Probing the Deuteron at Very Large Internal Momenta

We measure 2H(e,e′p)n cross sections at 4-momentum transfers of Q2 = 4.5 ± 0.5   (GeV/c)2 over a range of neutron recoil momenta pr, reaching up to ∼1.0  GeV/c. We obtain data at fixed neutron recoil angles θnq = 35°, 45°, and 75° with respect to the 3-momentum transfer →q. The new data agree well with previous data, which reached pr ∼ 500  MeV/c. At θnq = 35° and 45°, final state interactions, meson exchange currents, and isobar currents are suppressed and the plane wave impulse approximation provides the dominant cross section contribution. We compare the new data to recent theoretical calculations, where we observe a significant discrepancy for recoil momenta pr \u3e 700  MeV/c

Contribution to the Improvement of the Correlation Filter Method for Modal Analysis with a Spatial Light Modulator

Modal decomposition of light is essential to study its propagation properties in waveguides and photonic devices. Modal analysis can be carried out by implementing a computer-generated hologram acting as a match filter in a spatial light modulator. In this work, a series of aspects to be taken into account in order to get the most out of this method are presented, aiming to provide useful operational procedures. First of all, a method for filter size adjustment based on the standard fiber LP-mode symmetry is presented. The influence of the mode normalization in the complex amplitude encoding-inherent noise is then investigated. Finally, a robust method to measure the phase difference between modes is proposed. These procedures are tested by wavefront reconstruction in a conventional few-mode fiber

Contribution to the Improvement of the Correlation Filter Method for Modal Analysis with a Spatial Light Modulator

Modal decomposition of light is essential to study its propagation properties in waveguides and photonic devices. Modal analysis can be carried out by implementing a computer-generated hologram acting as a match filter in a spatial light modulator. In this work, a series of aspects to be taken into account in order to get the most out of this method are presented, aiming to provide useful operational procedures. First of all, a method for filter size adjustment based on the standard fiber LP-mode symmetry is presented. The influence of the mode normalization in the complex amplitude encoding-inherent noise is then investigated. Finally, a robust method to measure the phase difference between modes is proposed. These procedures are tested by wavefront reconstruction in a conventional few-mode fiber

Intervención educativa para la gingivitis crónica en adolescentes del Consultorio Médico de la Familia 10. Área Norte. Sancti Spíritus

Fundamento: La gingivitis crónica constituye un problema de salud bucal en los adolescentes, relacionado con los escasos conocimientos y factores de riesgo presentes. Objetivo: Aplicar la intervención educativa para modificar el nivel de conocimientos de los adolescentes sobre gingivitis crónica del CMF 10 de Sancti Spíritus. Metodología: Se realizó un estudio cuasi-experimental, con diseño de antes y después en el período de septiembre 2018 a febrero del 2019, la población fueron 196 adolescentes y la muestra 61 que presentaron gingivitis crónica. Las variables utilizadas: conocimientos sobre prevención de gingivitis, higiene bucal y presencia de gravedad de la gingivitis, los métodos: del nivel teórico, empírico (encuesta, entrevista, determinación de la IHBS, Índice Gingival de Löe y Silness y de la estadística descriptiva. Resultados: Los conocimientos antes de la intervención eran insuficientes (40.8 %), la gravedad de la enfermedad el 50.8 % presentaba gingivitis moderada y el 47.5 % mala higiene bucal; después de la intervención el 90.1 % tenía conocimientos suficientes, el 73.7 % sin alteración en las encías y 83.6 % buena higiene. Conclusiones: La intervención educativa logró elevar los conocimientos, disminuir la gravedad de la gingivitis y mejorar la higiene bucal de los adolescentes

The comprehensive restoration of the commercial corridors in the historic center of the city of Camagüey

