320 research outputs found
Urinary porphyrin excretion in hepatitis C infection
A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism. Moreover, there is evidence of a role of porphyrinopathies in hepatocarcinogenesis. The aim of our study was to obtain data on the prevalence and patterns of heme metabolism alterations in patients with chronic hepatitis C virus infection. Urinary porphyrin excretion was prospectively studied in 100 consecutive outpatients with chronic hepatitis C infection without signs of photosensitivity, using an ion-pair high performance liquid chromatography method. Increased total porphyrin excretion was found in 41 patients, with predominant excretion of coproporphyrins (whole study group: mean 146 mu g/g creatinine, interquartile range 76-186; normal <150), in 10 patients excretion exceeded 300 mu g/g creatinine. In the majority of all patients studied (75/100) an increased ratio of the relatively hydrophobic coproporphyrin isomer I to isomer III was found. In just one case, urinary porphyrin pattern characteristic for chronic hepatic porphyria was present (uroporphyrin > coproporphyrin, heptacarboxyporphyrin III increased) but the total porphyrin excretion was only slightly elevated in this case. In the whole group, total urinary porphyrin excretion correlated well with serum bilirubin and was inversely correlated with albumin and thrombin time. In conclusion, secondary coproporphyrinuria occurs frequently in heptatitis C infection, whereas in Germany, preclinical porphyria cutanea tarda seems to be rare in these patients
Zunehmende SchwÀche und Gewichtsabnahme bei einer 40-jÀhrigen Patientin mit Lungentuberkulose
Measuring of air valves and difusers
DiplomovĂĄ prĂĄce je zamÄĆena na problematiku distribuce vzduchu v obytnĂœch budo-vĂĄch. JejĂ hlavnĂ ÄĂĄst se vÄnuje experimentĂĄlnĂmu zkouĆĄenĂ koncovĂœch elementĆŻ pomocĂ kouĆovĂ© zkouĆĄky. DosaĆŸenĂ© vĂœsledky jsou aplikovĂĄny na nĂĄvrh vzduchotechniky v pasivnĂm rodinnĂ©m domÄ. DĂĄle je navrhnuto sĂĄlavĂ© vytĂĄpÄnĂ a energetickĂĄ optimalizace v programu PHPP.This master thesis is focused on the issue of air distribution in residential buildings. The main part of thesis is devoted to experimental testing of diffusers by a smoke test. Achieved results are applied to design of air conditioning in passive house. Radiant heating and energy optimalization in PHPP are also proposed.
Project technology of production hooped components and structural design tools
DiplomovĂĄ prĂĄce, vypracovanĂĄ v rĂĄmci inĆŸenĂœrskĂ©ho studia oboru 2307, pĆedklĂĄdĂĄ nĂĄvrh vĂœroby ohĂœbanĂ© souÄĂĄsti. MateriĂĄl souÄĂĄsti je ocel ÄSN 15 130. KusovĂĄ aĆŸ malosĂ©riovĂĄ vĂœroba. Na zĂĄkladÄ literĂĄrnĂ studie problematiky ohybu trubek bylo navrĆŸeno ohĂœbĂĄnĂ metodou navĂjenĂ. Pro tuto metodu byla navrĆŸena mechanickĂĄ ohĂœbaÄka s pomocnĂœm ramenem pro potĆebu ohĂœbĂĄnĂ s trnem a pĆesnĂ© vĂœroby prostorovĂœch ohybĆŻ.This diploma thesis has been elaborated within the Master's study of department 2307 that submits a production hooped component. The material of the component is steel ÄSN 15 130. Single â part as far as smallâlot production. On the basis of the literary study problems bend tubing was sugested the method: rotary draw bending. For this method was sugested mechanical bending machine with mandrel support arm, for bending with mandrel and exact bends in three â dimensional.
