Executive functions and attention processes in adolescents and young adults with intellectual disability

(1) Background: We made a comprehensive evaluation of executive functions (EFs) and attention processes in a group of adolescents and young adults with mild intellectual disability (ID). (2) Methods: 27 adolescents and young adults (14 females and 13 males) with ID, aged between 15.1 and 23 years (M = 17.4; SD = 2.04), were compared to a control group free of cognitive problems and individually matched for gender and age. (3) Results: As for EFs, individuals with ID were severely impaired on all subtests of the Behavioral Assessment of Dysexecutive Syndrome (BADS) battery. However, we also found appreciable individual differences, with eight individuals (approximately 30%) scoring within normal limits. On the attention tests, individuals with ID were not generally slower but presented specific deficits only on some attention tests (i.e., Choice Reaction Times, Color Naming and Color–Word Interference, and Shifting of Attention for Verbal and for Visual Targets). The role of a global factor (i.e., cognitive speed) was modest in contributing to the group differences; i.e., when present, group differences were selectively associated with specific task manipulations, not global differences in cognitive speed. (4) Conclusions: The study confirmed large group differences in EFs; deficits in attentional processing were more specific and occurred primarily in tasks taxing the selective dimension of attention, with performance on intensive tasks almost entirely spared

Observing Planetesimal Formation under Streaming Instability in the Rings of HD 163296

We introduce a new technique to determine the gas turbulence and surface density in bright disk rings, under the assumption that dust growth is limited by turbulent fragmentation at the ring center. We benchmark this prescription in HD 163296, showing that our measurements are consistent with available turbulence upper limits and agree with independent estimates of the gas surface density within a factor of 2. We combine our results with literature measurements of the dust surface density and grain size to determine the dust-to-gas ratio and Stokes number in the 67 and 100 au rings. Our estimates suggest that particle clumping is taking place under the effect of streaming instability (SI) in the 100 au ring. Even though in the presence of external isotropic turbulence this process might be hindered, we provide evidence that turbulence is nonisotropic in both rings and likely originates from mechanisms (such as ambipolar diffusion) that could ease particle clumping under SI. Finally, we determine the mass accretion rate under the assumption that the disk is in steady state and turbulence regulates angular momentum transport. Our results are in tension with spectroscopic measurements and suggest that other mechanisms might be responsible for accretion, in qualitative agreement with the detection of a magnetocentrifugal wind in this system. Applying our method to larger samples can be used to statistically assess if SI is a viable mechanism to form planetesimals in bright rings

Insecure adult attachment and reflective functioning as mechanisms of the relationship between traumatic life events and suicidal ideation: A path analysis

The relationship between traumatic life events and increased suicide risk has been well reported in literature. However, the complex nature of suicidality phenomena still hinders our ability to comprehend the mediation mechanism underlying this association. In this study, we examined the mediating role of adult attachment and reflective functioning in the relationship between traumatic life events and suicidal ideation. Nine hundred and fifty Italian adults completed an online survey evaluating traumatic life events, adult attachment, reflective functioning and suicidal ideation. The path analysis showed that the positive relationship between traumatic life events and suicidal ideation was partially mediated by attachment anxiety and reflective functioning. From a clinical point of view, these results support the relevance of evaluating and improving patients’ ability to mentalize as a part of psychotherapeutic intervention aimed at reducing suicidality in people with a history of traumatic experiences and attachment anxiety

Radio emission from the A3571 cluster complex: the final stage of a cluster merger?

In this paper we report and discuss the results of a radio survey in the A3571 cluster complex, a structure located in the Shapley Concentration core, and formed by the three clusters A3571, A3572 and A3575. The survey was carried out simultaneously at 22 cm and 13 cm with the Australia Telescope Compact Array, and led to the detection of 124 radio sources at 22 cm. The radio source counts in this region are in agreement with the background counts. Among the 36 radio sources with optical counterpart, six have measured redshift which places them at the distance of the A3571 cluster complex, and nine radio sources have optical counterparts most likely members of this cluster complex. All radio galaxies emit at low power level, i.e. logP$_{22cm}$ (W Hz$^{-1}$) $\le$ 22.6. A number of them are likely to be starburst galaxies. The radio luminosity function of early type galaxies is in agreement with that derived by Ledlow & Owen (1996) if we restrict our analysis to the A3571 cluster. On the basis of the multiwavelength properties of the A3571 cluster complex, we propose that it is a very advanced merger, and explain the radio properties derived from our study in the light of this hypothesis.Comment: 16 pages, in press on A&