A significant part of the historic center of Camagüey is a World Heritage Site and, in turn, has a high concentration of the main commercial corridors of the city. As these are considered to be highly central spaces where the public converges, and due to their heritage relevance and deterioration, it was decided to intervene. A comprehensive process of conservation was carried out using the Patrimonial Intervention Methodology developed by CECONS. The deterioration at the urban architectural level and its causes, as well as the degree of protection were identified. In addition, the valid actions to be executed according to buildings and surroundings were determined. As a result, urban compatibility and integrated project management were used in this comprehensive conservation project, which guaranteed the quality of the interventions and the joint participation of the population and institutions, together with a cultural revitalization plan that makes it possible to regain these spaces of coexistence as an expression of citizen identity.Parte significativa del centro histórico de Camagüey es Patrimonio Cultural de la Humanidad y concentra, a su vez, los principales corredores comerciales de la ciudad, considerados espacios de confluencia ciudadana y de alta centralidad los cuales, por su relevancia patrimonial y su degradación, se decidió intervenir. En ese proceso, se realizó una conservación integral, donde se aplicó la Metodología de Intervención Patrimonial desarrollada por el CECONS, con la detección de los deterioros a nivel urbano arquitectónico y sus causas, los grados de protección y las acciones válidas a ejecutar particularizadas según edificaciones y entorno. Como resultado, se utilizó en el proyecto de conservación integral la compatibilización urbana y la dirección integrada de proyectos, que garantizaron la calidad de las intervenciones y la participación mancomunada de la población y algunas instituciones, junto a un plan de dinamización cultural que permite el rescate de estos espacios de convivencia como expresión de la identidad ciudadana

Impact of in vitro HIV infection on human thymic regulatory T cell differentiation

BackgroundThe differentiation and function of immunosuppressive regulatory T cells (Tregs) is dictated by the master transcription factor FoxP3. During HIV infection, there is an increase in Treg frequencies in the peripheral blood and lymphoid tissues. This accentuates immune dysfunction and disease progression. Expression of FoxP3 by thymic Tregs (tTregs) is partially controlled by TGF-β. This cytokine also contributes to Treg development in the peripheral blood and lymphoid tissues. Although TGF-β mediates lymphoid tissue fibrosis and peripheral Treg differentiation in HIV-infected individuals, its role in the induction and maintenance of Tregs within the thymus during HIV infection remains unclear.MethodsThymocytes were isolated from fresh human thymic tissues obtained from pediatric patients undergoing cardiac surgery. Infection by both R5- and X4-tropic HIV-1 strains and TGF-β treatment of human thymocytes was performed in an in vitro co-culture model with OP9-DL1 cells expressing Notch ligand delta-like 1 without T cell receptor (TCR) activation.ResultsDespite high expression of CCR5 and CXCR4 by tTregs, FoxP3 +  CD3highCD8- thymocytes were much less prone to in vitro infection with R5- and X4-tropic HIV strains compared to FoxP3-CD3highCD8- thymocytes. As expected, CD3highCD4+ thymocytes, when treated with TGF-β1, upregulated CD127 and this treatment resulted in increased FoxP3 expression and Treg differentiation, but did not affect the rate of HIV infection. FoxP3 expression and Treg frequencies remained unchanged following in vitro HIV infection alone or in combination with TGF-β1.ConclusionFoxP3 expression and tTreg differentiation is not affected by in vitro HIV infection alone or the combination of in vitro HIV infection and TGF-β treatment

