GCformer: An Efficient Framework for Accurate and Scalable Long-Term Multivariate Time Series Forecasting

Transformer-based models have emerged as promising tools for time series forecasting. However, these model cannot make accurate prediction for long input time series. On the one hand, they failed to capture global dependencies within time series data. On the other hand, the long input sequence usually leads to large model size and high time complexity. To address these limitations, we present GCformer, which combines a structured global convolutional branch for processing long input sequences with a local Transformer-based branch for capturing short, recent signals. A cohesive framework for a global convolution kernel has been introduced, utilizing three distinct parameterization methods. The selected structured convolutional kernel in the global branch has been specifically crafted with sublinear complexity, thereby allowing for the efficient and effective processing of lengthy and noisy input signals. Empirical studies on six benchmark datasets demonstrate that GCformer outperforms state-of-the-art methods, reducing MSE error in multivariate time series benchmarks by 4.38% and model parameters by 61.92%. In particular, the global convolutional branch can serve as a plug-in block to enhance the performance of other models, with an average improvement of 31.93\%, including various recently published Transformer-based models. Our code is publicly available at https://github.com/zyj-111/GCformer

Potential Disease-Modifying Effects of Lithium Carbonate in Niemann-Pick Disease, Type C1

Background: Niemann-Pick disease type C1 (NP-C1) is a rare, autosomal-recessive neurodegenerative disorder with no United States Food and Drug Administration (FDA)-approved drug. Lithium has been shown to have considerable neuroprotective effects for neurological disorders such as bipolar disorder, Alzheimer’s disease and stroke and has been tested in many clinical trials. However, the pharmacological effect of lithium on NP-C1 neurodegenerative processes has not been investigated. The aim of this study was to provide an initial evaluation of the safety and feasibility of lithium carbonate in patients with NP-C1.Methods: A total of 13 patients diagnosed with NP-C1 who met the inclusion criteria received lithium orally at doses of 300, 600, 900, or 1,200 mg daily. The dose was reduced based on tolerance or safety observations. Plasma 7-ketocholesterol (7-KC), an emerging biomarker of NP-C1, was the primary endpoint. Secondary endpoints included NPC Neurological Severity Scores (NNSS) and safety.Results: Of the 13 patients with NP-C1 (12–33 years) enrolled, three withdrew (discontinuation of follow-up outpatient visits). The last observed post-treatment values of 7-KC concentrations (128 ng/ml, SEM 20) were significantly lower than pretreatment baselines values (185 ng/ml, SEM 29; p = 0.001). The mean NNSS was improved after lithium treatment at 12 months (p = 0.005). Improvement in swallowing capacity was observed in treated patients (p = 0.014). No serious adverse events were recorded in the patients receiving lithium.Conclusion: Lithium is a potential therapeutic option for NP-C1 patients. Larger randomized and double-blind clinical trials are needed to further support this finding.Clinical Trial Registration:ClinicalTrials.gov, NCT03201627

Socio-economic determinants of suicide rates in transforming China:A spatial-temporal analysis from 1990 to 2015

BACKGROUND: China has experienced dramatic social changes in the last three decades. This study aimed to investigate socio-economic factors related to suicide rates in China from 1990 to 2015, and examine how the impacts of these factors on suicide rates changed over time. METHODS: Suicide rates in 31 provinces in mainland China between 1990 and 2015 were obtained from the Global Burden of Disease (GBD) Study 2019. Temporal-spatial modelling was applied to assess the effects of GDP per capita, urbanization, migration, employment, divorce, proportions of children and older adults on provincial overall, male and female suicide rates. FINDINGS: The overall suicide rate in China declined from 18·1 /100,000 in 1990 to 8·6 /100,000 in 2015, with considerable spatial variation in the magnitude of decline across provinces. The protective effects of increasing in GDP per capita, and urbanization, on provincial suicide rate were strong in 1990 (log GDP: -3·56 [95% CI: -6·15, -0·96], urbanisation: -0·07 [-0·14, -0·01]), however these effects were negligible by 2015. The association between employment and suicide rates has shifted from positive to negative over the study period, while migration remained a constant risk factor for high suicide rates (0·04 [0.00, 0·09]). INTERPRETATION: This study highlighted the dynamic effects of economic and social factors on suicide rates in the context of transforming China. To maintain further reductions in suicide rates cannot rely simply on improving people's materialistic and economic conditions. A more holistic approach to improve overall population well-being is needed. FUNDING: Humanities and Social Sciences Prestigious Fellowship (37000320) and the General Research Fund (17611619) at the University of Hong Kong

A high-performance self-powered broadband photodetector based on a CH3NH3PbI3 perovskite/ZnO nanorod array heterostructure

Here we report a self-powered photodetector based on a ZnO/CH3NH3PbI3 heterojunction and a MoO3 hole-transport layer. The organolead iodide perovskite photodetector is sensitive to broadband wavelengths from the ultraviolet light to the entire visible light region (250-800 nm), showing a high photo-responsivity of 24.3 A W-1 and a high detectivity value of 3.56 × 1014 cm Hz1/2 W-1 at 500 nm without external bias voltage. Meanwhile, we found that the photodetective performances are closely related to the thickness of the MoO3 layer, which acts as a hole-transport layer and an electron-blocking layer and can effectively decrease the recombination of holes and electrons. Additionally, the as-fabricated photodetector exhibits good stability and only 9.3% photoelectric response current decay after a 3-month illumination test. The high detectivity and responsivity of such a ZnO nanorod/perovskite heterojunction are clearly demonstrated and should be widely applicable to other photoelectric detection devices.Peer reviewe

Additional file 1 of Effectiveness of human immunodeficiency virus prevention strategies by mapping the geographic dispersion pattern of human immunodeficiency virus prevalence in Nanning, China

Supplementary Material 1

Provenance of aeolian sands in the Hetao Plain, northwestern China

Patches of aeolian sand are distributed throughout the Hetao Plain, which pose threats to farming and agriculture. Identification of the provenance of the aeolian sands may help with efforts to alleviate ecological stress in Inner Mongolia and in the paleoenvironmental interpretation of sandy sequences. This study uses geochemical data to determine the provenance of aeolian sands from the Hetao Plain. Provenance discrimination diagrams revealed that the aeolian sands were mainly derived from mixed source felsic granites and granodiorites, which have undergone weak sedimentary recycling. The chemical index of alteration and A–CN–K data indicated that the aeolian sediments were transported over a short distance. Comparison of trace element and rare earth element (REE) ratios of the aeolian sands with rock samples from potential source areas has revealed that aeolian sand deposits in the Hetao Plain were mainly derived from Sertengshan and Yellow River sediments. The Langshan and Ordos Plateau may represent additional sand sources for the Hetao Plain