364 research outputs found

    A flaring X-ray pulsar in Dorado

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    A study of unusual gamma-ray bursts detected on March 5 and March 6, 1979 in the KONUS experiment on the Venera 11 and Venera 12 spacecraft shows their source to be flaring X-ray pulsar in Dorado

    Preliminary results of a gamma-ray burst study in the Konus experiment on the Venera-11 and Venera-12 space probes

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    Twenty-one gamma-ray bursts and 68 solar flares in the hard X-ray range were detected on Venera-11 and Venera-12 space probes during the initial 50-day observation period. Major characteristics of the equipment used and preliminary data on the temporal structure and energy spectra of the gamma-ray bursts are considered. The pattern of gamma-ray burst frequency distribution vs. intensity, N(S), is established

    Anomalous Thermal Stability of Metastable C_20 Fullerene

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    The results of computer simulation of the dynamics of fullerene C_20 at different temperatures are presented. It is shown that, although it is metastable, this isomer is very stable with respect to the transition to a lower energy configuration and retains its chemical structure under heating to very high temperatures, T ~ 3000 K. Its decay activation energy is found to be E_a ~ 7 eV. Possible decay channels are studied, and the height of the minimum potential barrier to decay is determined to be U = 5.0 eV. The results obtained make it possible to understand the reasons for the anomalous stability of fullerene C_20 under normal conditions.Comment: Slightly corrected version of the paper submitted to Phys. Solid Stat

    On Problem of Professional Training of Social Workers within the Framework of Higher Education

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    The issue of training of social workers in higher education is considered. The relevance of the research is caused by changes of socio-economic and technological nature, taking place in modern society, implying the training of specialists of higher level: β€œmulti-functional,” meeting international standards of training professionals to implement certain urgent tasks. Professionalization refers to the process of improving a person’s knowledge, skills and abilities in the context of an activity that involves the presence of a certain subject represented in the culture of a given society, and ways of working with it. The authors rely on the indicators of the level of professional training offered by Yu. P. Povarenkov: professional effectiveness, professional identity and professional maturity. The novelty of the research lies in destinguishing three levels of β€œco-existence essence” of professional training of social professionals: adaptive-orientational, subject-effective and innovative-creative. The authors dwell on the position, according to which the student evolves as a subject of activity only in certain educational conditions: motivating environment of the educational institution as a factor contributing to the active development of new knowledge, skills and abilities; well-organized training and education aimed at increasing the effectiveness of students and teachers; tracking the dynamics of creative development of students, their improvement in personal and professional relationships

    Intrusion detection and classification with autoencoded deep neural network

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    A Network Intrusion Detection System is a critical component of every internet connected system due to likely attacks from both external and internal sources. A NIDS is used to detect network born attacks such as denial of service attacks, malware, and intruders that are operating within the system. Neural networks have become an increasingly popular solution for network intrusion detection. Their capability of learning complex patterns and behaviors make them a suitable solution for differentiating between normal traffic and network attacks. In this paper, we have applied a deep autoencoded dense neural network algorithm for detecting intrusion or attacks in network connection and evaluated the algorithm with the benchmark NSL-KDD dataset. Our results showed an excellent performance with an overall detection accuracy of 99.3% for Probe, Remote to Local, Denial of Service and User to Root type of attacks. We also presented a comparison with recent approaches used in literature which showed a substantial improvement in terms of accuracy and speed of detection with the proposed algorithm

    Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

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    A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this study we have addressed this by investigating the immediate effects of WNT signalling activation within the stomach epithelium. We have specifically activated the WNT signalling pathway within the mouse adult gastric epithelium via deletion of either glycogen synthase kinase 3 (GSK3) or APC or via expression of a constitutively active Ξ²-catenin protein. WNT pathway deregulation dramatically affects stomach homoeostasis at very short latencies. In the corpus, there is rapid loss of parietal cells with fundic gland polyp (FGP) formation and adenomatous change, which are similar to those observed in familial adenomatous polyposis. In the antrum, adenomas occur from 4 days post-WNT activation. Taken together, these data show a pivotal role for WNT signalling in gastric homoeostasis, FGP formation and adenomagenesis. Loss of the parietal cell population and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral adenoma formation are immediate effects of nuclear Ξ²-catenin translocation and WNT target gene expression. Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach

    Risk of Venous Thromboembolic Complications in Patients with Atrial Fibrillation: a Systematic Review and Meta-analysis

