STRATEGIC ELEMENT IN HEALTH, OPERATIONAL AND FINANCIAL PERFORMANCE ASSESSMENT: EXAMPLE OF SELCUK UNIVERSITY MEDICAL FACULTY HOSPITAL

Today, transferring resources to the health sector, distribution of transferred resources between health care services, use of resources and quality of provided services are very important in countries. When it became clear that the growing importance of strategic management and development of institutions are connected to provide improvements not only in a sub-unit but also in all sub-unit and in an integrated manner, researches carried out in hospitals reached holistic and administrative size. For a holistic assessment managers focused on the measurement of hospital performance. In this study, we made the operational and financial data analysis of the Hospital of Selcuk University Faculty of Medicine that was established in 2001 and started it’s activities in 2009. In this context, firstly some basic financial ratios were calculated by ratio analysis method based on the hospital's balance sheet. In the study second, medical statistics which described as operational data were analyzed. In addition some assessment and recommendations were made by comparing basic analysis results to overall Turkey. In this way, the hospital's current financial and operational performances have comparatively been evaluated

Heterozygous Cc2d1a mice show sex-dependent changes in the Beclin-1/p62 ratio with impaired prefrontal cortex and hippocampal autophagy

Autism Spectrum Disorders (ASD) are a group of neurodevelopmental disorders characterized by repetitive behaviors, lack of social interaction and communication. CC2D1A is identified in patients as an autism risk gene. Recently, we suggested that heterozygous Cc2d1a mice exhibit impaired autophagy in the hippocampus. We now report the analysis of autophagy markers (Lc3, Beclin and p62) in different regions hippocampus, prefrontal cortex, hypothalamus and cerebellum, with an overall decrease in autophagy and changes in Beclin-1/p62 ratio in the hippocampus. We observed sex-dependent variations in transcripts and protein expression levels. Moreover, our analyses suggest that alterations in autophagy initiated in Cc2d1a heterozygous parents are variably transmitted to offspring, even when the offspring's genotype is wild type. Aberration in the autophagy mechanism may indirectly contribute to induce synapse alteration in the ASD brain

Evaluation of Excessive Daytime Sleepness, Anxiety and Depression Symptomatologies in Obesity

Aim: In this study, it was aimed to evaluate the excessive daytime sleepiness, anxiety and depression symptomatology in normal-weight, overweight and obese individuals. Methods: In the study, 605 people who applied to the family medicine outpatient clinic between 2020 November 25 and 2021 March 5 were included. The questionnaire form evaluating the sociodemographic characteristics of the participants, the Hospital Anxiety and Depression Scale and the Epworth Sleepiness Scale were administered using a face-to-face interview technique. Results: Overweight status in primary school, high school/adolescence, and university/twenties were higher in obese than in overweight. Additionally, it was higher in overweight than in normal weight. The risk of being overweight was 2.19 times higher and the risk of being obese was 6.07 times higher than those with obesity in their family compared to those who did not. Excessive daytime sleepiness was 2.95 times higher in obese than in normal weight. Anxiety symptoms were 1.97 times higher in obese than in normal weight. Depression symptoms were 2.77 times more in overweight and 2.99 times more in obese compared to normal-weight individuals. Conclusion: As a result of this study, it was revealed that excessive daytime sleepiness, anxiety and depression symptomatologies are more common in obese compared to normal weight

SINGLE CENTER AND SINGLE SURGEON EXPERIENCE AND THE RESULTS OF THE SURGICAL TREATMENT OF PILONIDAL SINUS

Aim: Pilonidal sinus is a disease deriving from hair follicules in the sacrococcygeal region. The aim of this study is to evaluate the results of patients with pilonidal sinus disease who underwent primary excision by single surgeon at single center. Material and methods: Between June 2007 and June 2010, 82 patients were enrolled in this study who operated at Ergani State Hospital. The age, sex, surgical techniques, anesthesia techniques, the time to return work, and the time of wound healing, complications and recurrences data were collected retrospectively. All patients underwent primary excision and left with open wound. Results: Between June 2007 and June 2010, 82 patients underwent primary excision and left with open wound at the same center by single surgeon. Twenty-three of patients were women (28%) and 59 were men (72%), the mean age was 23.5 (1438) years. Acute, chronic and recurrent diseases were detected in 17 (20.7%), 58 (70.8%) and 7 (8.5%) patients, respectively. Mean time to return work was 7 days (1-10), 4 patients were readmitted to hospital due to bleeding. Mean time of healing was 3 weeks (2-8). Conclusion: Primary excision with open wound is the most commonly used surgical technique in pilonidal sinus disease. It is contraversal which technique was the best in pilonidal sinus. As a result of the author experience, primary excision is safe and has the low recurrence risk

Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner

The IL-17-producing CD4+ T helper cell (Th17) differentiation is affected by stimulation of the aryl hydrocarbon receptor (AhR) pathway and by hypoxia-inducible factor 1 alpha (HIF-1α). In some cases, Th17 become non-pathogenic and produce IL-10. However, the initiating events triggering this phenotype are yet to be fully understood. Here, we show that such cells may be differentiated at low oxygen and regardless of AhR ligand treatment such as cigarette smoke extract. Hypoxia led to marked alterations of the transcriptome of IL-10-producing Th17 cells affecting genes involved in metabolic, anti-apoptotic, cell cycle, and T cell functional pathways. Moreover, we show that oxygen regulates the expression of CD52, which is a cell surface protein that has been shown to suppress the activation of other T cells upon release. Taken together, these findings suggest a novel ability for Th17 cells to regulate immune responses in vivo in an oxygen-dependent fashion

Effect of Different Weft Yarns, Twill Direction, and Washing Methods on Objective Hand Values of Denim Fabrics

Denim fabrics are products that provide durability and ease of use, and are used by young people or people of all ages who prefer comfortable wear in daily life. In this study, the objective hand values of denim fabrics with three weft yarn types (100% cotton elastane, 85% cotton 15% Modal elastane, and 85% cotton 15% Tencel elastane), two twill directions (3/1 Z and S), and four washing processes (bleach, enzyme, rinse, and stone) were investigated. For this purpose, the compressibility, overall flexural rigidity, drape, surface roughness, and shear rigidity values of industrial washed denim fabrics were measured. It was found that there was no statistically significant effect of weft yarn type on objective hand values, and washing differences were statistically significant on the objective hand values of the denim fabrics. The results showed that enzyme-washed fabrics show better hand and lower hardness properties; stone-washed fabrics have a higher fluffy feel, bleach-washed fabrics have worse hand, and rinse-washed fabrics have stiffer and rougher surfaces. It was also observed that the twill direction affects only the shear rigidity values of the denim fabrics

Antimicrobial Activity of Ankaferd Blood Stoppera (R) Against Nosocomial Bacterial Pathogens

The aim of this study is to investigate the in vitro antimicrobial activity of Ankaferd Blood StopperA (R) against methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus species, Escherichia coli, Pseudomonas species, Acinetobacter species and Klebsiella species of nosocomial origin. Ankaferd inhibited growth in 72.4% to 100% of the bacteria tested, depending on the type of the isolate. As a result, it can be stated that Ankaferd inhibits the in vitro growth of nosocomial bacteria. This is a novel, important finding since severe hospital infections coexist with many hemostatic disorders, and the use of Ankaferd may increase hemostatic potential in such clinical conditions

Identification and characterization of a novel glutaminase inhibitor

In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyse the conversion of glutamine to glutamate. GLS1 exists as two isozymes: kidney glutaminase (KGA) and glutaminase C (GAC). Several GLS inhibitors have been identified, of which DON (6-diazo-5-oxonorleucine), BPTES (bis-2-(5-phenylacetamido-1, 3, 4-thiadiazol-2-yl) ethyl sulphide), 968 (5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one) and CB839 (Telaglenastat) are the most widely used. However, these inhibitors have variable efficacy, specificity and bioavailability in research and clinical settings, implying the need for novel and improved GLS inhibitors. Based on this need, a diverse library of 28,000 compounds from Enamine was screened for inhibition of recombinant, purified GAC. From this library, one inhibitor designated compound 19 (C19) was identified with kinetic features revealing allosteric inhibition of GAC in the µm range. Moreover, C19 inhibits anti-CD3/CD28-induced CD4+ T-cell proliferation and cytokine production with similar or greater potency as compared to BPTES. Taken together, our data suggest that C19 has the potential to modulate GLS1 activity and alter metabolic activity of T cells