Poster on Presentation of Diyarbakır Plant Protection Research Station

Plant protection research station of Diyarbakır is the one of the research institution authorized by Ministry of Food Agriculture and Livestock to be lead institution on Organic Agriculture and Good Agricultural Practices

Determination of some physicochemical properties of honeys from Tokat region and their compliance with the Turkish Food Codex

Bu çalışmada; bitki çeşitliliğinin oldukça fazla olduğu Tokat ili ve ilçelerinden temin edilen balların bazı fiziksel ve kimyasal özellikleri belirlenmiştir. 2019 ve 2020 yıllarında 12 ilçeden temin edilen (toplam 24 adet) çiçek balı örneklerinin Türk Standartları (TS) 3036 Bal Standardı ve uluslararası standartlarda kabul görmüş analiz metotları ile yapılan bazı fizikokimyasal, pestisit ve mineral analizleri sonuçlarının Türk Gıda Kodeksi (TGK) Bal Tebliği’ne (2020/7) uygunlukları incelenmiştir. Bal örneklerinde nem miktarı %13,0-20,0; serbest asitlik 26±0,12-48±0,16 meq/kg; elektriksel iletkenlik 0,33-0,86 mS/cm; Hidroksimetilfurfural (HMF) miktarı 0,05-8,69 mg/kg; prolin değeri 422,56-1222,56 mg/kg; diastaz sayısı 0,0-10,9; protein ve ham bal Δ13 C farkı-0.84-1.23; C4 şeker oranı %0,0-5,26; sakkaroz miktarı %0,30- 1,96; früktoz+glikoz miktarı %62,54-76,67; früktoz/glikoz oranı 0,98-2,62 olarak belirlenmiştir. Bal örneklerinde toplam üç numunede pestisit tespit edilmiştir. Bunlar triamenol+triadimefon, metrafenone, cypermethrin, boscalid, deltamethrin, kresoxim methyl olup üç örnekte sınır değerleri aşılmış olup, diğer örneklerde ise limit değerleri aralığındadır. Balların mineral içerikleri (mg/kg); çinko (Zn) 0,0-24,306; nikel (Ni) 0,0-2,906; krom (Cr) 0,0- 3,850; mangan (Mn) 0,0-4,660; bakır (Cu) 0,0-17,099; kurşun (Pb) içeriği 0,314-2,729 aralığında tespit edilmiştir. Örneklerin toplam fenolik madde miktarları 254,14-776,94 μg GAE/g bal; serbest radikali giderme aktivitesi 129,47-587,37 μg TE/g bal; katyon radikali giderme aktivitesi 93,33-1187,78 μg TE/g bal aralıklarındadır.In this study; some physical and chemical properties of honey taken from the districts of Tokat province, where plant diversity is quite high, were determined. Results of some physicochemical, pesticide, and mineral analyses conducted with Turkish Standards (TS) 3036 Honey Standard and internationally accepted analysis methods of flower honey samples (24 in total) obtained from 12 districts in 2019 and 2020 Turkish Food Codex (TGK) Honey Communique (2020/7) has been investigated for compliance. Moisture content in honey samples is 13.0-20%; total acidity 26 }0.12- 48 }0.16 meq/kg; electrical conductivity 0.33-0.86 mS/cm; the amount of hydroxymethylfurfural (HMF) 0.05-8.69 mg/kg; proline value 422.56-1222.56 mg/kg; diastase number 0.0-10.9; protein and raw honey Δ13 C difference -0.84-1.23; C4 sugar content 0.0-5.26%; amount of sucrose 0.30-1.96%; fructose+glucose amount 62.54-76.67%; fructose/glucose ratio was determined as 0.98-2.62. Pesticides were detected in a total of three samples in honey samples. These are triamenol+triadimefon, metrafenone, cypermethrin, boscalid, deltamethrin, and kresoxim methyl. In three samples, the limit values are exceeded, and in the other samples, the limit values are in the range. Mineral content of honey (in mg/kg); zinc (Zn) 0.0-24.306; nickel (Ni) 0.0-2.906; chromium (Cr) 0.0-3.850; manganese (Mn) 0.0-4.660; copper (Cu) 0.0-17.099; lead (Pb) content was determined in the range of 0.314-2.729. The total phenolic content of the samples was 254.14-776.94 μg GAE/g honey; free radical scavenging activity was 129.47-587.37 μg TE/g honey; cation radical scavenging activity was in the range of 93.33-1187.78 μg TE/g honey

Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

: O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s disease Z. Hu, P. Wang, Y. Zhu, J. Zhao, M. Xiong, David A Bennett O11 A microRNA signature identifies subtypes of triple-negative breast cancer and reveals MIR-342-3P as regulator of a lactate metabolic pathway A. Hidalgo-Miranda, S. Romero-Cordoba, S. Rodriguez-Cuevas, R. Rebollar-Vega, E. Tagliabue, M. Iorio, E. D’Ippolito, S. Baroni O12 Transcriptome analysis identifies genes, enhancer RNAs and repetitive elements that are recurrently deregulated across multiple cancer types B. Kaczkowski, Y. Tanaka, H. Kawaji, A. Sandelin, R. Andersson, M. Itoh, T. Lassmann, the FANTOM5 consortium, Y. Hayashizaki, P. Carninci, A. R. R. Forrest O13 Elevated mutation and widespread loss of constraint at regulatory and architectural binding sites across 11 tumour types C. A. Semple O14 Exome sequencing provides evidence of pathogenicity for genes implicated in colorectal cancer E. A. Rosenthal, B. Shirts, L. Amendola, C. Gallego, M. Horike-Pyne, A. Burt, P. Robertson, P. Beyers, C. Nefcy, D. Veenstra, F. Hisama, R. Bennett, M. Dorschner, D. Nickerson, J. Smith, K. Patterson, D. Crosslin, R. Nassir, N. Zubair, T. Harrison, U. Peters, G. Jarvik, NHLBI GO Exome Sequencing Project O15 The tandem duplicator phenotype as a distinct genomic configuration in cancer F. Menghi, K. Inaki, X. Woo, P. Kumar, K. Grzeda, A. Malhotra, H. Kim, D. Ucar, P. Shreckengast, K. Karuturi, J. Keck, J. Chuang, E. T. Liu O16 Modeling genetic interactions associated with molecular subtypes of breast cancer B. Ji, A. Tyler, G. Ananda, G. Carter O17 Recurrent somatic mutation in the MYC associated factor X in brain tumors H. Nikbakht, M. Montagne, M. Zeinieh, A. Harutyunyan, M. Mcconechy, N. Jabado, P. Lavigne, J. Majewski O18 Predictive biomarkers to metastatic pancreatic cancer treatment J. B. Goldstein, M. Overman, G. Varadhachary, R. Shroff, R. Wolff, M. Javle, A. Futreal, D. Fogelman O19 DDIT4 gene expression as a prognostic marker in several malignant tumors L. Bravo, W. Fajardo, H. Gomez, C. Castaneda, C. Rolfo, J. A. Pinto O20 Spatial organization of the genome and genomic alterations in human cancers K. C. Akdemir, L. Chin, A. Futreal, ICGC PCAWG Structural Alterations Group O21 Landscape of targeted therapies in solid tumors S. Patterson, C. Statz, S. Mockus O22 Genomic analysis reveals novel drivers and progression pathways in skin basal cell carcinoma S. N. Nikolaev, X. I. Bonilla, L. Parmentier, B. King, F. Bezrukov, G. Kaya, V. Zoete, V. Seplyarskiy, H. Sharpe, T. McKee, A. Letourneau, P. Ribaux, K. Popadin, N. Basset-Seguin, R. Ben Chaabene, F. Santoni, M. Andrianova, M. Guipponi, M. Garieri, C. Verdan, K. Grosdemange, O. Sumara, M. Eilers, I. Aifantis, O. Michielin, F. de Sauvage, S. Antonarakis O23 Identification of differential biomarkers of hepatocellular carcinoma and cholangiocarcinoma via transcriptome microarray meta-analysis S. Likhitrattanapisal O24 Clinical validity and actionability of multigene tests for hereditary cancers in a large multi-center study S. Lincoln, A. Kurian, A. Desmond, S. Yang, Y. Kobayashi, J. Ford, L. Ellisen O25 Correlation with tumor ploidy status is essential for correct determination of genome-wide copy number changes by SNP array T. L. Peters, K. R. Alvarez, E. F. Hollingsworth, D. H. Lopez-Terrada O26 Nanochannel based next-generation mapping for interrogation of clinically relevant structural variation A. Hastie, Z. Dzakula, A. W. Pang, E. T. Lam, T. Anantharaman, M. Saghbini, H. Cao, BioNano Genomics O27 Mutation spectrum in a pulmonary arterial hypertension (PAH) cohort and identification of associated truncating mutations in TBX4 C. Gonzaga-Jauregui, L. Ma, A. King, E. Berman Rosenzweig, U. Krishnan, J. G. Reid, J. D. Overton, F. Dewey, W. K. Chung O28 NORTH CAROLINA macular dystrophy (MCDR1): mutations found affecting PRDM13 K. Small, A. DeLuca, F. Cremers, R. A. Lewis, V. Puech, B. Bakall, R. Silva-Garcia, K. Rohrschneider, M. Leys, F. S. Shaya, E. Stone O29 PhenoDB and genematcher, solving unsolved whole exome sequencing data N. L. Sobreira, F. Schiettecatte, H. Ling, E. Pugh, D. Witmer, K. Hetrick, P. Zhang, K. Doheny, D. Valle, A. Hamosh O30 Baylor-Johns Hopkins Center for Mendelian genomics: a four year review S. N. Jhangiani, Z. Coban