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    Aim: The aim of this meta-analysis and systematic review was to evaluate the possible connection between AF and VTE.Material and methods. Atrial fibrillation (AF) and atrial flutter (AFL) contribute to intra-atrial blood stasis which leads to thrombus formation with its embolization. There is some evidence that AF can be a risk factor for deep vein thrombosis (DVT) and pulmonary embolism (PE). The following databases were searched: PubMed (MEDLINE), EMBASE, Google Scholar, the Cochrane Central Register of Controlled Trials. The time frame for conducting a systematic literature search ranged from January 1, 1990 to November 1, 2021. The diagnosis of atrial fibrillation had to be confirmed by using ECG. The diagnosis of VTE could be made with Doppler imaging, ventilation/perfusion scan, CT angiography, venography, angiography or autopsy. Only the three studies with 102192 patients meeting the requirement were included in the meta-analysis.Results. The prevalence of DVT and PE were assessed using incidence rate ratios (IRR) method of the inverse variance random effects model and its 95% confidence interval (CI). The significant association between atrial fibrillation and pulmonary embolism was found (IRR, 4.18 95% Cl 1.958.98). Also there is obvious association between DVT and AF (IRR, 2.97 95% Cl 2.18-4.03).Conclusion. It can be concluded that the increased risk of developing VTE is associatedwith concomitant AF

    The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

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    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg2^2 3-Οƒ\sigma error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of z=1.32z=1.32. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is Eiso=5.54βˆ’0.24+0.26Γ—1052E_\mathrm{iso} = 5.54_{-0.24}^{+0.26} \times 10^{52} erg and Ep,rest≃280E_\mathrm{p, rest}\simeq280 keV, respectively, which is consistent with the Amati relation. The absence of a jet break in the optical light curve provides a lower limit on the half-opening angle of the jet ΞΈ=6.1\theta=6.1 deg. The observed EpeakE_\mathrm{peak} is consistent with the limit derived from the Ghirlanda relation. The joint Fermi GBM and Konus-Wind analysis shows that GRB 140801A could belong to the class of intermediate duration. The rapid detection of the optical counterpart of GRB 140801A is especially important regarding the upcoming experiments with large coordinate error-box areas.Comment: in press MNRAS, 201

    Π’Π½ΡƒΡ‚Ρ€ΠΈΠ±ΠΎΠ»ΡŒΠ½ΠΈΡ‡Π½Ρ‹Π΅ ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΎΠ½Π½Ρ‹Π΅ ослоТнСния Ρƒ онкоурологичСских Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…

