Search for the Radiative Capture d+d->^4He+\gamma Reaction from the dd\mu Muonic Molecule State

A search for the muon catalyzed fusion reaction dd --> ^4He +\gamma in the dd\mu muonic molecule was performed using the experimental \mu CF installation TRITON and NaI(Tl) detectors for \gamma-quanta. The high pressure target filled with deuterium at temperatures from 85 K to 800 K was exposed to the negative muon beam of the JINR phasotron to detect \gamma-quanta with energy 23.8 MeV. The first experimental estimation for the yield of the radiative deuteron capture from the dd\mu state J=1 was obtained at the level n_{\gamma}\leq 2\times 10^{-5} per one fusion.Comment: 9 pages, 3 Postscript figures, submitted to Phys. At. Nuc

A Precision Measurement of Nuclear Muon Capture on 3He

The muon capture rate in the reaction mu- 3He -> nu + 3H has been measured at PSI using a modular high pressure ionization chamber. The rate corresponding to statistical hyperfine population of the mu-3He atom is (1496.0 +- 4.0) s^-1. This result confirms the PCAC prediction for the pseudoscalar form factors of the 3He-3H system and the nucleon.Comment: 13 pages, 6 PostScript figure

Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation

Preclinical studies have demonstrated that the chemotherapeutic action of oxaliplatin, a third generation platinum derivative, is improved when combined with cetuximab, a monoclonal antibody inhibitor of epidermal growth factor receptors. To explore the mechanism of this synergistic benefit, we used HCT-8 and HCT-116, two human colon cancer cell lines, respectively, responsive and non-responsive to the oxaliplatin/cetuximab combination. We examined the effect of drug exposure on glutathione-S-transferase-mediated oxaliplatin detoxification, DNA–platinum adducts formation, cell cycle distribution, apoptosis, and the expression of multiple targets involved in DNA replication, recombination, and repair. The major changes we found in HCT-8 were a stimulation of oxaliplatin–DNA adduct formation associated with reduced expression of the key enzyme (excision repair cross complementation group1: ERCC1) in the key repair process of oxaliplatin–DNA platinum adduct, the nucleotide excision repair (NER), both at the mRNA and protein levels. We also observed a reduced expression of factors involved in DNA replication initiation, which correlates with an enrichment of cells in the G1 phase of the cell cycle as well as an acceleration of apoptosis. None of these changes occurred in the non-responsive HCT-116 cell that we used as a negative control. These findings support the fact that cetuximab potentiates the oxaliplatin-mediated cytotoxic effect as the result of inhibition of NER and also DNA replication initiation

Use of Polarization Lidar for Investigation of Meteorological Formations

This paper presents the results of theoretical and experimental, investigations of depolarization characteristics of different meteorological formations. Experimental investigations are carried out with a monostatic lidar. The ruby laser radiation is polarized in a vertical plane. The radiation reflected is accepted by a lens system of 150 rom in diameter and a viewing angle of 12' and further it is divided by Wollaston prism into the components polarized orthogonally. In this case the principal plane of the prism is exposed parallel with the laser polarization plane. Investigations show the degree of radiation polarization, reflected from water clouds, to be changed within 1/0.7 (seldom up to 0.6) depending on their density. In most cases a signal reflected from the cloud leading edge is polarized completely. The time shift is observed between polarized and crosspolarized components of a Fignal, reflected from a cloud, depending on the density of a meteorological object. While penetrating into the cloud depth a degree of polarization decreases up to 0.8-0.7, and the character of this decrease is different for various types of clouds. For crystal clouds the shift between the components of the reflected signal is not observed and the magnitude of polarization degree amounts to 0.1/0.3 in comparison with water clouds. The polarization degree of radiation reflected by fog is not less than 0.6, and that in the rains of average intensity (about 5 mm/h) is always about 1. The authors have suggested an algorithm of numerical solution of nonstationary transfer equation in the vector form to forecast the influence of multiple scattering effects on polarization characteristics of the lidar light signal. The method of statistical simulation (Monte-Carlo technique) forms the basis of the algorithm. Numerical estimates obtained for a model of stratocumulus at lambda = 0.6943 microns under boundary conditions close to the conditions of natural experiment being discussed proved to be in a good agreement with the results of observation. Specifically, Fig. 1 shows the profiles of polarization (p) versus depth (L) of the following drop formations: fog (curve 1) with horizontal meteorological visibility of 4 km two stratocumulus at a height of 1100 m with the attenuation factors delta = 0.01m(exp -1) (curve 2) and delta = 0.05m(exp -1) (curve 3). Curve 3 shows the results of numerical estimates and the value of their statistical error