Akdemir, M. N. Bainbridge, W. Charng, W. Wiszniewski, T. Gambin, E. Karaca, Y. Bayram, M. K. Eldomery, J. Posey, H. Doddapaneni, J. Hu, V. R. Sutton, D. M. Muzny, E. A. Boerwinkle, D. Valle, J. R. Lupski, R. A. Gibbs O31 Using read overlap assembly to accurately identify structural genetic differences in an ashkenazi jewish trio S. Shekar, W. Salerno, A. English, A. Mangubat, J. Bruestle O32 Legal interoperability: a sine qua non for international data sharing A. Thorogood, B. M. Knoppers, Global Alliance for Genomics and Health - Regulatory and Ethics Working Group O33 High throughput screening platform of competent sineups: that can enhance translation activities of therapeutic target H. Takahashi, K. R. Nitta, A. Kozhuharova, A. M. Suzuki, H. Sharma, D. Cotella, C. Santoro, S. Zucchelli, S. Gustincich, P. Carninci O34 The undiagnosed diseases network international (UDNI): clinical and laboratory research to meet patient needs J. J. Mulvihill, G. Baynam, W. Gahl, S. C. Groft, K. Kosaki, P. Lasko, B. Melegh, D. Taruscio O36 Performance of computational algorithms in pathogenicity predictions for activating variants in oncogenes versus loss of function mutations in tumor suppressor genes R. Ghosh, S. Plon O37 Identification and electronic health record incorporation of clinically actionable pharmacogenomic variants using prospective targeted sequencing S. Scherer, X. Qin, R. Sanghvi, K. Walker, T. Chiang, D. Muzny, L. Wang, J. Black, E. Boerwinkle, R. Weinshilboum, R. Gibbs O38 Melanoma reprogramming state correlates with response to CTLA-4 blockade in metastatic melanoma T. Karpinets, T. Calderone, K. Wani, X. Yu, C. Creasy, C. Haymaker, M. Forget, V. Nanda, J. Roszik, J. Wargo, L. Haydu, X. Song, A. Lazar, J. Gershenwald, M. Davies, C. Bernatchez, J. Zhang, A. Futreal, S. Woodman O39 Data-driven refinement of complex disease classification from integration of heterogeneous functional genomics data in GeneWeaver E. J. Chesler, T. Reynolds, J. A. Bubier, C. Phillips, M. A. Langston, E. J. Baker O40 A general statistic framework for genome-based disease risk prediction M. Xiong, L. Ma, N. Lin, C. Amos O41 Integrative large-scale causal network analysis of imaging and genomic data and its application in schizophrenia studies N. Lin, P. Wang, Y. Zhu, J. Zhao, V. Calhoun, M. Xiong O42 Big data and NGS data analysis: the cloud to the rescue O. Dobretsberger, M. Egger, F. Leimgruber O43 Cpipe: a convergent clinical exome pipeline specialised for targeted sequencing S. Sadedin, A. Oshlack, Melbourne Genomics Health Alliance O44 A Bayesian classification of biomedical images using feature extraction from deep neural networks implemented on lung cancer data V. A. A. Antonio, N. Ono, Clark Kendrick C. Go O45 MAV-SEQ: an interactive platform for the Management, Analysis, and Visualization of sequence data Z. Ahmed, M. Bolisetty, S. Zeeshan, E. Anguiano, D. Ucar O47 Allele specific enhancer in EPAS1 intronic regions may contribute to high altitude adaptation of Tibetans C. Zeng, J. Shao O48 Nanochannel based next-generation mapping for structural variation detection and comparison in trios and populations H. Cao, A. Hastie, A. W. Pang, E. T. Lam, T. Liang, K. Pham, M. Saghbini, Z. Dzakula O49 Archaic introgression in indigenous populations of Malaysia revealed by whole genome sequencing Y. Chee-Wei, L. Dongsheng, W. Lai-Ping, D. Lian, R. O. Twee Hee, Y. Yunus, F. Aghakhanian, S. S. Mokhtar, C. V. Lok-Yung, J. Bhak, M. Phipps, X. Shuhua, T. Yik-Ying, V. Kumar, H. Boon-Peng O50 Breast and ovarian cancer prevention: is it time for population-based mutation screening of high risk genes? I. Campbell, M.-A. Young, P. James, Lifepool O53 Comprehensive coverage from low DNA input using novel NGS library preparation methods for WGS and WGBS C. Schumacher, S. Sandhu, T. Harkins, V. Makarov O54 Methods for large scale construction of robust PCR-free libraries for sequencing on Illumina HiSeqX platform H. DoddapaneniR. Glenn, Z. Momin, B. Dilrukshi, H. Chao, Q. Meng, B. Gudenkauf, R. Kshitij, J. Jayaseelan, C. Nessner, S. Lee, K. Blankenberg, L. Lewis, J. Hu, Y. Han, H. Dinh, S. Jireh, K. Walker, E. Boerwinkle, D. Muzny, R. Gibbs O55 Rapid capture methods for clinical sequencing J. Hu, K. Walker, C. Buhay, X. Liu, Q. Wang, R. Sanghvi, H. Doddapaneni, Y. Ding, N. Veeraraghavan, Y. Yang, E. Boerwinkle, A. L. Beaudet, C. M. Eng, D. M. Muzny, R. A. Gibbs O56 A diploid personal human genome model for better genomes from diverse