Emerging strengths in Asia Pacific bioinformatics

The 2008 annual conference of the Asia Pacific Bioinformatics Network (APBioNet), Asia's oldest bioinformatics organisation set up in 1998, was organized as the 7th International Conference on Bioinformatics (InCoB), jointly with the Bioinformatics and Systems Biology in Taiwan (BIT 2008) Conference, Oct. 20–23, 2008 at Taipei, Taiwan. Besides bringing together scientists from the field of bioinformatics in this region, InCoB is actively involving researchers from the area of systems biology, to facilitate greater synergy between these two groups. Marking the 10th Anniversary of APBioNet, this InCoB 2008 meeting followed on from a series of successful annual events in Bangkok (Thailand), Penang (Malaysia), Auckland (New Zealand), Busan (South Korea), New Delhi (India) and Hong Kong. Additionally, tutorials and the Workshop on Education in Bioinformatics and Computational Biology (WEBCB) immediately prior to the 20th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Taipei Conference provided ample opportunity for inducting mainstream biochemists and molecular biologists from the region into a greater level of awareness of the importance of bioinformatics in their craft. In this editorial, we provide a brief overview of the peer-reviewed manuscripts accepted for publication herein, grouped into thematic areas. As the regional research expertise in bioinformatics matures, the papers fall into thematic areas, illustrating the specific contributions made by APBioNet to global bioinformatics efforts

Characterisation of Volatile Organic Compounds at Hotels in Southern China

In the recent years, there has been a dramatic growth in the development of hotels in Southern China to meet the rapid demand of business and tourism industry. The indoor air quality of the hotels has become an important consideration due to a large workforce that is engaged in this industry. The objective of this study was to characterise the volatile organic compounds (VOCs) found in the indoor air in 13 new hotels in Southern China and assess their possible health impact. A 2-day non-simultaneous sampling was carried out in each of the hotels. Decorating materials, cleansing agents and even local regional pollutants outside the hotels could have a contribution and worsen indoor air quality. Toluene level was as high as 498 mu g m(-3) in a hotel fitted with lots of plywood products. The highest concentrations of methylene chloride (34 mu g m(-3)) and total carbonyls (517 mu g m(-3)) were detected in a hotel where high VOCs cleansing agents were used in guest rooms. In a hotel located in an industrial centre, acetone concentration of 102 mu g m(-3) was found. The second highest total VOCs concentration (445 mu g m(-3)) was observed in a newly renovated hotel. Wooden interior fixtures and wall panels were identified as the major sources of VOCs and carbonyls found inside the guest rooms

Search for supersymmetry in pp collisions at in events with a single lepton, large jet multiplicity, and multiple b jets

Results are reported from a search for supersymmetry in pp collisions at a center-of-mass energy of 8 TeV, based on events with a single isolated lepton (electron or muon) and multiple jets, at least two of which are identified as b jets. The data sample corresponds to an integrated luminosity of 19.3 fb(-1) recorded by the CMS experiment at the LHC in 2012. The search is motivated by supersymmetric models that involve strong-production processes and cascade decays of new particles. The resulting final states contain multiple jets as well as missing transverse momentum from weakly interacting particles. The event yields, observed across several kinematic regions, are consistent with the expectations from standard model processes. The results are interpreted in the context of simplified supersymmetric scenarios with pair production of gluinos, where each gluino decays to a top quark-antiquark pair and the lightest neutralino. For the case of decays via virtual top squarks, gluinos with a mass smaller than 1.26 TeV are excluded for low neutralino masses

Searches for supersymmetry based on events with b jets and four W bosons in pp collisions at 8 TeV

Five mutually exclusive searches for supersymmetry are presented based on events in which b jets and four W bosons are produced in proton-proton collisions at root s = 8TeV. The data, corresponding to an integrated luminosity of 19.5 fb(-1), were collected with the CMS experiment at the CERN LHC in 2012. The five studies differ in the leptonic signature from the W boson decays, and correspond to all-hadronic, single-lepton, opposite-sign dilepton, same-sign dilepton, and >= 3 lepton final states. The results of the five studies are combined to yield 95% confidence level limits for the gluino and bottom-squark masses in the context of gluino and bottom-squark pair production, respectively. In the limit when the lightest supersymmetric particle is light, gluino and bottom squark masses are excluded below 1280 and 570 GeV, respectively

Search for excited quarks in the gamma plus jet final state in proton-proton collisions at root s=8 TeV

A search for excited quarks decaying into the gamma + jet final state is presented. The analysis is based on data corresponding to an integrated luminosity of 19.7 fb(-1) collected by the CMS experiment in proton-proton collisions at root s = 8 TeV at the LHC. Events with photons and jets with high transverse momenta are selected and the gamma + jet invariant mass distribution is studied to search for a resonance peak. The 95% confidence level upper limits on the product of cross section and branching fraction are evaluated as a function of the excited quark mass. Limits on excited quarks are presented as a function of their mass and coupling strength; masses below 3.5 TeV are excluded at 95% confidence level for unit couplings to their standard model partners

Measurement of the ratio B(t -> Wb)/B(t -> Wq) in pp collisions at root s=8 TeV

The ratio of the top-quark branching fractions R = B(t --> Wb)/B(t --> Wq), where the denominator includes the sum over all down-type quarks (q = b, s, d), is measured in the t (t) over bar dilepton final state with proton-proton collision data at root s = 8 TeV from an integrated luminosity of 19.7 fb(-1), collected with the CMS detector. In order to quantify the purity of the signal sample, the cross section is measured by fitting the observed jet multiplicity, thereby constraining the signal and background contributions. By counting the number of b jets per event, an unconstrained value of R = 1.014 +/- 0.003 (stat.) +/- 0.032 (syst.) is measured, in a good agreement with current precision measurements in electroweak and flavour sectors. A lower limit R > 0.955 at the 95% confidence level is obtained after requiring R 0.975 is set at 95% confidence level. The result is combined with a previous CMS measurement of the t-channel single-top-quark cross section to determine the top-quark total decay width, Gamma(t) = 1.36 +/- 0.02 (stat.)(-0.11)(+0.14) (syst.) GeV