The Swiss Household Panel 1999-2003: data for research on micro-social change

"Die Umfrage Leben in der Schweiz des Schweizer Haushalt Panels (SHP) bietet eine einzigartige longitudinale Datenbasis an. 1999 wurden 7.799 Personen von 5.074 Haushalten über ihre Lebensbedingungen befragt. Sämtliche 14-jährigen und älteren Personen, die in diesen Haushalten wohnen, sollen fortan während zehn bis fünfzehn Jahren in jährlichem Abstand befragt werden. Die Erhebung wird mittels computerunterstützten Telefoninterviews (CATI: Computer Assisted Telephone Interviewing) durchgeführt. Mittlerweile konnten die ersten zwei Befragungswellen erfolgreich realisiert werden. Anders als bei den vorwiegend auf sozioökonomischen Bedingungen ausgerichteten Panels - wie dem SOEP in Deutschland und dem BHPS in England - deckt das SHP ein breites Spektrum von Themen und sozialwissenschaftlichen Forschungsansätzen ab. Das Faktenmaterial wird ergänzt durch 'subjektive' Beurteilungen. Die Trägerschaft des SHPs besteht aus dem Schwerpunktprogramm SPP 'Zukunft Schweiz', dem Bundesamt für Statistik und der Universität Neuchâtel." (Autorenreferat)"The Living in Switzerland survey of the Swiss Household Panel (SHP) provides a unique longitudinal database in Switzerland. In 1999, 7,799 members of 5,074 households – from a stratified random sample of the permanent resident population of Switzerland – were interviewed about their living conditions. All household members aged 14 years and older are to be interviewed annually for 10 to 15 years. The SHP survey is conducted using computer-assisted telephone interviewing (CATI). To date, the first two waves have been carried out successfully. In comparison with panels such as the SOEP in Germany and the BHPS in Britain concentrating on socio-economic conditions, the SHP covers a broader range of topics and approaches in the social sciences. Subjective assessments complement the factual information. The SHP is a joint project run by the Swiss Priority Programme (SPP) 'Switzerland towards the Future', the Swiss Federal Statistical Office and the University of Neuchâtel." (author's abstract

Prompt interval temporal logic

Interval temporal logics are expressive formalisms for temporal representation and reasoning, which use time intervals as primitive temporal entities. They have been extensively studied for the past two decades and successfully applied in AI and computer science. Unfortunately, they lack the ability of expressing promptness conditions, as it happens with the commonly-used temporal logics, e.g., LTL: whenever we deal with a liveness request, such as \u201csomething good eventually happens\u201d, there is no way to impose a bound on the delay with which it is fulfilled. In the last years, such an issue has been addressed in automata theory, game theory, and temporal logic. In this paper, we approach it in the interval temporal logic setting. First, we introduce PROMPT-PNL, a prompt extension of the well-studied interval temporal logic PNL, and we prove the undecidability of its satisfiability problem; then, we show how to recover decidability (NEXPTIME-completeness) by imposing a natural syntactic restriction on it

Artificial neural networks allow the use of simultaneous measurements of Alzheimer Disease markers for early detection of the disease

BACKGROUND: Previous studies have shown that in platelets of mild Alzheimer Disease (AD) patients there are alterations of specific APP forms, paralleled by alteration in expression level of both ADAM 10 and BACE when compared to control subjects. Due to the poor linear relation among each key-element of beta-amyloid cascade and the target diagnosis, the use of systems able to afford non linear tasks, like artificial neural networks (ANNs), should allow a better discriminating capacity in comparison with classical statistics. OBJECTIVE: To evaluate the accuracy of ANNs in AD diagnosis. METHODS: 37 mild-AD patients and 25 control subjects were enrolled, and APP, ADM10 and BACE measures were performed. Fifteen different models of feed-forward and complex-recurrent ANNs (provided by Semeion Research Centre), based on different learning laws (back propagation, sine-net, bi-modal) were compared with the linear discriminant analysis (LDA). RESULTS: The best ANN model correctly identified mild AD patients in the 94% of cases and the control subjects in the 92%. The corresponding diagnostic performance obtained with LDA was 90% and 73%. CONCLUSION: This preliminary study suggests that the processing of biochemical tests related to beta-amyloid cascade with ANNs allows a very good discrimination of AD in early stages, higher than that obtainable with classical statistics methods