sequence data K. C. C. Worley, Y. Liu, D. S. T. Hughes, S. C. Murali, R. A. Harris, A. C. English, X. Qin, O. A. Hampton, P. Larsen, C. Beck, Y. Han, M. Wang, H. Doddapaneni, C. L. Kovar, W. J. Salerno, A. Yoder, S. Richards, J. Rogers, J. R. Lupski, D. M. Muzny, R. A. Gibbs O57 Development of PacBio long range capture for detection of pathogenic structural variants Q. Meng, M. Bainbridge, M. Wang, H. Doddapaneni, Y. Han, D. Muzny, R. Gibbs O58 Rhesus macaques exhibit more non-synonymous variation but greater impact of purifying selection than humans R. A. Harris, M. Raveenedran, C. Xue, M. Dahdouli, L. Cox, G. Fan, B. Ferguson, J. Hovarth, Z. Johnson, S. Kanthaswamy, M. Kubisch, M. Platt, D. Smith, E. Vallender, R. Wiseman, X. Liu, J. Below, D. Muzny, R. Gibbs, F. Yu, J. Rogers O59 Assessing RNA structure disruption induced by single-nucleotide variation J. Lin, Y. Zhang, Z. Ouyang P1 A meta-analysis of genome-wide association studies of mitochondrial dna copy number A. Moore, Z. Wang, J. Hofmann, M. Purdue, R. Stolzenberg-Solomon, S. Weinstein, D. Albanes, C.-S. Liu, W.-L. Cheng, T.-T. Lin, Q. Lan, N. Rothman, S. Berndt P2 Missense polymorphic genetic combinations underlying down syndrome susceptibility E. S. Chen P4 The evaluation of alteration of ELAM-1 expression in the endometriosis patients H. Bahrami, A. Khoshzaban, S. Heidari Keshal P5 Obesity and the incidence of apolipoprotein E polymorphisms in an assorted population from Saudi Arabia population K. K. R. Alharbi P6 Genome-associated personalized antithrombotical therapy for patients with high risk of thrombosis and bleeding M. Zhalbinova, A. Akilzhanova, S. Rakhimova, M. Bekbosynova, S. Myrzakhmetova P7 Frequency of Xmn1 polymorphism among sickle cell carrier cases in UAE population M. Matar P8 Differentiating inflammatory bowel diseases by using genomic data: dimension of the problem and network organization N. Mili, R. Molinari, Y. Ma, S. Guerrier P9 Vulnerability of genetic variants to the risk of autism among Saudi children N. Elhawary, M. Tayeb, N. Bogari, N. Qotb P10 Chromatin profiles from ex vivo purified dopaminergic neurons establish a promising model to support studies of neurological function and dysfunction S. A. McClymont, P. W. Hook, L. A. Goff, A. McCallion P11 Utilization of a sensitized chemical mutagenesis screen to identify genetic modifiers of retinal dysplasia in homozygous Nr2e3rd7 mice Y. Kong, J. R. Charette, W. L. Hicks, J. K. Naggert, L. Zhao, P. M. Nishina P12 Ion torrent next generation sequencing of recessive polycystic kidney disease in Saudi patients B. M. Edrees, M. Athar, F. A. Al-Allaf, M. M. Taher, W. Khan, A. Bouazzaoui, N. A. Harbi, R. Safar, H. Al-Edressi, A. Anazi, N. Altayeb, M. A. Ahmed, K. Alansary, Z. Abduljaleel P13 Digital expression profiling of Purkinje neurons and dendrites in different subcellular compartments A. Kratz, P. Beguin, S. Poulain, M. Kaneko, C. Takahiko, A. Matsunaga, S. Kato, A. M. Suzuki, N. Bertin, T. Lassmann, R. Vigot, P. Carninci, C. Plessy, T. Launey P14 The evolution of imperfection and imperfection of evolution: the functional and functionless fractions of the human genome D. Graur P16 Species-independent identification of known and novel recurrent genomic entities in multiple cancer patients J. Friis-Nielsen, J. M. Izarzugaza, S. Brunak P18 Discovery of active gene modules which are densely conserved across multiple cancer types reveal their prognostic power and mutually exclusive mutation patterns B. S. Soibam P19 Whole exome sequencing of dysplastic leukoplakia tissue indicates sequential accumulation of somatic mutations from oral precancer to cancer D. Das, N. Biswas, S. Das, S. Sarkar, A. Maitra, C. Panda, P. Majumder P21 Epigenetic mechanisms of carcinogensis by hereditary breast cancer genes J. J. Gruber, N. Jaeger, M. Snyder P22 RNA direct: a novel RNA enrichment strategy applied to transcripts associated with solid tumors K. Patel, S. Bowman, T. Davis, D. Kraushaar, A. Emerman, S. Russello, N. Henig, C. Hendrickson P23 RNA sequencing identifies gene mutations for neuroblastoma K. Zhang P24 Participation of SFRP1 in the modulation of TMPRSS2-ERG fusion gene in prostate cancer cell lines M. Rodriguez-Dorantes, C. D. Cruz-Hernandez, C. D. P. Garcia-Tobilla, S. Solorzano-Rosales P25 Targeted Methylation Sequencing of Prostate Cancer N. Jäger, J. Chen, R. Haile, M. Hitchins, J. D. Brooks, M. Snyder