated that miR-182-5p was downregulated, while TLR4 expression was upregulated in AR mice. Then we found that miR-182-5p mimic reduced the frequency of sneezing and nose rubbing of the AR mice. In addition, miR-182-5p mimic significantly increased ovalbumin (OVA)-specific IgE and leukotriene C4 expression levels in nasal lavage fluid (NLF) and serum of AR mice. miR-182-5p mimic decreased the number of inflammatory cells in NLF of AR mice. It also reduced the levels of inflammatory factors in the serum of AR mice, such as interleukin (IL)-4, IL-5, IL-13, IL-17 and tumor necrosis factor (TNF)-α, while increasing the release of IFN-γ and IL-2. Finally, miR-182-5p mimic inhibited NF-κB signaling pathway activation in AR mice. However, all effects of miR-182-5p mimic on AR mice were reversed by TLR4-plasmid. In conclusion, miR-182-5p/TLR4 axis may represent a novel therapeutic target for AR

An Optimal Energy Management Method for the Multi-Energy System with Various Multi-Energy Applications

As the development of the multi-energy system (MES), various ME applications are deployed. ME applications not only bring advanced functionalities to the MES, but also show great potentials in promoting the operation performance of the MES, especially improving the accommodation of renewable energy sources (RES). However, the realization of these potentials largely relies on the energy management, which shall facilitate the effective function of each ME application and the coordinated collaboration of all the ME applications. Without a comprehensive energy management methodology, ME applications may mutually interfere, which not only hinder the RES utilization, but also may harm the MES operation performance. In this premise, this paper integrates the energy management model of the combined cooling, heat and power plants, power-to-hydrogen/gas-to-power plants, and demand side management model of the EV charging loads into the energy management model of the MES, and proposes an comprehensive optimal day-ahead energy management framework to simultaneously improve the profit, RES utilization rate, and energy saving performance of the MES. To address the proposed optimization model, Elitist Non-dominated Sorting Genetic algorithm II algorithm is employed to heuristically find the Pareto-optimal results. Finally, case studies prove the effectiveness of the proposed methodology

Non-precious metal activated MoSi<inf>2</inf>N<inf>4</inf> monolayers for high-performance OER and ORR electrocatalysts: A first-principles study

Developing high-performance electrocatalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is crucial for energy conversion and storage. Recently, a new type of two-dimensional material MoSi2N4 was successfully synthesized and received considerable attention because of novel properties and potential applications. Herein, by means of first principles calculation, the OER/ORR activities of 3d transition metal (TM) atoms embedded MoSi2N4 (TM@MSN) were investigated. The calculated results indicate that TM atoms on MoSi2N4 exhibit good electrochemical stability. On TM sites, Ti@MSN shows the highest OER activity with an overpotential of 0.48 V, whereas Cr@MSN is the most active ORR catalyst with an overpotential of 0.48 V. The Si site (Si−N1−Cu) of Cu@MSN follows the dual-site mechanism, exhibiting the same OER/ORR overpotential as that of N site (0.55/0.65 V). Interestingly, the outer N site (Zn−N1) of Zn@MSN achieves the lowest OER overpotential of 0.38 V, better than that of the state-of-the-art RuO2 catalyst. We demonstrate that 3d TM atoms not only serve as active sites themselves but also activate the host atoms to improve OER/ORR performance of MoSi2N4. Our work opens new windows of opportunity for developing novel catalysts beyond the precious metal-based electrocatalysts for efficient energy conversion and storage.publishedVersio

Dexmedetomidine–Oxycodone combination for conscious sedation during colonoscopy in obese patients: A randomized controlled trial

Background: Obesity is a risk factor for sedation-related respiratory depression during colonoscopy. In a colonoscopy, propofol is frequently used because of its strong sedative and hypnotic properties. However, propofol is associated with marked respiratory depression. The objective of this trial was to investigate the effectiveness and safety of dexmedetomidine plus oxycodone for conscious sedation during colonoscopy in obese patients. Methods: A total of 120 patients had colonoscopies, and they were divided into two groups at random: Dexmedetomidine and oxycodone were used to sedate group Dex + oxy; while group Pro + oxy received anesthesia with propofol plus oxycodone. Parameters including blood pressure, heart rate, respiration, blood oxygen saturation, injection pain, and recovery time were recorded for both groups. Results: The incidence of hypoxemia was significantly reduced in group Dex + oxy compared with group Pro + oxy (4.9% vs 20.3%, P = 0.011). Blood pressure was lower, and heart rate was higher in group Pro + oxy compared with group Dex + oxy (P < 0.05). In addition, group Dex + oxy showed a significantly shorter caecal insertion time, recovery time to orientation, and recovery time to walking than group Pro + oxy (P < 0.05). Endoscopist satisfaction scores were significantly higher in group Dex + oxy compared with group Pro + oxy (P = 0.042). Conclusion: For obese patients, dexmedetomidine plus oxycodone effectively sedate them with few adverse effects, while also reducing colonoscopy operation difficulty by allowing obese patients to reposition. Thus, dexmedetomidine plus oxycodone could be used safely as a conscious sedation method for colonoscopy in obese patients. Trial registration: The protocol was registered at www.chictr.org.cn (ChiCTR1800017283, July 21, 2018)

Enhancing Self-Leadership in Online Fitness Education and Training: Exploring Strategies and Addressing Challenges Among Social Media Influencers in Henan Province, China

The advent of social media platforms has brought about a paradigm shift in the dissemination of information, consequently giving rise to a new breed of individuals known as Social Media Influencers (SMIs). These SMIs have exerted a substantial influence on individuals and society as a whole. Within the domain of fitness education and training, the emergence of Social Media Influencers (SMIs) has significantly disrupted conventional approaches to disseminating information. The purpose of this study is to examine the SMIs’ practices of self-leadership and further explained in terms of their challenges, practices, and strategies of online fitness coaching. Qualitative interviews, coding, and thematic analysis were used to address three key research questions. From findings, these SMIs practice several contextual challenges; which include creating quality digital content, lack of creativity, low digital literacy, lack of financial, physical, and marketing skills, falling out of trends, designing unique programs, and adapting to changing environments. To overcome these challenges, SMIs practice self-leadership by upskilling in content and digital marketing, graphic design, and video-making, seeking constant feedback, leveraging word-of-mouth inquiries, and participating in trending workshops and interest groups. By effectively managing these challenges, SMIs can provide valuable fitness education to their audience and have a significant impact on promoting health and wellness