Análise da integração veículo-pavimento em problemas ferroviários

-As crescentes demandas pelo transporte de cargas e de passageiros reafirmam a importância do transporte ferroviário para o Brasil. Desta forma, os investimentos em técnicas para manutenção preditiva e simulação computacional de vias têm ganhado espaço, principalmente devido aos altos custos de manutenção das ferrovias. Em alguns casos, estima-se que o valor despendido com a manutenção de uma linha férrea corresponda a algo entre 15% e 30% dos custos totais de sua operação. Além da questão econômica, outro fator que motiva pesquisas na área ferroviária está relacionado à segurança do uso das vias. Há relatos de acidentes causados por problemas de baixa rigidez do conjunto trilho-dormente-lastro, por exemplo, que poderiam ter sido evitados com a realização de medições dinâmicas e/ou simulações computacionais para identificar os eventuais problemas do sistema. Desta forma, metodologias que avaliem de maneira eficiente a qualidade de estruturas ferroviárias vêm sendo desenvolvidas, incluindo o presente trabalho. Assim, este apresenta uma comparação entre os desempenhos de dois modelos numéricos-computacionais baseados no Método dos Elementos Finitos capazes de simular o comportamento dinâmico do sistema veículo-pavimento em estruturas ferroviárias. Ambos os modelos consideram a estrutura ferroviária (trilhos, dormentes e lastro) da mesma maneira. As diferenças entre um e outro são relativas às considerações feitas para o veículo rolante. No modelo mais simples não são consideradas as forças inerciais da massa do veículo durante seu deslocamento sobre a via. No outro modelo, mais sofisticado, atribui-se graus de liberdade ao veículo e faz-se uma análise dinâmica acoplada do sistema, considerando as forças de inércia provenientes dos deslocamentos do trem. Para validação dos modelos desenvolvidos, serão apresentados resultados experimentais obtidos por processamento de imagem durante um ensaio realizado em um trecho de uma ferrovia da MRS Logística próximo à cidade de Barra do Piraí - RJ. Por fim, será apresentada também uma metodologia para avaliação da qualidade da via que procura identificar perdas de rigidez dos conjuntos dormente-lastro. Tendo-se como incógnitas do problema as constantes de mola que modelam a rigidez do pavimento (conjunto dormente-lastro), busca-se determinar os valores destas constantes que melhor ajustem os deslocamentos verticais dos trilhos diante da passagem de trens a valores tomados como referência. Os deslocamentos verticais tomados como referência no ajuste das constantes elásticas de mola são obtidos por simulação computacional utilizando o modelo mais simples desenvolvido e o processo de ajuste de curvas de deslocamentos é realizado via algoritmos genéticos. Esta metodologia pode servir de base para uma avaliação das condições reais de rigidez de uma via férrea, bastando-se para isso que se utilize resultados experimentais como valores de referência

Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils

How IL-6 expression is regulated in human neutrophils has remained unclear. Here the authors show, using highly purified neutrophils, that TLR8 or TLR4 signalling activates latent enhancers and cooperates with autocrine TNFα to induce IL-6 transcription

Disease and Healing in Ancient Societies: Dental Calculus Residues and Skeletal Pathology Data Indicate Age and Sex-Biased Medicinal Practices among Native Californians

The health of humans is intricately linked to the substances - both food and non-dietary items -we ingest. Adverse health outcomes related to smoking of products like tobacco and other psychoactive substances are clearly established in modern populations but are less well understood for ancient communities. Grasping these dynamics is further complicated by the curative, religious, and medicinal context of many of these substances, which have often been commodified, refined, and altered in recent history. As part of a larger collaboration with the Muwekma Ohlone Tribe dedicated to understanding medicinal plant use among native Californians, we present a summary of new metabolomic data from three Middle and Late-period ancestral heritage Ohlone sites: Thámien Rúmmeytak (CA-SCL-128), ’Ayttakiš ’Éete Hiramwiš Trépam-tak (CA-ALA-677/H/H), and Sii Tuupentak (CA-ALA-565/H/H). Using a UPLC-MS platform, we analyze chemical residues from 95 human dental calculus samples from 50 burials. Employing multivariate statistics, we co-analyzed demographic and skeletal pathology data with chemical residue profiles. We considered skeletal markers for a series of oral and postcranial health conditions. Results indicate sex and age biases in consumption patterns. Periodontitis stands out as the most significant local factor for changes in the oral metabolome. However, while chemical markers of oral diseases may be related to pathogen activity, associations between residues and postcranial conditions such as osteoarthritis suggest traditional curative practices and the ingestion of medicinal substances. Hence, our study yields new insights into the broader context of illness and healing in the past

Tools for delivering entomopathogenic fungi to malaria mosquitoes: effects of delivery surfaces on fungal efficacy and persistence.

BACKGROUND\ud \ud Entomopathogenic fungi infection on malaria vectors increases daily mortality rates and thus represents a control measure that could be used in integrated programmes alongside insecticide-treated bed nets (ITNs) and indoor residual spraying (IRS). Before entomopathogenic fungi can be integrated into control programmes, an effective delivery system must be developed.\ud \ud METHODS\ud \ud The efficacy of Metarhizium anisopliae ICIPE-30 and Beauveria bassiana I93-825 (IMI 391510) (2 × 10(10) conidia m(-2)) applied on mud panels (simulating walls of traditional Tanzanian houses), black cotton cloth and polyester netting was evaluated against adult Anopheles gambiae sensu stricto. Mosquitoes were exposed to the treated surfaces 2, 14 and 28 d after conidia were applied. Survival of mosquitoes was monitored daily.\ud \ud RESULTS\ud \ud All fungal treatments caused a significantly increased mortality in the exposed mosquitoes, descending with time since fungal application. Mosquitoes exposed to M. anisopliae conidia on mud panels had a greater daily risk of dying compared to those exposed to conidia on either netting or cotton cloth (p < 0.001). Mosquitoes exposed to B. bassiana conidia on mud panels or cotton cloth had similar daily risk of death (p = 0.14), and a higher risk than those exposed to treated polyester netting (p < 0.001). Residual activity of fungi declined over time; however, conidia remained pathogenic at 28 d post application, and were able to infect and kill 73 - 82% of mosquitoes within 14 d.\ud \ud CONCLUSION\ud \ud Both fungal isolates reduced mosquito survival on immediate exposure and up to 28 d after application. Conidia were more effective when applied on mud panels and cotton cloth compared with polyester netting. Cotton cloth and mud, therefore, represent potential substrates for delivering fungi to mosquitoes in the field