P26 Mutant TPMT alleles in children with acute lymphoblastic leukemia from México City and Yucatán, Mexico S. Jiménez-Morales, M. Ramírez, J. Nuñez, V. Bekker, Y. Leal, E. Jiménez, A. Medina, A. Hidalgo, J. Mejía P28 Genetic modifiers of Alström syndrome J. Naggert, G. B. Collin, K. DeMauro, R. Hanusek, P. M. Nishina P31 Association of genomic variants with the occurrence of angiotensin-converting-enzyme inhibitor (ACEI)-induced coughing among Filipinos E. M. Cutiongco De La Paz, R. Sy, J. Nevado, P. Reganit, L. Santos, J. D. Magno, F. E. Punzalan , D. Ona , E. Llanes, R. L. Santos-Cortes , R. Tiongco, J. Aherrera, L. Abrahan, P. Pagauitan-Alan; Philippine Cardiogenomics Study Group P32 The use of “humanized” mouse models to validate disease association of a de novo GARS variant and to test a novel gene therapy strategy for Charcot-Marie-Tooth disease type 2D K. H. Morelli, J. S. Domire, N. Pyne, S. Harper, R. Burgess P34 Molecular regulation of chondrogenic human induced pluripotent stem cells M. A. Gari, A. Dallol, H. Alsehli, A. Gari, M. Gari, A. Abuzenadah P35 Molecular profiling of hematologic malignancies: implementation of a variant assessment algorithm for next generation sequencing data analysis and clinical reporting M. Thomas, M. Sukhai, S. Garg, M. Misyura, T. Zhang, A. Schuh, T. Stockley, S. Kamel-Reid P36 Accessing genomic evidence for clinical variants at NCBI S. Sherry, C. Xiao, D. Slotta, K. Rodarmer, M. Feolo, M. Kimelman, G. Godynskiy, C. O’Sullivan, E. Yaschenko P37 NGS-SWIFT: a cloud-based variant analysis framework using control-accessed sequencing data from DBGAP/SRA C. Xiao, E. Yaschenko, S. Sherry P38 Computational assessment of drug induced hepatotoxicity through gene expression profiling C. Rangel-Escareño, H. Rueda-Zarate P40 Flowr: robust and efficient pipelines using a simple language-agnostic approach;ultraseq; fast modular pipeline for somatic variation calling using flowr S. Seth, S. Amin, X. Song, X. Mao, H. Sun, R. G. Verhaak, A. Futreal, J. Zhang P41 Applying “Big data” technologies to the rapid analysis of heterogenous large cohort data S. J. Whiite, T. Chiang, A. English, J. Farek, Z. Kahn, W. Salerno, N. Veeraraghavan, E. Boerwinkle, R. 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Polfus, CHARGE and NHLBI Exome Sequence Project Working Groups P48 Association of adipoq gene with type 2 diabetes and related phenotypes in african american men and women: The jackson heart study S. Davis, R. Xu, S. Gebeab, P Riestra, A Gaye, R. Khan, J. Wilson, A. Bidulescu P49 Common variants in casr gene are associated with serum calcium levels in koreans S. H. Jung, N. Vinayagamoorthy, S. H. Yim, Y. J. Chung P50 Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with multiple exponential functions Y. Zhou, S. Xu P51 A Bayesian framework for generalized linear mixed models in genome-wide association studies X. Wang, V. Philip, G. Carter P52 Targeted sequencing approach for the identification of the genetic causes of hereditary hearing impairment A. A. Abuzenadah, M. Gari, R. Turki, A. Dallol P53 Identification of enhancer sequences by ATAC-seq open chromatin profiling A. Uyar, A. Kaygun, S. Zaman, E. Marquez, J. George, D. Ucar P54 Direct enrichment for the rapid preparation of targeted NGS libraries C. L. Hendrickson, A. Emerman, D. Kraushaar, S. Bowman, N. Henig, T. Davis, S. Russello, K. Patel P56 Performance of the Agilent D5000 and High Sensitivity D5000 ScreenTape assays for the Agilent 4200 Tapestation System R. Nitsche, L. Prieto-Lafuente P57 ClinVar: a multi-source archive for variant interpretation M. Landrum, J. Lee, W. Rubinstein, D. Maglott P59 Association of functional variants and protein physical interactions of human MUTY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome Z. Abduljaleel, W. Khan, F. A. Al-Allaf, M. Athar , M. M. Taher, N. Shahzad P60 Modification of the microbiom constitution in the gut using chicken IgY antibodies resulted in a reduction of acute graft-versus-host disease after experimental bone marrow transplantation A. Bouazzaoui, E. Huber, A. Dan, F. A. Al-Allaf, W. Herr, G. Sprotte, J. Köstler, A. Hiergeist, A. Gessner, R. Andreesen, E. Holler P61 Compound heterozygous mutation in the LDLR gene in Saudi patients suffering severe hypercholesterolemia F. Al-Allaf, A. Alashwal, Z. Abduljaleel, M. Taher, A. Bouazzaoui, H. Abalkhail, A. Al-Allaf, R. Bamardadh, M. Atha