First aid provided by persons after spine and spinal cord injury
Name: First aid provided by persons after spine and spinal cord injury The aim of the work: The aim of my bachelor thesis is to find out the practical possibilities of first aid in people after spine and spinal cord injury. Next task was to find out if the people tied to a wheelchair are able to provide first aid with sufficient quality. Methodology of the work: I have used three methods of data collection. The first method to identify personal history and basic theoretical knowledge in monitored group was an survey inquiry. The second method was an uncontrolled conversation to which I found additional information. The third method of data collection was observation, where I followed the practical possibilities, procedures and first aid technique in solving selected life threatening situations in individuals. Results of the work: Based on observations, I have found that all probands are able to evaluate the state of consciousness, to pass through the airways, and are able to provide first aid for strangulation by a foreign object and stopping breathing of the child within 1 year. I also found that probes with lesion height to Th7 are able to place the adult patient in a stabilized position and, if necessary, to initiate the resuscitation of an individual who is unconscious and does not breathe...NĂĄzev prĂĄce: PrvnĂ pomoc poskytovanĂĄ osobami po poranÄnĂ pĂĄteĆe a mĂchy CĂle prĂĄce: CĂlem mĂ© bakalĂĄĆskĂ© prĂĄce je zjistit jakĂ© jsou praktickĂ© moĆŸnosti pĆi poskytovĂĄnĂ prvnĂ pomoci u osob po poranÄnĂ pĂĄteĆe a mĂchy. DĂĄle pak zjistit, zdali jedinci upoutanĂ na invalidnĂ vozĂk jsou schopni dostateÄnÄ kvalitnÄ poskytnout prvnĂ pomoc. Metodika prĂĄce: V prĂĄci jsem pouĆŸil tĆi metody sbÄru dat. PrvnĂ metodou, kterĂĄ slouĆŸila ke zjiĆĄtÄnĂ osobnĂ anamnĂ©zy a zĂĄkladnĂch teoretickĂœch znalostĂ u sledovanĂ©ho souboru, bylo anketnĂ ĆĄetĆenĂ. Druhou metodou byl neĆĂzenĂœ rozhovor, kterĂœm jsem zjistil doplĆujĂcĂ informace. TĆetĂ metodou sbÄru dat bylo pozorovĂĄnĂ, kde jsem sledoval praktickĂ© moĆŸnosti, postupy a techniku prvnĂ pomoci pĆi ĆeĆĄenĂ vybranĂœch ĆŸivot ohroĆŸujĂcĂch situacĂ u jednotlivĂœch probandĆŻ. VĂœsledky prĂĄce: Na zĂĄkladÄ pozorovĂĄnĂ jsem zjistil, ĆŸe vĆĄichni probandi jsou schopni vyhodnotit stav vÄdomĂ, zprĆŻchodnit dĂœchacĂ cesty a jsou schopni poskytnout prvnĂ pomoc pĆi duĆĄenĂ cizĂm tÄlesem a pĆi zĂĄstavÄ dechu u dĂtÄte do 1 roku. DĂĄle jsem zjistil, ĆŸe probandi s vĂœĆĄkou lĂ©ze do Th7 jsou schopni uloĆŸit dospÄlĂ©ho pacienta do stabilizovanĂ© polohy a popĆĂpadÄ zahĂĄjit resuscitaci jedince, kterĂœ je v bezvÄdomĂ a nedĂœchĂĄ pravidelnÄ. Dle zĂskanĂœch vĂœsledkĆŻ z testu teoretickĂœch znalostĂ bylo zjiĆĄtÄno, ĆŸe vĆĄichni jedinci majĂ...ZdravotnĂ TV a tÄlovĂœchovnĂ© lĂ©kaĆstvĂFaculty of Physical Education and SportFakulta tÄlesnĂ© vĂœchovy a sport
Psychiatric and psychosocial outcome of orthotopic liver transplantation
Background. The study aimed to explore the prevalence of psychiatric disorders among orthotopic liver transplantation (OLT) recipients, and to investigate how psychiatric morbidity was linked to health-related quality of life (HRQOL). Methods: We recruited 75 patients who had undergone OLT a median of 3.8 years previously (range = 5-129 months). Psychiatric morbidity was assessed using the Structural Clinical Interview for the IDSM-III-R. Psychometric observer-rating and self-rating scales were administered to evaluate cognitive functioning (SKT), depressive symptomatology (HAMD(17)), Posttraumatic stress symptoms (PTSS-10), social support (SSS), and HRQOL (SF-36 Health Status Questionnaire). Treatment characteristics were obtained from medical records. Results: 22.7% (n = 17) of our sample had a current or probable psychiatric diagnosis according to DSM-III-R: 2.7% full posttraumatic stress disorder (PTSD) (n = 2), 2.7% major depressive disorder (MDD) comorbid to full PTSD (n = 2), 1.3% MDD comorbid to partial PTSD (n = 1), and 16% partial PTSD (n = 12). Patients with PTSD symptoms demonstrated lower cognitive performance, higher severity of depressive symptoms and more unfavorable perception of social support. OLT-related PTSD symptomatology was associated with maximal decrements in HRQOL. The duration of intensive care treatment, the number of medical complications, and the occurrence of acute rejection were positively correlated with the risk of PTSD symptoms subsequent to OLT. Conclusion: OLT-related PTSD symptomatology impairing HRQOL is a complication for a subgroup of OLT recipients. Health-care providers should be aware of the possible presence of PTSD in OLT survivors. Copyright (C) 2002 S. KargerAG, Basel
Serum proteome profiling identifies novel and powerful markers of cystic fibrosis liver disease.
Cystic Fibrosis associated liver disease (CFLD) develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools for CFLD are lacking. Within this study, we aimed to identify new experimental biomarkers for the detection of CFLD.
45 CF patients were included in the study and received transient elastography. Differential regulation of 220 different serum proteins was assessed in a subgroup of patients with and without CFLD. Most interesting candidate proteins were further quantified and validated by ELISA in the whole patient cohort. To assess a potential relation of biomarker expression to the degree of hepatic fibrosis, serum biomarkers were further determined in 18 HCV patients where liver histology was available.
43 serum proteins differed at least 2-fold in patients with CFLD compared to those without liver disease as identified in proteome profiling. In ELISA quantifications, TIMP-4 and Endoglin were significantly up-regulated in patients with CFLD as diagnosed by clinical guidelines or increased liver stiffness. Pentraxin-3 was significantly decreased in patients with CFLD. Serum TIMP-4 and Endoglin showed highest values in HCV patients with liver cirrhosis compared to those with fibrosis but without cirrhosis. At a cut-off value of 6.3 kPa, transient elastography compassed a very high diagnostic accuracy and specificity for the detection of CFLD. Among the biomarkers, TIMP-4 and Endoglin exhibited a high diagnostic accuracy for CFLD. Diagnostic sensitivities and negative predictive values were increased when elastography and TIMP-4 and Endoglin were combined for the detection of CFLD.
Serum TIMP-4 and Endoglin are increased in CFLD and their expression correlates with hepatic staging. Determination of TIMP-4 and Endoglin together with transient elastography can increase the sensitivity for the non-invasive diagnosis of CFLD
Effectivness of Basic Life Support in Children Provided by Wheelchair Users
NĂĄzev prĂĄce: Efektivita zĂĄkladnĂ neodkladnĂ© resuscitace dÄtĂ poskytovanĂĄ osobami na vozĂku CĂle prĂĄce: CĂlem mĂ© diplomovĂ© prĂĄce je vyhodnotit efektivitu zĂĄkladnĂ neodkladnĂ© resuscitace dÄtĂ do 1 roku provĂĄdÄnou osobami na vozĂku ve tĆech zvolenĂœch polohĂĄch umĂstÄnĂ resuscitaÄnĂ figurĂny. Na zĂĄkladÄ porovnĂĄnĂ vĂœsledkĆŻ pĆi umĂstÄnĂ figurĂny na klĂnÄ, na vyvĂœĆĄenĂ© podloĆŸce a na zemi vyhodnotit nejvhodnÄjĆĄĂ polohu pro provedenĂ zĂĄkladnĂ neodkladnĂ© resuscitace. Metodika prĂĄce: VĂœzkumnĂœ soubor tvoĆilo 10 osob s poĆĄkozenĂm mĂchy (4 s tetraplegiĂ a 6 s paraplegiĂ), kteĆĂ ke svĂ©mu pohybu uĆŸĂvajĂ invalidnĂ vozĂk. V prĂĄci byly pouĆŸity tĆi metody sbÄru dat. PrvnĂ metodou, kterĂĄ byla pouĆŸita, bylo anketnĂ ĆĄetĆenĂ, kterĂ© slouĆŸilo k zĂskĂĄnĂ anamnestickĂœch ĂșdajĆŻ u sledovanĂ©ho souboru. Druhou metodou sbÄru dat bylo pozorovĂĄnĂ probandĆŻ v prĆŻbÄhu poskytovĂĄnĂ prvnĂ pomoci. TĆetĂ zvolenou metodou bylo mÄĆenĂ pomocĂ zaĆĂzenĂ SimPad SkillReporter a resuscitaÄnĂ figurĂny Resusci Baby QCPR. MÄĆenĂ slouĆŸilo ke zhodnocenĂ efektivity zĂĄkladnĂ neodkladnĂ© resuscitace dÄtĂ po dobu 5 minut ve tĆech vybranĂœch polohĂĄch. VĂœsledky prĂĄce: Na zĂĄkladÄ pozorovĂĄnĂ a mÄĆenĂ bylo zjiĆĄtÄno, ĆŸe vĆĄichni probandi jsou schopni zvednout a manipulovat s figurĂnou o hmotnosti 10 kilogramĆŻ. DalĆĄĂm pozitivnĂm vĂœsledkem tĂ©to prĂĄce bylo zjiĆĄtÄnĂ, ĆŸe 8 z...Name: Effectivness of Basic Life Support in Children Provided by Wheelchair Users Objectives: The aim of this diploma thesis is to evaluate the effectiveness of elementary emergency resuscitation children under 1yr of age with three selected positions of resuscitation manikin in persons using a wheelchair for their movement. Based on the comparison of the results when positioning the manikin on a lap, on a mat and on the ground, aim is to evaluate the most suitable position for performing elementary emergency resuscitation. Method: The research group consisted of ten people with spinal cord injury (four with tetraplegia and six with paraplegia), who use wheelchair for their movement. Three methods of data collection were used in this work. A survey was used for the first method, which obtained anamnestic data of the research group. The second method of data collection was the observation of probands during first aid. The third selected method was a measurement using a SimPad SkillReporter and a Resusci Baby QCPR resuscitation manikin. The measurement was used to evaluate the effectiveness of elementary emergency resuscitation of children for five minutes in three selected positions. Results: Based on observations and measurements, it was found that all probands are able to lift and manipulate a...ZdravotnĂ TV a tÄlovĂœchovnĂ© lĂ©kaĆstvĂFakulta tÄlesnĂ© vĂœchovy a sportuFaculty of Physical Education and Spor
Ventilation of the Education Building
BakalĂĄĆskĂĄ prĂĄce se zabĂœvĂĄ zhodnocenĂm stavu vnitĆnĂho mikroklimatu ĆĄkolskĂ©ho objektu pĆed a po rekonstrukci vĂœplĆovĂœch otvorĆŻ. Na zĂĄkladÄ vlastnĂch uskuteÄnÄnĂœch mÄĆenĂ je navrĆŸeno nucenĂ© vÄtrĂĄnĂ pomocĂ dvou vzduchotechnickĂœch zaĆĂzenĂ, kterĂ© zajistĂ poĆŸadovanĂ© mikroklima vĆĄech uÄeben.This bachelor thesis deals with the evaluation of the current state indoor microclimate of educational object before and after the reconstruction of windows. On the basis of my own measurements there is designed a forced ventilation using two air-conditioning systems which ensure a required microclimate of all classrooms.
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