Study protocol: the development of a randomised controlled trial testing a postcard intervention designed to reduce suicide risk among young help-seekers

<p>Abstract</p> <p>Background</p> <p>Suicidal behaviour and deliberate self harm are common among adolescents. Limited evidence exists regarding interventions that can reduce risk; however research indicates that maintaining contact either via letter or postcard with at-risk adults following discharge from services can reduce risk. The aim of the study is to test a postcard intervention among people aged 15-24 who presented to mental health services but are not accepted, yet are at risk of suicide.</p> <p>Methods/design</p> <p>The study is a 3-year randomised controlled trial conducted at Orygen Youth Health Research Centre in Melbourne Australia. Participants are young help-seekers aged 15-24 who are at risk of suicide. Participants will be recruited over a 12 month period. The intervention comprises a regular postcard to be sent monthly for 12 months. The postcard enquires after their well being and includes information regarding individual sources of help and evidence-based self help strategies. Participants are assessed at baseline, 12 and 18 months.</p> <p>Discussion</p> <p>This paper describes the development of a study which aims to reduce suicide risk in a sample of young help-seekers. If effective, this intervention could have significant clinical and research implications for a population who can be hard to treat and difficult to research.</p> <p>Trial Registration</p> <p>The study was registered with the Australian Clinical Trials Registry; number: ACTRN012606000274572.</p

Positive outcome expectancy mediates the relationship between social influence and Internet addiction among senior high-school students

Background and aims Based on the foundations of Bandura’s social cognitive theory and theory of triadic influence (TTI) theoretical framework, this study was designed to examine the mediating role of positive outcome expectancy of Internet use in the relationship between social influence and Internet addiction (IA) in a large representative sample of senior high-school students in Taiwan. Methods Using a cross-sectional design, 1,922 participants were recruited from senior high schools throughout Taiwan using both stratified and cluster sampling, and a comprehensive survey was administered. Results Structural equation modeling and bootstrap analyses results showed that IA severity was significantly and positively predicted by social influence, and fully mediated through positive outcome expectancy of Internet use. Discussion and conclusions The results not only support Bandura’s social cognitive theory and TTI framework, but can also serve as a reference to help educational agencies and mental health organizations design programs and create policies that will help in the prevention of IA among adolescents

Effects of Fall Dormancy, Cutting Frequency, and K Application Rate on Dry Matter Yield and Nutritive Value of Alfalfa

[Introduction] This study was conducted to determine the effect of the cutting frequency and K application rate on the dry matter yield (DMY) and nutritive value of new alfalfa varieties in Korea. [Material and Methods] The sowing date and rate were September 21, 2019, and 20 kg/ha, respectively. The treatment was by the split-split plot design, and the main plot was the Fall dormancy (FD) of 3 (Rugged Rancher), 4 (SW4113), and 9 (SW9720), the sub-plot was excess 40 day (LCF), from 31 to 40 days (MCF), and under 30 day (HCF) times of cutting frequency (CF), and the sub-sub plot was 150 (K 150), 300 (K 300), and 450 (K 450) kg/ha of K application rate. The first harvest reached 10% of the flowering, and after the first harvest, it was conducted according to the cutting frequency treatment. The survey contents were investigated as DMY, Crude protein (CP), Neutral detergent fiber (NDF), Acid detergent fiber (ADF), and K content. [Results and Discussion] K 450 of DMY was significantly higher than K 150 (p \u3c 0.05). The CF was not significant at each level (p \u3e 0.05). FD 3 and FD 4 of DMY were significantly higher than FD 9 (p \u3c 0.05). The CP, NDF, and ADF according to FD and CF were significantly different at each treatment (p \u3c 0.05). The CP and ADF according to the K treatment were significantly higher at K 150 than K 300 and K 450 (p \u3c 0.05). In addition, the NDF according to the K treatment was significantly higher in K 150 and K 450 than K 300 (p \u3c 0.05). The K content of alfalfa significantly differed according to the K treatment (p \u3c 0.05). Therefore, it is judged that a high DMY can be expected when the K application rate, cutting frequency, and FD is 450 kg/ha, HCF, and 4, respectively

Projectile Δ\Delta Excitations in p(p,n)Nπp(p,n)N\pi Reactions

It has recently been proven from measurements of the spin-transfer coefficients $D_{xx}$ and $D_{zz}$ that there is a small but non-vanishing $\Delta S=0$ component $\sigma_{0}$, in the inclusive $p(p,n)N\pi\,$ reaction cross section $\sigma\,$. It is shown that the dominant part of the measured $\sigma_{0}$ can be explained in terms of the projectile $\Delta$ excitation mechanism. An estimate is further made of contributions to $\sigma_{0}$ from s-wave rescattering process. It is found that s-wave rescattering contribution is much smaller than the contribution coming from projectile $\Delta$ excitation mechanism. The addition of s-wave rescattering contribution to the dominant part, however, improves the fit to the data.Comment: 9 pages, Revtex, figures can be obtained upon reques

Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways

Scope: To investigate the effect of sulforaphane (SFN) on the abnormal lipid metabolism and underlying mechanisms.  Methods and results: Models with abnormal lipid metabolism were established both in rats and human hepatocytes. Hepatic steatosis was detected by H&E and oil red O staining. The structure of endoplasmic reticulum was visualized by transmission electron microscopy. The expressions of X-box binding protein 1 (XBP1), protein kinase-like ER kinase (PERK), sterol regulatory element binding protein-1c (SREBP1c) and lipogenic enzymes were determined by real-time PCR and western blot analysis. SFN lowered the content of triglyceride and cholesterol. SFN alleviated the swelling of endoplasmic reticulum (ER) and decreased the perimeter of ER. SFN significantly decreased the expressions of acetyl CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase. SFN inhibited SREBP1c by blocking the PERK. Meanwhile, SFN suppressed ACC1 and SCD1 via blocking the formation of splicing-type XBP1. The key roles of XBP1 and SREBP1c in SFN-reduced lipid droplets were confirmed by a timed sequence of measurement according to time points.  Conclusion: SFN improved abnormal lipid metabolism via both ER stress -dependent and -independent pathways

An Investigation of Telecom Mobile Data Billing Plans

In the recent years, mobile operators have provided many billing alternatives such as limited and unlimited billing plans, and shared and non-shared data plans for the users with different needs. A non-shared data plan is designed for a single user with a limited monthly data allowance. On the other hand, the monthly data allowance of a shared data plan is shared by a group of users with multiple devices. The mobile operators often conduct the primary price study to compare their billing plans, which shows the relationship between the prices of the billing plans against the fixed amounts of data usage. Although the primary price study can easily and quickly draw the conclusions, it only provides rough billing plan suggestions. In reality, the amounts of data usage are not fixed, and therefore should be measured from commercial mobile networks to reflect the user behaviors on data usage. This paper proposes an analytical approach by using the measured data of Chunghwa Telecom Co., Ltd. (CHT), the largest telecommunications company in Taiwan, to derive the expected payments of various billing plans. The results of the analytical model are more accurate than those of the primary price study, and therefore provide better suggestions for billing plan selection. Other mobile operators can easily use our model to analyze the billing alternatives with their measured data

Last Glacial Fluctuation of Fluvial Wetland Environment of Korea -with an Special Reference of Fluvial Organic Mud Formations

Korea Institute of Geosciences and Mineral ResourcesScedule:17-18 March 2003, Vemue: Kanazawa, Japan, Kanazawa Citymonde Hotel, Project Leader : Hayakawa, Kazuichi, Symposium Secretariat: XO kamata, Naoto, Edited by:Kamata, Naoto

Performance measurement systems, TQM, and multi-level firm performance: a person-organisation fit perspective

For firms implementing TQM, there is a need to redesign performance measurement systems (PMS). Innovated PMS ought to have measurement diversity in their structure with considering the spirit of TQM and emphasize the congruence of goals between employees and firms by adding the viewpoint of person-organisation fit (P-O fit). This paper adopts structural equation modeling (SEM) to examine Taiwanese manufacturing firms to study the association between the P-O fit of PMS and the implementation of TQM, as well as the effects of the adaptation of both to firm performance. Particularly, this paper examines firm performance at multiple levels and gathers data from multiple sources, including archival files and self-reported data from surveys

Nasal commensal Staphylococcus epidermidis enhances interferon-λ-dependent immunity against influenza virus

Background Staphylococcus epidermidis is one of the most abundant colonizers of healthy human mucosa including that in the respiratory tract. As the respiratory microbiome has been linked to host immune responses, this study sought to determine the role of nasal mucosa-associated S. epidermidis in innate immune responses against the influenza A virus (IAV). S. epidermidis strains were isolated from nasal mucus samples of healthy individuals. The effects of these mucosa-derived commensal strains on interferon (IFN)-dependent innate immunity and IAV infection dynamics were tested in vitro using normal human nasal epithelial (NHNE) cells and human turbinate mucosa. The effects of S. epidermidis on antiviral immunity were also tested in vivo using an acute IAV infection mouse model. Results Exposure of NHNE cells to nasal mucosa-derived S. epidermidis increased IFN-λ mRNA and secreted protein levels in the absence of viral stimulation. In the context of IAV infection, NHNE exposure to S. epidermidis prevented an increase in the viral burden, as revealed by IAV PA mRNA abundance, IAV nucleoprotein levels, and viral titers. S. epidermidis also enhanced transcription of IFN-stimulated genes independently of Toll-like receptor 2 and further induced IFN-λ production in IAV-infected cells by promoting phosphorylation of interferon regulatory factor 7. In a murine infection model, S. epidermidis prevented the spread of IAV to the lungs by stimulating IFN-λ innate immunity and suppressing IAV replication in the nasal mucosa. Conclusion The human nasal commensal S. epidermidis mediates front-line antiviral protection against IAV infection through modulation of IFN-λ-dependent innate immune mechanisms in the nasal mucosa, thereby demonstrating the role of host-bacterial commensalism in shaping human antiviral responses.This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Kim et al. Microbiome (2019) 7:80 Page 10 of 12 Education (2016R1D1A1B01014116 to H.J.K.) and (2017M3A9F3041233 to S.S.Y.). This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C1337 to H.J.K), and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2014M3A9D5A01073865 to J.Y.C