Comparison of tiletamine-zolazepam and tiletamine-zolazepam-ketamine-xylazine administered intravenously in dogs

The anaesthetic effects of intravenous administration oftiletamine (2.5 mg/kg) - zolazepam (2.5 mg/kg) mixture (TZ), and tiletamine (0.5 mglkg) - zolazepam (0.5 mg/kg) - ketamine (1.6 mg/kg) - xylazine (0.4 mg/kg) mixture (TKX) were evaluated in ten dogs. Atropine sulphate at a dose rate ofO.05 mg/kg was administered concurrently with the anaesthetic mixtures. Both mixtures produced rapid, smooth induction, and allowed intubation. The TKX mixture produced longer skin clamp analgesia and immobilisation, better jaw relaxation, with shorter and smoother recovery compared to TZ injection. The TKX mixture induced significant but transient pallor of mucous membranes « 2 min). The TZ mixture resulted in increased heart rate and a higher respiratory rate compared to TKX mixture. Haemoglobin saturation was < 90% in some dogs following either mixture. The TKX mixture can be considered as an alternative injectable mixture to TZ for short and minimally invasive procedures in patients that have no cardiopulmonary dysfunction

A Clustering System for Dynamic Data Streams Based on Metaheuristic Optimisation

open access articleThis article presents the Optimised Stream clustering algorithm (OpStream), a novel approach to cluster dynamic data streams. The proposed system displays desirable features, such as a low number of parameters and good scalability capabilities to both high-dimensional data and numbers of clusters in the dataset, and it is based on a hybrid structure using deterministic clustering methods and stochastic optimisation approaches to optimally centre the clusters. Similar to other state-of-the-art methods available in the literature, it uses “microclusters” and other established techniques, such as density based clustering. Unlike other methods, it makes use of metaheuristic optimisation to maximise performances during the initialisation phase, which precedes the classic online phase. Experimental results show that OpStream outperforms the state-of-the-art methods in several cases, and it is always competitive against other comparison algorithms regardless of the chosen optimisation method. Three variants of OpStream, each coming with a different optimisation algorithm, are presented in this study. A thorough sensitive analysis is performed by using the best variant to point out OpStream’s robustness to noise and resiliency to parameter changes

An unclassified tibial plateau fracture: Reverse Schatzker type IV.

The most commonly accepted system of classification for tibia plateau fractures is that of Schatzker. Increasingly, both high energy injuries and atypical osteoporotic fragility failures have led to more complex, unusual and previously undescribed fracture patterns being recognized. We present a case of a patient with a previously unreported pattern of tibia plateau fracture and knee dislocation. We highlight the challenges confronted and present the management and the outcomes of his injury. A 28-year old male motorcyclist was involved in a head on collision with a truck and was transferred by helicopter to our level 1 major trauma centre emergency department. His injuries were a circumferential degloving injury to his left leg and a right lateral tibial plateau fracture/knee dislocation. The pattern of the lateral tibial plateau fracture was unique and did not fit any recognised classification system. The patient received a spanning external fixator initially and after latency of 12 days for soft tissue resuscitation he underwent definite fixation through an antero-lateral approach to the proximal tibia with two cannulated 6.5 mm partially threaded screws and an additional lateral proximal tibia plate in buttress mode. A hinged knee brace was applied with unrestricted range of motion post-operatively and free weight bearing were permitted post operatively. At the 6 months follow up, the patient walks without aids and with no limp. Examination revealed a stable joint and full range of motion. Plain radiographs revealed that the fracture healed with good alignment and the fixation remained stable. High energy injuries can lead to more complicated fracture patterns, which challenge the orthopaedic surgeons in their management. It is crucial to understand the individual fracture pattern and the possible challenges that may occur. This study reports a lateral tibia plateau fracture/dislocation which perhaps is best described as a reverse Schatzker IV type fracture

Blue Swimmer Crab ( Portunus armatus ) and Mud Crab Scylla serrata and Scylla olivacea ) Resources in the North Coast and Gascoyne Coast Bioregions, Western Australia

Blue swimmer crab (Portunus armatus) are found along the entire Western Australia (WA) coast, in a range of estuarine, inshore and continental shelf areas (\u3c50 m). In the North Coast Bioregion (NCB), commercial fishing primarily occurs as part of the Pilbara Crab Managed Fishery (PCMF) which spans the inshore waters from Onslow through to Port Hedland, with most fishing activity taking place around Nickol Bay