Search for an exotic S=-2, Q=-2 baryon resonance at a mass near 1862 MeV in quasi-real photoproduction

A search for an exotic baryon resonance with $S=-2, Q=-2$ has been performed in quasi-real photoproduction on a deuterium target through the decay channel $\Xi^- \pi^- \to \Lambda \pi^- \pi^- \to p \pi^- \pi^- \pi^-$. No evidence for a previously reported $\Xi^{--}(1860)$ resonance is found in the $\Xi^- \pi^-$invariant mass spectrum. An upper limit for the photoproduction cross section of 2.1 nb is found at the 90% confidence level. The photoproduction cross section for the $\Xi^{0}(1530)$ is found to be between 9 and 24 nb

Evidence for a narrow |S|=1 baryon state at a mass of 1528 MeV in quasi-real photoproduction

Evidence for a narrow baryon state is found in quasi-real photoproduction on a deuterium target through the decay channel p K^0_S --> p pi^+ pi^-. A peak is observed in the p K^0_S invariant mass spectrum at 1528 +/- 2.6 (stat) +/-2.1 (syst) MeV. Depending on the background model,the naive statistical significance of the peak is 4--6 standard deviations and its width may be somewhat larger than the experimental resolution of sigma=4.3 -- 6.2 MeV. This state may be interpreted as the predicted S=+1 exotic Theta^{+}(uuddbar(s)) pentaquark baryon. No signal for an hypothetical Theta^{++} baryon was observed in the pK^+ invariant mass distribution. The absence of such a signal indicates that an isotensor Theta is excluded and an isovector Theta is unlikely.Comment: 8 pages, 4 figure

The HERMES Polarized Hydrogen and Deuterium Gas Target in the HERA Electron Storage Ring

The HERMES hydrogen and deuterium nuclear-polarized gas targets have been in use since 1996 with the polarized electron beam of HERA at DESY to study the spin structure of the nucleon. Polarized atoms from a Stern-Gerlach Atomic Beam Source are injected into a storage cell internal to the HERA electron ring. Atoms diffusing from the center of the storage cell into a side tube are analyzed to determine the atomic fraction and the atomic polarizations. The atoms have a nuclear polarization, the axis of which is defined by an external magnetic holding field. The holding field was longitudinal during 1996-2000, and was changed to transverse in 2001. The design of the target is described, the method for analyzing the target polarization is outlined, and the performance of the target in the various running periods is presented

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage 5–8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL 9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage 3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES +KI67 + unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB

Retrieval of the tropospheric aerosol microphysical characteristics from the data of multifrequency lidar sensing

Regular lidar measurements of the vertical distribution of aerosol optical parameters are carried out in Tomsk (56°N, 85°E) since April, 2011. We present the results of retrieval of microphysical characteristics from the data of measurements by means of Raman lidar in 2013. Section 2 is devoted to the theoretical aspects of retrieving the particle size distribution function U(r) (SDF) assuming a known complex refractive index m (CRI). It is shown that the coarse fraction cannot be retrieved unambiguously. When estimating U(r) and m together (section 3), the retrieved refractive index is non-linearly related to the optical coefficients and the distribution function, which leads to appearance of different, including false values of m. The corresponding U(r) differs only slightly, so the inaccuracy in m does not essentially affect the retrieval of the distribution function