Production of the Y(4260) State in B Meson Decay

We calculate the branching ratio for the production of the meson $Y(4260)$ in the decay $B^- \to Y(4260)K^-$. We use QCD sum rules approach and we consider the $Y(4260)$ to be a mixture between charmonium and exotic tetraquark, $[\bar{c}\bar{q}][qc]$, states with $J^{PC}=1^{--}$. Using the value of the mixing angle determined previously as: $\theta=(53.0\pm0.5)^\circ$, we get the branching ratio $\mathcal{B}(B\to Y(4260)K)=(1.34\pm0.47)\times10^{-6}$, which allows us to estimate an interval on the branching fraction $3.0 \times 10^{-8} < {\mathcal B}_{_Y} < 1.8 \times 10^{-6}$ in agreement with the experimental upper limit reported by Babar Collaboration.Comment: 5 pages, 2 figures, 1 table. arXiv admin note: text overlap with arXiv:1105.134

Y(4260) as a mixed charmonium-tetraquark state

Using the QCD sum rule approach we study the Y(4260) state assuming that it can be described by a mixed charmonium-tetraquark current with $J^{PC}=1^{--}$ quantum numbers. For the mixing angle around $\theta \approx (53.0\pm 0.5)^{0}$, we obtain a value for the mass which is in good agreement with the experimental mass of the Y(4260). However, for the decay width we find the value \Ga_Y \approx (1.0\pm 0.2) MeV which is not compatible with the experimental value \Ga \approx (88\pm 23) MeV. Therefore, we conclude that, although we can explain the mass of the Y(4260), this state cannot be described as a mixed charmonium-tetraquark state since, with this assumption, we can not explain its decay width.Comment: 9 pages, 6 figure

Smart Cities and M³: Rapid Research, Meaningful Metrics and Co-Design

The research described in this paper is undertaken under the banner of the smart city, a concept that captures the way urban spaces are re-made by the incursion of new technology. Much of smart is centred on converting everyday activities into data, and using this data to generate knowledge mediated by technology. Ordinary citizens, those that may have their lives impacted by the technology, usually are not properly involved in the ‘smartification’ process. Their perceptions, concerns and expectations should inform the conception and development of smart technologies at the same extent. How to engage general public with smart cities research is the central challenge for the Making Metrics Meaningful (MMM) project. Applying a rapid participatory method, ‘Imagine’ over a five-month period (March – July) the research sought to gain insights from the general public into novel forms of information system innovation. This brief paper describes the nature of the accelerated research undertaken and explores some of the themes which emerged in the analysis. Generic themes, beyond the remit of an explicit transport focus, are developed and pointers towards further research directions are discussed. Participatory methods, including engaging with self- selected transport users actively through both picture creation and programmatically specific musical ‘signatures’ as well as group discussion, were found to be effective in eliciting users’ own concerns, needs and ideas for novel information systems

TLEP, first step in a long-term vision for HEP

The discovery of H(126) has renewed interest in circular e+e- colliders that can operate as Higgs factories, which benefit from three unique characteristics: i) high luminosity and reliability, ii) the availability of several interaction points, iii) superior beam energy accuracy. TLEP is an e+e- storage ring of 80-km circumference that can operate with very high luminosity from the Z peak (90 GeV) to the top quark pair threshold (350 GeV). It can achieve transverse beam polarization at the Z peak and WW threshold, giving it unparalleled accuracy on the beam energy. A preliminary study indicates that an 80 km tunnel could be constructed around CERN. Such a tunnel would allow a 100 TeV proton-proton collider to be established in the same ring (VHE-LHC), offering a long term vision.Comment: This is a contribution to the the Snowmass process 2013: Frontier Capabilitie

Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery.

Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment

The unfolded protein response (UPR) is a eukaryotic cellular adaptive mechanism that functions to cope with stress of the endoplasmic reticulum (ER). Accumulating evidence demonstrates that the tumor microenvironment contains stressors that elicit a UPR, which has been demonstrated to be a cell-intrinsic mechanism crucial for tumorigenesis. In addition, the UPR is a source of proinflammatory signaling whose downstream mediators may hamper antitumor immunity. We discuss how the UPR may impair Ag presentation, which could result in defective T cell priming, also leading to tumor escape and growth. Further, we discuss the recent finding that ER stress and attendant proinflammation can be transmitted from ER-stressed tumor cells to myeloid cells. The ideas presented suggest that, in addition to being a cell-intrinsic mechanism of tumor survival, the tumor UPR can serve as a cell-extrinsic regulator of tumorigenesis by remodeling the immune response in the tumor microenvironment

Partitioning Well-clustered Graphs with k-Means and Heat Kernel

We study a suitable class of well-clustered graphs that admit good k-way partitions and present the first almost-linear time algorithm for with almost-optimal approximation guarantees partitioning such graphs. A good k-way partition is a partition of the vertices of a graph into disjoint clusters (subsets) $\{S_i\}_{i=1}^k$, such that each cluster is better connected on the inside than towards the outside. This problem is a key building block in algorithm design, and has wide applications in community detection and network analysis. Key to our result is a theorem on the multi-cut and eigenvector structure of the graph Laplacians of these well-clustered graphs. Based on this theorem, we give the first rigorous guarantees on the approximation ratios of the widely used k-means clustering algorithms. We also give an almost-linear time algorithm based on heat kernel embeddings and approximate nearest neighbor data structures

Dealing with uncertainties in angles-only initial orbit determination

A method to deal with uncertainties in initial orbit determination (IOD) is presented. This is based on the use of Taylor differential algebra (DA) to nonlinearly map uncertainties from the observation space to the state space. When a minimum set of observations is available, DA is used to expand the solution of the IOD problem in Taylor series with respect to measurement errors. When more observations are available, high order inversion tools are exploited to obtain full state pseudo-observations at a common epoch. The mean and covariance of these pseudo-observations are nonlinearly computed by evaluating the expectation of high order Taylor polynomials. Finally, a linear scheme is employed to update the current knowledge of the orbit. Angles-only observations are considered and simplified Keplerian dynamics adopted to ease the explanation. Three test cases of orbit determination of artificial satellites in different orbital regimes are presented to discuss the feature and performances of the proposed methodology