Submarine landslides on the upper southeast Australian passive continental margin – preliminary findings

The southeast Australian passive continental margin is narrow, steep and sediment-deficient, and characterized by relatively low rates of modern sedimentation. Upper slope (\u3c1200m) sediments comprise mixtures of calcareous and terrigenous sand and mud. Three of twelve sediment cores recovered from geologically-recent, submarine landslides located offshore New South Wales/Queensland (NSW/QLD) are interpreted to have sampled failure surfaces at depths of between 85 cm and 220 cm below the present-day seabed. Differences in sediment physical properties are recorded above and below the three slide-plane boundaries. Sediment taken directly above the inferred submarine landslide failure surfaces and presumed to be post-landslide, returned radiocarbon ages of 15.8 ka, 20.7 ka and 20.1 ka. The last two ages correspond to adjacent slide features, which are inferred to be consistent with their being triggered by a single event such as an earthquake. Slope stability models based on classical soil mechanics and measured sediment shearstrengths indicate that the upper slope sediments should be stable. However, multibeam sonar data reveal that many upper slope landslides occur across the margin and that submarine landsliding is a common process. We infer from these results that: a) an unidentified mechanism regularly acts to reduce the shear resistance of these sediments to the very low values required to enable slope failure, and/or b) the margin experiences seismic events that act to destabilise the slope sediments

Cultural respect encompassing simulation training: being heard about health through broadband

BACKGROUND: Cultural Respect Encompassing Simulation Training (CREST) is a learning program that uses simulation to provide health professional students and practitioners with strategies to communicate sensitively with culturally and linguistically diverse (CALD) patients. It consists of training modules with a cultural competency evaluation framework and CALD simulated patients to interact with trainees in immersive simulation scenarios. The aim of this study was to test the feasibility of expanding the delivery of CREST to rural Australia using live video streaming; and to investigate the fidelity of cultural sensitivity - defined within the process of cultural competency which includes awareness, knowledge, skills, encounters and desire - of the streamed simulations. DESIGN AND METHODS: In this mixed-methods evaluative study, health professional trainees were recruited at three rural academic campuses and one rural hospital to pilot CREST sessions via live video streaming and simulation from the city campus in 2014. Cultural competency, teaching and learning evaluations were conducted. RESULTS: Forty-five participants rated 26 reliable items before and after each session and reported statistically significant improvement in 4 of 5 cultural competency domains, particularly in cultural skills (P<0.05). Qualitative data indicated an overall acknowledgement amongst participants of the importance of communication training and the quality of the simulation training provided remotely by CREST. CONCLUSIONS: Cultural sensitivity education using live video-streaming and simulation can contribute to health professionals\u27 learning and is effective in improving cultural competency. CREST has the potential to be embedded within health professional curricula across Australian universities to address issues of health inequalities arising from a lack of cultural sensitivity training. Significance for public healthThere are significant health inequalities for migrant populations. They commonly have poorer access to health services and poorer health outcomes than the Australian-born population. The factors are multiple, complex and include language and cultural barriers. To address these disparities, culturally competent patient-centred care is increasingly recognised to be critical to improving care quality, patient satisfaction, patient compliance and patient outcomes. Yet there is a lack of quality in the teaching and learning of cultural competence in healthcare education curricula, particularly in rural settings where qualified trainers and resources can be limited. The Cultural Respect Encompassing Simulation Training (CREST) program offers opportunities to health professional students and practitioners to learn and develop communication skills with professionally trained culturally and linguistically diverse simulated patients who contribute their experiences and health perspectives. It has already been shown to contribute to health professionals\u27 learning and is effective in improving cultural competency in urban settings. This study demonstrates that CREST when delivered via live video-streaming and simulation can achieve similar results in rural settings

Submarine Landslides, Canyons, and Morphological Evolution of the East Australian Continental Margin

