364 research outputs found
A flaring X-ray pulsar in Dorado
A study of unusual gamma-ray bursts detected on March 5 and March 6, 1979 in the KONUS experiment on the Venera 11 and Venera 12 spacecraft shows their source to be flaring X-ray pulsar in Dorado
Preliminary results of a gamma-ray burst study in the Konus experiment on the Venera-11 and Venera-12 space probes
Twenty-one gamma-ray bursts and 68 solar flares in the hard X-ray range were detected on Venera-11 and Venera-12 space probes during the initial 50-day observation period. Major characteristics of the equipment used and preliminary data on the temporal structure and energy spectra of the gamma-ray bursts are considered. The pattern of gamma-ray burst frequency distribution vs. intensity, N(S), is established
Anomalous Thermal Stability of Metastable C_20 Fullerene
The results of computer simulation of the dynamics of fullerene C_20 at
different temperatures are presented. It is shown that, although it is
metastable, this isomer is very stable with respect to the transition to a
lower energy configuration and retains its chemical structure under heating to
very high temperatures, T ~ 3000 K. Its decay activation energy is found to be
E_a ~ 7 eV. Possible decay channels are studied, and the height of the minimum
potential barrier to decay is determined to be U = 5.0 eV. The results obtained
make it possible to understand the reasons for the anomalous stability of
fullerene C_20 under normal conditions.Comment: Slightly corrected version of the paper submitted to Phys. Solid
Stat
On Problem of Professional Training of Social Workers within the Framework of Higher Education
The issue of training of social workers in higher education is considered. The relevance of the research is caused by changes of socio-economic and technological nature, taking place in modern society, implying the training of specialists of higher level: βmulti-functional,β meeting international standards of training professionals to implement certain urgent tasks. Professionalization refers to the process of improving a personβs knowledge, skills and abilities in the context of an activity that involves the presence of a certain subject represented in the culture of a given society, and ways of working with it. The authors rely on the indicators of the level of professional training offered by Yu. P. Povarenkov: professional effectiveness, professional identity and professional maturity. The novelty of the research lies in destinguishing three levels of βco-existence essenceβ of professional training of social professionals: adaptive-orientational, subject-effective and innovative-creative. The authors dwell on the position, according to which the student evolves as a subject of activity only in certain educational conditions: motivating environment of the educational institution as a factor contributing to the active development of new knowledge, skills and abilities; well-organized training and education aimed at increasing the effectiveness of students and teachers; tracking the dynamics of creative development of students, their improvement in personal and professional relationships
Intrusion detection and classification with autoencoded deep neural network
A Network Intrusion Detection System is a critical component of every internet connected system due to likely attacks from both external and internal sources. A NIDS is used to detect network born attacks such as denial of service attacks, malware, and intruders that are operating within the system. Neural networks have become an increasingly popular solution for network intrusion detection. Their capability of learning complex patterns and behaviors make them a suitable solution for differentiating between normal traffic and network attacks. In this paper, we have applied a deep autoencoded dense neural network algorithm for detecting intrusion or attacks in network connection and evaluated the algorithm with the benchmark NSL-KDD dataset. Our results showed an excellent performance with an overall detection accuracy of 99.3% for Probe, Remote to Local, Denial of Service and User to Root type of attacks. We also presented a comparison with recent approaches used in literature which showed a substantial improvement in terms of accuracy and speed of detection with the proposed algorithm
