Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.publishe

Understanding How University Students Use Perceptions of Consent, Wantedness, and Pleasure in Labeling Rape.

While the lack of consent is the only determining factor in considering whether a situation is rape or not, there is sufficient evidence that participants conflate wantedness with consent and pleasurableness with wantedness. Understanding how people appraise sexual scenarios may form the basis to develop appropriate educational packages. We conducted two large-scale qualitative studies in two UK universities in which participants read vignettes describing sexual encounters that were consensual or not, wanted or unwanted and pleasurable or not pleasurable. Participants provided free-text responses as to whether they perceived the scenarios to be rape or not and why they made these judgments. The second study replicated the results of the first and included a condition where participants imagined themselves as either the subject or initiator of the sexual encounter. The results indicate that a significant portion of our participants held attitudes reflecting rape myths and tended to blame the victim. Participants used distancing language when imagining themselves in the initiator condition. Participants indicated that they felt there were degrees of how much a scenario reflected rape rather than it simply being a dichotomy (rape or not). Such results indicate a lack of understanding of consent and rape and highlight avenues of potential educational materials for schools, universities or jurors

Self-Reported Sexual Assault in Convicted Sex Offenders and Community Men

Although self-reported sexual assault perpetrated by men against women has been well documented among college men, less is known about self-reported perpetration among convicted sex offenders and community men. This study provides unique descriptive and comparative information on sexual assaults in these understudied populations. Participants were 40 convicted sex offenders and 49 demographically-comparable community men who completed the Sexual Experiences Survey (SES; Abbey, Parkhill, & Koss, 2005; Koss, Gidycz, & Wisniewski, 1987) and other surveys to capture the promiscous sex and hostile masculinity pathways posited by the confluence model (Malamuth, 2003). We found notably few differences between sex offenders and community men in the rate and severity of sexual assault perpetration and the tactics used to obtain unwanted sexual contact. Specifically, 68% of sex offenders and 59% of community men acknowledged they had perpetrated sexual assault. Both groups used guilt and anger as the most frequent tactics to obtain unwanted sexual activity from their female victims. Consistent with the confluence model, an impersonal orientation towards sexual relationships was associated with sexual assault for both sex offenders and community men. Future directions for research on sexual assault perpetration and violence prevention efforts are discussed in light of these findings

Effects of an Increase in Group Size on the Social Behavior of a Group of Rough-Toothed Dolphins (Steno bredanensis)

Little is known about the social structure of rough-toothed dolphins (Steno bredanensis), but general knowledge of dolphin social structure suggests that individual dolphins often engage in multiple social relationships. In the wild, roughtoothed dolphins often swim in tight subgroups, consistent with the notion that social bonds and proximity to others are important for this species. Such behavior may also facilitate physical contact, which has been demonstrated to play important roles in social interactions in other dolphin species. In this study, the social behavior of captive rough-toothed dolphins was examined before and after the unification of two separate animal groups (both subgroups, n = 3) to investigate the effects of an increase in group size and a change in social structure on social behavior. The strongest new social partnership was between two juvenile males. Prior to the merger of subgroups, one of the juvenile males spent more time with a juvenile female. This dyad maintained a high interaction rate; however, after the move, this male significantly increased interaction rates with another juvenile male. The results of this study demonstrate that the integration of two small social groups provided opportunities for new social relationships to form but did not affect stable social partnerships that already existed. The formation of new social partnerships appeared to be influenced by age and gender. Although these results are based on a captive population, they provide insight into social behaviors that may be relevant to understanding the dynamic social structure of dolphin societies in the wild as well as in captive settings

Do Some Students Need Special Protection From Research on Sex and Trauma? New Evidence for Young Adult Resilience in “Sensitive Topics” Research

Institutional review boards (IRBs) have expressed concerns that certain individuals or groups, such as participants who are younger, ethnic minorities, or who have certain psychological or personality traits, may be particularly distressed when participating in "sensitive topics" research. This study examined the effects of several demographic and individual difference factors (i.e., age, sex, ethnicity, religiosity, Big Five personality traits, and baseline psychological distress levels) on reactions to participation in sensitive topics research. Participants were 504 undergraduates who completed an extensive battery of either trauma/sex questionnaires or cognitive tests and rated their positive and negative emotional reactions and the perceived benefits and mental costs of participating. They also compared research participation to normal life stressors. Our findings indicated that individual difference and demographic risk factors do not increase participant distress after participating in sex/trauma research over and above that experienced after participating in traditionally minimal-risk cognitive tasks. Participants generally found research participation less distressing than normal life stressors and even enjoyable

Do Some Students Need Special Protection From Research on Sex and Trauma? New Evidence for Young Adult Resilience in “Sensitive Topics” Research

Institutional review boards (IRBs) have expressed concerns that certain individuals or groups, such as participants who are younger, ethnic minorities, or who have certain psychological or personality traits, may be particularly distressed when participating in "sensitive topics" research. This study examined the effects of several demographic and individual difference factors (i.e., age, sex, ethnicity, religiosity, Big Five personality traits, and baseline psychological distress levels) on reactions to participation in sensitive topics research. Participants were 504 undergraduates who completed an extensive battery of either trauma/sex questionnaires or cognitive tests and rated their positive and negative emotional reactions and the perceived benefits and mental costs of participating. They also compared research participation to normal life stressors. Our findings indicated that individual difference and demographic risk factors do not increase participant distress after participating in sex/trauma research over and above that experienced after participating in traditionally minimal-risk cognitive tasks. Participants generally found research participation less distressing than normal life stressors and even enjoyable