Virtual water highway: water use efficiency in global food trade

International audienceAmid an increasing water scarcity in many parts of the world, virtual water trade as both a policy instrument and practical means to balance the regional, national and global water budget has received much attention in recent years. Built upon the knowledge of virtual water accounting in the literature, this study examines the efficiency of the resource use embodied in the global virtual water trade from the perspectives of exporting and importing countries. Different characteristics between "green" and "blue" virtual water corresponding to rainfed and irrigated agriculture are elaborated. The investigation reveals that the virtual water flows primarily from countries of high water productivity to countries of low water productivity, generating a global saving of water resources. Meanwhile, the domination of green virtual water in the total virtual water trade constitutes low opportunity costs and environmental impacts as opposed to blue virtual water. The results suggest efficiency gains in the global food trade in terms of water resource utilization. The study raises awareness of negative impacts of increasing reliance on irrigation for food production in many countries, including food exporting countries. The findings of the study call for a greater emphasis on rainfed agriculture to improve global food security and environmental sustainability

Analyses of impacts of China's international trade on its water resources and uses

This study provides an insight into the impact of China's international trade of goods and services on its water resources and uses. Virtual water flows associated with China's international trade are quantified in an input-output framework. The analysis is scaled down to the sectoral and provincial levels to trace the origins and destinations of virtual water flows associated with the international trade. The results show that China is a net virtual water exporter of 4.8 × 10<sup>10</sup> m<sup>3</sup> yr<sup>−1</sup>, accounting for 2.1% of its renewable water resources and 8.6% of the total water use. Water scarce regions tend to have higher percentages of virtual water export relative to their water resources and water uses. In the water scarce Huang-Huai-Hai region, the net virtual water export accounts for 8.0% of the region's water resources and 11.3% of its water uses. For individual sectors, major net virtual water exporters are those where agriculture provides raw materials in the initial process of the production chain. The results suggest that China's economic gains from being a world "manufacture factory" have come at a high cost to its water resources

Phase detection at the quantum limit with multi-photon Mach-Zehnder interferometry

We study a Mach-Zehnder interferometer fed by a coherent state in one input port and vacuum in the other. We explore a Bayesian phase estimation strategy to demonstrate that it is possible to achieve the standard quantum limit independently from the true value of the phase shift and specific assumptions on the noise of the interferometer. We have been able to implement the protocol using parallel operation of two photon-number-resolving detectors and multiphoton coincidence logic electronics at the output ports of a weakly-illuminated Mach-Zehnder interferometer. This protocol is unbiased and saturates the Cramer-Rao phase uncertainty bound and, therefore, is an optimal phase estimation strategy.Comment: 4 pages, 5 figures replaced fig. 1 to correct graphics bu

Stable manifolds and homoclinic points near resonances in the restricted three-body problem

The restricted three-body problem describes the motion of a massless particle under the influence of two primaries of masses $1-\mu$ and $\mu$ that circle each other with period equal to $2\pi$. For small $\mu$, a resonant periodic motion of the massless particle in the rotating frame can be described by relatively prime integers $p$ and $q$, if its period around the heavier primary is approximately $2\pi p/q$, and by its approximate eccentricity $e$. We give a method for the formal development of the stable and unstable manifolds associated with these resonant motions. We prove the validity of this formal development and the existence of homoclinic points in the resonant region. In the study of the Kirkwood gaps in the asteroid belt, the separatrices of the averaged equations of the restricted three-body problem are commonly used to derive analytical approximations to the boundaries of the resonances. We use the unaveraged equations to find values of asteroid eccentricity below which these approximations will not hold for the Kirkwood gaps with $q/p$ equal to 2/1, 7/3, 5/2, 3/1, and 4/1. Another application is to the existence of asymmetric librations in the exterior resonances. We give values of asteroid eccentricity below which asymmetric librations will not exist for the 1/7, 1/6, 1/5, 1/4, 1/3, and 1/2 resonances for any $\mu$ however small. But if the eccentricity exceeds these thresholds, asymmetric librations will exist for $\mu$ small enough in the unaveraged restricted three-body problem

The influence of wind direction on the capture of the wood warbler (Phylloscopus sibilatrix), an uncommon migratory species in the western Mediterranean

