Architecture of a GPS-based road management system

Malfunctioning traffic lights, potholes and roads in bad condition are only a few of the innumerable common thoroughfare problems that occasionally contribute to accidents. People tend to ignore reporting those issues as the channels for making a complaint is inconvenient. Accuracy of complaints is also at doubt as it tends to be general eg. Pothole at Ampang Road, in front of a police station. This paper presents the architecture of a Global Positioning System (GPS) based approach for reporting thoroughfare problems via Global System for Mobile Communications (GSM) for road maintenance management environment. To increase accuracy and efficiency, GPS can be used as it enables the tracking and tracing of the three figures of a GPS receiver’s coordinates namely longitude, latitude and altitude. Data like location, date and time will be optimized by mapping the site of where the thoroughfare problem exists in a map, with the intention that the relevant authorities could identify the spot and have the problems resolved responsively. The proposed system will serve as a handier and convenient alternative means for road users to send complaints to the relevant authorities, in addition to the existing channels, so that these issues could be addressed in a timely manner

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

SummarySLX4 interacts with several endonucleases to resolve structural barriers in DNA metabolism. SLX4 also interacts with telomeric protein TRF2 in human cells. The molecular mechanism of these interactions at telomeres remains unknown. Here, we report the crystal structure of the TRF2-binding motif of SLX4 (SLX4TBM) in complex with the TRFH domain of TRF2 (TRF2TRFH) and map the interactions of SLX4 with endonucleases SLX1, XPF, and MUS81. TRF2 recognizes a unique HxLxP motif on SLX4 via the peptide-binding site in its TRFH domain. Telomeric localization of SLX4 and associated nucleases depend on the SLX4-endonuclease and SLX4-TRF2 interactions and the protein levels of SLX4 and TRF2. SLX4 assembles an endonuclease toolkit that negatively regulates telomere length via SLX1-catalyzed nucleolytic resolution of telomere DNA structures. We propose that the SLX4-TRF2 complex serves as a double-layer scaffold bridging multiple endonucleases with telomeres for recombination-based telomere maintenance

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

Funder: Funding details are provided in the Supplementary MaterialAbstractPolygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally-efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, “select and shrink for summary statistics” (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestry; 7,669 women of East Asian ancestry; 1,072 women of African ancestry, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestry. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38(95%CI:1.28–1.48,AUC:0.588) per unit standard deviation, in women of European ancestry; 1.14(95%CI:1.08–1.19,AUC:0.538) in women of East Asian ancestry; 1.38(95%CI:1.21-1.58,AUC:0.593) in women of African ancestry; hazard ratios of 1.37(95%CI:1.30–1.44,AUC:0.592) in BRCA1 pathogenic variant carriers and 1.51(95%CI:1.36-1.67,AUC:0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.</jats:p

Effects of prime decision-maker's wage on corruption level.

Many studies have confirmed the negative correlation between public sector wages and corruption level. However, corruption should not be curbed from below, but right at the top. Hence, this study attmepts to investgate the relationship between the wage of prime decision-maker and corruption level in each country

Hotel promotions in Singapore, Malaysia, & Indonesia

This project purports to study the finer details of the promotions strategies of hotels in Singapore, Malaysia, and Indonesia. In each country, we will attempt to draw the differences between the 3-star and the 5-star hotels. Promotions, being traditionally one of the four pillars of marketing, seems to be an area not really covered in its full glory in the marketing mix of most hotels. There is extreme emphasis on product, both in the tangible and intangible areas; pricing, where it is seen as a major competitive force, and distribution, the old cliche about the importance of location, location, location requires no repetition. In the three countries studied, promotions seem to be secondary and most of the promotions undertaken were on a reactive basis, though there are more promotional programmes that are now more proactive in nature. Promotions should be an integral part of the marketing mix of any hotel as communications from the service provider to the customer ~ past, present or potential is crucial to ensure success. We have approached this study from the point of view of the customer as we feel that the customer is of the utmost importance to a business. Indeed, without customers, no business can survive. Hence, the customers are the ultimate determinants of the success of hotels promotional efforts. In addition to the analysis of the current promotional practices, this research also seeks to forecast possible future trends in promotional methods and media in the hospitality industry. Hence, this research could be used as a reference for determing the possibie means with which hotels could reach their target customers more effectively and efficiently in future.BUSINES