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

The neglected tropical diseases (NTDs) are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA), and together produce a burden of disease that may be equivalent to up to one-half of SSA's malaria disease burden and more than double that caused by tuberculosis. Approximately 85% of the NTD disease burden results from helminth infections. Hookworm infection occurs in almost half of SSA's poorest people, including 40–50 million school-aged children and 7 million pregnant women in whom it is a leading cause of anemia. Schistosomiasis is the second most prevalent NTD after hookworm (192 million cases), accounting for 93% of the world's number of cases and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease representing a significant cause of disability and reduction in the region's agricultural productivity. There is a dearth of information on Africa's non-helminth NTDs. The protozoan infections, human African trypanosomiasis and visceral leishmaniasis, affect almost 100,000 people, primarily in areas of conflict in SSA where they cause high mortality, and where trachoma is the most prevalent bacterial NTD (30 million cases). However, there are little or no data on some very important protozoan infections, e.g., amebiasis and toxoplasmosis; bacterial infections, e.g., typhoid fever and non-typhoidal salmonellosis, the tick-borne bacterial zoonoses, and non-tuberculosis mycobaterial infections; and arboviral infections. Thus, the overall burden of Africa's NTDs may be severely underestimated. A full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19

The clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. The identification of clinical and laboratory predictors of poor prognosis may assist clinicians in monitoring strategies and therapeutic decisions

Beam test performance of a prototype module with Short Strip ASICs for the CMS HL-LHC tracker upgrade

The Short Strip ASIC (SSA) is one of the four front-end chips designed for the upgrade of the CMS Outer Tracker for the High Luminosity LHC. Together with the Macro-Pixel ASIC (MPA) it will instrument modules containing a strip and a macro-pixel sensor stacked on top of each other. The SSA provides both full readout of the strip hit information when triggered, and, together with the MPA, correlated clusters called stubs from the two sensors for use by the CMS Level-1 (L1) trigger system. Results from the first prototype module consisting of a sensor and two SSA chips are presented. The prototype module has been characterized at the Fermilab Test Beam Facility using a 120 GeV proton beam

Cholera epidemic in Yemen, 2016–18: an analysis of surveillance data

Summary: Background: In war-torn Yemen, reports of confirmed cholera started in late September, 2016. The disease continues to plague Yemen today in what has become the largest documented cholera epidemic of modern times. We aimed to describe the key epidemiological features of this epidemic, including the drivers of cholera transmission during the outbreak. Methods: The Yemen Health Authorities set up a national cholera surveillance system to collect information on suspected cholera cases presenting at health facilities. Individual variables included symptom onset date, age, severity of dehydration, and rapid diagnostic test result. Suspected cholera cases were confirmed by culture, and a subset of samples had additional phenotypic and genotypic analysis. We first conducted descriptive analyses at national and governorate levels. We divided the epidemic into three time periods: the first wave (Sept 28, 2016, to April 23, 2017), the increasing phase of the second wave (April 24, 2017, to July 2, 2017), and the decreasing phase of the second wave (July 3, 2017, to March 12, 2018). We reconstructed the changes in cholera transmission over time by estimating the instantaneous reproduction number, Rt. Finally, we estimated the association between rainfall and the daily cholera incidence during the increasing phase of the second epidemic wave by fitting a spatiotemporal regression model. Findings: From Sept 28, 2016, to March 12, 2018, 1 103 683 suspected cholera cases (attack rate 3·69%) and 2385 deaths (case fatality risk 0·22%) were reported countrywide. The epidemic consisted of two distinct waves with a surge in transmission in May, 2017, corresponding to a median Rt of more than 2 in 13 of 23 governorates. Microbiological analyses suggested that the same Vibrio cholerae O1 Ogawa strain circulated in both waves. We found a positive, non-linear, association between weekly rainfall and suspected cholera incidence in the following 10 days; the relative risk of cholera after a weekly rainfall of 25 mm was 1·42 (95% CI 1·31–1·55) compared with a week without rain. Interpretation: Our analysis suggests that the small first cholera epidemic wave seeded cholera across Yemen during the dry season. When the rains returned in April, 2017, they triggered widespread cholera transmission that led to the large second wave. These results suggest that cholera could resurge during the ongoing 2018 rainy season if transmission remains active. Therefore, health authorities and partners should immediately enhance current control efforts to mitigate the risk of a new cholera epidemic wave in Yemen. Funding: Health Authorities of Yemen, WHO, and Médecins Sans Frontières

Observing Planetesimal Formation under Streaming Instability in the Rings of HD 163296

Abstract We introduce a new technique to determine the gas turbulence and surface density in bright disk rings, under the assumption that dust growth is limited by turbulent fragmentation at the ring center. We benchmark this prescription in HD 163296, showing that our measurements are consistent with available turbulence upper limits and agree with independent estimates of the gas surface density within a factor of 2. We combine our results with literature measurements of the dust surface density and grain size to determine the dust-to-gas ratio and Stokes number in the 67 and 100 au rings. Our estimates suggest that particle clumping is taking place under the effect of streaming instability (SI) in the 100 au ring. Even though in the presence of external isotropic turbulence this process might be hindered, we provide evidence that turbulence is nonisotropic in both rings and likely originates from mechanisms (such as ambipolar diffusion) that could ease particle clumping under SI. Finally, we determine the mass accretion rate under the assumption that the disk is in steady state and turbulence regulates angular momentum transport. Our results are in tension with spectroscopic measurements and suggest that other mechanisms might be responsible for accretion, in qualitative agreement with the detection of a magnetocentrifugal wind in this system. Applying our method to larger samples can be used to statistically assess if SI is a viable mechanism to form planetesimals in bright rings.</jats:p