Peran Kepuasan Nasabah Memediasi Corporate Social Responsibility dengan Loyalitas Nasabah (Studi pada Nasabah Bank Bni di Kota Denpasar)

This study was conducted to determine the role of customer satisfaction in mediating the effect of corporate social responsibility to the loyalty nasabahpada BNI bank customers in the city of Denpasar. The number of samples taken are as many as 100 respondents, using a non-probability sampling technique with purposive sampling method. Data collected through questionnaires. Data analysis techniques used in this research is the technique of path analysis (path analysis) which is an extension of the multiple linear regression analysis is useful for estimating the causal relationships between variables are then issued in the form of SPSS software for windows. These results indicate that customer satisfaction has a significant impact in mediating the effect of corporate social responsibility on customer loyalty in BNI bank in Denpasar. The implications of this study are advised to BNI bank in Denpasar in order to communicate the CSR activities that have been done in order to further increase customer satisfaction and customer loyalty increase

Perbandingan Pendapatan USAhatani Padimenggunakan Sistem Tanam Jajar Legowo Dengan Sistem Tanam Sri ( System of Rice Intensification) ( Studi Kasus Di Subak Giri Desa Bungbungan, Kecamatan Banjarangkan Kabupaten Klungkung)

This study aims to: (1) Funding and acceptance rice farming which uses the system of planting Jajar Legowo with SRI planting system; (2) Analyze the rice farming income ratio that uses Jajar Legowo planting system with SRI planting system; and (3) Constraints faced by farmers in the village of the District Bungbungan Banjarangkan, Klungkung in implementing or managing rice farming which uses Jajar Legowo planting system with SRI planting system. Determination of the respondents using Proportional Random Sampling method is 15% taken from each population that is 30 respondents to Legowo row planting system and 30 den response to SRI method of planting. The results showed that farm income using Legowo row planting system is Rp.17.032.100 / 1 hectare / season planting and cropping system SRI is 17.0911.000 / 1 hectare / growing season. T-test results showed that Legowo row planting system is not significantly different from rice farming income using SRI planting system. Based on the findings in this study it is suggested that the government's role as supervisor of the field is further enhanced by providing instructor-educator on how to combat pests and method of application of the system of rice farming in order to obtain maximum results and to improve the income of rice farming is advisable to minimize the obstacles encountered farmers with the provision of the means of production through the development of cooperatives and provide more intensive counseling especially on pests and diseases

Gross genomic damage measured by DNA image cytometry independently predicts gastric cancer patient survival

BACKGROUND: DNA aneuploidy reflects gross genomic changes. It can be measured by flow cytometry (FCM-DNA) or image cytometry (ICM-DNA). In gastric cancer, the prevalence of DNA aneuploidy has been reported to range from 27 to 100%, with conflicting associations with clinicopathological variables. The aim of our study was to compare the DNA ploidy status measured using FCM-DNA and ICM-DNA in gastric cancer and to evaluate its association with clinicopathological variables. METHODS: Cell nuclei were isolated from 221 formalin-fixed, paraffin-embedded gastric cancer samples. DNA ploidy was assessed using FCM-DNA and ICM-DNA. RESULTS: A total of 178 (80.5%) gastric cancer samples were classified as DNA aneuploid using FCM-DNA, compared with 172 (77.8%) gastric cancer samples when using ICM-DNA. Results obtained from both methods were concordant in 183 (82.8%) cases (kappa = 0.48). Patients with ICM-DNA diploid gastric cancer survived significantly longer than those with ICM-DNA aneuploid gastric cancer (log rank 10.1, P = 0.001). For FCM-DNA data, this difference did not reach statistical significance. The multivariate Cox model showed that ICM-DNA ploidy status predicted patient survival independently of tumour-node-metastasis status. CONCLUSION: ICM-DNA ploidy status is an independent predictor of survival in gastric cancer patients and may therefore be a more clinically relevant read out of gross genomic damage than FCM-DNA. British Journal of Cancer (2009) 101, 1011-1018. doi:10.1038/sj.bjc.6605266 www.bjcancer.com (C) 2009 Cancer Research U

Genetic Evidence Supporting the Association of Protease and Protease Inhibitor Genes with Inflammatory Bowel Disease: A Systematic Review

As part of the European research consortium IBDase, we addressed the role of proteases and protease inhibitors (P/PIs) in inflammatory bowel disease (IBD), characterized by chronic mucosal inflammation of the gastrointestinal tract, which affects 2.2 million people in Europe and 1.4 million people in North America. We systematically reviewed all published genetic studies on populations of European ancestry (67 studies on Crohn's disease [CD] and 37 studies on ulcerative colitis [UC]) to identify critical genomic regions associated with IBD. We developed a computer algorithm to map the 807 P/PI genes with exact genomic locations listed in the MEROPS database of peptidases onto these critical regions and to rank P/PI genes according to the accumulated evidence for their association with CD and UC. 82 P/PI genes (75 coding for proteases and 7 coding for protease inhibitors) were retained for CD based on the accumulated evidence. The cylindromatosis/turban tumor syndrome gene (CYLD) on chromosome 16 ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4), all located on chromosome 3. For UC, 18 P/PI genes were retained (14 proteases and 4protease inhibitors), with a considerably lower amount of accumulated evidence. The ranking of P/PI genes as established in this systematic review is currently used to guide validation studies of candidate P/PI genes, and their functional characterization in interdisciplinary mechanistic studies in vitro and in vivo as part of IBDase. The approach used here overcomes some of the problems encountered when subjectively selecting genes for further evaluation and could be applied to any complex disease and gene family

Cellular and molecular mechanisms of endothelial dysfunction in diabetes.

In healthy individuals, the vascular endothelium regulates an intricate balance of factors that maintain vascular homeostasis and normal arterial function. Functional disruption of the endothelium is known to be an early event that underlies the development of subsequent cardiovascular disease (CVD) including atherosclerosis and coronary heart disease. In addition, the rising global epidemic of type 2 diabetes is a significant problem conferring a significantly higher risk of CVD to individuals in whom endothelial dysfunction is also notable. This review first summarises the role of endothelium in health and explores and evaluates the impact of diabetes on endothelial function. The characteristic features of insulin resistance and other metabolic disturbances that may underlie long-term changes in vascular endothelial function (metabolic memory) are described along with proposed cellular, molecular and epigenetic mechanisms. Through understanding the underlying mechanisms, novel targets for future therapies to restore endothelial homeostasis and 'drive' a reparative cellular phenotype are explored