The benefit of high-resolution operational weather forecasts for flash flood warning

International audienceIn Mediterranean Europe, flash flooding is one of the most devastating hazards in terms of human life loss and infrastructures. Over the last two decades, flash floods brought losses of a billion Euros of damage in France alone. One of the problems of flash floods is that warning times are very short, leaving typically only a few hours for civil protection services to act. This study investigates if operationally available shortrange numerical weather forecasts together with a rainfall-runoff model can be used as early indication for the occurrence of flash floods. One of the challenges in flash flood forecasting is that the watersheds are typically small and good observational networks of both rainfall and discharge are rare. Therefore, hydrological models are difficult to calibrate and the simulated river discharges cannot always be compared with ground "truth". The lack of observations in most flash flood prone basins, therefore, lead to develop a method where the excess of the simulated discharge above a critical threshold can provide the forecaster with an indication of potential flood hazard in the area with leadtimes of the order of the weather forecasts. This study is focused on the Cévennes-Vivarais region in the Southeast of the Massif Central in France, a region known for devastating flash floods. The critical aspects of using numerical weather forecasting for flash flood forecasting are being described together with a threshold – exceedance. As case study the severe flash flood event which took place on 8–9 September 2002 has been chosen. The short-range weather forecasts, from the Lokalmodell of the German national weather service, are driving the LISFLOOD model, a hybrid between conceptual and physically based rainfall-runoff model. Results of the study indicate that high resolution operational weather forecasting combined with a rainfall-runoff model could be useful to determine flash floods more than 24 hours in advance

A piecewise-linear reduced-order model of squeeze-film damping for deformable structures including large displacement effects

This paper presents a reduced-order model for the Reynolds equation for deformable structure and large displacements. It is based on the model established in [11] which is piece-wise linearized using two different methods. The advantages and drawbacks of each method are pointed out. The pull-in time of a microswitch is determined and compared to experimental and other simulation data.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838

Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic

DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that has been developed within the last 2 decades from basic laboratory science to Phase 2 clinical trials. It uses ANX776 (fluorescently labelled Annexin A5) to identify stressed and apoptotic cells in the living eye. During its development, DARC has undergone biochemistry optimisation, scale-up and GMP manufacture and extensive preclinical evaluation. Initially tested in preclinical glaucoma and optic neuropathy models, it has also been investigated in Alzheimer, Parkinson's and Diabetic models, and used to assess efficacy of therapies. Progression to clinical trials has not been speedy. Intravenous ANX776 has to date been found to be safe and well-tolerated in 129 patients, including 16 from Phase 1 and 113 from Phase 2. Results on glaucoma and AMD patients have been recently published, and suggest DARC with an AI-aided algorithm can be used to predict disease activity. New analyses of DARC in GA prediction are reported here. Although further studies are needed to validate these findings, it appears there is potential of the technology to be used as a biomarker. Much larger clinical studies will be needed before it can be considered as a diagnostic, although the relatively non-invasive nature of the nasal as opposed to intravenous administration would widen its acceptability in the future as a screening tool. This review describes DARC development and its progression into Phase 2 clinical trials from lab-based research. It discusses hypotheses, potential challenges, and regulatory hurdles in translating technology

Shortening Sow Restraint Period During Lactation Improves Production and Decreases Hair Cortisol Concentrations in Sows and Their Piglets

Food animal welfare is an issue of great concern, as society has a responsibility for animals under human care. Pork is the most consumed meat worldwide, with more than a billion pigs being slaughtered globally every year. Still, in most countries, sows are restrained in farrowing crates throughout lactation. In these crates, sows arc confined with bars to an area that is just slightly larger than their body. Thus, moving and turning around, grooming, or expressing other natural behaviors are typically impossible. In this study, we utilized a simple and practical modification of conventional farrowing crates to designed farrowing pens, by removable confinement bars, which provide the flexibility to change the housing system from one to another. Our objective was to examine the parameters of production and hair cortisol concentrations after different restraint periods during lactation. Analyses included data from 77 sows and their 997 piglets. Sows were housed in farrowing crates, but the confinement bars were removed after different periods, from 3 days post-farrowing to full restraint. For certain analyses, sows were grouped into Short or Long Restraint groups (3-10 days vs 13-24 days, respectively). Multiple linear regression revealed that for any additional day in restraint of the sows, piglets\u27 weaning rate decreases by 0.4% (P \u3c 0.05). Moreover, the total number of weaned piglets per litter was higher in the Short Restraint group as compared to the Long Restraint group (10.4 +/- 0.3 vs 9.7 +/- 0.3, respectively; P \u3c 0.05). Accordingly, total litter weight on the weaning day tended to be higher in the Short Restraint group (68.8 +/- 2.2 vs 64.9 +/- 1.8 kg; P = 0.1210). The requirement for medical treatments during lactation (e.g., antibiotics, NSAID) tended to be less frequent in the Short Restraint group (Sows: 21.9% vs 40%; P = 0.1219. Piglets: 2.4% vs 17.1%; P = 0.0609). Hair cortisol as a marker for chronic stress during lactation decreased when the restraint period was shortened in both sows and piglets. Our analysis revealed that sows\u27 hair cortisol is a significant mediator between the restraint of the sow and its piglets\u27 hair cortisol (Sobel test; P \u3c0.05). For every day of sows\u27 restraint sows\u27 hair cortisol increased by 05 pg/mg, and for any additional unit of sows\u27 hair cortisol, piglets\u27 hair cortisol increased by 0.36 pg/mg. In condusion, sustainable swine farming management can be beneficial for both animals and farmers; limiting sow restraint during lactation is expected to reduce stress, enhance welfare and production, and potentially improve the economics of swine operations. (C) 2020 The Authors. Published by Elsevier Inc. on behalf of The Animal Consortium

