Spatial analysis of CO and PM10 pollutants in Tehran city

     Nowadays, air pollution in cities with regard to its harmful outcomes has been turned into one of the serious challenges in urban management. Pollutants as Carbon monoxide, sulfur dioxide, and the aerosols that are known to be among the most important factors related to heart, vascular, and lung disease, have underlined public welfare and health, and the organizations concerned with community health undertake remarkable expenses for disease coming out of these pollutants per year. Awareness of the air situation and its quality over periods and the process of air pollutants’ changes in locations, and especially detection of high risk places can play an important and efficient role in urban health management and land use policy-making. In this paper, for the prediction of the possibility of occurring a pollutant in different locations, based on location information, one modern method of analysis entitled indicator kriging method is introduced. Since, nowadays, CO and PM10 are the two major pollutants in Tehran city, using the mentioned method, the probability of occurrence of each of them in Dey 1390 along with their accuracy is being measured and then a map is provided for the possible occurrence of these pollutants over the whole city of Tehran. 

Bioactive compounds from Acokanthera oblongifolia

One cardiotonic glycoside, three triterpenes and one steroidal glycoside were isolated from Acokanthera oblongifolia fruits (pericarp) growing in Libya. Their structures were investigated by extensive application of IR, MS, 1DNMR and 2DNMR spectroscopy. The isolated compounds have evidenced in-vitro cytotoxicity on selected human cell lines (A-549, H-1299) when compared to doxorubicin. Keywords: Cardenolide; Acokanthera oblongifolia; antitumor activity; lung carcinoma cell line (A-549, H-1299)

Effect of Laser-Assisted Hair Removal (LAHR) on the Quality of Life and Depression in Hirsute Females: A Single-Arm Clinical Trial

Introduction: Hirsutism, mainly due to poly cystic ovary syndrome (PCOS), causes stress, anxiety and depression in females. LAHR is currently accepted as a good treatment option for hirsutism. The goal of the current study was to ascertain how LAHR affected the degree of hirsutism, quality of life, and depression in hirsute females. Methods: A single arm before/after clinical trial was designed and performed in the Razi Hospital Laser Clinic over a 15-months period. All hirsute females visiting Razi hospital laser clinic, were enrolled and received three sessions of LAHR every 4-6 weeks if they were interested and signed an informed consent. Before the commencement of LAHR and six to eight weeks after the last session, the Ferriman-Gallwey score (hirsutism severity), Beck score (depression index) and DLQI score (quality of life index) were calculated and stored. Results: There were 80 subjects in all. The mean± (SD) of the Ferriman-Gallwey score was reduced from 7.05 ± 2.27 to 4.91 ± 2.41, p<0.001. Beck depression score’s mean± (SD) was reduced from 13.3 ± 8.7 to 10.2 ± 8.4, p<0.001 and mean± (SD) of DLQI score was decreased from 5.6 ± 5.2 to 3.5 ± 2.3, p<0.001. No significant complication were reported. Conclusion:   LAHR can improve hirsutism related depression and degradation of quality of life as well as hirsutism physical signs

Repair of rat cranial bone defect by using amniotic fluid-derived mesenchymal stem cells in polycaprolactone fibrous scaffolds and platelet-rich plasma

Introduction: Tissue regenerative medicine strategies, as a promising alternative has become of major interest to the reconstruction of critical size bone defects. This study evaluated the effects of the simultaneous application of polycaprolactone (PCL), amniotic fluid mesenchymal stem cells (AF-MSCs) and platelet-rich plasma (PRP) on the repair of rat cranial bone defects. Methods: The AF-MSCs were isolated at the end of the second week of pregnancy in rats. PRP obtained from rat blood and the random PCL fibrous scaffolds were prepared using the electrospinning method. Circular full thickness (5 mm) bone defects were developed on both sides of the parietal bones (animal number=24) and the scaffolds containing AF-MSCs and PRP were implanted in the right lesions. Thereafter, after eight weeks the histological and immunohistochemistry studies were performed to evaluate the bone formation and collagen type I expression. Results: The spindle-shaped mesenchymal stem cells were isolated and the electron microscope images indicated the preparation of a random PCL scaffold. Immunohistochemical findings showed that collagen type I was expressed by AF-MSCs cultured on the scaffold. The results of hematoxylin and eosin (H & E) staining indicated the formation of blood vessels in the presence of PRP. Additionally, immunofluorescence findings suggested that PRP had a positive effect on collagen type I expression. Conclusion: The simultaneous application of fibrous scaffold + AF-MSCs + PRP has positive effects on bone regeneration. This study showed that PRP can affect the formation of new blood vessels in the scaffold transplanted in the bone defect

Evaluation of Smokers' Attitudes about Tobacco Control Program and Obstacles to the Implementation of this Program in Tehran

