Prescription Opioid Abuse in Prison Settings: A Systematic Review of Prevalence, Practice and Treatment Responses

Background To systematically review the quantitative and qualitative evidence base pertaining to the prevalence, practice of, and treatment response to the diversion of prescribed opiates in the prison setting. Methods Medline, Embase, CINAHL, PsycINFO, Google Scholar, ASSIA and Science Direct databases were searched for papers from 1995 to the present relevant to the abuse of prescribed opiate medication. Identified journals and their reference lists were hand searched for other relevant articles. Of the abstracts identified as relevant, full text papers were retrieved and critiqued against the inclusion criteria for the review. Results Three hundred and fifty-five abstracts were identified, leading to 42 full-text articles being retrieved. Of those, 10 papers were included in the review. Significant differences in abuse behaviours between different countries were reported. However, a key theme emerged from the data regarding a culture of nasal administration of prescribed sublingual buprenorphine within some prisons due to 3 both reduced prevalence of injection within prison and reduced supplies of illicit drugs within prison. The buprenorphine/naloxone preparation appears to be less amenable to abuse. The review highlighted a paucity of empirical research pertaining to both prevalence of the phenomenon and treatment responses. Clinical and research implications Healthcare providers within prisons need to prescribe opioids in the least abuseable preparation since the risk of abuse is significant, despite widespread processes of supervised dispensing. Prescription medication abuse is not limited to opioids and the predominant drug of abuse in an individual prison can rapidly change according to availability

Investigation of dietary fiber, protein, vitamin E and other nutritional compounds of banana flower of two cultivars grown in China

The nutritional composition of banana flowers of two cultivars [cvs. Baxijiao (AAA) and Paradisical (AAB)] grown in Hainan of China has been studied. Flower samples were collected and extracted according to methods of Association of Official Analytical Chemists (AOAC). Results showed thatbanana flowers contained abundant dietary fiber (4.96-5.74 g/100g) and proteins (1.62-2.07 g/100 g). The major amino acids are glycine, leucine, alanine, and aspartic acid. Lysine had a lowest chemical score of 64% among the essential amino acids. In both species, flowers contained a higher composition of unsaturated fatty acids (65-66%), mainly the linoleic acid, while saturated fatty acids (mainly palmitic acid) is low. The contents of vitamin E, total saponin and flavonoids were 0.87-1.07, 0.12 and 5.27–5.90mg/100 g, respectively. This study provides a fundamental nutritional data of banana flowers which can be essential in food science

W3 Is a New Wax Locus That Is Essential for Biosynthesis of beta-Diketone, Development of Glaucousness, and Reduction of Cuticle Permeability in Common Wheat

Citation: Zhang, Z. Z., Wei, W. J., Zhu, H. L., Challa, G. S., Bi, C. L., Trick, H. N., & Li, W. L. (2015). W3 Is a New Wax Locus That Is Essential for Biosynthesis of beta-Diketone, Development of Glaucousness, and Reduction of Cuticle Permeability in Common Wheat. Plos One, 10(10), 21. doi:10.1371/journal.pone.0140524The cuticle plays important roles in plant development, growth and defense against biotic and abiotic attacks. Crystallized epicuticular wax, the outermost layer of cuticle, is visible as white-bluish glaucousness. In crops like barley and wheat, glaucousness is trait of adaption to the dry and hot cultivation conditions, and hentriacontane-14,16-dione (beta-diketone) and its hydroxy derivatives are the major and unique components of cuticular wax in the upper parts of adult plants. But their biosynthetic pathway and physiological role largely remain unknown. In the present research, we identified a novel wax mutant in wheat cultivar Bobwhite. The mutation is not allelic to the known wax production gene loci W1 and W2, and designated as W3 accordingly. Genetic analysis localized W3 on chromosome arm 2BS. The w3 mutation reduced 99% of beta-diketones, which account for 63.3% of the total wax load of the wild-type. W3 is necessary for beta-diketone synthesis, but has a different effect on beta-diketone hydroxylation because the hydroxy-beta-diketones to beta-diketone ratio increased 11-fold in the w3 mutant. Loss of beta-diketones caused failure to form glaucousness and significant increase of cuticle permeability in terms of water loss and chlorophyll efflux in the w3 mutant. Transcription of 23 cuticle genes from five functional groups was altered in the w3 mutant, 19 down-regulated and four up-regulated, suggesting a possibility that W3 encodes a transcription regulator coordinating expression of cuticle genes. Biosynthesis of beta-diketones in wheat and their implications in glaucousness formation and drought and heat tolerance were discussed.Citation: Zhang, Z., . . . & Wanlong, Li. (2015). W3 Is a New Wax Locus That Is Essential for Biosynthesis of β-Diketone, Development of Glaucousness, and Reduction of Cuticle Permeability in Common Wheat. PLoS One, 10(10), 1-21. https://doi.org/10.1371/journal.pone.014052

On higher analogues of Courant algebroids

In this paper, we study the algebraic properties of the higher analogues of Courant algebroid structures on the direct sum bundle $TM\oplus\wedge^nT^*M$ for an $m$-dimensional manifold. As an application, we revisit Nambu-Poisson structures and multisymplectic structures. We prove that the graph of an $(n+1)$-vector field $\pi$ is closed under the higher-order Dorfman bracket iff $\pi$ is a Nambu-Poisson structure. Consequently, there is an induced Leibniz algebroid structure on $\wedge^nT^*M$. The graph of an $(n+1)$-form $\omega$ is closed under the higher-order Dorfman bracket iff $\omega$ is a premultisymplectic structure of order $n$, i.e. \dM\omega=0. Furthermore, there is a Lie algebroid structure on the admissible bundle $A\subset\wedge^{n}T^*M$. In particular, for a 2-plectic structure, it induces the Lie 2-algebra structure given in \cite{baez:classicalstring}.Comment: 13 page

