Cryptographic techniques used to provide integrity of digital content in long-term storage

The main objective of the project was to obtain advanced mathematical methods to guarantee the verification that a required level of data integrity is maintained in long-term storage. The secondary objective was to provide methods for the evaluation of data loss and recovery. Additionally, we have provided the following initial constraints for the problem: a limitation of additional storage space, a minimal threshold for desired level of data integrity and a defined probability of a single-bit corruption. With regard to the main objective, the study group focused on the exploration methods based on hash values. It has been indicated that in the case of tight constraints, suggested by PWPW, it is not possible to provide any method based only on the hash values. This observation stems from the fact that the high probability of bit corruption leads to unacceptably large number of broken hashes, which in turn stands in contradiction with the limitation for additional storage space. However, having loosened the initial constraints to some extent, the study group has proposed two methods that use only the hash values. The first method, based on a simple scheme of data subdivision in disjoint subsets, has been provided as a benchmark for other methods discussed in this report. The second method ("hypercube" method), introduced as a type of the wider class of clever-subdivision methods, is built on the concept of rewriting data-stream into a n-dimensional hypercube and calculating hash values for some particular (overlapping) sections of the cube. We have obtained interesting results by combining hash value methods with error-correction techniques. The proposed framework, based on the BCH codes, appears to have promising properties, hence further research in this field is strongly recommended. As a part of the report we have also presented features of secret sharing methods for the benefit of novel distributed data-storage scenarios. We have provided an overview of some interesting aspects of secret sharing techniques and several examples of possible applications

The role of NF-κB transcription factor in cellular response to ionizing radiation

The NF-κB transcription factor is involved in different aspects of the cellular response to stress, including atypical NF-κB pathway activated by damage induced by ionizing radiation. Moreover, NF-κB could be involved in the regulation of genes activated by other stress-responsive factors. Here we aimed to perform the integrative genomics screening to compare subsets of NF-κB-dependent genes induced by a pro-inflammatory stimulus and a high dose of ionizing radiation and also to identify new genes potentially co-regulated by NF-κB and p53 transcription factors in irradiated cells. Methods. The RelA-containing NF-κB dimers were activated by TNFα cytokine (classical proinflammatory pathway) and a single 4 or 10 Gy dose (atypical radiation-induced pathway) in human osteosarcoma cells. NF-κB-dependent and p53-dependent genes were identified using the gene expression profiling (by RNA-Seq) in cells with downregulated RELA or TP53 combined with the global profiling of RelA and p53 binding sites (by ChIP-Seq). Candidate genes were subsequently validated by quantitative PCR. Results: There were 37 NF-κB-dependent protein-coding genes identified: in all cases RelA bound in their regulatory regions upon activation while downregulation of RELA suppressed their stimulus-induced upregulation, which apparently indicated the positive regulation mode (this set of genes included a few “novel” NF-κB-dependent species). The kinetics of the NF-κB activation was slower in cells exposed to radiation than in cytokine-stimulated ones. However, subsets of NF-κB-dependent genes upregulated by both types of stimuli were essentially the same. Moreover, we identified a subset of radiation-modulated genes whose expression was affected by silencing of both TP53 and RELA, and a subset of radiation-upregulated genes where radiation stimulated binding of both p53 and RelA. For three genes an antagonistic effect of both transcription factors was observed: IL4I1 was activated by NF-κB and inhibited by p53, while CDKN1A and SERPINE1 were activated by p53 and inhibited by NF-κB. Moreover, RRAD was putatively co-activated by both factors. Conclusions: One could expect that similar cellular processes resulting from activation of the NF-κB pathway could be induced in cells responding to pro-inflammatory cytokines and in cells where so-called “sterile inflammation” response was initiated by radiation-induced damage. Moreover, certain stress-responsive genes induced by ionizing radiation could be co-regulated by NF-κB and p53.publishedVersio

Platelets augment respiratory burst in neutrophils activated by selected species of gram-positive or gram-negative bacteria.