Integrated pest management of Tuta absoluta: practical implementations across different world regions

The South American tomato pinworm, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae), has invaded most Afro-Eurasian countries and is threatening worldwide tomato production. Various strategies have been developed and implemented to manage this pest. Here, we present a timely review on the up-to-date development and practical implementation of integrated pest management (IPM) programs for tomato crops across different world regions infested by T. absoluta. While insecticide resistance is a growing concern, biological control via releasing or conserving arthropod natural enemies and sex pheromone-based biotechnical control are the most successful management practices. Agronomic control-related research is an emerging area where the soil fertilization and/or irrigation, as well as breeding of resistant cultivars, has the potential to enhance IPM effectiveness. Grower survey responses in the native areas (i.e., South America), early-invaded areas (i.e., first report between 2006 and 2012) and newly invaded areas (i.e., first report after 2012) showed that the control programs evolved along with the areas and time since invasion. Growers in the early-invaded areas shifted more rapidly from chemical control to biological control compared to those from the native area. In all concerned regions, the pest control failure risk following chemical insecticide applications and the high cost associated with either biological or biotechnical control methods have been the greatest concerns for growers. The information gathered from the native and/or early-invaded areas may help achieve a more effective management in newly invaded areas. Lastly, researchers are expected to break the bottlenecks of some key issues that would enable lowering application cost of novel biorational alternative management options