Blue Swimmer Crab ( Portunus armatus ) Resource in the West Coast Bioregion, Western Australia Part 1: Peel Harvey Estuary, Cockburn Sound and Swan Canning Estuary

Blue swimmer crabs (Portunus armatus) are found along the entire coastline of Western Australia in a range of estuarine, inshore and continental shelf areas (\u3c50 m). In the West Coast Bioregion (WCB), crab fisheries are centred in estuaries and coastal embayments from Geographe Bay to the Swan River. Commercial fisheries include the Cockburn Sound Crab Managed Fishery (CSCMF), the Warnbro Sound Crab Managed Fishery, the Swan-Canning Estuary (SCE) Crab Fishery (Area 1 of the West Coast Estuarine Managed Fishery (WCEMF)), Peel-Harvey Crab Fishery (Area 2 of the WCEMF), Hardy Inlet (Area 3 of the WCEMF) and the Mandurah to Bunbury Developing Crab Fishery (Area 1, Comet Bay and Area 2, Mandurah-Bunbury)

The Private Provision of Public Goods: An Analysis of Homes on Golf Courses

This paper examines the joint production of golf and real estate development. The empirical results of this analysis show that, over time, golf courses are being constructed less for recreational golf and more for contractual assurance of green open space for homes. We believe that this fundamentally provides some evidence that the demand for environmental quality is growing and that markets are increasingly able to find creative contracting mechanisms to satisfy demands for public goods

Mechanism of Enhancement in Electromagnetic Properties of MgB2 by Nano SiC Doping

A comparative study of pure, SiC, and C doped MgB2 wires has revealed that the SiC doping allowed C substitution and MgB2 formation to take place simultaneously at low temperatures. C substitution enhances Hc2, while the defects, small grain size, and nanoinclusions induced by C incorporation and low-temperature processing are responsible for the improvement in Jc. The irreversibility field (Hirr) for the SiC doped sample reached the benchmarking value of 10 T at 20 K, exceeding that of NbTi at 4.2 K. This dual reaction model also enables us to predict desirable dopants for enhancing the performance properties of MgB2

Catatonic Episodes Related to Substance Use: A Cross-Sectional Study Using Electronic Healthcare Records

OBJECTIVE: Substance use has increasingly been linked to the onset of catatonic episodes; however, no large observational studies have examined this association. This study aimed to identify catatonic episodes temporally associated with acute intoxication, withdrawal or chronic substance use, investigate which substances were involved, and compare clinical characteristics of substance-related and non-substance-related catatonic episodes. METHODS: This study retrospectively identified all catatonic episodes recorded in an electronic case register hosted at a large secondary mental health trust in London, UK. Episodes were categorized as substance-related if the clinical record reported either a positive urine drug screen, an ICD-10 diagnosis of a mental or behavioral disorder due to substance use, or documented substance use between two weeks prior to the catatonic episode and the date of the catatonic episode. RESULTS: 108 of 2130 catatonic episodes (5.1%) were deemed substance-related. The number of contemporaneously reported substance-related episodes increased between 2007 and 2016 [r = 0.72, p = 0.02]. Episodes in the context of acute intoxication (n = 54) were most frequently related to cannabis (n = 31) or cocaine (n = 5) use, whilst those in the context of drug withdrawal (n = 8) were most commonly related to alcohol, opioids and benzodiazepines. There were 50 episodes of catatonia associated with chronic substance use without intoxication or withdrawal, of which the majority were related to cannabis use (n = 37). 21 episodes had overlapping intoxication, withdrawal and chronic use of different substances within an episode. Compared to catatonic episodes not related to substance use, episodes of substance-related catatonia occurred in individuals who were younger (mean age 31.3 years [SD 12.2] vs 35.7 years [SD 16.3], p = 0.01) and more likely to be men (74.0% vs 54.3%, p < 0.001). The clinical features of catatonia were similar between the two groups. CONCLUSIONS: A relatively small proportion of catatonic episodes were temporally associated with reported substance use within their electronic records. Substance-related catatonic episodes were mostly related to cannabis use, but other substances including cocaine, alcohol, opioids and benzodiazepines were sometimes implicated. This is likely an underestimate of substance-related catatonia use due to issues with documentation and appropriate investigation