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this study we have addressed this by investigating the immediate effects of WNT signalling activation within the stomach epithelium. We have specifically activated the WNT signalling pathway within the mouse adult gastric epithelium via deletion of either glycogen synthase kinase 3 (GSK3) or APC or via expression of a constitutively active Ξ²-catenin protein. WNT pathway deregulation dramatically affects stomach homoeostasis at very short latencies. In the corpus, there is rapid loss of parietal cells with fundic gland polyp (FGP) formation and adenomatous change, which are similar to those observed in familial adenomatous polyposis. In the antrum, adenomas occur from 4 days post-WNT activation. Taken together, these data show a pivotal role for WNT signalling in gastric homoeostasis, FGP formation and adenomagenesis. Loss of the parietal cell population and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral adenoma formation are immediate effects of nuclear Ξ²-catenin translocation and WNT target gene expression. Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach
Risk of Venous Thromboembolic Complications in Patients with Atrial Fibrillation: a Systematic Review and Meta-analysis
Aim: The aim of this meta-analysis and systematic review was to evaluate the possible connection between AF and VTE.Material and methods. Atrial fibrillation (AF) and atrial flutter (AFL) contribute to intra-atrial blood stasis which leads to thrombus formation with its embolization. There is some evidence that AF can be a risk factor for deep vein thrombosis (DVT) and pulmonary embolism (PE). The following databases were searched: PubMed (MEDLINE), EMBASE, Google Scholar, the Cochrane Central Register of Controlled Trials. The time frame for conducting a systematic literature search ranged from January 1, 1990 to November 1, 2021. The diagnosis of atrial fibrillation had to be confirmed by using ECG. The diagnosis of VTE could be made with Doppler imaging, ventilation/perfusion scan, CT angiography, venography, angiography or autopsy. Only the three studies with 102192 patients meeting the requirement were included in the meta-analysis.Results. The prevalence of DVT and PE were assessed using incidence rate ratios (IRR) method of the inverse variance random effects model and its 95% confidence interval (CI). The significant association between atrial fibrillation and pulmonary embolism was found (IRR, 4.18 95% Cl 1.958.98). Also there is obvious association between DVT and AF (IRR, 2.97 95% Cl 2.18-4.03).Conclusion. It can be concluded that the increased risk of developing VTE is associatedwith concomitant AF
The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A
We report the early discovery of the optical afterglow of gamma-ray burst
(GRB) 140801A in the 137 deg 3- error-box of the Fermi Gamma-ray
Burst Monitor (GBM). MASTER is the only observatory that automatically react to
all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart
was discovered solely from its GBM localization. The optical afterglow of GRB
140801A was found by MASTER Global Robotic Net 53 sec after receiving the
alert, making it the fastest optical detection of a GRB from a GBM error-box.
Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA
of SAO RAS reveals a redshift of . We performed optical and
near-infrared photometry of GRB 140801A using different telescopes with
apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many
ways. The rest-frame bolometric isotropic energy release and peak energy of the
burst is erg and
keV, respectively, which is consistent with the
Amati relation. The absence of a jet break in the optical light curve provides
a lower limit on the half-opening angle of the jet deg. The
observed is consistent with the limit derived from the
Ghirlanda relation. The joint Fermi GBM and Konus-Wind analysis shows that GRB
140801A could belong to the class of intermediate duration. The rapid detection
of the optical counterpart of GRB 140801A is especially important regarding the
upcoming experiments with large coordinate error-box areas.Comment: in press MNRAS, 201
ΠΠ½ΡΡΡΠΈΠ±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΡΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ Ρ ΠΎΠ½ΠΊΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