Spectral Parameters for Scattering Amplitudes in N=4 Super Yang-Mills Theory

49 pages, 20 figures; v2: typos fixedPlanar N=4 Super Yang-Mills theory appears to be a quantum integrable four-dimensional conformal theory. This has been used to find equations believed to describe its exact spectrum of anomalous dimensions. Integrability seemingly also extends to the planar space-time scattering amplitudes of the N=4 model, which show strong signs of Yangian invariance. However, in contradistinction to the spectral problem, this has not yet led to equations determining the exact amplitudes. We propose that the missing element is the spectral parameter, ubiquitous in integrable models. We show that it may indeed be included into recent on-shell approaches to scattering amplitude integrands, providing a natural deformation of the latter. Under some constraints, Yangian symmetry is preserved. Finally we speculate that the spectral parameter might also be the regulator of choice for controlling the infrared divergences appearing when integrating the integrands in exactly four dimensions.Peer reviewe

Numerical results for the exact spectrum of planar AdS4/CFT3

We compute the anomalous dimension for a short single-trace operator in planar ABJM theory at intermediate coupling. This is done by solving numerically the set of Thermodynamic Bethe Ansatz equations which are expected to describe the exact spectrum of the theory. We implement a truncation method which significantly reduces the number of integral equations to be solved and improves numerical efficiency. Results are obtained for a range of 't Hooft coupling lambda corresponding to $0 \leq h(\lambda) \leq 1$, where h(lambda) is the interpolating function of the AdS4/CFT3 Bethe equations.Comment: v3: corrected Acknowledgements section; v4: minor changes, published version; v5: fixed typos in Eq. (3.9

Exploring professionals' understanding, interpretation and implementation of the 'appropriate medical treatment test' in the 2007 amendment of the Mental Health Act 1983.

BACKGROUND: The appropriate medical treatment test (ATT), included in the Mental Health Act (MHA) (1983, as amended 2007), aims to ensure that detention only occurs when treatment with the purpose of alleviating a mental disorder is available. AIMS: As part of the Assessing the Impact of the Mental Health Act (AMEND) project, this qualitative study aimed to assess professionals' understanding of the ATT, and its impact on clinical practice. METHOD: Forty-one professionals from a variety of mental health subspecialties were interviewed. Interviews were coded related to project aims, and themes were generated in an inductive process. RESULTS: We found that clinicians are often wholly relied upon for the ATT. Considered treatment varied depending on the patient's age rather than diagnosis. The ATT has had little impact on clinical practice. CONCLUSIONS: Our findings suggest the need to review training and support for professionals involved in MHA assessments, with better-defined roles. This may enable professionals to implement the ATT as its designers intended. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license

A Calibration Method for the Integrated Design of Finishing Robotic Workcells in the Aerospace Industry

Industrial robotics provides high flexibility and reconfigurability, cost effectiveness and user friendly programming for many applications but still lacks in accuracy. An effective workcell calibration reduces the errors in robotic manufacturing and contributes to extend the use of industrial robots to perform high quality finishing of complex parts in the aerospace industry. A novel workcell calibration method is embedded in an integrated design framework for an in-depth exploitation of CAD-based simulation and offline programming. The method is composed of two steps: a first offline calibration of the workpiece-independent elements in the workcell layout and a final automated online calibration of workpiece-dependent elements. The method is finally applied to a robotic workcell for finishing aluminum housings of helicopter gear transmissions, characterized by complex and non-repetitive shapes, and by severe dimensional and geometrical accuracy demands. Experimental results demonstrate enhanced performances of the robotic workcell and improved final quality of the housings

Scattering of Giant Magnons in CP^3

We study classical scattering phase of CP^2 dyonic giant magnons in R_t x CP^3. We construct two-soliton solutions explicitly by the dressing method. Using these solutions, we compute the classical time delays for the scattering of giant magnons, and compare them to boundstate S-matrix elements derived from the conjectured AdS_4/CFT_3 S-matrix by Ahn and Nepomechie in the strong coupling limit. Our result is consistent with the conjectured S-matrix. The dyonic solutions play an essential role in revealing the polarization dependence of scattering phase.Comment: 29 pages; v2: minor corrections; v3: minor corrections, references added ; v4: minor corrections ; v5: minor corrections based on the published versio

Lepton Flavor Violation in the SUSY-GUT Models with Lopsided Mass Matrix

The tiny neutrino masses measured in the neutrino oscillation experiments can be naturally explained by the supersymmetric see-saw mechanism. If the supersymmetry breaking is mediated by gravity, the see-saw models may predict observable lepton flavor violating effects. In this work, we investigate the lepton flavor violating process $\mu\to e\gamma$ in the kind of neutrino mass models based on the idea of the ``lopsided'' form of the charged lepton mass matrix. The constraints set by the muon anomalous magnetic moment are taken into account. We find the present models generally predict a much larger branching ratio of $\mu\to e\gamma$ than the experimental limit. Conversely, this process may give strong constraint on the lepton flavor structure. Following this constraint we then find a new kind of the charged lepton mass matrix. The feature of the structure is that both the elements between the 2-3 and 1-3 generations are ``lopsided''. This structure produces a very small 1-3 mixing and a large 1-2 mixing in the charged lepton sector, which naturally leads to small $Br(\mu\to e\gamma)$ and the LMA solution for the solar neutrino problem.Comment: 24 pages, 8 figure