Points of Interest Coverage with Connectivity Constraints using Wireless Mobile Sensors

Part 7: Network Topology ConfigurationInternational audienceThe coverage of Points of Interest (PoI) is a classical requirement in mobile wireless sensor applications. Optimizing the sensors self-deployment over a PoI while maintaining the connectivity between the sensors and the sink is thus a fundamental issue. This article addresses the problem of autonomous deployment o f mobile sensors that need to cover a predefined PoI with a connectivity constraints and provides the solution to it using Relative Neighborhood Graphs (RNG). Our deployment scheme minimizes the number of sensors used for connectivity thus increasing the number of monitoring sensors. Analytical results, simulation results and real implementation are provided to show the efficiency of our algorithm

Predicting wet age-related macular degeneration (AMD) using DARC (detecting apoptosing retinal cells) AI (artificial intelligence) technology

Objectives: To assess a recently described CNN (convolutional neural network) DARC (Detection of Apoptosing Retinal Cells) algorithm in predicting new Subretinal Fluid (SRF) formation in Age-related-Macular-Degeneration (AMD). Methods: Anonymized DARC, baseline and serial OCT images (n = 427) from 29 AMD eyes of Phase 2 clinical trial (ISRCTN10751859) were assessed with CNN algorithms, enabling the location of each DARC spot on corresponding OCT slices (n = 20,629). Assessment of DARC in a rabbit model of angiogenesis was performed in parallel. Results: A CNN DARC count >5 at baseline was significantly (p = 0.0156) related to development of new SRF throughout 36 months. Prediction rate of eyes using unique DARC spots overlying new SRF had positive predictive values, sensitivities and specificities >70%, with DARC count significantly (p < 0.005) related to the magnitude of SRF accumulation at all time points. DARC identified earliest stages of angiogenesis in-vivo. Conclusions: DARC was able to predict new wet-AMD activity. Using only an OCT-CNN definition of new SRF, we demonstrate that DARC can identify early endothelial neovascular activity, as confirmed by rabbit studies. Although larger validation studies are required, this shows the potential of DARC as a biomarker of wet AMD, and potentially saving vision-loss

Energy-efficient full-range oscillation analysis of parallel-plate electrostatically actuated MEMS resonators

This is the peer reviewed version of the following article: “Fargas Marques, A., Costa Castelló, R. (2017) Energy-efficient full-range oscillation analysis of parallel-plate electrostatically actuated MEMS resonators, 1-13.” which has been published in final form at [doi: 10.1007/s11071-017-3633-8]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."Electrostatic parallel-plate actuators are a common way of actuating microelectromechanical systems, both statically and dynamically. Nevertheless, actuation voltages and oscillations are limited by the nonlinearity of the actuator that leads to the pull-in phenomena. This work presents a new approach to obtain the electrostatic parallel-plate actuation voltage, which allows to freely select the desired frequency and amplitude of oscillation. Harmonic Balance analysis is used to determine the needed actuation voltage and to choose the most energy-efficient actuation frequency. Moreover, a new two-sided actuation approach is presented that allows to actuate the device in all the stable range using the Harmonic Balance Voltage.Peer ReviewedPostprint (author's final draft

Cost-effectiveness of febrile neutropenia prevention with primary versus secondary G-CSF prophylaxis for adjuvant chemotherapy in breast cancer: a systematic review

The adoption of primary (PP) versus secondary prophylaxis (SP) of febrile neutropenia (FN), with granulocyte colony-stimulating factors (G-CSF), for adjuvant chemotherapy (AC) regimens in breast cancer (BC) could be affected by its “value for money”. This systematic review examined (i) cost-effectiveness of PP versus SP, (ii) FN threshold at which PP is cost-effective including the guidelines 20 % threshold and (iii) potential impact of G-CSF efficacy assumptions on outcomes. The systematic review identified all cost-effectiveness/cost-utility analyses (CEA/CUA) involving PP versus SP G-CSF for AC in BC that met predefined inclusion/exclusion criteria. Five relevant CEA/CUA were identified. These CEA/CUA examined different AC regimens (TAC = 2; FEC-D = 1; TC = 2) and G-CSF formulations (filgrastim “F” = 4; pegfilgrastim “P” = 4) with varying baseline FN—risk (range 22–32 %), mortality (range 1.4–6.0 %) and utility (range 0.33–0.47). The potential G-CSF benefit, including FN risk reduction with P versus F, varied among models. Overall, relative to SP, PP was not associated with good value for money, as per commonly utilized CE thresholds, at the baseline FN rates examined, including the consensus 20 % FN threshold, in most of these studies. The value for money associated with PP versus SP was primarily dependent on G-CSF benefit assumptions including reduced FN mortality and improved BC survival. PP G-CSF for FN prevention in BC patients undergoing AC may not be a cost-effective strategy at the guidelines 20 % FN threshold