Magnetically frustrated synthetic end member Mn2(PO4)OH in the triplite-triploidite family

The manganese end member of triplite-triploidite series of compounds, Mn2(PO4)OH, is synthesized by a hydrothermal method. Its crystal structure is refined in the space group P21/c with a = 12.411(1) Å, b = 13.323(1) Å, c = 10.014(1) Å, β = 108.16(1), V = 1573.3 Å3, Z = 8, and R = 0.0375. Evidenced in measurements of magnetization M and specific heat Cp, Mn2(PO4)OH reaches a long range antiferromagnetic order at TN = 4.6 K. As opposed to both triplite Mn2(PO4)F and triploidite-type Co2(PO4)F, the title compound is magnetically frustrated being characterized by the ratio of Curie-Weiss temperature Θ to Néel temperature TN of about 20. The large value of frustration strength Θ/TN stems from the twisted saw tooth chain geometry of corner sharing triangles of Mn polyhedra, which may be isolated within tubular fragments of a triploidite crystal structure. © 2017 The Royal Society of Chemistry.We thank E. V. Guseva for the X-ray spectral analysis of the sample and N. V. Zubkova for her help in the X-ray experiment. This work was supported by the Ministry of Education and Science of the Russian Federation in the framework of Increase Competitiveness Program of NUST "MISiS" project K2-2016-066 and by RFBR projects 15-05-06742, 16-02-00021 and 17-02-00211. The work was supported by Act 211 Government of the Russian Federation, contracts 02.A03.21.0004, 02.A03.21.0006 and 02.A03.21.0011

A Novel Mineral-like Copper Phosphate Chloride with a Disordered Guest Structure: Crystal Chemistry and Magnetic Properties

Novel copper phosphate chloride has been obtained under middle-temperature hydrothermal conditions. Its crystal structure was established based on the low-temperature X-ray diffraction data: Na2 Li0.75 (Cs,K)0.5 [Cu5 (PO4)4 Cl]·3.5(H2 O,OH), sp. gr. C2/m, a = 19.3951(8) Å, b = 9.7627(3) Å, c = 9.7383(4) Å, β = 99.329(4)◦, T = 150 K, MoKα (λ = 0.71073 Å), R = 0.049. The crystal structure includes tetrameric copper clusters as the main building blocks, which are built of four CuO4 Cl pyra-mids sharing apical Cl vertices. The clusters are combined through phosphate groups and additional copper-centered polyhedra to form two mostly ordered periodic layers. between the layers and inside the framework channels, alkali ions, H2 O molecules, or OH groups are statistically distributed. Na2 Li0.75 (Cs,K)0.5 [Cu5 (PO4)4 Cl]·3.5(H2 O,OH) is a synthetic modification of a sampleite-polymorph of the lavendulan mineral group and represents a new member in a mero-plesiotype series of copper phosphates and arsenates, for which the crystal structures contain two-periodic [Cu4 X(TO4)4 ]∞ modules (T = As, P; X = Cl, O). Magnetically, this phase exhibits the phase transition at TC = 6.5 K, below which it possesses a weak ferromagnetic moment. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This work, in part of magnetic measurements, was supported by the Megagrant Program of the Government of the Russian Federation, project 075-15-2021-604. The crystal chemical research was provided by state budget research project AAAA-A16-116033010121-7, N 6-5

Breaking of chalk fallen onto the floor

This problem was presented at the IPT 2022. The main goal was to find out What is the maximum height a piece of chalk might be dropped without breaking for a given surface, estimate parameters on which the height depends and suggest throwing techniques which minimize the breakage probabilit

КЛИНИКО-ЭПИДЕМИОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ГРУППОВОЙ ЗАБОЛЕВАЕМОСТИ ЭНТЕРОВИРУСНОЙ ИНФЕКЦИЕЙ КОКСАКИ А 16 У ДЕТЕЙ

Federal Service on Customers' Rights Protection and Human Well-Being Surveillance in Orenburg Region, Orenburg The authors presented the results of the clinical and epidemiological analysis of enterovirus coxsackievirus A-16 group morbidity among kindergarten children in the Orenburg region occurring in the form of the syndrome of ≪hand-foot-mouth≫ with exantem. 20 children were involved in the epidemic process, 72,2% of the children are 1—2 years old, they became a source of infection to other groups of children. The disease had a mild course and did not require special treatment.Представлены результаты клинико-эпидемиологического анализа групповой заболеваемости детей детского сада Оренбургской области энтеровирусной инфекцией Коксаки А16, протекавшей с экзантемой в виде синдрома «рука-нога-рот». В эпидемический процесс было вовлечено 20 детей, из них 72,2% детей 1—2 лет, ставших источниками распространения инфекции в другие группы детей. Заболевание имело легкое течение и не требовало специального лечения

Berry phases for the nonlocal Gross-Pitaevskii equation with a quadratic potential

A countable set of asymptotic space -- localized solutions is constructed by the complex germ method in the adiabatic approximation for the nonstationary Gross -- Pitaevskii equation with nonlocal nonlinearity and a quadratic potential. The asymptotic parameter is 1/T, where $T\gg1$ is the adiabatic evolution time. A generalization of the Berry phase of the linear Schr\"odinger equation is formulated for the Gross-Pitaevskii equation. For the solutions constructed, the Berry phases are found in explicit form.Comment: 13 pages, no figure