Neutrophils and platelets circulate in blood system and play important physiological roles as part of immunological system. Neutrophils are the first line of host defense against various intruders, and platelets are satellite cells cooperating with other components of defense system. Recent studies report about the cooperation among these types of cells. We analyzed the effect of platelets on oxygen burst in neutrophils triggered by Staphylococcus aureus and Escherichia coli bacteria in vitro. The effect of platelets on oxygen burst in neutrophils was measured by luminol enhanced chemiluminescence. Opsonized and non-opsonized bacteria were used as activators. Activation of neutrophils with live non-opsonized and opsonized bacteria in the presence of platelets increased the oxygen burst as compared to the same system without platelets. The gram-positive bacteria (Staphylococcus aureus) were causing higher activation than gram-negative bacteria (Escherichia coli). This work demonstrate that platelets potentate the response of neutrophils augmenting their respiratory burst in vitro when triggered by bacteria

Post activation potentiation (PAP) and its application in the development of speed and explosive strength in female soccer players: A review

The presented review presents the results of current research on the use of PAP during resistance training of soccer players. Researchers who have examined the mechanism behind PAP following complex strength training, have established a relationship between post-activation potentiation and improvements in speed and explosive strength of athletes. Most of the presented papers in this review have confirmed the effectiveness of PAP in eliciting performance in tasks requiring speed, jumping ability and agility in soccer players. These studies were discussed in detail in terms of research groups, methods, training means and study results. Many of these publications have also considered the aspect of rest intervals between the conditioning exercise and the subsequent explosive activity. Most authors indicate the necessity to individualize the time of the rest interval, depending on the athletes training status, strength level and most of all on the intensity and volume of the conditioning exercise. Some scientists have also attempted to incorporate PAP into warm-up protocols, especially prior to speed and power training sessions. A two-way analysis of the impact of PAP, separately on sprint speed and power of the players. The focus was on demonstrating the positive or negative impact of activating exercises on the two variables discussed. The last part of the paper presents the conclusions drawn based on the results of the studies and suggests the objectives of future research. Most publications have documented the results for male participants, whereas little data is available regarding the use of PAP in female soccer players

Early careers of tertiary graduates in Poland: employability, earnings, and differences between public and private higher education

Poland's system of higher education has expanded rapidly in the last quarter century. Not all graduates of the massified educational system have succeeded in the labor market. Part of the public debate regarding the labor market performance of graduates focuses on the performance of graduates who attended private institutions and part-time programs. As yet, there has been no detailed research into the career paths of recent university graduates in Poland, let alone a comprehensive investigation of the differences between the performance of graduates of various types of studies. In this paper, we present the newly created Polish Graduate Tracking System. We use data from the system to evaluate the labor market performance of recent graduates and to demonstrate the differences between graduates of public and private education. Overall, the privately educated graduates fare better on the labor market, but a more in-depth analysis shows that this could be attributed to their strategy of early entry into the labor market

Combined Pseudo-Random Sequence Generator for Cybersecurity

Random and pseudo-random number and bit sequence generators with a uniform distribution law are the most widespread and in demand in the market of pseudo-random generators. Depending on the specific field of application, the requirements for their implementation and the quality of the generator’s output sequence change. In this article, we have optimized the structures of the classical additive Fibonacci generator and the modified additive Fibonacci generator when they work together. The ranges of initial settings of structural elements (seed) of these generators have been determined, which guarantee acceptable statistical characteristics of the output pseudo-random sequence, significantly expanding the scope of their possible application, including cybersecurity. When studying the statistical characteristics of the modified additive Fibonacci generator, it was found that they significantly depend on the signal from the output of the logic circuit entering the structure. It is proved that acceptable statistical characteristics of the modified additive Fibonacci generator, and the combined generator realized on its basis, are provided at odd values of the module of the recurrent equation describing the work of such generator. The output signal of the combined generator has acceptable characteristics for a wide range of values of the initial settings for the modified additive Fibonacci generator and the classic additive Fibonacci generator. Regarding the use of information security, it is worth noting the fact that for modern encryption and security programs, generators of random numbers and bit sequences and approaches to their construction are crucial and critical

Perylene-Based Chromophore as a Versatile Dye for Light Amplification

One of the challenges for modern optoelectronics is to find versatile, easily adaptable components for novel laser-based technologies. A very attractive perylene-derivative chromophore in different organic matrices for high-performance light amplification is discussed and outlined. Our approach demonstrates the outstandingly compatible laser dye and a viable strategy to provide an effective optical gain for stimulated emission enhancement. Through structural control, we produce simple optical devices embedded in organic matrices, such as poly(methyl methacrylate), nematic liquid crystalline (NLC) mixture, and a hybrid emulsion system (poly(vinyl alcohol) PVA + NLC mesophase). Importantly, we investigate and compare the spectroscopy of differently constructed organic systems in terms of stimulated-emission thresholds and light amplification process efficiency. Moreover, we report the effects of tunability for LC cells by an applied external electric field stimulus. Future directions of laser systems are outlined with an emphasis on the role of the perylene derivative. The studies meet current challenges in the field of modern organic technologies dedicated to various optoelectronic systems, including touch screens, displays, and Li-Fi networks