The objective of the study was to analyze the taxonomic structure of urinary infection pathogens and determine the susceptibility of ESKAPE group microorganisms (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus spp.) isolated from cancer patients with nosocomial infections in 2018β2020 to antimicrobials.Materials and methods. 413 (71.9 %) strains of ESKAPE group bacteria from 228 patients were studied. Microorganisms were identified and antibiotic resistance was determined using Vitek-2 System (France) and MicroScan WalkAway (Germany / USA) analyzers.Results and conclusion. All gram-positive microorganisms were highly sensitive to vancomycin and teicoplanin, linezolid, tigecycline, and daptomycin, which can be used in the treatment if clinical indications are seen. Among gram-negative bacteria, the percentage of ESBL producers was 60β70 %, the percentage of carbapenem-resistant bacteria was minimalfor E. coli, rnmpared to the rest - 40β50 %, demonstrating the need to limit the use of carbapenems in the clinic.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β Π°Π½Π°Π»ΠΈΠ· ΡΠ°ΠΊΡΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ Ρ ΠΎΠ½ΠΊΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
, ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π³ΡΡΠΏΠΏΡ ESKAPE (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus spp.), Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ Π²ΡΠ΄Π΅Π»ΡΠ΅ΠΌΡΡ
ΠΏΡΠΈ Π½ΠΎΠ·ΠΎΠΊΠΎΠΌΠΈΠ°Π»ΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡΡ
ΠΈ ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ
Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡΡ ΠΊ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ, Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ 2018β2020 Π³Π³.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΎΡ 228 Π±ΠΎΠ»ΡΠ½ΡΡ
(574 ΡΡΠ°ΠΌΠΌΠ° ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ²). ΠΠ°ΠΊΡΠ΅ΡΠΈΠΈ Π³ΡΡΠΏΠΏΡ ESKAPE ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 413 (71,9 %) ΡΡΠ°ΠΌΠΌΠΎΠ². ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈΡ
Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½Π°Π»ΠΈΠ·Π°ΡΠΎΡΠ°Ρ
Vitek-2 System (Π€ΡΠ°Π½ΡΠΈΡ), MicroScan WalkAway (ΠΠ΅ΡΠΌΠ°Π½ΠΈΡ / Π‘Π¨Π).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠ΅ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ Π±Π°ΠΊΡΠ΅ΡΠΈΠΈ Π±ΡΠ»ΠΈ Π²ΡΡΠΎΠΊΠΎΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½Ρ ΠΊ Π²Π°Π½ΠΊΠΎΠΌΠΈΡΠΈΠ½Ρ ΠΈ ΡΠ΅ΠΉΠΊΠΎΠΏΠ»Π°Π½ΠΈΠ½Ρ, Π»ΠΈΠ½Π΅Π·ΠΎΠ»ΠΈΠ΄Ρ, ΡΠΈΠ³Π΅ΡΠΈΠΊΠ»ΠΈΠ½Ρ ΠΈ Π΄Π°ΠΏΡΠΎΠΌΠΈΡΠΈΠ½Ρ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ. Π‘ΡΠ΅Π΄ΠΈ Π³ΡΠ°ΠΌ-ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠ² Π±Π΅ΡΠ°-Π»Π°ΠΊΡΠ°ΠΌΠ°Π·ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 60β 70 %, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ Π±ΡΠ»ΠΎ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ E. coli β 6 %, Π΄Π»Ρ ΠΎΡΡΠ°Π»ΡΠ½ΡΡ
β 40β50 %, ΡΡΠΎ Π΄ΠΈΠΊΡΡΠ΅Ρ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΡΠ±Π°ΠΏΠ΅Π½Π΅ΠΌΠΎΠ² Π² ΠΎΠ½ΠΊΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅
Salinity modulates thermotolerance, energy metabolism and stress response in amphipods Gammarus lacustris
Temperature and salinity are important abiotic factors for aquatic invertebrates. We investigated the influence of different salinity regimes on thermotolerance, energy metabolism and cellular stress defense mechanisms in amphipods Gammarus lacustris Sars from two populations. We exposed amphipods to different thermal scenarios and determined their survival as well as activity of major antioxidant enzymes (peroxidase, catalase, glutathione S-transferase) and parameters of energy metabolism (content of glucose, glycogen, ATP, ADP, AMP and lactate). Amphipods from a freshwater population were more sensitive to the thermal challenge, showing higher mortality during acute and gradual temperature change compared to their counterparts from a saline lake. A more thermotolerant population from a saline lake had high activity of antioxidant enzymes. The energy limitations of the freshwater population (indicated by low baseline glucose levels, downward shift of the critical temperature of aerobic metabolism and inability to maintain steady-state ATP levels during warming) was observed, possibly reflecting a trade-off between the energy demands for osmoregulation under the hypo-osmotic condition of a freshwater environment and protection against temperature stress
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