Australia’s continental margins were generally assumed as relatively inactive; offshore eastern Australia, the Tasman Basin’s margin experiences low rates of sedimentation, seismicity, and geological changes. Bathymetry collected over two voyages on the RV Southern Surveyor have revealed ubiquitous mass failure scars along the East Australian Continental Margin (EACM), with the slopes presenting landslides, canyons, gullies, and other erosional features. These range from shallow-seated upper slope slides mobilising volumes of ~<0.5 km3, to larger middle-slope slump scars incised deeply into the slope that probably displaced volumes of several km3. Dredge samples have been collected from failure scarps and slide. The material is composed of siliciclastic and carbonate silt/sand; biostratigraphic ages indicate that the margin’s geomorphic features formed during the Neogene. Mechanically, the sediment samples are consolidated, rarely weakly-cemented, but mostly unlithified. Numerical modelling based on their geotechnical properties indicates that the slopes are statically stable, and external triggers such as a large earthquake (≥M7) are required to induce failure. None of the other commonly invoked triggers (e.g. rapid sedimentation, isostatic rebound, weak layers, gas hydrate dissociation) appear to be applicable to the setting. Thus the EACM presents a paradox: a tectonically-stable margin with low sedimentation, presenting evidence of large and widespread failure. The dredge samples and slope geometry strongly suggest that the continental slopes are inherently stable. An integrative model posits that the combination of increased seismicity and the intensified oceanic currents during the Late Miocene and Pliocene caused extensive slope dissection and failure. This thesis will investigate the morphological evolution of the EACM using bathymetric data and sediment samples, and examine various aspects of the integrative model through a series of case studies

The psychophysiological effects of Tai-chi and exercise in residential Schizophrenic patients: a 3-arm randomized controlled trial

BACKGROUND: Patients with schizophrenia are characterized by high prevalence rates and chronicity that often leads to long-term institutionalization. Under the traditional medical model, treatment usually emphasizes the management of psychotic symptoms through medication, even though anti-psychotic drugs are associated with severe side effects, which can diminish patients’ physical and psychological well-being. Tai-chi, a mind-body exercise rooted in Eastern health philosophy, emphasizes the motor coordination and relaxation. With these potential benefits, a randomized controlled trial (RCT) is planned to investigate the effects of Tai-chi intervention on the cognitive and motor deficits characteristic of patients with schizophrenia. METHODS/DESIGN: A 3-arm RCT with waitlist control design will be used in this study. One hundred and fifty three participants will be randomized into (i) Tai-chi, (ii) exercise or (iii) waitlist control groups. Participants in both the Tai-chi and exercise groups will receive 12-weeks of specific intervention, in addition to the standard medication and care received by the waitlist control group. The exercise group will serve as a comparison, to delineate any unique benefits of Tai-chi that are independent of moderate aerobic exercise. All three groups will undergo three assessment phases: (i) at baseline, (ii) at 12 weeks (post-intervention), and (iii) at 24 weeks (maintenance). All participants will be assessed in terms of symptom management, motor coordination, memory, daily living function, and stress levels based on self-perceived responses and a physiological marker. DISCUSSION: Based on a promising pilot study conducted prior to this RCT, subjects in the Tai-chi intervention group are expected to be protected against deterioration of motor coordination and interpersonal functioning. They are also expected to have better symptoms management and lower stress level than the other treatment groups. TRIAL REGISTRATION: The trail has been registered in the Clinical Trials Center of the University of Hong Kong (HKCTR-1453)

A New Technique for the Calculation and 3D Visualisation of Magnetic Complexities on Solar Satellite Images

YesIn this paper, we introduce two novel models for processing real-life satellite images to quantify and then visualise their magnetic structures in 3D. We believe this multidisciplinary work is a real convergence between image processing, 3D visualization and solar physics. The first model aims to calculate the value of the magnetic complexity in active regions and the solar disk. A series of experiments are carried out using this model and a relationship has been indentified between the calculated magnetic complexity values and solar flare events. The second model aims to visualise the calculated magnetic complexities in 3D colour maps in order to identify the locations of eruptive regions on the Sun. Both models demonstrate promising results and they can be potentially used in the fields of solar imaging, space weather and solar flare prediction and forecasting

Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis. The discovery analysis includes 3299 individuals, with validation in a separate dataset of 1522 individuals. Five metabolite associations with SDB PCs are discovered and replicated. SDB PC1, characterized by frequent respiratory events common in older and male adults, is associated with pregnanolone and progesterone-related sulfated metabolites. SDB PC2, characterized by short respiratory event length and self-reported restless sleep, enriched in young adults, is associated with sphingomyelins. Metabolite risk scores (MRSs), representing metabolite signatures associated with the two SDB PCs, are associated with 6-year incident hypertension and diabetes. These MRSs have the potential to serve as biomarkers for SDB, guiding risk stratification and treatment decisions

