Association of interleukin-6 polymorphisms with obesity or metabolic traits in young Mexican-Americans

Objective The objective of the study is to investigate the association of interleukin-6 (IL6) promoter single-nucleotide polymorphisms rs1800797 (-597 G/A) and rs1800796 (-572 G/C) with obesity or metabolic syndrome in Mexican-Americans. Methods The rs1800797 and rs1800796 single-nucleotide polymorphisms were genotyped in Mexican-Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high-sensitive C-reactive protein (hs-CRP). Results Significant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs-CRP levels. The rs1800797 variant showed no associations with metabolic traits but was associated with higher IL6 levels and lower hs-CRP levels. Conclusions Findings in this study support the anti-inflammatory, anti-obesity and glucose homeostatic roles of IL6 in Mexican-American youth

La célula

Primera unidad del capítulo de Introducción para la materia de Biología Celular y Molecular de la Licenciatura de Nutrición Clínica de la Facultad de Medicina de la Benemérita Universidad Autónoma de Puebla. Descripción general de los tipos de células que conforman a los organismos vivos así como la clasificación de acuerdo al tipo de célula de los cinco reinos de los organismos vivos

Relationship of triglycerides/high density lipoprotein-cholesterol index with antioxidant defense and outstanding association with high sensitive c-reactive protein in Mexican subjects

"The TriGlycerides/High-Density Lipoprotein- Cholesterol (TG/HDL-C) ratio is a new index that has been proposed to estimate CardioVascular Risk (CVR). However, the relationship between this index with the antioxidant defense and inflammation is unknown. The aim of the study was to determine the relationship between the TG/HDL-C index with antioxidant defense and inflammation marker in Mexican subjects. Materials and Methods: In the study, Mexican subjects participated who were anthropometrically, biochemically, and clinically characterized. The TG/HDL-C index was calculated by dividing TG levels by HDL-C levels; a cut-off point >3 was considered CVR. The study subjects were divided into three groups: 1) subjects without CVR; 2) subjects with CVR, and 3) subjects with Type 2 Diabetes (T2D). In the subjects, we evaluated antioxidant defense by determine SuperOxide Dismutase (SOD) and Glutathione Peroxidase (GPx) activities, and high sensitive C-Reactive Protein (hsCRP) as inflammation marker"

Dry Eye Disease Association with Computer Exposure Time Among Subjects with Computer Vision Syndrome

Purpose: To assess the time of exposure to the computer and dry eye disease (DED) in subjects with computer vision syndrome (CVS).Methods: A cross-sectional study was conducted in office workers, computer users of both sexes, with an age range of 18– 45 years without comorbidities; we included 108 subjects divided into 3 groups according to the time of computer exposure in hours per day (H/D): 8 (n = 39). A specific questionnaire was applied to them on the exposure time and the type of visual display terminal (VDT) used, as well as the computer vision symptoms scale (CVSS17). DED was diagnosed with the Ocular Surface Disease Index (OSDI). Ocular surface damage and signs of DED were evaluated with the tear rupture time test (TBUT), the integrity of the ocular surface by ocular surface staining (OSS) and the production of the aqueous basal tear film using the Schirmer test.Results: Average computer exposure time, measured differently, was positively correlated with DED development. The computer exposure time measured in hours per year and TBUT showed a significant negative correlation (p < 0.001) (rho − 0.463). Years of computer exposure and staining of the ocular surface showed a significant positive correlation (p < 0 0.001; rho 0.404). The accumulated exposure time was negatively correlated with TBUT (p < 0.001; rho − 0.376) and positively with OSS (p < 0.001; rho 0.433). Schirmer test did not correlate with computer exposure time.Conclusion: The prolonged time of exposure to the computer in subjects with CVS was significantly correlated with the DED tests, in the different ways of measuring it; but not with the Schirmer test.Keywords: computer vision syndrome, dry eye disease

Índice TG/HDL para identificar a sujetos con síndrome metabólico en población mexicana

"El índice triglicéridos/lipoproteína de alta densidad (TG/HDL) ha sido propuesto como un indicador de riesgo cardiovascular. En México, existe un estudio en adultos jóvenes que lo relaciona con resistencia a la insulina, pero no se ha definido un punto de corte que distinga a sujetos con síndrome metabólico. Objetivo: Determinar el punto de corte para el índice TG/HDL que identifique a sujetos con síndrome metabólico en población mexicana"