The of method of xenon therapies in obstetrics

The purpose of work: to prove application of a method of xenon’s therapy for treatment of stress at women in during labors. Research is executed on 10 healthy volunteers - 10 women. Subsequently, after the informed consent, sessions xenon’s therapies have been executed at 11 first labor women before labors with the purpose preventive of labor’s stress, the group of the control has made 10 women. The control of gas structure of a respiratory mix was carried out by means of gas analyzer GKM-03-«INSOVT». Diagnostics of stress and adaptable reactions was spent on parameters of leukocytes formulas. Studying of jet and personal alarm was carried out by means of psychological CH.D.Spielberg's techniques - by JU.L.Khanin. Researches were carried out up to labor before procedure of xenon’s therapy and day after labor. The received results testify that procedure of xenon therapies by duration till 3 minutes is safe, the maintenance of oxygen in an inhaled mix does not fall below 21 %, and xenon’s inhalations possess antistressor effect and can be used for preventive of labor stress at women.Цель исследования: обосновать применение метода терапии ксеноном для лечения стресса у женщин в родах. Первоначально исследование было проведено на 10 женщинах-добровольцах в отделении гинекологии в день оперативного вмешательства. В дальнейшем с целью профилактики родового стресса, после информированного согласия, перед родами были проведены сеансы кислородно-ксеноновой смесью у 11 беременных первородящих женщин. Контрольная группа первородящих женщин включала 10 человек. Контроль газового состава дыхательной смеси осуществлялся с помощью газоанализатора ГКМ-ОЗ-ИНСОВТ. Диагностика стресса и адаптационных реакций проводилась по показателям лейкоцитарной формулы. Изучение реактивной и личностной тревоги осуществлялось с помощью психодиагностической методики Ч.Д. Спилберга - Ю.Л. Ханина. Исследования выполнялись до родов перед процедурой терапии ксеноном и через сутки после родов. Полученные результаты свидетельствуют о том, что процедура ксеноновой терапии длительностью до Зх минут является безопасной, т.к. содержание кислорода во вдыхаемой смеси не опускается ниже 21%, а сами ксеноновые ингаляции обладают антистрессорным эффектом и могут быть использованы для профилактики родового стресса беременных женщин

The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila

Activation of the forkhead box transcription factor FoxO is suggested to be involved in dopaminergic (DA) neurodegeneration in a Drosophila model of Parkinson's disease (PD), in which a PD gene product LRRK2 activates FoxO through phosphorylation. In the current study that combines Drosophila genetics and biochemical analysis, we show that cyclic guanosine monophosphate (cGMP)-dependent kinase II (cGKII) also phosphorylates FoxO at the same residue as LRRK2, and Drosophila orthologues of cGKII and LRRK2, DG2/For and dLRRK, respectively, enhance the neurotoxic activity of FoxO in an additive manner. Biochemical assays using mammalian cGKII and FoxO1 reveal that cGKII enhances the transcriptional activity of FoxO1 through phosphorylation of the FoxO1 S319 site in the same manner as LRRK2. A Drosophila FoxO mutant resistant to phosphorylation by DG2 and dLRRK (dFoxO S259A corresponding to human FoxO1 S319A) suppressed the neurotoxicity and improved motor dysfunction caused by co-expression of FoxO and DG2. Nitric oxide synthase (NOS) and soluble guanylyl cyclase (sGC) also increased FoxO's activity, whereas the administration of a NOS inhibitor L-NAME suppressed the loss of DA neurons in aged flies co-expressing FoxO and DG2. These results strongly suggest that the NO-FoxO axis contributes to DA neurodegeneration in LRRK2-linked PD

Can social protection improve sustainable development goals for adolescent health?

Background The first policy action outlined in the Sustainable Development Goals (SDGs) is the implementation of national social protection systems. This study assesses whether social protection provision can impact 17 indicators of five key health-related SDG goals amongst adolescents in South Africa. Methods We conducted a longitudinal survey of adolescents (10-18 years) between 2009 and 2012. Census areas were randomly selected in two urban and two rural health districts in two South African provinces, including all homes with a resident adolescent. Household receipt of social protection in the form of ‘cash’ (economic provision) and ‘care’ (psychosocial support) social protection, and health-related indicators within five SDG goals were assessed. Gender-disaggregated analyses included multivariate logistic regression, testing for interactions between social protection and socio-demographic covariates, and marginal effects models. Findings Social protection was associated with significant adolescent risk reductions in 12 of 17 gender-disaggregated SDG indicators, spanning SDG 2 (hunger); SDG 3 (AIDS, tuberculosis, mental health and substance abuse); SDG 4 (educational access); SDG 5 (sexual exploitation, sexual and reproductive health); and SDG 16 (violence perpetration). For six of 17 indicators, combined cash plus care showed enhanced risk reduction effects. Two interactions showed that effects of care varied by poverty level for boys’ hunger and girls’ school dropout. For tuberculosis, and for boys’ sexual exploitation and girls’ mental health and violence perpetration, no effects were found and more targeted or creative means will be needed to reach adolescents on these challenging burdens. Interpretation National social protection systems are not a panacea, but findings suggest that they have multiple and synergistic positive associations with adolescent health outcomes. Such systems may help us rise to the challenges of health and sustainable development.</p