Small-scale Magnetic Flux Ropes in the First two Parker Solar Probe Encounters

Small-scale magnetic flux ropes (SFRs) are a type of structures in the solar wind that possess helical magnetic field lines. In a recent report (Chen & Hu 2020), we presented the radial variations of the properties of SFR from 0.29 to 8 au using in situ measurements from the Helios, ACE/Wind, Ulysses, and Voyager spacecraft. With the launch of the Parker Solar Probe (PSP), we extend our previous investigation further into the inner heliosphere. We apply a Grad-Shafranov-based algorithm to identify SFRs during the first two PSP encounters. We find that the number of SFRs detected near the Sun is much less than that at larger radial distances, where magnetohydrodynamic (MHD) turbulence may act as the local source to produce these structures. The prevalence of Alfvenic structures significantly suppresses the detection of SFRs at closer distances. We compare the SFR event list with other event identification methods, yielding a dozen well-matched events. The cross-section maps of two selected events confirm the cylindrical magnetic flux rope configuration. The power-law relation between the SFR magnetic field and heliocentric distances seems to hold down to 0.16 au.Comment: Accepted by ApJ on 2020 Sep 1

Understandings of spirituality and its role in illness recovery in persons with schizophrenia and mental-health professionals: a qualitative study

BACKGROUND: Spirituality has received increased attention in the psychiatric literature; however, it remains underexplored on a global level. Knowledge about spirituality of persons with schizophrenia is often hampered by positive and negative symptoms, which limit their expression of spiritual needs and shift mental-health professionals’ focus from spiritual care to symptom control. Differences in the ways that the two parties understand spirituality may create different expectations and further hinder the provision of high-quality holistic care. This study investigated the meaning and roles of spirituality from the perspectives of persons with schizophrenia and mental-health professionals. METHODS: A qualitative design with semi-structured individual interviews was adopted. The analysis was based on data collected from interviews with 18 clients diagnosed with schizophrenia and 19 mental-health professionals from public hospitals and mental-health community rehabilitation centres in Hong Kong. Data were collected and analysed based on grounded theory principles. RESULTS: Both clients and professionals regarded spirituality as an inherent part of a person’s well-being, clients’ rehabilitation, and their lives in general. At the personal level, the clients’ descriptions were more factual, concrete, short term, and affective, whereas the professionals’ descriptions were more abstract, complex, and cognitive. At the communal level, both parties had a similar understanding of spirituality but different interpretations of its role in recovery from mental illness. The clients regarded spirituality as a source of giving and receiving love and care, whereas the professionals regarded it as a means of receiving support and managing symptoms. CONCLUSIONS: Building a common understanding on the concept of spirituality and the significant role it plays in rehabilitation between clients and mental-health professionals is an essential first step to support clients’ spiritual health. Clients tend to seek for stability, peace, and growth rather than an existential quest; while professionals hold a more pathological perspective, viewing spirituality as a means to relieve symptoms, increase social acceptance, and cope with illness experiences. The differential understanding of the two perspectives provides insight and perhaps a roadmap for developing spiritual assessments and holistic care in the psychiatric context

Cell Cycle-Related Cyclin B1 Quantification

To obtain non-relative measures of cell proteins, purified preparations of the same proteins are used as standards in Western blots. We have previously quantified SV40 large T antigen expressed over a several fold range in different cell lines and correlated the average number of molecules to average fluorescence obtained by cytometry and determined cell cycle phase related expression by calculation from multi-parametric cytometry data. Using a modified approach, we report quantification of endogenous cyclin B1 and generation of the cell cycle time related expression profile.Recombinant cyclin B1 was purified from a baculovirus lysate using an antibody affinity column and concentrated. We created fixed cell preparations from nocodazole-treated (high cyclin B1) and serum starved (low cyclin B1) PC3 cells that were either lyophilized (for preservation) or solubilized. The lysates and purified cyclin B1 were subjected to Western blotting; the cell preparations were subjected to cytometry, and fluorescence was correlated to molecules. Three untreated cell lines (K562, HeLa, and RKO) were prepared for cytometry without lyophilization and also prepared for Western blotting. These were quantified by Western blotting and by cytometry using the standard cell preparations.The standard cell preparations had 1.5 x 10(5) to 2.5 x 10(6) molecules of cyclin B1 per cell on average (i.e., 16-fold range). The average coefficient of variation was 24%. Fluorescence varied 12-fold. The relationship between molecules/cell (Western blot) and immunofluorescence (cytometry) was linear (r(2) = 0.87). Average cyclin B1 levels for the three untreated cell lines determined by Western blotting and cytometry agreed within a factor of 2. The non-linear rise in cyclin B1 in S phase was quantified from correlated plots of cyclin B1 and DNA content. The peak levels achieved in G2 were similar despite differences in lineage, growth conditions, and rates of increase through the cell cycle (range: 1.6-2.2 x 10(6) molecules per cell).Net cyclin B1 expression begins in G1 in human somatic cells lines; increases non-linearly with variation in rates of accumulation, but peaks at similar peak values in different cell lines growing under different conditions. This suggests tight quantitative end point control