Tuberculosis en la Ciudad de la Habana, 1995-1999

OBJECTIVE: Tuberculosis is a worldwide health problem getting a prioritized attention by the Cuban National Health System. To describe the main indicators of the Cuban Tuberculosis Control Program. METHODS: Based on surveillance data from the Provincial Center of Hygiene and Epidemiology, the health care network and strategies of the tuberculosis control program were reviewed; incidence rates, case finding indicators, diagnosis and case management were described. RESULTS: Eight subjects with respiratory symptoms were found per 1,000 attending general medical care services. The incidence rates of all tuberculosis types declined from 16.4 in 1995 to 12.0 x 10(5) people in 1999. Pulmonary tuberculosis incidence rate was reduced from 15.1 in1995 to 10.4 x 10(5) in 1999, whereas extrapulmonary tuberculosis had an increment from 1.3 to 1.6 x 10(5) in the same period. Of all new cases, 40-50 % were diagnosed at multispecialty clinics, 67.6% were diagnosed by positive smears, 15.2 % by positive cultures, 13.8 % by clinical and X-rays evidences only; and 0.9 % and 1.5 % were respectively diagnosed by biopsy and necropsy. There was an increase in the incidence rate in the age group 15-64 years in 1996 and 1997 but it declined again in 1998 and 1999. The age group 64 years and over showed a rate reduction from 1995 to 1999. In general, incidence rates diminished in the overall period. The average delay between onset of symptoms and diagnosis improved from 42 days in 1995 to 28.6 days in 1999. CONCLUSIONS: There seems to be a halt in reporting trends of new cases in 1996. Tuberculosis indicators reveal satisfactory changes in the study period.OBJETIVO: La tuberculosis es un importante problema mundial de salud que recibe una atención priorizada del Sistema de Salud Cubano. Lo objetivo del trabajo es describir el comportamiento de los indicadores del Programa de Control de Tuberculosis cubano. MÉTODOS: A partir de una revisión de los documentos de la vigilancia de la tuberculosis en los registros del Centro Provincial de Higiene y Epidemiología se expone la infraestructura sanitaria, las estrategias del Programa de Control en la ciudad, se describen las tasas de incidencia, indicadores de localización, diagnóstico y manejo de casos. RESULTADOS: Se hallaron 8 sintomáticos respiratorios por cada mil consultantes de medicina general; la tasa de incidencia de tunerculosis en todas sus formas descendió de 16,4 (1995) a 12,0x105 habitantes (1999); la tuberculosis pulmonar descendió de 15,1 a 10,45 habitantes mientras la tuberculosis extrapulmonar ascendió de 1,3 a 1,6 x 105 habitantes, en igual período. Del total de los casos nuevos, el 40-50% fueron identificados en los policlínicos, el 67% fueron diagnosticados por baciloscopías, el 15,2% por cultivos, el 13.8% sólo por evidencias clínicas y radiológicas; el 0,9% y el 1,5%, respectivamente, fueron diagnosticados por biopsia o hallazgos de necropsia. Los grupos de 15-64 años incrementaron su incidencia en 1996-1997 y disminuyeron en 1998-1999; los casos >;64 años de edad disminuyeron progresivamente de 1995 a 1999; en general, la tasa de incidencia de casos disminuyó. La demora promedio entre primeros síntomas y diagnóstico mejoró de 42 días en 1995 a 28,6 en 1999. CONCLUSIONES: La reversión de la tendencia de la notificación de casos nuevos parece haberse detenido en 1996. La situación de los indicadores de tuberculosis revelan cambios satisfactorios en el período analizado

Especies de Ciatostomas Resistentes al Albendazol en Equinos, Cuba

This study aimed to evaluate the efficacy of anthelmintic used in an equine ranch in Cuba. The faecal egg count reduction test of Strongyles (FECRT) was used to evaluate albendazole and ivermectin. Thirty-three horses were selected (18 treated with albendazole, 15 treated with ivermectin). The egg count reduction for albendazole was 38% for micronized albendazole and 33% for albendazole sulfoxide. Ivermectin effectiveness was 100%. Subsequently, four horses that showed high counts of eggs after the albendazole treatment were treated with ivermectin on day 17 after the initial deworming to collect resistant nematodes in the faeces. These nematodes were morphologically identified. It was possible to identified 493 specimens: Cylicocyclus nassatus, Cyathostomum catinatum, Cylicostephanus longibursatus, Cylicostephanus goldi and Cylicostephanus minutus which represented 78.5, 7.7, 6.5, 3.9 and 3.4% respectively. This has been the first report for Cylicostephanus minutus in equines in Cuba. It is concluded that at least five of species of cyathostomes were resistant to albendazole.Con el objetivo de evaluar la eficacia antihelmíntica de las presentaciones empleadas en los equinos de un rancho cubano, se realizó un test de reducción del recuento fecal de huevos de estróngilos (TRCFH) frente al albendazol y a la ivermectina, administrados vía oral. Se seleccionaron 33 equinos (albendazol 18; ivermectina 15). La reducción del conteo de huevos frente al albendazol varió entre 38% para el albendazol micronizado y 33% para el albendazol sulfóxido. La eficacia de la ivermectina fue del 100%. Posteriormente, a cuatro equinos con altos recuentos de huevos de los grupos tratados con albendazol se les hizo una segunda desparasitación con ivermectina en el día 17 posterior a la dosificación inicial para colectar los nematodos resistentes al benzimidazol en las heces. Estos nematodos fueron identificados morfológicamente. Del total de nematodos colectados, se identificaron 493 pertenecientes a las especies Cylicocyclus nassatus, Cyathostomum catinatum, Cylicostephanus longibursatus, Cylicostephanus goldi y Cylicostephanus minutus, las cuales representaron el 78.5, 7.7, 6.5, 3.9 y 3.4%, respectivamente. Este fue el primero reporte de C. minutus en equinos de Cuba. Se concluye que al menos cinco de las especies de ciatostomas fueron resistentes al albendazol