Theory Of Mind Characteristics And Metacognitive Functions Of Fibromyalgia Patients And Their Relationships With İnterpretation Of Symptoms And Disease

FMS‘li hastalarda üstbiliĢsel iĢlevler ve zihin kuramı özelliklerinin belirti yorumlama ve hastalık üzerine etkileri araĢtırılmıĢtır. FMS‘li hastaların daha patolojik üstbiliĢsel iĢlevlere ve daha düĢük zihin kuramı puanlarına sahip oldukları görülmüĢtür. Regresyon katsayılarının anlamlılığına iliĢkin t-testi sonuçları incelendiğinde ise, sadece ÜstbiliĢ-30 toplam, A Aleksitimi Ölçeği Duygusal BileĢen Alt Ölçeği ve A Aleksitimi Ölçeği Duygusal Deneyim Çözme ve Ġfade Etme Alt Ölçeği puanlarının FMEA toplam puanı üzerinde önemli bir yordayıcı olduğu görülmüĢtür. Bu konuda daha büyük bir örneklemde daha fazla çalıĢmaya ihtiyaç vardırThe effects of metacognitive functions and theory of mind characteristics on symptom interpretation and disease were investigated in patients with FMS. Patients with FMS had more pathological metacognitive functions and lower mental theory scores. When the t-test results related to the significance of regression coefficients were examined, it was seen that only Metacognition-30 total, A Alexithymia Scale Emotional Component Subscale and A Alexithymia Scale Emotional Experience Solving and Expression Sub-Scale scores were significant predictors of FMEA total score. Further studies are needed in a larger sample

Diyarbakır ve Mardin İllerinde Domates alanlarında Canavarotu Türleri Orobanche aegyptiaca Pers. ve O. ramosa Linnaeus (Orobanchaceae) üzerinde Pytomyza orobanchia Kaltenbach (Diptera: Agromyzidae)’nın Etkinliğinin Araştırılması

This study was carried out to investigate efficiency of Phytomyza orobanchia Kaltenbach, 1864 (Diptera: Agromyzidae) on Orobanche aegyptiaca and O. ramosa parasitizing tomato crops under natural conditions, in Southeast Anatolia Region (Diyarbakır and Mardin provinces) in 2008. Trials were practiced using a randomized parcel design with five release ratios (0, 4, 6 and 8 pupae/cage and open field control) and with six replicate each. Highly significant differences were detected among treatments in both locations. The differences among treatments were ordered from the most effective ones to the least as; 8, 6 pupae/cage, open field control, 4 pupae/cage, and control lattices that without releasing pupae. The efficiency of P. orobanchia increased significantly by increasing the number of released P. orobanchia pupae, while there was no effect in control cages. Compared to pupae released cages open fields showed almost the same activity levels of P. orobanchia as that four pupae or sometime slightly higher than four pupae. Obtained data may provide valuable information for improving effective biological control program in the frame of integrated pest management of Orobanche aegyptiaca and O. ramosa.Bu çalışma, Orobanche aegyptiaca ve O. ramosa canavar otu türleri üzerinde beslenen Phytomyza orobanchia Kaltenbach, 1864 (Diptera: Agromyzidae)’nın bu türler üzerinde etkinliğini araştırmak amacıyla Mardin ve Diyarbakır illerinde domates yetiştirilen alanlarda 2008 yılında yürütülmüştür. Denemeler tesadüf parselleri deneme desenine göre 5 karakter (0, 4, 6 ve 8 pupa salınmış kafesler ve açık alan kontrolleri) ve 6 tekerrür olarak kurulmuştur. Her iki lokasyonda da karakterler arasında çok önemli fark görülmüştür. Karakterler arasındaki fark etkinlik durumuna göre en yüksekten en düşüğe doğru; 8 pupa salınmış kafesler, 6 pupa salınmış kafesler, açık alan kontrolleri, 4 pupa salınmış kafesler ve pupa salımı yapılmamış kafesler olarak sıralanmıştır. Pupa salımı arttıkça P. orobanchia etkinliği önemli ölçüde artarken, pupa salınmamış kafesler de etkinlik hiç görülmemiştir. Açık alanda P. orobanchia etkinliği ile kafes altındaki etkinlik karşılaştırıldığında açık alan etkinliğinin 4 pupa salımı yapılmış kafeslerden biraz daha etkin olduğu saptanmıştır. Elde edilen veriler, O. aegyptiaca ve O. ramosa’nın kontrol altına alınması için entegre mücadele çerçevesinde biyolojik mücadele programının geliştirilmesinde kıymetli bilgiler sağlayabili

