Patterns of Pathomorphological Changes in Acute Necrotizing Pancreatitis

Acinar necrosis is the basic microscopic sign of acute necrotizing pancreatitis (ANP). Microcirculation disorder is one of the major factors in the pathogenesis and morphogenesis of ANP besides free radicals and damage of enzymatic origin. This study is dedicated to the description of microscopic changes in the pancreatic stroma in ANP, which leads to destruction of the exocrine pancreas with a putative mechanism of endocrine function preservation. This study has been carried out on histological samples of pancreas from 224 patients with ANP. Histological staining was performed with hematoxylin-eosin (H&E), Masson, Gomori methods, and PAS. Microscopy was performed with magnifications of 40×, 100×, and 400×. Vascular endothelial desquamation, stasis, and sludge are typical changes in microcirculation observed in early stages of ANP. Initially, parietal circular intravascular microthrombosis accompanied by endothelial desquamation as early as stromal swelling occurs with no detectable necrosis. Residual stroma appears between areas of necrosis and intact pancreatic tissue. Mucoid swelling is first seen in the perivascular spaces extending to the parenchyma and changing into fibrinoid imbibition causing further necrosis. Reticulin argyrophilic backbone surrounding the pancreatic acini and small ducts decompose. Pancreatic structures, which may be preserved in necrotic tissue, include nerves, major ducts, and Langerhans islets

Innovation and investment safety as the condition for neo-industrial development

The paper suggests considering neo-industrial development that is represented as alternative to post-industrialism from the perspective of provision of innovation and investment safety of the country. Authors make an effort to determine economic and institutional backgrounds and criteria of safety of innovation and investment activities. Specification of categorical framework used in researched sphere was conducted; in particular, it was suggested to consider innovation and investment safety the key part of national economic safety. On the basis of regression analysis the appraisal of relation between the size of internal expenditures for research and development and living standards in the country was held - it has demonstrated rather weak relation between researched variables during a short period of time. In addition, the work formulates the key problems in the sphere of innovation and investment safety in Russia and suggests proposals on their solution.peer-reviewe

Immune-metabolic genesis of pathological processes

This article deals with metabolic-immune processes at rest and under stress conditions, which, in turn, results in the development of immune-dependent and immune-associated disorders. The authors also analyzed metabolic effects of immunomodulators. Based on the analysis of the literature and own clinical and experimental data, the authors identified the ability of metabolic factors to regulate immunological processe

Immune reactions as induction factors and correction of the pathology

On clinical models of infectious, somatic, malignant, and other diseases, the ability of immune responses to induce pathological processes due to competition, “pathogenicity”, hypersensitivity, and insufficiency has been shown. We are talking about the competitiveness of antibacterial and antiviral immunity, when the deployment of cellular and humoral immune responses weaken both defense mechanisms, competition of allergy and immune deficiency, which aggravates and modifies it, and antiviral immunity often induces a number of pathological conditions of the body. This is due to the inability of antiviral antibodies to completely inactivate the antireceptor structures of virions, interact with them without changing their function, and even stimulate a viral infection, induce autoimmune reactions. The protective system of interferons, which often cause side reactions, is also faulty. In  the  body, immunopathological reactions develop, manifested by immediate and delayed hypersensitivity, which have alternative properties – protective and damaging and autoimmune reactions, mainly with a negative effect. The mechanisms of the processes are discussed in detail in the review. The “inferiority” of immune reactions, respectively, cellular, humoral, phagocytic links, incomplete consistency of anticancer immunity, virus-induced immunodeficiencies are comprehensively covered. Such “alternativeness” of the considered immune reactions, at the same time, turns out to be a necessary condition for eliminating the emerging disorders of the organism’s reactivity. These include specificity and non-specificity, stimulation and suppression, variability and integration of immune responses. At the same time, immunoregulatory reactions are individual and interrelated, develop regionally and systemically and provide degradation of exogenous and endogenous objects and immune activation. All these aspects are discussed in detail in the review

Determination of the muon charge sign with the dipolar spectrometers of the OPERA experiment

The OPERA long-baseline neutrino-oscillation experiment has observed the direct appearance of $\nu_\tau$ in the CNGS $\nu_\mu$ beam. Two large muon magnetic spectrometers are used to identify muons produced in the $\tau$ leptonic decay and in $\nu_\mu^{CC}$ interactions by measuring their charge and momentum. Besides the kinematic analysis of the $\tau$ decays, background resulting from the decay of charmed particles produced in $\nu_\mu^{CC}$ interactions is reduced by efficiently identifying the muon track. A new method for the charge sign determination has been applied, via a weighted angular matching of the straight track-segments reconstructed in the different parts of the dipole magnets. Results obtained for Monte Carlo and real data are presented. Comparison with a method where no matching is used shows a significant reduction of up to 40\% of the fraction of wrongly determined charges.Comment: 10 pages. Improvements in the tex

Limits on muon-neutrino to tau-neutrino oscillations induced by a sterile neutrino state obtained by OPERA at the CNGS beam

The OPERA experiment, exposed to the CERN to Gran Sasso $\nu_\mu$ beam, collected data from 2008 to 2012. Four oscillated $\nu_\tau$ Charged Current interaction candidates have been detected in appearance mode, which are consistent with $\nu_\mu \to \nu_\tau$ oscillations at the atmospheric $\Delta m^2$ within the "standard" three-neutrino framework. In this paper, the OPERA $\nu_\tau$ appearance results are used to derive limits on the mixing parameters of a massive sterile neutrino.Comment: 11 pages, 4 figures; reference to Planck result updated in the Introduction. Submitted to JHE

Procedure for short-lived particle detection in the OPERA experiment and its application to charm decays

The OPERA experiment, designed to perform the first observation of $\nu_\mu \rightarrow \nu_\tau$ oscillations in appearance mode through the detection of the $\tau$ leptons produced in $\nu_\tau$ charged current interactions, has collected data from 2008 to 2012. In the present paper, the procedure developed to detect $\tau$ particle decays, occurring over distances of the order of 1 mm from the neutrino interaction point, is described in detail. The results of its application to the search for charmed hadrons are then presented as a validation of the methods for $\nu_\tau$ appearance detection

Observation of nu_tau appearance in the CNGS beam with the OPERA experiment

The OPERA experiment is searching for nu_mu -> nu_tau oscillations in appearance mode i.e. via the direct detection of tau leptons in nu_tau charged current interactions. The evidence of nu_mu -> nu_tau appearance has been previously reported with three nu_tau candidate events using a sub-sample of data from the 2008-2012 runs. We report here a fourth nu_tau candidate event, with the tau decaying into a hadron, found after adding the 2012 run events without any muon in the final state to the data sample. Given the number of analysed events and the low background, nu_mu -> nu_tau oscillations are established with a significance of 4.2sigma.Comment: Submitted to Progress of Theoretical and Experimental Physics (PTEP