484 research outputs found
Correlations of Heavy Quarks Produced at Large Hadron Collider
We study the correlations of heavy quarks produced in relativistic heavy ion
collisions and find them to be quite sensitive to the effects of the medium and
the production mechanisms. In order to put this on a quantitative footing, as a
first step, we analyze the azimuthal, transverse momentum, and rapidity
correlations of heavy quark-anti quark () pairs in
collisions at (). This sets the stage for the
identification and study of medium modification of similar correlations in
relativistic collision of heavy nuclei at the Large Hadron Collider. Next we
study the additional production of charm quarks in heavy ion collisions due to
multiple scatterings, {\it viz.}, jet-jet collisions, jet-thermal collisions,
and thermal interactions. We find that these give rise to azimuthal
correlations which are quite different from those arising from prompt initial
production at leading order and at next to leading order.Comment: 26 pages, 15 figures. Three new figures added, comparison to
experimental data included, abstract and discussion expande
Empirical determination of charm quark energy loss and its consequences for azimuthal anisotropy
We propose an empirical model to determine the form of energy loss of charm
quarks due to multiple scatterings in quark gluon plasma by demanding a good
description of production of D mesons and non-photonic electrons in
relativistic collision of heavy nuclei at RHIC and LHC energies. Best results
are obtained when we approximate the momentum loss per collision , where is a constant depending on the
centrality and the centre of mass energy. Comparing our results with those
obtained earlier for drag coefficients estimated using Langevin equation for
heavy quarks we find that up to half of the energy loss of charm quarks at top
RHIC energy could be due to collisions while that at LHC energy at 2760 GeV/A
the collisional energy loss could be about one third of the total. Estimates
are obtained for azimuthal anisotropy in momentum spectra of heavy mesons, due
to this energy loss. We further suggest that energy loss of charm quarks may
lead to an enhanced production of D-mesons and single electrons at low in
AA collisions.Comment: 11 pages, 3 figures, Typographical errors corrected, Key-words and
PACS indices added, sequence of figures corrected, references added in
section 3, discussions expande
P53 long noncoding RNA regulatory network in cancer development
Studies have suggested that aberrant expression of lncRNAs as a molecular‐genomic signature may play important roles in cancer biology. Accordingly, it is important to elucidate the mechanisms by which the crosstalk between lncRNAs and p53 occurs in the development of numerous cancers. Here, we review how several classes of lncRNAs and p53 pathways are linked together in controlling the cell cycle and apoptosis in various cancer cells in both human and mouse model system
Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population
Background. Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes.The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities. Methods. We evaluated 5,519 healthy, Brazilian subjects (43 ± 10 years, 78% males), free of known cardiovascular disease. Those with \u3c2 metabolic risk factors (MRF) were considered metabolically healthy, and thosewith BMI ≥ 25 kg/m2 and/or waist circumference meetingNCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound. Results. Overall, 40% of OWindividuals were metabolically healthy, and 12% normal-weight had ≥2 MRF.The prevalence of elevated CRP (≥3mg/dL) and HS inMHO versus normal weight metabolically healthy group was 22% versus 12%, and 40%versus 8%respectively ( \u3c 0.001). BothMHOindividuals andmetabolically unhealthy normal weight (MUNW) phenotypes were associated with elevated hsCRP and HS. Conclusion. Our study suggests that MHO and MUNW phenotypes may not be benign and physicians should strive to treat individuals in these subgroups to reverse these conditions
Precision Measurement of the Weak Mixing Angle in Moller Scattering
We report on a precision measurement of the parity-violating asymmetry in
fixed target electron-electron (Moller) scattering: A_PV = -131 +/- 14 (stat.)
+/- 10 (syst.) parts per billion, leading to the determination of the weak
mixing angle \sin^2\theta_W^eff = 0.2397 +/- 0.0010 (stat.) +/- 0.0008 (syst.),
evaluated at Q^2 = 0.026 GeV^2. Combining this result with the measurements of
\sin^2\theta_W^eff at the Z^0 pole, the running of the weak mixing angle is
observed with over 6 sigma significance. The measurement sets constraints on
new physics effects at the TeV scale.Comment: 4 pages, 2 postscript figues, submitted to Physical Review Letter
Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study
This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplant during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Nine hundred lung transplant recipients were included. Median follow-up time from transplant to end of follow-up was 3.51 years. In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Residual confounding could not be ruled out because of the use of proxy variables to control for some confounders. Benefits of voriconazole use when prescribed to lung transplant recipients should be carefully weighed versus the potential risk of SCC. This article is protected by copyright. All rights reserved
Observation of Parity Nonconservation in Moller Scattering
We report a measurement of the parity-violating asymmetry in fixed target
electron-electron (Moller) scattering: A_PV = -175 +/- 30 (stat.) +/- 20
(syst.) parts per billion. This first direct observation of parity
nonconservation in Moller scattering leads to a measurement of the electron's
weak charge at low energy Q^e_W = -0.053 +/- 0.011. This is consistent with the
Standard Model expectation at the current level of precision:
sin^2\theta_W(M_Z)_MSbar = 0.2293 +/- 0.0024 (stat.) +/- 0.0016 (syst.) +/-
0.0006 (theory).Comment: Version 3 is the same as version 2. These versions contain minor text
changes from referee comments and a change in the extracted value of Q^e_W
and sin^2\theta_W due to a change in the theoretical calculation of the
bremsstrahulung correction (ref. 16
Inclusive cross section and double helicity asymmetry for pi^0 production in p+p collisions at sqrt(s) = 62.4 GeV
The PHENIX experiment presents results from the RHIC 2006 run with polarized
proton collisions at sqrt(s) = 62.4 GeV for inclusive pi^0 production at
mid-rapidity. Unpolarized cross section results are measured for transverse
momenta p_T = 0.5 to 7 GeV/c. Next-to-leading order perturbative quantum
chromodynamics calculations are compared with the data, and while the
calculations are consistent with the measurements, next-to-leading logarithmic
corrections improve the agreement. Double helicity asymmetries A_LL are
presented for p_T = 1 to 4 GeV/c and probe the higher range of Bjorken_x of the
gluon (x_g) with better statistical precision than our previous measurements at
sqrt(s)=200 GeV. These measurements are sensitive to the gluon polarization in
the proton for 0.06 < x_g < 0.4.Comment: 387 authors from 63 institutions, 10 pages, 6 figures, 1 table.
Submitted to Physical Review D. Plain text data tables for the points plotted
in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
Cross sections and double-helicity asymmetries of midrapidity inclusive charged hadrons in p+p collisions at sqrt(s)=62.4 GeV
Unpolarized cross sections and double-helicity asymmetries of
single-inclusive positive and negative charged hadrons at midrapidity from p+p
collisions at sqrt(s)=62.4 GeV are presented. The PHENIX measurements for 1.0 <
p_T < 4.5 GeV/c are consistent with perturbative QCD calculations at
next-to-leading order in the strong coupling constant, alpha_s. Resummed pQCD
calculations including terms with next-to-leading-log accuracy, yielding
reduced theoretical uncertainties, also agree with the data. The
double-helicity asymmetry, sensitive at leading order to the gluon polarization
in a momentum-fraction range of 0.05 ~< x_gluon ~< 0.2, is consistent with
recent global parameterizations disfavoring large gluon polarization.Comment: PHENIX Collaboration. 447 authors, 12 pages, 5 figures, 5 tables.
Submitted to Physical Review
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