The wood warbler (Phylloscopus sibilatrix) is a migratory species in the western Mediterranean wintering in the Gulf of Guinea region, West Africa. In autumn and spring, this species, along with the populations breeding in Ireland and Britain, uses the Italian peninsula as its main axis of migration. From the data of captured birds at several ringing stations in the western Mediterranean (Balearic Islands and coastal Iberian Peninsula), we analyzed capture rates of the species during spring migration from 1993 to 2007. Based on the selection of days with a significant number of captures and those without captures, we analyzed the effect of wind direction over the western Mediterranean to determine a relationship between winds and the number of captures. From a total of 663 wood warblers captured between 1993 and 2007, a total of 31 days have been selected as significant days with a high number of captures, and 31 days have been selected as no-capture days. On days of maximum captures, winds coming from an easterly direction, i.e. Algeria and Tunisia, were dominant, indicating days with a clear eastern component. Contrary to expected results, captures were also made on days when the wind direction was predominantly from a northerly direction. Analysis of the origin of the winds in north eastern Spain (western Mediterranean) revealed that the majority of northerly winds originated from Africa and not from Europe as is usual for this region. Days or periods selected as no-capture days were characterized by winds coming from a northerly (European origin) or westerly direction

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes

Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy. We studied the mechanism of impaired renal re-uptake of thiamine in diabetes. Expression of thiamine transporter proteins THTR-1 and THTR-2 in normal human kidney sections examined by immunohistochemistry showed intense polarised staining of the apical, luminal membranes in proximal tubules for THTR-1 and THTR-2 of the cortex and uniform, diffuse staining throughout cells of the collecting duct for THTR-1 and THTR-2 of the medulla. Human primary proximal tubule epithelial cells were incubated with low and high glucose concentration, 5 and 26 mmol/l, respectively. In high glucose concentration there was decreased expression of THTR-1 and THTR-2 (transporter mRNA: −76% and −53% respectively, p<0.001; transporter protein −77% and −83% respectively, p<0.05), concomitant with decreased expression of transcription factor specificity protein-1. High glucose concentration also produced a 37% decrease in apical to basolateral transport of thiamine transport across cell monolayers. Intensification of glycemic control corrected increased fractional excretion of thiamine in experimental diabetes. We conclude that glucose-induced decreased expression of thiamine transporters in the tubular epithelium may mediate renal mishandling of thiamine in diabetes. This is a novel mechanism of thiamine insufficiency linked to diabetic nephropathy

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus

Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin. A number of C-type lectins recognise oligosaccharides rich in mannose and fucose – sugars with similar structures to glucose. This raises the possibility that high glucose conditions in diabetes affect protein-oligosaccharide interactions via competitive inhibition. Mannose binding lectin, soluble DC-SIGN & DC-SIGNR, and surfactant protein D, were tested for carbohydrate binding in the presence of glucose concentrations typical of diabetes, via surface plasmon resonance and affinity chromatography. Complement activation assays were performed in high glucose. DC-SIGN and DC-SIGNR expression in adipose tissues was examined via immunohistochemistry. High glucose inhibited C-type lectin binding to high-mannose glycoprotein and binding of DC-SIGN to fucosylated ligand (blood group B) was abrogated in high glucose. Complement activation via the lectin pathway was inhibited in high glucose and also in high trehalose - a nonreducing sugar with glucoside stereochemistry. DC-SIGN staining was seen on cells with DC morphology within omental and subcutaneous adipose tissues. We conclude that high glucose disrupts C-type lectin function, potentially illuminating new perspectives on susceptibility to infectious and inflammatory disease in diabetes. Mechanisms involve competitive inhibition of carbohydrate-binding within sets of defined proteins, in contrast to broadly indiscriminate, irreversible glycation of proteins

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities and cognitive deficits commonly observed in psychiatric disorders. Here, we report the identification of a subset of cortical astrocytes that are competent for regulating dopamine (DA) homeostasis during postnatal development of the prefrontal cortex (PFC), allowing for optimal DA-mediated maturation of excitatory circuits. Such control of DA homeostasis occurs through the coordinated activity of astroglial vesicular monoamine transporter 2 (VMAT2) together with organic cation transporter 3 and monoamine oxidase type B, two key proteins for DA uptake and metabolism. Conditional deletion of VMAT2 in astrocytes postnatally produces loss of PFC DA homeostasis, leading to defective synaptic transmission and plasticity as well as impaired executive functions. Our findings show a novel role for PFC astrocytes in the DA modulation of cognitive performances with relevance to psychiatric disorders