Interpretable Sequence Clustering

Categorical sequence clustering plays a crucial role in various fields, but the lack of interpretability in cluster assignments poses significant challenges. Sequences inherently lack explicit features, and existing sequence clustering algorithms heavily rely on complex representations, making it difficult to explain their results. To address this issue, we propose a method called Interpretable Sequence Clustering Tree (ISCT), which combines sequential patterns with a concise and interpretable tree structure. ISCT leverages k-1 patterns to generate k leaf nodes, corresponding to k clusters, which provides an intuitive explanation on how each cluster is formed. More precisely, ISCT first projects sequences into random subspaces and then utilizes the k-means algorithm to obtain high-quality initial cluster assignments. Subsequently, it constructs a pattern-based decision tree using a boosting-based construction strategy in which sequences are re-projected and re-clustered at each node before mining the top-1 discriminative splitting pattern. Experimental results on 14 real-world data sets demonstrate that our proposed method provides an interpretable tree structure while delivering fast and accurate cluster assignments.Comment: 11 pages, 6 figure

Experimental realization of chiral Landau levels in two-dimensional Dirac cone systems with inhomogeneous effective mass

Chiral zeroth Landau levels are topologically protected bulk states that give rise to chiral anomaly. Previous discussions on such chiral Landau levels are based on three-dimensional Weyl degeneracies. Their realizations using two-dimensional Dirac point systems, being more promising for future applications, were never reported before. Here we propose a theoretical and experimental scheme for realizing chiral Landau levels in a photonic system. By introducing an inhomogeneous effective mass through breaking local parity inversion symmetries, the zeroth-order chiral Landau levels with one-way propagation characteristics are experimentally observed. In addition, the robust transport of the chiral zeroth mode against defects in the system is experimentally tested. Our system provides a new pathway for the realization of chiral Landau levels in two-dimensional Dirac systems, and may potentially be applied in device designs utilizing the transport robustness

Experimental demonstration of non-adjacent band topology connecting multiple nodal links

Nodal links are special configurations of band degeneracies in the momentum space, where nodal line branches encircle each other. In PT symmetric systems, nodal lines can be topologically characterized using the eigenvector frame rotations along an encircling loop and the linking structure can be described with non-Abelian frame charges interacting among adjacent bands. In this paper, we present a photonic multiple nodal links system, where non-adjacent band topology is proposed to characterize the hidden relation between nodal lines from non-adjacent band pairs. Through an orthogonal nodal chain, the nodal line from the lower two bands predicts the existence of nodal lines formed between the higher bands. We designed and fabricated a metamaterial, with which the multiple nodal links and non-adjacent band topology are experimentally demonstrated

Experimental observation of non-Abelian earring nodal links in phononic crystals

Nodal lines are symmetry-protected one-dimensional band degeneracies in momentum space, which can appear in numerous topological configurations such as nodal rings, chains, links, and knots. Very recently, non-Abelian topological physics has been proposed in space-time inversion (PT) symmetric systems, and attract widespread attention. One of the most special configurations in non-Abelian system is the earring nodal link, composing of a nodal chain linking with an isolated nodal line, is signature of non-Abelian topology and cannot be elucidated using Abelian topological classifications. However, the earring nodal links have not been yet observed in real system. Here we design the phononic crystals with earring nodal links, and verify its non-Abelian topologicial charge in full-wave simulations. Moreover, we experimentally observed two different kinds of earring nodal links by measuring the band structures for two phononic crystals. Specifically, we found that the order of the nodal chain and line can switch after band inversion but their link cannot be severed. Our work provides experimental evidence for phenomena unique to non-Abelian band topology and our simple acoustic system provides a convenient platform for studying non-Abelian charges.Comment: 14 pages, 3 figure

Synthesis, structural and chemosensitivity studies of arena d6 metal complexes having N-phenyl-N'-(pyridyl/pyrimidyl) thiourea derivatives

The d6 metal complexes of thiourea derivatives were synthesized to investigate its cytotoxicity. Treatment of various N‐phenyl‐N ́ pyridyl/pyrimidyl thiourea ligands with half‐sandwich d6 metal precursors yielded a series of cationic com- plexes. Reactions of ligand (L1‐L3) with [(p‐cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) led to the formation of a series of cationic complexes bearing gen- eral formula [(arene)M(L1)к2(N,S)Cl]+, [(arene)M(L2)к2(N,S)Cl]+ and [(arene) M(L3)к2(N,S)Cl]+ [arene = p‐cymene, M = Ru (1, 4, 7); Cp*, M = Rh (2, 5, 8); Cp*, Ir (3, 6, 9)]. These compounds were isolated as their chloride salts. X‐ray crystallographic studies of the complexes revealed the coordination of the ligands to the metal in a bidentate chelating N,S‐ manner. Further the cytotox- icity studies of the thiourea derivatives and its complexes evaluated against HCT‐116 (human colorectal cancer), MIA‐PaCa‐2 (human pancreatic cancer) and ARPE‐19 (non‐cancer retinal epithelium) cancer cell lines showed that the thiourea ligands displayed no activity. Upon complexation however, the metal compounds possesses cytotoxicity and whilst potency is less than cisplatin, several complexes exhibited greater selectivity for HCT‐116 or MIA‐ PaCa‐2 cells compared to ARPE‐19 cells than cisplatin in vitro. Rhodium complexes of thiourea derivatives were found to be more potent as compared to ruthenium and iridium complexes.<br/

Quantum Cognitive Modeling: New Applications and Systems Research Directions

Expanding the benefits of quantum computing to new domains remains a challenging task. Quantum applications are concentrated in only a few domains, and driven by these few, the quantum stack is limited in supporting the development or execution demands of new applications. In this work, we address this problem by identifying both a new application domain, and new directions to shape the quantum stack. We introduce computational cognitive models as a new class of quantum applications. Such models have been crucial in understanding and replicating human intelligence, and our work connects them with quantum computing for the first time. Next, we analyze these applications to make the case for redesigning the quantum stack for programmability and better performance. Among the research opportunities we uncover, we study two simple ideas of quantum cloud scheduling using data from gate-based and annealing-based quantum computers. On the respective systems, these ideas can enable parallel execution, and improve throughput. Our work is a contribution towards realizing versatile quantum systems that can broaden the impact of quantum computing on science and society

MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells

Stem cell transplantation is one of most valuable methods in the treatment of myocardial infarction, and adipose-derived stem cells (ASCs) are becoming a hot topic in medical research. Previous studies have shown that ASCs can be differentiated into cardiomyocyte-like cells, but the efficiency and survival rates are low. We investigated the role and mechanism of microRNA-1 (miR-1) in the differentiation of ASCs into cardiomyocyte-like cells. ASCs and cardiomyocytes were isolated from neonatal rats. We constructed lentivirus for overexpressing miR-1 and used DAPT, an antagonist of the Notch1 pathway, for in vitro analyses. We performed cocultures with ASCs and cardiomyocytes. The differentiation efficiency of ASCs was detected by cell-specific surface antigens. Our results showed that miR-1 can promote the expression of Notch1 and reduce the expression of Hes1, a Notch pathway factor, and overexpression of miR-1 can promote the differentiation of ASCs into cardiomyocyte-like cells, which may occur by regulating Notch1 and Hes1