Dynamic magnetic hysteresis behavior and dynamic phase diagrams in the kinetic cylindrical ising nanotube

Zamana bağlı periyodik olarak değişen dış manyetik alanın (h(wt)) etkisinde kinetik silindirik Ising nanotüp sisteminin mıknatıslanmasının (m(wt)) doğası (zamanla değişimi) korelasyonlu etkin alan teorisi ve Glauber-tipi stokhastik dinamiği kullanılarak çalışıldı. Farklı sıcaklık değerlerinde m(wt) ve h(wt) nin zamanla değişimi incelendi ve dinamik manyetik histeresis davranışları araştırıldı. Dinamik mıknatıslanma, histeresis ilmek alanları ve korelasyonların sıcaklığa bağlılığı yani dinamik geçişlerin doğası (kesikli veya sürekli yani birinci- veya ikinci- derece faz geçişleri) karekterize etmek için ve de dinamik faz geçiş sıcaklıklarını elde etmek için araştırıldı. Üç farklı düzlemde dinamik faz diyagramları sunuldu ve denge ve denge dışı durumların sonuçları karşılaştırıldı. Faz diyagramları dinamik üçlü kritik, yalıtılmış kritik ve çoklu kritik ve üçlü kritik nokta sergiler. Sonuçların, deneysel ve teorik sonuçlar ile uyum içerisinde olduğu tespit edildi.The nature (time variation) of response magnetizations m(wt) of the kinetic cylindrical Ising nanotube in the presence of a time varying periodically external magnetic field h(wt) is studied by employing the effective-field theory (EFT) with correlations as well as the Glauber-type stochastic dynamics. We have determined the time variations of m(wt) and h(wt) for various temperatures, and investigated the dynamic magnetic hysteresis behavior. Temperature dependence of the dynamic magnetizations, hysteresis loop areas and correlations are investigated in order to characterize the nature (first- or second-order) of the dynamic transitions as well as to obtain the dynamic phase transition temperatures. We also present the dynamic phase diagrams in the three different planes and compare the results of the equilibrium and nonequilibrium states. The phase diagrams exhibit dynamic tricritical, isolated critical, multicritical and triple points. The results are in good agreement with some experimental and theoretical results

Determination of population changes of Laodelphax striatellus (Fallen, 1826) and Sogatella vibix (Haupt, 1927) (Hemiptera: Delphacidae) by using different sampling methods in second crop maize in Diyarbakır province

Diyarbakır ili ikinci ürün mısır alanlarında 2005 ve 2006 yıllarında yürütülen bu çalışmada Laodelphax striatellus (Fallen, 1826) ve Sogatella vibix (Haupt, 1927) Delphacidae (Hemiptera) türlerinin popülasyon gelişmesi sarı yapışkan tuzak ve D-Vac ile incelenmiştir. L. striatellus temmuz ayı başından itibaren örnekleme yapılan alanlarda görüldüğü; sarı yapışkan tuzaklarda D-Vac’a göre daha fazla sayıda birey toplandığı belirlenmiştir. Benzer şekilde S. vibix temmuz ayı ortasında ikinci ürün mısırda görülmüş hem sarı yapışkan tuzak hem de D-Vac’da ağustos ayı sonunda en yüksek sayıda birey toplanmıştır. Ortalama L. striatellus ve S. vibix birey sayıları yıllar, örnekleme yapılan haftalar, tarlalar ve uygulanan örnekleme yöntemleri bakımından önemli farklılık göstermiştir. Bununla beraber, L. striatellus’un populasyon yoğunlukları S. vibix populasyonunun aksine, 2 tarla arasında farklı bulunmamıştır.The aim of present study was to investigate population changes of Laodelphax striatellus (Fallen, 1826) and Sogatella vibix (Haupt, 1927) Delphacidae (Hemiptera) by using yellow sticky traps and D-Vac in second crop maize fields of Diyarbakır province in 2005 and 2006. The first individuals of L. striatellus were recorded in the traps in early july and its higher densities were caught in yellow sticky traps than that of D-Vac. Similarly, S. vibix individuals were first seen in the middle of july, while its highest densities were caught by both traps in august. Mean numbers of L. striatellus and S. vibix were significantly changed by the years of study, sampling weeks, sampling fields and the sampling methods utilized. However, population densities of L. striatellus were not different between two locations in contrast to S. vibix population