Resource Allocation for Device-to-Device Communications Underlaying Heterogeneous Cellular Networks Using Coalitional Games

Heterogeneous cellular networks (HCNs) with millimeter wave (mmWave) communications included are emerging as a promising candidate for the fifth generation mobile network. With highly directional antenna arrays, mmWave links are able to provide several-Gbps transmission rate. However, mmWave links are easily blocked without line of sight. On the other hand, D2D communications have been proposed to support many content based applications, and need to share resources with users in HCNs to improve spectral reuse and enhance system capacity. Consequently, an efficient resource allocation scheme for D2D pairs among both mmWave and the cellular carrier band is needed. In this paper, we first formulate the problem of the resource allocation among mmWave and the cellular band for multiple D2D pairs from the view point of game theory. Then, with the characteristics of cellular and mmWave communications considered, we propose a coalition formation game to maximize the system sum rate in statistical average sense. We also theoretically prove that our proposed game converges to a Nash-stable equilibrium and further reaches the near-optimal solution with fast convergence rate. Through extensive simulations under various system parameters, we demonstrate the superior performance of our scheme in terms of the system sum rate compared with several other practical schemes.Comment: 13 pages, 12 figure

Integrating biomedical, ecological, and sustainability sciences to manage emerging infectious diseases

Globalization accelerates the mobilization of microorganisms via international trade and transport. Growth in population, increasing connectivity, and rapid urbanization all exacerbate the consequent risk of pandemics of zoonotic diseases. Global problems require global solutions, particularly the co-ordination of international research in biomedical sciences, global ecology, and sustainability

On Non-Cooperative Multiple-Target Tracking with Wireless Sensor Networks

In this paper, we propose an approach to track multiple non-cooperative targets with wireless sensor networks. Most existing tracking algorithms can not be directly applied to non-cooperative target tracking because they assume the access to signals from individual targets for tracking by assuming that: 1) there is only one target in a field; 2) signals from different co-operative targets can be differentiated; or 3) interference caused by signals from other targets is negligible because of attenuation. We propose a general approach for tracking non-cooperative targets. The tracking algorithm first separates the aggregate signals from multiple indistinguishable targets via the blind source separation (BSS) algorithms. Through the analysis on both the temporal and spatial correlation of the separated individual signals, the tracking algorithm determines the location of a target and its moving track. A voting scheme based on the spatial information is designed to better estimate the moving track. Furthermore, we analyze and discuss the influence of signal attenuation and the tracking resolution of the proposed tracking approach. Our experiments show that the proposed approach can both accurately and precisely track multiple indistinguishable moving targets

Application of biochar to soil reduces cancer risk via rice consumption: a case study in Miaoqian village, Longyan, China

Consumption of rice contaminated with potentially toxic elements (PTEs) is a major pathway for human exposure to PTEs. This is particularly true in China's so called "Cancer Villages". In this study, sewage sludge biochar (SSBC) was applied to soil (at 5% and 10%) to suppress PTE phytoavailability and as a consequence to reduce PTE levels in rice grown in mining impacted paddy soils. Risk assessment indicated that SSBC addition (10%) markedly (P≤0.05) decreased the daily intake, associated with the consumption of rice, of PTEs (As, Cd, Co, Cu, Mn, Pb and Zn by: 68, 42, 55, 29, 43, 38 and 22%, respectively). In treatments containing SSBC (10%) the health quotient (HQ) indices for PTEs (except for As, Cu and Mn) were <1, indicating that SSBC suppressed the health risk associated with PTEs in rice. The addition of SSBC (10%) markedly (P≤0.01) reduced AsIII (72%), dimethylarsinic acid (DMA) (74%) and AsV (62%) concentrations in rice. Consequentially, following SSBC application (10%), the incremental lifetime cancer (ILTR) value for iAs (AsIII+AsV) associated with the consumption of rice was significantly (P≤0.01) reduced by 66%. These findings suggest that SSBC could be a useful soil amendment to mitigating PTE exposure, through rice consumption, in China's "Cancer Villages"

Microbial mediated arsenic biotransformation in wetlands

Arsenic (As) is a pervasive environmental toxin and carcinogenic metalloid. It ranks at the top of the US priority List of Hazardous Substances and causes worldwide human health problems. Wetlands, including natural and artificial ecosystems (i.e. paddy soils) are highly susceptible to As enrichment; acting not only as repositories for water but a host of other elemental/chemical moieties. While macro-scale processes (physical and geological) supply As to wetlands, it is the micro-scale biogeochemistry that regulates the fluxes of As and other trace elements from the semi-terrestrial to neighboring plant/aquatic/atmospheric compartments. Among these fine-scale events, microbial mediated As biotransformations contribute most to the element’s changing forms, acting as the ‘switch’ in defining a wetland as either a source or sink of As. Much of our understanding of these important microbial catalyzed reactions follows relatively recent scientific discoveries. Here we document some of these key advances, with focuses on the implications that wetlands and their microbial mediated transformation pathways have on the global As cycle, the chemistries of microbial mediated As oxidation, reduction and methylation, and future research priorities areas

Expression of HER2 in high-grade urothelial carcinoma based on Chinese expert consensus and the clinical effects of disitamab vedotin-tislelizumab combination therapy in the treatment of advanced patients

Background: A vast number of researchers have discovered high levels of human epidermal growth factor receptor-2 (HER2) expression in urothelial carcinoma (UC), but they do not use a uniform scoring system. Based on the 2021 edition of clinical pathological expert consensus on HER-2 testing in UC in China, we investigated the expression level and clinical significance of HER2 in high-grade UC. Furthermore, we looked at the prognosis of patients with locally advanced/metastatic UC after combining HER2 targeting antibody-drug conjugates (ADC) medication disitamab vedotin (DV) with programmed cell death protein 1 (PD-1) inhibitor tislelizumab.Patients and methods: From 2019 to 2022, we collected paraffin specimens of UC from the Department of Urology at the Provincial Hospital Affiliated to Shandong First Medical University. HER2 expression-related factors were investigated. Patients with advanced UC who have failed systemic chemotherapy at least once and had received immune checkpoint inhibitor (ICI) medication during second-line treatment were selected and treated with DV in combination with tislelizumab. We assessed the therapy’s efficacy and safety.Results: 185 patients with high-grade UC were included in this investigation. 127 patients (68.7%) were HER2 positive (IHC 2+/3+) according to the 2021 Clinical pathological expert consensus on HER2 testing in UC in China. The clinical stage of UC differed statistically significantly between the HER2-and HER2+ groups (p = 0.019). Sixteen advanced UC patients were treated with DV and tislelizumab for a median of 14 months. The disease control rate was 87.5%, while the objective response rate (ORR) was 62.5%. The ORR of HER2+ individuals was higher than that of HER2-individuals (70.0% vs. 50.0%). The median progression-free survival or overall survival was not reached. In this study, the incidence of treatment-related adverse events was 68.8% (11/16), with all of them being grade 1 or 2 adverse reactions.Conclusion: HER2 protein expressed at a high percentage in UC, and 68.7% patients expressed HER2 positive (IHC 2+/3+). HER2+ expression is positively correlated with higher clinical stage of UC. HER2 targeted ADC drug disitamab vedotin combining with PD-1 inhibitor tislelizumab has shown efficacy, safety and controllable adverse reactions in the treatment of advanced UC