This study aimed to assess the status of cigarette marketing in Tehran and the attitude of smokers toward smoking Behavior and tobacco control programs in smokers of Tehran. This cross-sectional study was conducted on 608 volunteer smokers in Tehran City. Using a stratified cluster random sampling method, the study population involved smokers who used at least one cigarette per day. The data collection tool was an anonymous self-administered questionnaire including basic information and questions related to participants' attitude toward smoking habits (Cronbach's alpha; 78.19%.). (72.9%) of the participants started smoking at the age of 10 to 19 years and 72.2% used foreign cigarettes. Each person spends a daily average of 30690 riyals for cigarettes. Being tempted (28.0%), feeling euphoria (27.8%) and getting nervous (25.5%) were the most common reasons of restarting cigarette smoking after cessation. A majority of the participants believed that smoking in public places was a violation of the rights of others and smoking should be avoided in such places. 61 Iranian and foreign cigarette brands available in the market that some foreign cigarettes were smuggled. Most smokers start smoking as teenagers, then smoking prevention programs should focus on adolescents as the most vulnerable age group. Raising the retail price of tobacco products through increasing taxes can reduce consumption particularly among first starters and youth. increasing taxes and prices of tobacco products may be effective when simultaneous effective measures are implemented to eliminate all kinds of illicit trade in all forms of tobacco products

A systematic review of literature on sustaining decision-making in healthcare organizations amid imperfect information in the Big Data era

first_pagesettingsOrder Article Reprints Open AccessSystematic Review A Systematic Review of Literature on Sustaining Decision-Making in Healthcare Organizations Amid Imperfect Information in the Big Data Era by Glory Urekwere Orlu 1ORCID,Rusli Bin Abdullah 1,2,*ORCID,Zeinab Zaremohzzabieh 2,Yusmadi Yah Jusoh 1ORCID,Shahla Asadi 3ORCID,Yousef A. M. Qasem 1ORCID,Rozi Nor Haizan Nor 1 andWan Mohd Haffiz bin Mohd Nasir 1 1 Faculty of Computer Science and Information Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia 2 Institute for Social Science Studies, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia 3 School of Computing & Engineering, University of Gloucestershire, Cheltenham GL50 2RH, UK * Author to whom correspondence should be addressed. Sustainability 2023, 15(21), 15476; https://doi.org/10.3390/su152115476 Received: 1 June 2023 / Revised: 12 July 2023 / Accepted: 13 July 2023 / Published: 31 October 2023 Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract The significance of big data analytics (BDA) has benefited the health sector by leveraging the potential insights and capabilities of big data in decision making. However, every implementation of BDA within the healthcare field faces difficulties due to incomplete or flawed information that necessitates attention and resolution. The purpose of this systematic literature review is to accomplish two main objectives. Firstly, it aims to synthesize the various elements that contribute to imperfect information in BDA and their impact on decision-making processes within the healthcare sector. This involves identifying and analyzing the factors that can result in imperfect information in BDA applications. Secondly, the review intends to create a taxonomy specifically focused on imperfect information within the context of BDA in the health sector. The study conducted a systematic review of the literature, specifically focusing on studies written in English and published up until February 2023. We also screened and retrieved the titles, abstracts, and potentially relevant studies to determine if they met the criteria for inclusion. As a result, they obtained a total of 58 primary studies. The findings displayed that the presence of uncertainty, imprecision, vagueness, incompleteness, and complexity factors in BDA significantly impacts the ability to sustain effective decision-making in the healthcare sector. Additionally, the study highlighted that the taxonomy for imperfect information in BDA provides healthcare managers with the means to utilize suitable strategies essential for successful implementation when dealing with incomplete information in big data. These findings have practical implications for BDA service providers, as they can leverage the findings to attract and promote the adoption of BDA within the healthcare sector

Global, regional, and national burden of chronic kidney disease, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI

Morbidity and mortality from road injuries: results from the Global Burden of Disease Study 2017

BackgroundThe global burden of road injuries is known to follow complex geographical, temporal and demographic patterns. While health loss from road injuries is a major topic of global importance, there has been no recent comprehensive assessment that includes estimates for every age group, sex and country over recent years.MethodsWe used results from the Global Burden of Disease (GBD) 2017 study to report incidence, prevalence, years lived with disability, deaths, years of life lost and disability-adjusted life years for all locations in the GBD 2017 hierarchy from 1990 to 2017 for road injuries. Second, we measured mortality-to-incidence ratios by location. Third, we assessed the distribution of the natures of injury (eg, traumatic brain injury) that result from each road injury.ResultsGlobally, 1 243 068 (95% uncertainty interval 1 191 889 to 1 276 940) people died from road injuries in 2017 out of 54 192 330 (47 381 583 to 61 645 891) new cases of road injuries. Age-standardised incidence rates of road injuries increased between 1990 and 2017, while mortality rates decreased. Regionally, age-standardised mortality rates decreased in all but two regions, South Asia and Southern Latin America, where rates did not change significantly. Nine of 21 GBD regions experienced significant increases in age-standardised incidence rates, while 10 experienced significant decreases and two experienced no significant change.ConclusionsWhile road injury mortality has improved in recent decades, there are worsening rates of incidence and significant geographical heterogeneity. These findings indicate that more research is needed to better understand how road injuries can be prevented

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin