437 research outputs found
Green chemistry in Brazil
The philosophy of green chemistry has been very well received in Latin America's research and development programs. In this review we describe the green chemistry contributions of Brazilian research groups over the last three years.Centro de Investigación y Desarrollo en Ciencias Aplicada
Green chemistry in Brazil
The philosophy of green chemistry has been very well received in Latin America's research and development programs. In this review we describe the green chemistry contributions of Brazilian research groups over the last three years.Centro de Investigación y Desarrollo en Ciencias Aplicada
Green chemistry in Brazil
The philosophy of green chemistry has been very well received in Latin America's research and development programs. In this review we describe the green chemistry contributions of Brazilian research groups over the last three years.Centro de Investigación y Desarrollo en Ciencias Aplicada
Individualized treatment of genotype 1 Naïve patients : an Italian multicenter field practice experience
Background: Triple therapy including Telaprevir or Boceprevir still represents in many European countries the standard of
care for patients with Hepatitis C Virus genotype 1 infection. The number of patients who received this treatment resulted
generally lower than expected. We investigated, among na\u131\ua8ve patients, number and characteristics of treatment candidates
who were started on triple or dual therapy in comparison to those who were deferred.
Patients and Methods: 621 na\u131\ua8ve treatment candidates were prospectively evaluated at each center. Factors associated
with decision to defer or treat with dual or triple therapy were investigated by univariate and multivariate analyses. Rates of
Sustained Virological Response and safety profile were analysed.
Results: Of candidates to treatment, 33% did not received it. It was mostly due to high risk of Interferon-induced
decompensation. Of 397 patients who were started on treatment, 266 (67%) received triple, 131 dual. Among patient
receiving treatment, unfavorable IL28B, severe liver damage and higher albumin were independently associated with the
physician decision to administer triple therapy. Sustained Virological Response after dual therapy was 66.4%, after triple
73.7% (p = 0.14). 142 patients received Telaprevir. The choice of Telaprevir-based therapy was associated with higher Body
Mass Index and advanced liver disease. Sustained Virological Response rates were 71.1% after Telaprevir and 76.6% after
Boceprevir.
Conclusions: Individualizing treatment with available regimens allows to maximize Sustained Virological Response and to
reduce the number of patients who remain untreated. High proportion of patients with severe liver damage urgently need
Interferon free treatment
a novel plasma source for sterilization of living tissues
A source for the production of low-power plasmas at atmospheric pressure, to be used for the nondamaging sterilization of living tissues, is presented. The source, powered by radiofrequency and working with a helium flow, has a specific configuration, studied to prevent the formation of electric arcs dangerous to living matter. It is capable of killing different types of bacteria with a decimal reduction time of 1?2?min; on the contrary, human cells such as conjunctival fibroblasts were found to be almost unharmed by the plasma. A high concentration of OH radicals, likely to be the origin of the sterilizing effect, is detected through their UV emission lines. The effect of the UV and the OH radicals on the fibroblasts was analysed and no significant effects were detected
Latest investigations on fluctuations, ELM filaments and turbulent transport in the SOL of ASDEX Upgrade
When TADs go bad: chromatin structure and nuclear organisation in human disease
Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, including self-interacting domains called topologically associating domains (TADs). This arrangement is thought to bring enhancers into closer physical proximity with their target genes, which often are located hundreds of kilobases away in linear genomic distance. TADs are demarcated by boundary regions bound by architectural proteins, such as CTCF and cohesin, although much remains to be discovered about the structure and function of these domains. Recent studies of TAD boundaries disrupted in engineered mouse models show that boundary mutations can recapitulate human developmental disorders as a result of aberrant promoter-enhancer interactions in the affected TADs. Similar boundary disruptions in certain cancers can result in oncogene overexpression, and CTCF binding sites at boundaries appear to be hyper-mutated across cancers. Further insights into chromatin organisation, in parallel with accumulating whole genome sequence data for disease cohorts, are likely to yield additional valuable insights into the roles of noncoding sequence variation in human disease
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