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    The objective of the study was to analyze the taxonomic structure of urinary infection pathogens and determine the susceptibility of ESKAPE group microorganisms (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus spp.) isolated from cancer patients with nosocomial infections in 2018β€”2020 to antimicrobials.Materials and methods. 413 (71.9 %) strains of ESKAPE group bacteria from 228 patients were studied. Microorganisms were identified and antibiotic resistance was determined using Vitek-2 System (France) and MicroScan WalkAway (Germany / USA) analyzers.Results and conclusion. All gram-positive microorganisms were highly sensitive to vancomycin and teicoplanin, linezolid, tigecycline, and daptomycin, which can be used in the treatment if clinical indications are seen. Among gram-negative bacteria, the percentage of ESBL producers was 60β€”70 %, the percentage of carbapenem-resistant bacteria was minimalfor E. coli, rnmpared to the rest - 40β€”50 %, demonstrating the need to limit the use of carbapenems in the clinic.ЦСль исслСдования β€” Π°Π½Π°Π»ΠΈΠ· таксономичСской структуры Π²ΠΎΠ·Π±ΡƒΠ΄ΠΈΡ‚Π΅Π»Π΅ΠΉ урологичСских ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΉ Ρƒ онкоурологичСских Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…, сравнСниС Ρ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ ΠΊ Π°Π½Ρ‚ΠΈΠ±ΠΈΠΎΡ‚ΠΈΠΊΠ°ΠΌ ΠΌΠΈΠΊΡ€ΠΎΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π³Ρ€ΡƒΠΏΠΏΡ‹ ESKAPE (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus spp.), Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ часто выдСляСмых ΠΏΡ€ΠΈ Π½ΠΎΠ·ΠΎΠΊΠΎΠΌΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… инфСкциях ΠΈ ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‰ΠΈΡ… наибольшСй Ρ€Π΅Π·ΠΈΡΡ‚Π΅Π½Ρ‚Π½ΠΎΡΡ‚ΡŒΡŽ ΠΊ Π°Π½Ρ‚ΠΈΠ±ΠΈΠΎΡ‚ΠΈΠΊΠ°ΠΌ, Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ 2018β€”2020 Π³Π³.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ микробиологичСских исслСдований биологичСских ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ² ΠΎΡ‚ 228 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… (574 ΡˆΡ‚Π°ΠΌΠΌΠ° ΠΌΠΈΠΊΡ€ΠΎΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠΎΠ²). Π‘Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΈ Π³Ρ€ΡƒΠΏΠΏΡ‹ ESKAPE составили 413 (71,9 %) ΡˆΡ‚Π°ΠΌΠΌΠΎΠ². Π˜Π΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡ Π²Ρ‹Π΄Π΅Π»Π΅Π½Π½Ρ‹Ρ… ΠΌΠΈΠΊΡ€ΠΎΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΈ установлСниС ΠΈΡ… Π°Π½Ρ‚ΠΈΠ±ΠΈΠΎΡ‚ΠΈΠΊΠΎΡ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ‹ Π½Π° автоматичСских микробиологичСских Π°Π½Π°Π»ΠΈΠ·Π°Ρ‚ΠΎΡ€Π°Ρ… Vitek-2 System (Ѐранция), MicroScan WalkAway (ГСрмания / БША).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ Π·Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ВсС Π³Ρ€Π°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΈ Π±Ρ‹Π»ΠΈ Π²Ρ‹ΡΠΎΠΊΠΎΡ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ ΠΊ Π²Π°Π½ΠΊΠΎΠΌΠΈΡ†ΠΈΠ½Ρƒ ΠΈ Ρ‚Π΅ΠΉΠΊΠΎΠΏΠ»Π°Π½ΠΈΠ½Ρƒ, Π»ΠΈΠ½Π΅Π·ΠΎΠ»ΠΈΠ΄Ρƒ, Ρ‚ΠΈΠ³Π΅Ρ†ΠΈΠΊΠ»ΠΈΠ½Ρƒ ΠΈ Π΄Π°ΠΏΡ‚ΠΎΠΌΠΈΡ†ΠΈΠ½Ρƒ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ Π² Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ клиничСских ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΠΉ. Π‘Ρ€Π΅Π΄ΠΈ Π³Ρ€Π°ΠΌ-ΠΎΡ‚Ρ€ΠΈΡ†Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ количСство ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚ΠΎΠ² Π±Π΅Ρ‚Π°-Π»Π°ΠΊΡ‚Π°ΠΌΠ°Π·Ρ€Π°ΡΡˆΠΈΡ€Π΅Π½Π½ΠΎΠ³ΠΎ спСктра составило 60β€” 70 %, количСство карбапСнСмрСзистСнтных Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ Π±Ρ‹Π»ΠΎ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹ΠΌ Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ E. coli β€” 6 %, для ΠΎΡΡ‚Π°Π»ΡŒΠ½Ρ‹Ρ… β€” 40β€”50 %, Ρ‡Ρ‚ΠΎ Π΄ΠΈΠΊΡ‚ΡƒΠ΅Ρ‚ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡ΠΈΡ‚ΡŒ использованиС ΠΊΠ°Ρ€Π±Π°ΠΏΠ΅Π½Π΅ΠΌΠΎΠ² Π² онкоурологичСской ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅

    Salinity modulates thermotolerance, energy metabolism and stress response in amphipods Gammarus lacustris

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    Temperature and salinity are important abiotic factors for aquatic invertebrates. We investigated the influence of different salinity regimes on thermotolerance, energy metabolism and cellular stress defense mechanisms in amphipods Gammarus lacustris Sars from two populations. We exposed amphipods to different thermal scenarios and determined their survival as well as activity of major antioxidant enzymes (peroxidase, catalase, glutathione S-transferase) and parameters of energy metabolism (content of glucose, glycogen, ATP, ADP, AMP and lactate). Amphipods from a freshwater population were more sensitive to the thermal challenge, showing higher mortality during acute and gradual temperature change compared to their counterparts from a saline lake. A more thermotolerant population from a saline lake had high activity of antioxidant enzymes. The energy limitations of the freshwater population (indicated by low baseline glucose levels, downward shift of the critical temperature of aerobic metabolism and inability to maintain steady-state ATP levels during warming) was observed, possibly reflecting a trade-off between the energy demands for osmoregulation under the hypo-osmotic condition of a freshwater environment and protection against temperature stress
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